BacMap

Definition	Prochlorococcus marinus str. NATL1A, complete genome.
Accession	NC_008819
Length	1,864,731

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The map label for this gene is rot [H]

Identifier: 124025696

GI number: 124025696

Start: 907994

End: 908431

Strand: Direct

Name: rot [H]

Synonym: NATL1_09891

Alternate gene names: 124025696

Gene position: 907994-908431 (Clockwise)

Preceding gene: 124025695

Following gene: 124025698

Centisome position: 48.69

GC content: 37.9

Gene sequence:

>438_bases
ATGTCTAAAGTATTGATGGAAACAGATAAAGGCCAATTGACGATTGACCTCTTTGATAATGATGCACCCAAAACAGTAGA
AAACTTTTTGAAGCTTGTTAAAGAAGGTTTTTACAATGGCCTTTCTTTTCACAGAGTCATTAATGGGTTTATGGCTCAAG
GGGGATGTCCAAACACAAGAGAGGGCTCACGAGGGATGCCTGGCACTGGAGGCCCTGGATATTCAATCAATTGTGAAATT
AATCCAAACAAACATGAAGCTGGATCTCTTTCTATGGCCCACGCAGGTAAGGATACTGGTGGTAGCCAATTCTTTTTAGT
TCATGCTCCACAACCACATTTGGATGGAGTACATACTGTTTTTGGTAAAACTAATGATATGAAAATTCTTCTATCTATCA
CTAATGGTACAAAGATTAATAGTGTAAGTATTGTTTAA

Upstream 100 bases:

>100_bases
AAGATAATTGAATTATGTTCAATTAAACTTTAAGTATACATATTATACTTTCTGCAATAAACTTTAAAAGTAGTTATTAT
TAGAAAAATTTATTTGAGTT

Downstream 100 bases:

>100_bases
TAGACTTAAATTTATTATCTTATCTTATAATTAACTCCATTCGAAAGTACTGGTCTTATCTTTTAAATTCCAATCAAATA
ATGGCGAATTTTCAAAATTT

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MSKVLMETDKGQLTIDLFDNDAPKTVENFLKLVKEGFYNGLSFHRVINGFMAQGGCPNTREGSRGMPGTGGPGYSINCEI
NPNKHEAGSLSMAHAGKDTGGSQFFLVHAPQPHLDGVHTVFGKTNDMKILLSITNGTKINSVSIV

Sequences:

>Translated_145_residues
MSKVLMETDKGQLTIDLFDNDAPKTVENFLKLVKEGFYNGLSFHRVINGFMAQGGCPNTREGSRGMPGTGGPGYSINCEI
NPNKHEAGSLSMAHAGKDTGGSQFFLVHAPQPHLDGVHTVFGKTNDMKILLSITNGTKINSVSIV
>Mature_144_residues
SKVLMETDKGQLTIDLFDNDAPKTVENFLKLVKEGFYNGLSFHRVINGFMAQGGCPNTREGSRGMPGTGGPGYSINCEIN
PNKHEAGSLSMAHAGKDTGGSQFFLVHAPQPHLDGVHTVFGKTNDMKILLSITNGTKINSVSIV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=128, Percent_Identity=44.53125, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI24308049, Length=139, Percent_Identity=41.726618705036, Blast_Score=93, Evalue=8e-20,
Organism=Homo sapiens, GI19557636, Length=130, Percent_Identity=42.3076923076923, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI4505991, Length=137, Percent_Identity=42.3357664233577, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI64276486, Length=122, Percent_Identity=39.344262295082, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI4758950, Length=144, Percent_Identity=40.9722222222222, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI6631100, Length=124, Percent_Identity=42.741935483871, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI4826932, Length=125, Percent_Identity=38.4, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI256017253, Length=128, Percent_Identity=42.1875, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI221139811, Length=128, Percent_Identity=42.1875, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI256017251, Length=128, Percent_Identity=42.1875, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI10863927, Length=123, Percent_Identity=45.5284552845528, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI42560244, Length=124, Percent_Identity=40.3225806451613, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI209417936, Length=120, Percent_Identity=43.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI30102944, Length=120, Percent_Identity=43.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI219842199, Length=120, Percent_Identity=43.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI20911035, Length=137, Percent_Identity=38.6861313868613, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI178057341, Length=126, Percent_Identity=42.8571428571429, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI310129267, Length=128, Percent_Identity=41.40625, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310120620, Length=128, Percent_Identity=41.40625, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310110104, Length=128, Percent_Identity=41.40625, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI5454154, Length=135, Percent_Identity=37.7777777777778, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI150418007, Length=121, Percent_Identity=38.8429752066116, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI22547212, Length=126, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI7657473, Length=126, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI22547215, Length=126, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI5031987, Length=120, Percent_Identity=40, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI310127646, Length=126, Percent_Identity=39.6825396825397, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310114371, Length=126, Percent_Identity=39.6825396825397, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310119221, Length=126, Percent_Identity=39.6825396825397, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786736, Length=107, Percent_Identity=40.1869158878505, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789763, Length=141, Percent_Identity=34.7517730496454, Blast_Score=67, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=138, Percent_Identity=44.2028985507246, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71980594, Length=124, Percent_Identity=43.5483870967742, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71980590, Length=124, Percent_Identity=43.5483870967742, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17506311, Length=148, Percent_Identity=40.5405405405405, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997782, Length=124, Percent_Identity=39.5161290322581, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=155, Percent_Identity=37.4193548387097, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17506307, Length=134, Percent_Identity=41.7910447761194, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17552780, Length=117, Percent_Identity=44.4444444444444, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17565860, Length=139, Percent_Identity=38.1294964028777, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17551282, Length=126, Percent_Identity=40.4761904761905, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17551284, Length=126, Percent_Identity=40.4761904761905, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=125, Percent_Identity=40.8, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17566266, Length=142, Percent_Identity=38.7323943661972, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17552782, Length=128, Percent_Identity=39.0625, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=130, Percent_Identity=40.7692307692308, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539498, Length=119, Percent_Identity=41.1764705882353, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17552784, Length=126, Percent_Identity=37.3015873015873, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32563659, Length=129, Percent_Identity=35.6589147286822, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=131, Percent_Identity=43.5114503816794, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320510, Length=131, Percent_Identity=41.2213740458015, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320359, Length=134, Percent_Identity=40.2985074626866, Blast_Score=78, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321848, Length=132, Percent_Identity=42.4242424242424, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323246, Length=132, Percent_Identity=39.3939393939394, Blast_Score=72, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17986117, Length=127, Percent_Identity=44.0944881889764, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19922376, Length=125, Percent_Identity=41.6, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922912, Length=136, Percent_Identity=42.6470588235294, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21357249, Length=130, Percent_Identity=40, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24650807, Length=125, Percent_Identity=40.8, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI20130249, Length=130, Percent_Identity=43.8461538461538, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24652460, Length=123, Percent_Identity=38.2113821138211, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355677, Length=135, Percent_Identity=39.2592592592593, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24664125, Length=118, Percent_Identity=42.3728813559322, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357783, Length=118, Percent_Identity=42.3728813559322, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586038, Length=138, Percent_Identity=38.4057971014493, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45549139, Length=118, Percent_Identity=41.5254237288136, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647301, Length=117, Percent_Identity=40.1709401709402, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136360, Length=118, Percent_Identity=36.4406779661017, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15551; Mature: 15420

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVLMETDKGQLTIDLFDNDAPKTVENFLKLVKEGFYNGLSFHRVINGFMAQGGCPNTR
CCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
EGSRGMPGTGGPGYSINCEINPNKHEAGSLSMAHAGKDTGGSQFFLVHAPQPHLDGVHTV
CCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCEEEE
FGKTNDMKILLSITNGTKINSVSIV
CCCCCCEEEEEEECCCCEEEEEEEC
>Mature Secondary Structure 
SKVLMETDKGQLTIDLFDNDAPKTVENFLKLVKEGFYNGLSFHRVINGFMAQGGCPNTR
CCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
EGSRGMPGTGGPGYSINCEINPNKHEAGSLSMAHAGKDTGGSQFFLVHAPQPHLDGVHTV
CCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCEEEE
FGKTNDMKILLSITNGTKINSVSIV
CCCCCCEEEEEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA