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The map label for this gene is hemA

Identifier: 124025513

GI number: 124025513

Start: 742341

End: 743666

Strand: Direct

Name: hemA

Synonym: NATL1_08061

Alternate gene names: 124025513

Gene position: 742341-743666 (Clockwise)

Preceding gene: 124025512

Following gene: 124025514

Centisome position: 39.81

GC content: 39.22

Gene sequence:

>1326_bases
ATGCATATTGCTGTCGTCGGTCTTAGCCATCGCACGGCCCCTGTCGAAGTGCGTGAAAAGCTAAGTATCCCAGAAGAACT
GGTTGAGAGATCGTTTAATAATTTAAAGAAAATTGATCAAATATTAGAAGTTTCCATATTGAGCACATGTAACAGACTTG
AAATTTATAGCTTAGTTAAGGACCCGCAATTGGGAATAGAGGCAATTAAATCTTTTCTTCTTGAATTCTCGGGCCTTGAG
GATGAGATTCTTTCACCTCACTTATTTAATTATGTCCAAGAGAAAGCAGTCTCTCATGTGATGAGGGTTTCTGCGGGTTT
GGATAGTTTGGTTTTAGGAGAGGGTCAGATCCTTTCTCAAGTAAAAAAAATGGTACGTCTTGGCCAAGATCATCACAGCC
TAGGACCTATCTTGAATAGATTGTTAACTCAGGCCGTTAGTACAGGCAAGCGCGTAAGAAGCGAGACAAATCTTGGAACA
GGAGCAGTTTCTATAAGTTCTGCAGCTGTAGAACTAGCTCAATTGAAACTTGGCCAAGCGCATGGAAGAGATCAATTGAT
GACTTTAGAAACTGAAAAGGTCGCTGTTGTTGGCGCTGGTCGAATGAGCCGTTTGTTGCTTCAGCATCTCCAATCAAAAG
GATGTTGTTCACTCACGCTTCTAAATAGAACAAGAAAAAGGGCTGAGGACCTTTCAGCAGCGTTTCCCGATATTCAAATT
GATTGTCAATTAATAGATGAGCTTGATAGTTGTCTCTCTCTAAGTACTCTTGTATTTACGAGCACAGCGGCTAATGAGCC
AATTATTGATGCCGAAAAATTGATAAATATCGATAGAAAACCTTTACTTAGACTTATCGATATTGGAGTTCCGAGGAATA
TTTCTTCTGATGCAAAATCAGTTTCTGGAATAGAATCTCATGATGTTGATGATCTTCAAGAAGTTGTTTCAAGAAACCAA
GAGGCAAGACAAAAGCTCGCCCTAGAAGCAGAAGGATTGATAGAGGAAGAATGTCGTGTTTTTCTAGAATGGTGGGATAG
CTTAGCTGCTGTTCCGACAATTAATTGCCTTAGATCTTCTTTGGAGTCAATCAGAAAAGAAGAACTTCAGAAGGCATTAA
GCAGAATGGGTCCTGATTTTTCCGCTAGAGAACGAAAAGTTGTTGAGGCATTAAGCAAGGGAATCATTAACAAAATTCTT
CACACTCCAGTAACAAAATTAAGAGCTCCTCAATCGAGGAATGATCGTAGAGATTCTCTTGATGTGATTGAAAAACTTTT
TAATCTTGATGTTTCTAGTTCTTTAAATAAGCCCAAAAACAACTGA

Upstream 100 bases:

>100_bases
TGATCAAACAGCAAGGTTTACCAATACAGTTCACATCAAAGATGGTGCTCAAAGCATCTCTTTGAAGTGATAGTTAAGTA
AATGAAGTAAGGGGCTATTT

Downstream 100 bases:

>100_bases
TATTGTTATTTACTTTTGTAATTCTTACTACTTATCACTTTTTACTGGATTAATGAGCACTCTATCCAGTAGGTTTGCTC
CGAATAGCCGATTAATAGTG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MHIAVVGLSHRTAPVEVREKLSIPEELVERSFNNLKKIDQILEVSILSTCNRLEIYSLVKDPQLGIEAIKSFLLEFSGLE
DEILSPHLFNYVQEKAVSHVMRVSAGLDSLVLGEGQILSQVKKMVRLGQDHHSLGPILNRLLTQAVSTGKRVRSETNLGT
GAVSISSAAVELAQLKLGQAHGRDQLMTLETEKVAVVGAGRMSRLLLQHLQSKGCCSLTLLNRTRKRAEDLSAAFPDIQI
DCQLIDELDSCLSLSTLVFTSTAANEPIIDAEKLINIDRKPLLRLIDIGVPRNISSDAKSVSGIESHDVDDLQEVVSRNQ
EARQKLALEAEGLIEEECRVFLEWWDSLAAVPTINCLRSSLESIRKEELQKALSRMGPDFSARERKVVEALSKGIINKIL
HTPVTKLRAPQSRNDRRDSLDVIEKLFNLDVSSSLNKPKNN

Sequences:

>Translated_441_residues
MHIAVVGLSHRTAPVEVREKLSIPEELVERSFNNLKKIDQILEVSILSTCNRLEIYSLVKDPQLGIEAIKSFLLEFSGLE
DEILSPHLFNYVQEKAVSHVMRVSAGLDSLVLGEGQILSQVKKMVRLGQDHHSLGPILNRLLTQAVSTGKRVRSETNLGT
GAVSISSAAVELAQLKLGQAHGRDQLMTLETEKVAVVGAGRMSRLLLQHLQSKGCCSLTLLNRTRKRAEDLSAAFPDIQI
DCQLIDELDSCLSLSTLVFTSTAANEPIIDAEKLINIDRKPLLRLIDIGVPRNISSDAKSVSGIESHDVDDLQEVVSRNQ
EARQKLALEAEGLIEEECRVFLEWWDSLAAVPTINCLRSSLESIRKEELQKALSRMGPDFSARERKVVEALSKGIINKIL
HTPVTKLRAPQSRNDRRDSLDVIEKLFNLDVSSSLNKPKNN
>Mature_441_residues
MHIAVVGLSHRTAPVEVREKLSIPEELVERSFNNLKKIDQILEVSILSTCNRLEIYSLVKDPQLGIEAIKSFLLEFSGLE
DEILSPHLFNYVQEKAVSHVMRVSAGLDSLVLGEGQILSQVKKMVRLGQDHHSLGPILNRLLTQAVSTGKRVRSETNLGT
GAVSISSAAVELAQLKLGQAHGRDQLMTLETEKVAVVGAGRMSRLLLQHLQSKGCCSLTLLNRTRKRAEDLSAAFPDIQI
DCQLIDELDSCLSLSTLVFTSTAANEPIIDAEKLINIDRKPLLRLIDIGVPRNISSDAKSVSGIESHDVDDLQEVVSRNQ
EARQKLALEAEGLIEEECRVFLEWWDSLAAVPTINCLRSSLESIRKEELQKALSRMGPDFSARERKVVEALSKGIINKIL
HTPVTKLRAPQSRNDRRDSLDVIEKLFNLDVSSSLNKPKNN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=431, Percent_Identity=33.4106728538283, Blast_Score=203, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_PROM1 (A2C1K4)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014629.1
- ProteinModelPortal:   A2C1K4
- SMR:   A2C1K4
- STRING:   A2C1K4
- GeneID:   4779244
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_08061
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   PMAR167555:NATL1_08061-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48889; Mature: 48889

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIAVVGLSHRTAPVEVREKLSIPEELVERSFNNLKKIDQILEVSILSTCNRLEIYSLVK
CEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
DPQLGIEAIKSFLLEFSGLEDEILSPHLFNYVQEKAVSHVMRVSAGLDSLVLGEGQILSQ
CCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHH
VKKMVRLGQDHHSLGPILNRLLTQAVSTGKRVRSETNLGTGAVSISSAAVELAQLKLGQA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
HGRDQLMTLETEKVAVVGAGRMSRLLLQHLQSKGCCSLTLLNRTRKRAEDLSAAFPDIQI
CCCCCEEEEECCCEEEECCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEE
DCQLIDELDSCLSLSTLVFTSTAANEPIIDAEKLINIDRKPLLRLIDIGVPRNISSDAKS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCHHHHH
VSGIESHDVDDLQEVVSRNQEARQKLALEAEGLIEEECRVFLEWWDSLAAVPTINCLRSS
HCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LESIRKEELQKALSRMGPDFSARERKVVEALSKGIINKILHTPVTKLRAPQSRNDRRDSL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHH
DVIEKLFNLDVSSSLNKPKNN
HHHHHHHCCCHHHHCCCCCCC
>Mature Secondary Structure
MHIAVVGLSHRTAPVEVREKLSIPEELVERSFNNLKKIDQILEVSILSTCNRLEIYSLVK
CEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
DPQLGIEAIKSFLLEFSGLEDEILSPHLFNYVQEKAVSHVMRVSAGLDSLVLGEGQILSQ
CCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHH
VKKMVRLGQDHHSLGPILNRLLTQAVSTGKRVRSETNLGTGAVSISSAAVELAQLKLGQA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
HGRDQLMTLETEKVAVVGAGRMSRLLLQHLQSKGCCSLTLLNRTRKRAEDLSAAFPDIQI
CCCCCEEEEECCCEEEECCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEE
DCQLIDELDSCLSLSTLVFTSTAANEPIIDAEKLINIDRKPLLRLIDIGVPRNISSDAKS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCHHHHH
VSGIESHDVDDLQEVVSRNQEARQKLALEAEGLIEEECRVFLEWWDSLAAVPTINCLRSS
HCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LESIRKEELQKALSRMGPDFSARERKVVEALSKGIINKILHTPVTKLRAPQSRNDRRDSL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHH
DVIEKLFNLDVSSSLNKPKNN
HHHHHHHCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA