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The map label for this gene is cobW [H]

Identifier: 124025523

GI number: 124025523

Start: 751612

End: 752667

Strand: Direct

Name: cobW [H]

Synonym: NATL1_08161

Alternate gene names: 124025523

Gene position: 751612-752667 (Clockwise)

Preceding gene: 124025522

Following gene: 124025524

Centisome position: 40.31

GC content: 36.84

Gene sequence:

>1056_bases
ATGAGCGCTAATCGTCTACCAGTTACGGTAGTTACAGGATTCTTAGGTTCTGGTAAAACCACACTCTTGAGGTATCTTTT
ACGTGAAGGGAATCAACGTCTAGCTGTAGTTGTTAATGAATTTGGAACAGTTGGTTTAGATGGAGACCTTCTTAAAAACT
GTGGGCTTTGCCCTGATGATGAAGTAGAGGAAAGAATAGTTGAGTTAAATAATGGCTGCTTATGTTGCACTGTTCAAGAG
GACTTCCTTCCTGCAATGGAAGCTTTGCTTCTTAGATCAAATCAGCTTGATGGAATCATTATTGAAACCAGTGGTCTTGC
TTTGCCAAAGCCTTTACTTCAAGCTCTTAATTGGCCTGCAATGAGAAATAAGGTTTTTATTAATGGAGTCGTCACTTTAG
TTGATGGATATGCTCTCTCAAATGGAAGCCCAGTGGGTGATTTGAAAAGTATTAATCAACAAATAACAACTGACAAAAGT
ATTGATCATTTAACTCCAATAAATGAGCTTTTTAGAGATCAATTGATTTCTGCTGATCTCGTTTTAATTAGTAGGTCAGA
TTTGCTTTCTGCAAAAAGTTTTTCATTGGTTAGGGATGAGGTGAAAAAGCAAGGGAATTCCATTACTAATATTCTGCCAA
TATCTAATGGAAAAATTGAACCTTCAGTAATTCTCGGCCTTTGCAAAGAACAAAACAATATTTCTCGATCAGATCAAAAT
GACCATGACCATGACCATGACCATGACCATGACCATGACCATGACCATGTTGATGTAATAAGTGAGCATTTAAGATTCGA
ATTCCCAATTGATAAGGATCTATTGAAAGAAATACTTGTAAAACTAGTTTCGGAATATCAAATTCTTCGTATAAAAGGGA
GATGCTGGATAGAGGGTAAGGCTTTGCCTCTTCAGATCCAAATGGTTGGATGTAGATTTAATTCATGGTTTGAGAGTGCG
AATGATGATTCTTGGAAACCTTCTAAGGCTGGAATTGATTTAGTCTCTTTGAGTCTGAAAGGCGGAGTTGAAAAAGCTTT
TGAATCTTCCTTTTAA

Upstream 100 bases:

>100_bases
AACAAAAAGAACTATGTAACATGGCTTCTGGAACAAATTCAAAGACTGATGAGGATACCAGTTACAGTCTAGGTTGCTGA
GTTATTAAACAAAAATAAAA

Downstream 100 bases:

>100_bases
TTAATTGGTTCAAATTATTATATTTATATTAAAAATAGGTTGTATTTCTATTTTTATCCGCGATTCTTTGTGAGTTAGGA
GATAATTCTCTTGAAGCAAT

Product: putative cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSANRLPVTVVTGFLGSGKTTLLRYLLREGNQRLAVVVNEFGTVGLDGDLLKNCGLCPDDEVEERIVELNNGCLCCTVQE
DFLPAMEALLLRSNQLDGIIIETSGLALPKPLLQALNWPAMRNKVFINGVVTLVDGYALSNGSPVGDLKSINQQITTDKS
IDHLTPINELFRDQLISADLVLISRSDLLSAKSFSLVRDEVKKQGNSITNILPISNGKIEPSVILGLCKEQNNISRSDQN
DHDHDHDHDHDHDHDHVDVISEHLRFEFPIDKDLLKEILVKLVSEYQILRIKGRCWIEGKALPLQIQMVGCRFNSWFESA
NDDSWKPSKAGIDLVSLSLKGGVEKAFESSF

Sequences:

>Translated_351_residues
MSANRLPVTVVTGFLGSGKTTLLRYLLREGNQRLAVVVNEFGTVGLDGDLLKNCGLCPDDEVEERIVELNNGCLCCTVQE
DFLPAMEALLLRSNQLDGIIIETSGLALPKPLLQALNWPAMRNKVFINGVVTLVDGYALSNGSPVGDLKSINQQITTDKS
IDHLTPINELFRDQLISADLVLISRSDLLSAKSFSLVRDEVKKQGNSITNILPISNGKIEPSVILGLCKEQNNISRSDQN
DHDHDHDHDHDHDHDHVDVISEHLRFEFPIDKDLLKEILVKLVSEYQILRIKGRCWIEGKALPLQIQMVGCRFNSWFESA
NDDSWKPSKAGIDLVSLSLKGGVEKAFESSF
>Mature_350_residues
SANRLPVTVVTGFLGSGKTTLLRYLLREGNQRLAVVVNEFGTVGLDGDLLKNCGLCPDDEVEERIVELNNGCLCCTVQED
FLPAMEALLLRSNQLDGIIIETSGLALPKPLLQALNWPAMRNKVFINGVVTLVDGYALSNGSPVGDLKSINQQITTDKSI
DHLTPINELFRDQLISADLVLISRSDLLSAKSFSLVRDEVKKQGNSITNILPISNGKIEPSVILGLCKEQNNISRSDQND
HDHDHDHDHDHDHDHVDVISEHLRFEFPIDKDLLKEILVKLVSEYQILRIKGRCWIEGKALPLQIQMVGCRFNSWFESAN
DDSWKPSKAGIDLVSLSLKGGVEKAFESSF

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=228, Percent_Identity=33.7719298245614, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI33469141, Length=228, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI148727351, Length=228, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI146231952, Length=228, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI223941779, Length=203, Percent_Identity=34.9753694581281, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI119120938, Length=142, Percent_Identity=38.7323943661972, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223941776, Length=231, Percent_Identity=32.034632034632, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1788499, Length=202, Percent_Identity=31.6831683168317, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082430, Length=349, Percent_Identity=25.214899713467, Blast_Score=92, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6324356, Length=135, Percent_Identity=34.8148148148148, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 38961; Mature: 38830

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANRLPVTVVTGFLGSGKTTLLRYLLREGNQRLAVVVNEFGTVGLDGDLLKNCGLCPDD
CCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCH
EVEERIVELNNGCLCCTVQEDFLPAMEALLLRSNQLDGIIIETSGLALPKPLLQALNWPA
HHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCH
MRNKVFINGVVTLVDGYALSNGSPVGDLKSINQQITTDKSIDHLTPINELFRDQLISADL
HCCEEEEEEEEEECCCEEECCCCCCHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHCCCE
VLISRSDLLSAKSFSLVRDEVKKQGNSITNILPISNGKIEPSVILGLCKEQNNISRSDQN
EEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHEEHHCCCCCCCCCCC
DHDHDHDHDHDHDHDHVDVISEHLRFEFPIDKDLLKEILVKLVSEYQILRIKGRCWIEGK
CCCCCCCCCCCCCCCHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCEEEEECCEEEECCC
ALPLQIQMVGCRFNSWFESANDDSWKPSKAGIDLVSLSLKGGVEKAFESSF
CCEEEEEEEEEEHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCC
>Mature Secondary Structure 
SANRLPVTVVTGFLGSGKTTLLRYLLREGNQRLAVVVNEFGTVGLDGDLLKNCGLCPDD
CCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCH
EVEERIVELNNGCLCCTVQEDFLPAMEALLLRSNQLDGIIIETSGLALPKPLLQALNWPA
HHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCH
MRNKVFINGVVTLVDGYALSNGSPVGDLKSINQQITTDKSIDHLTPINELFRDQLISADL
HCCEEEEEEEEEECCCEEECCCCCCHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHCCCE
VLISRSDLLSAKSFSLVRDEVKKQGNSITNILPISNGKIEPSVILGLCKEQNNISRSDQN
EEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHEEHHCCCCCCCCCCC
DHDHDHDHDHDHDHDHVDVISEHLRFEFPIDKDLLKEILVKLVSEYQILRIKGRCWIEGK
CCCCCCCCCCCCCCCHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCEEEEECCEEEECCC
ALPLQIQMVGCRFNSWFESANDDSWKPSKAGIDLVSLSLKGGVEKAFESSF
CCEEEEEEEEEEHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]