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The map label for this gene is nuoN [H]

Identifier: 124027087

GI number: 124027087

Start: 169766

End: 171277

Strand: Direct

Name: nuoN [H]

Synonym: Hbut_0190

Alternate gene names: 124027087

Gene position: 169766-171277 (Clockwise)

Preceding gene: 124027086

Following gene: 124027088

Centisome position: 10.18

GC content: 58.86

Gene sequence:

>1512_bases
GTGGCCAGCGGAGTGGAGACAGTTACCCTTAGCGCTCCTCTGCTCTGGCTGGCAGTGGCAGCCCCAATAGCAGCTGGCAT
TGTAAGCGGCTTCGCTGGCCGCAGCATCAGCGCTAAGGGCCACACAGCGCTAGCTACAGTGTCGTGGCTTGTATCGCTGC
TACTCCTATTCCCAGCCCTAGGCCACGCACTCGCAGGCAGGGTTGTAGTCGACCCATTTTACGGGGAGGTGCCAGGCCTA
GGTGTATTCGCCCTGTTCATGGATGCGGTGTCAGCCATACTGGCGCTGAGCGTTGTGCTGGTAAGCCTCATCATAGCAGT
GTATAGTAGGCCATACATGGAGCACCGCTTTGAGGAACTCGGCGGCGGGAGCTGGGGCACCTACTTCCTACTATACCAGC
TATTCACAGCCGGCATGCTGGGCGCAGTACTAGCCAGTAACACTATCCTCTTCTACCTCTTCCTAGAGCTCACCTTAATA
CCAAGTGGCCTCCTCATAGCGCTATACGGGTATGGGGATCGGCTGAGGGTAGCCCTCCTATACCTAGTCTGGACCCACGT
CGGCACACTGCTGTACCTGCTCGGCGTATTCATCTCCGGGGCCTACGACATCTACGTGCCTGATACCGGCTACACAGTGG
CAGCATTCACTGGACTACTGCCGCTAGCACTGATAATTGTTGGGCTCGGCGTAAAGATGGCTATGGCTGGCATACACTTC
TGGCTCCCCTACGCCCACGCAGAAGCACCAACACCAGTCTCAGCACTACTATCCCCACTCTTCATCGGCGTTGGTGGCTA
TGCGTTATTCCGCGTTGGCGTAGGCATGTTCCAGGCTGACTGGGCCACGCTACGCCCCATACTGTTCGCCTGGGCGGTAG
CGACAATGCTCTACGGTGGCTTCCTTGTGCTGGTACAGCAGGATGTCAAGAGGCTCTTCGCCTACAGCAGTATATCCCAG
ATGGGCTACATTATGCTCGGACTCTCCGTAGCAAACCCCGAGGCTGAGGCAGGAGCAATACTCCACTACATGTCCCACGC
GCTGGGCAAGGCAATCCTCTTCGGCGTCGCCGGTGTCTTCATCGTGGCGCTCGGCACGAGGAATATCAGGGAGATGGGTG
GCCTCCTAGGCGTGATGCCCTACACCGGCAGCATAGCCCTGACAGGCTTCATGCTCATCTCGGGGCTACCGCCAACCCTC
GGTATGTGGAGCGAGGTGCTCCTAGTATTCGGCTACGCCAAGTGGGCAATGGGTCTCGGGCTAGGACTCTTCCTGCTAAC
AGCTGCTCTCGTGGCAGCAGCCATGTCGCTCACCGTTGTCTACAGTTTCCAGACCTTCCGCCTCGTATTCCTCGGCCGCC
GTGGCCCGGCAGCCGAGCGGGGCGGGGAGAGCCACGCATCCAGCCTCATAGCCCCCTTGTTGGCCCTCGCGGTTCTCGGT
GTCACCCTGTTTGTTGCTGCGGGTGTACTCGTGGATCCACTCGTAGACTTCCTAAGGGTGGTGTATGGCTAG

Upstream 100 bases:

>100_bases
AGCCGAGATAGCCATAGTTATCGCGCTCACCGTGCTCGCGTTTAGGAAAAAGCAGAGCCTGGATATGGAGTCCATGACCG
AGGCGAGGGGGTGAGCCGTG

Downstream 100 bases:

>100_bases
GGGGTGATGCCTAATGGTTGAGCCTGGCGTTGCAGCTCTCGTGGCGGTGTTCGCGGAGTATGCCGCGGCACTTGTAGCCC
TACTGCTGGGTGCTGCTGGA

Product: NADH-quinone oxidoreductase chain M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MASGVETVTLSAPLLWLAVAAPIAAGIVSGFAGRSISAKGHTALATVSWLVSLLLLFPALGHALAGRVVVDPFYGEVPGL
GVFALFMDAVSAILALSVVLVSLIIAVYSRPYMEHRFEELGGGSWGTYFLLYQLFTAGMLGAVLASNTILFYLFLELTLI
PSGLLIALYGYGDRLRVALLYLVWTHVGTLLYLLGVFISGAYDIYVPDTGYTVAAFTGLLPLALIIVGLGVKMAMAGIHF
WLPYAHAEAPTPVSALLSPLFIGVGGYALFRVGVGMFQADWATLRPILFAWAVATMLYGGFLVLVQQDVKRLFAYSSISQ
MGYIMLGLSVANPEAEAGAILHYMSHALGKAILFGVAGVFIVALGTRNIREMGGLLGVMPYTGSIALTGFMLISGLPPTL
GMWSEVLLVFGYAKWAMGLGLGLFLLTAALVAAAMSLTVVYSFQTFRLVFLGRRGPAAERGGESHASSLIAPLLALAVLG
VTLFVAAGVLVDPLVDFLRVVYG

Sequences:

>Translated_503_residues
MASGVETVTLSAPLLWLAVAAPIAAGIVSGFAGRSISAKGHTALATVSWLVSLLLLFPALGHALAGRVVVDPFYGEVPGL
GVFALFMDAVSAILALSVVLVSLIIAVYSRPYMEHRFEELGGGSWGTYFLLYQLFTAGMLGAVLASNTILFYLFLELTLI
PSGLLIALYGYGDRLRVALLYLVWTHVGTLLYLLGVFISGAYDIYVPDTGYTVAAFTGLLPLALIIVGLGVKMAMAGIHF
WLPYAHAEAPTPVSALLSPLFIGVGGYALFRVGVGMFQADWATLRPILFAWAVATMLYGGFLVLVQQDVKRLFAYSSISQ
MGYIMLGLSVANPEAEAGAILHYMSHALGKAILFGVAGVFIVALGTRNIREMGGLLGVMPYTGSIALTGFMLISGLPPTL
GMWSEVLLVFGYAKWAMGLGLGLFLLTAALVAAAMSLTVVYSFQTFRLVFLGRRGPAAERGGESHASSLIAPLLALAVLG
VTLFVAAGVLVDPLVDFLRVVYG
>Mature_502_residues
ASGVETVTLSAPLLWLAVAAPIAAGIVSGFAGRSISAKGHTALATVSWLVSLLLLFPALGHALAGRVVVDPFYGEVPGLG
VFALFMDAVSAILALSVVLVSLIIAVYSRPYMEHRFEELGGGSWGTYFLLYQLFTAGMLGAVLASNTILFYLFLELTLIP
SGLLIALYGYGDRLRVALLYLVWTHVGTLLYLLGVFISGAYDIYVPDTGYTVAAFTGLLPLALIIVGLGVKMAMAGIHFW
LPYAHAEAPTPVSALLSPLFIGVGGYALFRVGVGMFQADWATLRPILFAWAVATMLYGGFLVLVQQDVKRLFAYSSISQM
GYIMLGLSVANPEAEAGAILHYMSHALGKAILFGVAGVFIVALGTRNIREMGGLLGVMPYTGSIALTGFMLISGLPPTLG
MWSEVLLVFGYAKWAMGLGLGLFLLTAALVAAAMSLTVVYSFQTFRLVFLGRRGPAAERGGESHASSLIAPLLALAVLGV
TLFVAAGVLVDPLVDFLRVVYG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=366, Percent_Identity=30.0546448087432, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI251831116, Length=282, Percent_Identity=28.0141843971631, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1788831, Length=315, Percent_Identity=29.5238095238095, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788827, Length=340, Percent_Identity=28.5294117647059, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788829, Length=363, Percent_Identity=30.5785123966942, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788613, Length=290, Percent_Identity=28.6206896551724, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1788614, Length=425, Percent_Identity=34.1176470588235, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI145693160, Length=248, Percent_Identity=29.4354838709677, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI2367154, Length=433, Percent_Identity=24.0184757505774, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53152; Mature: 53021

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGVETVTLSAPLLWLAVAAPIAAGIVSGFAGRSISAKGHTALATVSWLVSLLLLFPAL
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GHALAGRVVVDPFYGEVPGLGVFALFMDAVSAILALSVVLVSLIIAVYSRPYMEHRFEEL
HHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GGGSWGTYFLLYQLFTAGMLGAVLASNTILFYLFLELTLIPSGLLIALYGYGDRLRVALL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
YLVWTHVGTLLYLLGVFISGAYDIYVPDTGYTVAAFTGLLPLALIIVGLGVKMAMAGIHF
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPYAHAEAPTPVSALLSPLFIGVGGYALFRVGVGMFQADWATLRPILFAWAVATMLYGG
HHCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLVLVQQDVKRLFAYSSISQMGYIMLGLSVANPEAEAGAILHYMSHALGKAILFGVAGVF
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IVALGTRNIREMGGLLGVMPYTGSIALTGFMLISGLPPTLGMWSEVLLVFGYAKWAMGLG
HHHHCCCHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LGLFLLTAALVAAAMSLTVVYSFQTFRLVFLGRRGPAAERGGESHASSLIAPLLALAVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
VTLFVAAGVLVDPLVDFLRVVYG
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASGVETVTLSAPLLWLAVAAPIAAGIVSGFAGRSISAKGHTALATVSWLVSLLLLFPAL
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GHALAGRVVVDPFYGEVPGLGVFALFMDAVSAILALSVVLVSLIIAVYSRPYMEHRFEEL
HHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GGGSWGTYFLLYQLFTAGMLGAVLASNTILFYLFLELTLIPSGLLIALYGYGDRLRVALL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
YLVWTHVGTLLYLLGVFISGAYDIYVPDTGYTVAAFTGLLPLALIIVGLGVKMAMAGIHF
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPYAHAEAPTPVSALLSPLFIGVGGYALFRVGVGMFQADWATLRPILFAWAVATMLYGG
HHCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLVLVQQDVKRLFAYSSISQMGYIMLGLSVANPEAEAGAILHYMSHALGKAILFGVAGVF
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IVALGTRNIREMGGLLGVMPYTGSIALTGFMLISGLPPTLGMWSEVLLVFGYAKWAMGLG
HHHHCCCHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LGLFLLTAALVAAAMSLTVVYSFQTFRLVFLGRRGPAAERGGESHASSLIAPLLALAVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
VTLFVAAGVLVDPLVDFLRVVYG
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA