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The map label for this gene is fmt

Identifier: 124025755

GI number: 124025755

Start: 966259

End: 967269

Strand: Direct

Name: fmt

Synonym: NATL1_10481

Alternate gene names: 124025755

Gene position: 966259-967269 (Clockwise)

Preceding gene: 124025754

Following gene: 124025757

Centisome position: 51.82

GC content: 32.34

Gene sequence:

>1011_bases
GTGAAGATTGTTTTTTGGGGAACGCCTAAATATGCCGCAGAAAATTTAAGAACCATCGTTAAGGCCGGCTACGAAGTTAT
AGCTGTAGTTACACAACCAGACAGAAAGCGTGGAAGGGGCAAAAAATTGTCACCATCTCCAGTAAAAGAAGCTGCTGAAG
AACTATCCATACCTGTCTACGCAACACATTCAATAAGTAAAGATCAAAAAACAAAAGAGTTACTACTTAATTTGAAAGCT
GATGTTTATCTAGTTGTTGCTTTTGGTCAAATTCTTCCAAAAGAGATATTAGATCAGCCAAATCTTGGATGCTGGAATAG
CCACGCTTCTCTGCTTCCTGCTTGGAGAGGAGCAGCACCAATTCAGTGGAGCATAATTAATGCTGACACCAAGACTGGTA
TTTGTATTATGTCAATGGAAGAAGGCTTAGATACAGGACCAGTTATTGAACAAGAGTCAACAATTATAAAGGATTCAGAT
AATCTTGAGATACTTACTAATAGACTATCGAGAATGTCATCAAAACTTTTACTTAAGTCACTAGAAAAAATAAAGCTAAC
CAAAGGATTAAACAAATCATCAAGACTTAAAAAATTGAATGCAATTGACCAGACAAACTTAAAAGGTAGTCCAAGTTATG
CAAGACAAATAACAAAAGAAGACAATTTAATAGATTGGAATCAAGATGCAAAAAAGATAATAAAAAAAATTCAGGGATTA
TACCCAAATGCGTATACATTTTATAATGCTAAAAGAATAAAGATTTTAGAAGCAATCATATCTTCCGATAATAATCAATC
TAAAGAAAGTCAAGATATAAAAAATCAATCAAAAACAAATAGAATACCTGGAGAAATAATTATGATAAATAAACAAATTG
GTATAAAATTAATGACAAATGATTATCCTATTCTAATTAAATATGCACAGTTAGAAGGCAAAAAAGCAACAGACAGTTAT
ACGTTATCAATCCAGTCAAATCTTAGCATCAATGATAAACTTGGAAGCTAA

Upstream 100 bases:

>100_bases
TTTTATCAAGTATTGTAAAAATTGAAGATGAACAGATAGTTACACATCAAGGCATCAGCCCACATGTTTGGGTTGAGAAC
ATTTCAATTACTGGGGAAGC

Downstream 100 bases:

>100_bases
ACATTATTAATAGAACTATCCTTCTTTGAAAAGCCCCATATAAAAAGAAATAACATTACCAAGAAGAATAAATATTCAGG
TATAACTAATTTGAATAAAA

Product: putative methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKIVFWGTPKYAAENLRTIVKAGYEVIAVVTQPDRKRGRGKKLSPSPVKEAAEELSIPVYATHSISKDQKTKELLLNLKA
DVYLVVAFGQILPKEILDQPNLGCWNSHASLLPAWRGAAPIQWSIINADTKTGICIMSMEEGLDTGPVIEQESTIIKDSD
NLEILTNRLSRMSSKLLLKSLEKIKLTKGLNKSSRLKKLNAIDQTNLKGSPSYARQITKEDNLIDWNQDAKKIIKKIQGL
YPNAYTFYNAKRIKILEAIISSDNNQSKESQDIKNQSKTNRIPGEIIMINKQIGIKLMTNDYPILIKYAQLEGKKATDSY
TLSIQSNLSINDKLGS

Sequences:

>Translated_336_residues
MKIVFWGTPKYAAENLRTIVKAGYEVIAVVTQPDRKRGRGKKLSPSPVKEAAEELSIPVYATHSISKDQKTKELLLNLKA
DVYLVVAFGQILPKEILDQPNLGCWNSHASLLPAWRGAAPIQWSIINADTKTGICIMSMEEGLDTGPVIEQESTIIKDSD
NLEILTNRLSRMSSKLLLKSLEKIKLTKGLNKSSRLKKLNAIDQTNLKGSPSYARQITKEDNLIDWNQDAKKIIKKIQGL
YPNAYTFYNAKRIKILEAIISSDNNQSKESQDIKNQSKTNRIPGEIIMINKQIGIKLMTNDYPILIKYAQLEGKKATDSY
TLSIQSNLSINDKLGS
>Mature_336_residues
MKIVFWGTPKYAAENLRTIVKAGYEVIAVVTQPDRKRGRGKKLSPSPVKEAAEELSIPVYATHSISKDQKTKELLLNLKA
DVYLVVAFGQILPKEILDQPNLGCWNSHASLLPAWRGAAPIQWSIINADTKTGICIMSMEEGLDTGPVIEQESTIIKDSD
NLEILTNRLSRMSSKLLLKSLEKIKLTKGLNKSSRLKKLNAIDQTNLKGSPSYARQITKEDNLIDWNQDAKKIIKKIQGL
YPNAYTFYNAKRIKILEAIISSDNNQSKESQDIKNQSKTNRIPGEIIMINKQIGIKLMTNDYPILIKYAQLEGKKATDSY
TLSIQSNLSINDKLGS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=307, Percent_Identity=26.3843648208469, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI164663775, Length=274, Percent_Identity=25.9124087591241, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI21614513, Length=323, Percent_Identity=26.625386996904, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789683, Length=324, Percent_Identity=36.4197530864198, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1788589, Length=258, Percent_Identity=25.1937984496124, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI133930964, Length=271, Percent_Identity=25.830258302583, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319458, Length=267, Percent_Identity=27.7153558052434, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550868, Length=260, Percent_Identity=28.4615384615385, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28571984, Length=181, Percent_Identity=32.5966850828729, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585660, Length=174, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_PROM1 (A2C296)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014871.1
- ProteinModelPortal:   A2C296
- SMR:   A2C296
- STRING:   A2C296
- GeneID:   4781201
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_10481
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   WRGAGPI
- ProtClustDB:   CLSK715870
- BioCyc:   PMAR167555:NATL1_10481-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 37601; Mature: 37601

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVFWGTPKYAAENLRTIVKAGYEVIAVVTQPDRKRGRGKKLSPSPVKEAAEELSIPVY
CEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCCCCCCHHHHHHHHCCCCEE
ATHSISKDQKTKELLLNLKADVYLVVAFGQILPKEILDQPNLGCWNSHASLLPAWRGAAP
EECCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCHHCHHCCCCCC
IQWSIINADTKTGICIMSMEEGLDTGPVIEQESTIIKDSDNLEILTNRLSRMSSKLLLKS
EEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
LEKIKLTKGLNKSSRLKKLNAIDQTNLKGSPSYARQITKEDNLIDWNQDAKKIIKKIQGL
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
YPNAYTFYNAKRIKILEAIISSDNNQSKESQDIKNQSKTNRIPGEIIMINKQIGIKLMTN
CCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEC
DYPILIKYAQLEGKKATDSYTLSIQSNLSINDKLGS
CCEEEEEEEECCCCCCCCEEEEEEECCCEECCCCCC
>Mature Secondary Structure
MKIVFWGTPKYAAENLRTIVKAGYEVIAVVTQPDRKRGRGKKLSPSPVKEAAEELSIPVY
CEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCCCCCCHHHHHHHHCCCCEE
ATHSISKDQKTKELLLNLKADVYLVVAFGQILPKEILDQPNLGCWNSHASLLPAWRGAAP
EECCCCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCHHCHHCCCCCC
IQWSIINADTKTGICIMSMEEGLDTGPVIEQESTIIKDSDNLEILTNRLSRMSSKLLLKS
EEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
LEKIKLTKGLNKSSRLKKLNAIDQTNLKGSPSYARQITKEDNLIDWNQDAKKIIKKIQGL
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
YPNAYTFYNAKRIKILEAIISSDNNQSKESQDIKNQSKTNRIPGEIIMINKQIGIKLMTN
CCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEC
DYPILIKYAQLEGKKATDSYTLSIQSNLSINDKLGS
CCEEEEEEEECCCCCCCCEEEEEEECCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA