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The map label for this gene is lpxD [H]

Identifier: 124025534

GI number: 124025534

Start: 760384

End: 761436

Strand: Reverse

Name: lpxD [H]

Synonym: NATL1_08271

Alternate gene names: 124025534

Gene position: 761436-760384 (Counterclockwise)

Preceding gene: 124025535

Following gene: 124025533

Centisome position: 40.83

GC content: 35.23

Gene sequence:

>1053_bases
ATGCAATTCATTGAAATTGTCGAAAAACTGAAGAAAGGTCAATCTGGTGTCGTTGACTTTAAAATTAAAAACAATCCAGT
TATTTTAACCGCAGCTTCTTTAGAAAAAGCCAAGGATAATGACATAAGTTTTCTAGACAATAATAGTCCATTAAATCTTA
GAAATCTCATAGAGACTTCAAAAGCATCTGCTCTATTATTACCAGCAAATGATACTTATATTATTGAAATAGCAAAGAAA
ATTTCAGTTGATTGGATAATACTTAAAGAGCCCAAGATTGCTTTTGCTGAAACATTAGAGTTTCTTTATCCTTCTAATGT
GGAAAGTGAAGGCATACATAAAAGTGCGGTCATCGGTCAGAATGTAAAAATTGGTCTTGGAGTTTCAATCGGAGCTAATG
CTTATATTGGAGATAATACAGAAATTGGAGCTGGGACTATCATTCATGCAGGCGTTGTTCTATATAGAAATGTAAGAATT
GGTTCCAAAAATTTAATTCACGCAAATAGTGTTATTCATTCTGGATCTAAACTTGGTGACAAATGTGTAATTAATGCCAA
TGCTGTTATTGGTGGTGAAGGTTTTGGATTCGTGCCCACATCAAATGGATGGAAGAAAATGCCTCAAGTGGGAATAGTTA
TTTTAAAAAATAAAGTAGAAGTTGGTAGTGGATCAACGATTGATAGGCCTTCAGTAGGAGAGACAATAATTGGTGAAGAT
ACAAAAATTGATAACCTAGTTCAAATTGGTCATGGAGTAACTACTGGTAAAGGATGTGCTATGGCTGCTCAAGTTGGAAT
TGCTGGAGGAGCACAGATTGGAGACGGAGTTATACTTGCTGGACAAGTTGGTATCAGTAATAGAGTCAAAATTGGCGACG
GAGTGATAGCCAGTTCTAAAACAGGAATAGTATCCAATATTGAAGCAGGAACTGTTGTTAGCGGATTCCCTGCTATTCCA
AATAAATTATGGTTGAGATGCTCTGCTAATTTCAAAAAACTACCTGAGATAGCAAAAGCTATTCGTCAATTAGATCGAAA
AAAATCCAGGTAA

Upstream 100 bases:

>100_bases
AACAGGATCTCCTCTAGTTATCCACCGAGATGTTCTGGTTCTAACAAGTGAATAACTCAGATAACAATACTAATTTTCAC
TTCCCCAATCAAATCAAATC

Downstream 100 bases:

>100_bases
GTTTTCTACTTGATTAAGAACACAAAATGAAGTCTTACAAAATAACATTATTGCCAGGAGATGGAATTGGTCCAGAGATA
ACAAACGTCACTCATAAAAT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MQFIEIVEKLKKGQSGVVDFKIKNNPVILTAASLEKAKDNDISFLDNNSPLNLRNLIETSKASALLLPANDTYIIEIAKK
ISVDWIILKEPKIAFAETLEFLYPSNVESEGIHKSAVIGQNVKIGLGVSIGANAYIGDNTEIGAGTIIHAGVVLYRNVRI
GSKNLIHANSVIHSGSKLGDKCVINANAVIGGEGFGFVPTSNGWKKMPQVGIVILKNKVEVGSGSTIDRPSVGETIIGED
TKIDNLVQIGHGVTTGKGCAMAAQVGIAGGAQIGDGVILAGQVGISNRVKIGDGVIASSKTGIVSNIEAGTVVSGFPAIP
NKLWLRCSANFKKLPEIAKAIRQLDRKKSR

Sequences:

>Translated_350_residues
MQFIEIVEKLKKGQSGVVDFKIKNNPVILTAASLEKAKDNDISFLDNNSPLNLRNLIETSKASALLLPANDTYIIEIAKK
ISVDWIILKEPKIAFAETLEFLYPSNVESEGIHKSAVIGQNVKIGLGVSIGANAYIGDNTEIGAGTIIHAGVVLYRNVRI
GSKNLIHANSVIHSGSKLGDKCVINANAVIGGEGFGFVPTSNGWKKMPQVGIVILKNKVEVGSGSTIDRPSVGETIIGED
TKIDNLVQIGHGVTTGKGCAMAAQVGIAGGAQIGDGVILAGQVGISNRVKIGDGVIASSKTGIVSNIEAGTVVSGFPAIP
NKLWLRCSANFKKLPEIAKAIRQLDRKKSR
>Mature_350_residues
MQFIEIVEKLKKGQSGVVDFKIKNNPVILTAASLEKAKDNDISFLDNNSPLNLRNLIETSKASALLLPANDTYIIEIAKK
ISVDWIILKEPKIAFAETLEFLYPSNVESEGIHKSAVIGQNVKIGLGVSIGANAYIGDNTEIGAGTIIHAGVVLYRNVRI
GSKNLIHANSVIHSGSKLGDKCVINANAVIGGEGFGFVPTSNGWKKMPQVGIVILKNKVEVGSGSTIDRPSVGETIIGED
TKIDNLVQIGHGVTTGKGCAMAAQVGIAGGAQIGDGVILAGQVGISNRVKIGDGVIASSKTGIVSNIEAGTVVSGFPAIP
NKLWLRCSANFKKLPEIAKAIRQLDRKKSR

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=322, Percent_Identity=33.2298136645963, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36879; Mature: 36879

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFIEIVEKLKKGQSGVVDFKIKNNPVILTAASLEKAKDNDISFLDNNSPLNLRNLIETS
CCHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHCC
KASALLLPANDTYIIEIAKKISVDWIILKEPKIAFAETLEFLYPSNVESEGIHKSAVIGQ
CCCEEEEECCCEEEEEEEECCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHEECC
NVKIGLGVSIGANAYIGDNTEIGAGTIIHAGVVLYRNVRIGSKNLIHANSVIHSGSKLGD
CEEEEEEEEECCCEEECCCCCCCCCHHEECCEEEEEEEEECCCCEEEEHHHHHCCCCCCC
KCVINANAVIGGEGFGFVPTSNGWKKMPQVGIVILKNKVEVGSGSTIDRPSVGETIIGED
EEEEECCEEECCCCCEECCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCCEECCCC
TKIDNLVQIGHGVTTGKGCAMAAQVGIAGGAQIGDGVILAGQVGISNRVKIGDGVIASSK
CCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCEEECCCEEECCC
TGIVSNIEAGTVVSGFPAIPNKLWLRCSANFKKLPEIAKAIRQLDRKKSR
CCCEECCCCCCEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQFIEIVEKLKKGQSGVVDFKIKNNPVILTAASLEKAKDNDISFLDNNSPLNLRNLIETS
CCHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHCC
KASALLLPANDTYIIEIAKKISVDWIILKEPKIAFAETLEFLYPSNVESEGIHKSAVIGQ
CCCEEEEECCCEEEEEEEECCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHEECC
NVKIGLGVSIGANAYIGDNTEIGAGTIIHAGVVLYRNVRIGSKNLIHANSVIHSGSKLGD
CEEEEEEEEECCCEEECCCCCCCCCHHEECCEEEEEEEEECCCCEEEEHHHHHCCCCCCC
KCVINANAVIGGEGFGFVPTSNGWKKMPQVGIVILKNKVEVGSGSTIDRPSVGETIIGED
EEEEECCEEECCCCCEECCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCCEECCCC
TKIDNLVQIGHGVTTGKGCAMAAQVGIAGGAQIGDGVILAGQVGISNRVKIGDGVIASSK
CCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCEEECCCEEECCC
TGIVSNIEAGTVVSGFPAIPNKLWLRCSANFKKLPEIAKAIRQLDRKKSR
CCCEECCCCCCEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA