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The map label for this gene is galE [H]

Identifier: 124025560

GI number: 124025560

Start: 783035

End: 784081

Strand: Direct

Name: galE [H]

Synonym: NATL1_08531

Alternate gene names: 124025560

Gene position: 783035-784081 (Clockwise)

Preceding gene: 124025555

Following gene: 124025561

Centisome position: 41.99

GC content: 33.62

Gene sequence:

>1047_bases
ATGCGGGTTCTTTTAACTGGTGGTGCAGGATTTATAGGTTCCCATATAGCCTTGTTGTTGCTCGAAAGAGGGTACGATGT
TTTGATATTAGATTCATTTGCTAATAGTTCATCAAATGTTATCGAGCGCATTGAAAATTTTCTAGATAATAAAGCCCTAA
AATATAAACTAAGAGTTATAAATGGTGATATTAGAGATAAGCAAATACTTGAGAGCATTTTCTCAAAATGTGTAAAGGAA
AATAAACCGATAGAAGTAGTTATACATCTTGCTGGTGTTAAGTCTGTATGCGAATCTTTGACTAATCCTCTTTATTATTG
GGATGTAAATGTATCTGGAACATTAAATTTATTACTTACGATGAAAGATTATCAATGTTACTCCCTTGTCTTTAGTAGTA
GTGCAACTATCTATGGTTTATCTGATTATGTCCCTATCTTAGAAGAACAAAAGATTTCACCAATTACACCCTATGGTCAA
ACCAAAGTTGCTGTTGAAAATTTGTTTTATGATTTATATAAATCTAATGTGAATTTATGGAAAATTTGTTCCTTGCGTTA
TTTTAATCCTGTTGGTGCGCACCCTTCTGGCCTGATTGGCGAGGATCCAAGAGGAATTCCTAATAATCTGTTCCCTTTTA
TAACTCAAGTAGCAATAGGAAGACAAAAGATTTTAAACATTTATGGAGATGATTGGGAAACAAAGGATGGTTCAGGGATT
CGTGATTATGTTCATATTATTGATTTAGCAGAAGGACATCTAGCCTCAATAGATTATTTAAATACCAGTGAATCATGTTT
AGAGTTTATCAATTTAGGCTCTGGTAAAGGGTATTCTGTATTTCAGATTATTCGGCAATTTGAGTTGTCTACAGGGTGTA
GTATTCCTTTTTCAATTGAAAGTCGAAGAGATGGTGATGTGGCAGTCTCTTACGCAGATATATCAAAAGCCAAGAGATTA
TTAAGTTGGACTCCTAAGAGATCCTTAGAACAGATTTGCCTAGATGGATGGAATTGGCAAATTAAAAATCCAAATGGTTA
TGGATAA

Upstream 100 bases:

>100_bases
ATATTATGTTAATCTATTATTTAGAATTAATAGGAAAATCCGTACTTTTATAAGAAAACGTTGAAAAACTTTTTCTATAT
TAAATATATACATATCTATT

Downstream 100 bases:

>100_bases
TTTATTCGTTTCAGTTTTTACAGATATTGGCATTGTCATTTTTCAAATATCCTATTCTCTAAATTTCTAGAATAGTTAAA
GGTCATTGCCCTCTTTCTTG

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MRVLLTGGAGFIGSHIALLLLERGYDVLILDSFANSSSNVIERIENFLDNKALKYKLRVINGDIRDKQILESIFSKCVKE
NKPIEVVIHLAGVKSVCESLTNPLYYWDVNVSGTLNLLLTMKDYQCYSLVFSSSATIYGLSDYVPILEEQKISPITPYGQ
TKVAVENLFYDLYKSNVNLWKICSLRYFNPVGAHPSGLIGEDPRGIPNNLFPFITQVAIGRQKILNIYGDDWETKDGSGI
RDYVHIIDLAEGHLASIDYLNTSESCLEFINLGSGKGYSVFQIIRQFELSTGCSIPFSIESRRDGDVAVSYADISKAKRL
LSWTPKRSLEQICLDGWNWQIKNPNGYG

Sequences:

>Translated_348_residues
MRVLLTGGAGFIGSHIALLLLERGYDVLILDSFANSSSNVIERIENFLDNKALKYKLRVINGDIRDKQILESIFSKCVKE
NKPIEVVIHLAGVKSVCESLTNPLYYWDVNVSGTLNLLLTMKDYQCYSLVFSSSATIYGLSDYVPILEEQKISPITPYGQ
TKVAVENLFYDLYKSNVNLWKICSLRYFNPVGAHPSGLIGEDPRGIPNNLFPFITQVAIGRQKILNIYGDDWETKDGSGI
RDYVHIIDLAEGHLASIDYLNTSESCLEFINLGSGKGYSVFQIIRQFELSTGCSIPFSIESRRDGDVAVSYADISKAKRL
LSWTPKRSLEQICLDGWNWQIKNPNGYG
>Mature_348_residues
MRVLLTGGAGFIGSHIALLLLERGYDVLILDSFANSSSNVIERIENFLDNKALKYKLRVINGDIRDKQILESIFSKCVKE
NKPIEVVIHLAGVKSVCESLTNPLYYWDVNVSGTLNLLLTMKDYQCYSLVFSSSATIYGLSDYVPILEEQKISPITPYGQ
TKVAVENLFYDLYKSNVNLWKICSLRYFNPVGAHPSGLIGEDPRGIPNNLFPFITQVAIGRQKILNIYGDDWETKDGSGI
RDYVHIIDLAEGHLASIDYLNTSESCLEFINLGSGKGYSVFQIIRQFELSTGCSIPFSIESRRDGDVAVSYADISKAKRL
LSWTPKRSLEQICLDGWNWQIKNPNGYG

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=354, Percent_Identity=44.0677966101695, Blast_Score=310, Evalue=9e-85,
Organism=Homo sapiens, GI56118217, Length=354, Percent_Identity=44.0677966101695, Blast_Score=310, Evalue=9e-85,
Organism=Homo sapiens, GI189083684, Length=354, Percent_Identity=44.0677966101695, Blast_Score=310, Evalue=9e-85,
Organism=Homo sapiens, GI42516563, Length=341, Percent_Identity=27.5659824046921, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI7657641, Length=294, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1786974, Length=348, Percent_Identity=43.9655172413793, Blast_Score=310, Evalue=9e-86,
Organism=Escherichia coli, GI1788366, Length=369, Percent_Identity=23.3062330623306, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71982035, Length=356, Percent_Identity=45.2247191011236, Blast_Score=301, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71982038, Length=358, Percent_Identity=45.5307262569832, Blast_Score=300, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6319493, Length=352, Percent_Identity=46.0227272727273, Blast_Score=318, Evalue=1e-87,
Organism=Drosophila melanogaster, GI19923002, Length=354, Percent_Identity=44.3502824858757, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI21356223, Length=342, Percent_Identity=27.4853801169591, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 39036; Mature: 39036

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLTGGAGFIGSHIALLLLERGYDVLILDSFANSSSNVIERIENFLDNKALKYKLRVI
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEE
NGDIRDKQILESIFSKCVKENKPIEVVIHLAGVKSVCESLTNPLYYWDVNVSGTLNLLLT
CCCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCEEEEEECCCCEEEEEEE
MKDYQCYSLVFSSSATIYGLSDYVPILEEQKISPITPYGQTKVAVENLFYDLYKSNVNLW
ECCCEEEEEEEECCCEEEECCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
KICSLRYFNPVGAHPSGLIGEDPRGIPNNLFPFITQVAIGRQKILNIYGDDWETKDGSGI
EEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCH
RDYVHIIDLAEGHLASIDYLNTSESCLEFINLGSGKGYSVFQIIRQFELSTGCSIPFSIE
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEC
SRRDGDVAVSYADISKAKRLLSWTPKRSLEQICLDGWNWQIKNPNGYG
CCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCC
>Mature Secondary Structure
MRVLLTGGAGFIGSHIALLLLERGYDVLILDSFANSSSNVIERIENFLDNKALKYKLRVI
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEE
NGDIRDKQILESIFSKCVKENKPIEVVIHLAGVKSVCESLTNPLYYWDVNVSGTLNLLLT
CCCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCEEEEEECCCCEEEEEEE
MKDYQCYSLVFSSSATIYGLSDYVPILEEQKISPITPYGQTKVAVENLFYDLYKSNVNLW
ECCCEEEEEEEECCCEEEECCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
KICSLRYFNPVGAHPSGLIGEDPRGIPNNLFPFITQVAIGRQKILNIYGDDWETKDGSGI
EEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCH
RDYVHIIDLAEGHLASIDYLNTSESCLEFINLGSGKGYSVFQIIRQFELSTGCSIPFSIE
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEC
SRRDGDVAVSYADISKAKRLLSWTPKRSLEQICLDGWNWQIKNPNGYG
CCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]