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The map label for this gene is sds [H]

Identifier: 124025385

GI number: 124025385

Start: 622668

End: 623639

Strand: Direct

Name: sds [H]

Synonym: NATL1_06761

Alternate gene names: 124025385

Gene position: 622668-623639 (Clockwise)

Preceding gene: 124025384

Following gene: 124025387

Centisome position: 33.39

GC content: 38.17

Gene sequence:

>972_bases
ATGACCACAGCCACGGAAATTCTTCAACCTGTAGAACTTGATCTAGAAGCGTTGCTTTTGGATCTTCGCAGCCTCATAGG
TGCTGGGCACCCTATTTTGCAGGCTGCTGCAGAACATCTTTTTAGTGCGGGCGGTAAACGTTTAAGACCTGGAATTGTTT
TATTAATTTCGAGAGCTTTGACTTCTGAAAAGGAACTTCCTCTGAAGCATCGGAAATTGGCCCAGATTACTGAGATGATT
CATACCGCTTCTCTTGTTCATGATGATGTCGTTGATGAAGCTGATACCCGAAGAGGTGTTGAAACTGTCCATAGTAGATT
TGATCCTAGGATAGCTGTTCTTGCTGGAGATTTTCTATTTGCTCAAGCAAGTTGGCATTTAGCAAATCTTGAGAATTTAG
AGGTCGTTAAATTGTTAAGTAGGGTGATTATGGATCTAGCTGAAGGTGAAATAAAGCAGGGTCTTAATAGATTTGATTCA
AGTCAATCTTTTGAGAGTTATTTAGAAAAAAGTTATTGTAAAACGGCCTCACTAATTGCTAATAGTTCCAAGGCTATTGG
TGTTTTATCTGATGTCGATCAAGAGAGCTTAAATTCACTCTATTTTTTTGGAAGACAATTAGGACTAGCTTTTCAAGTGG
TTGATGATATTCTCGACTTTACGGGGAATGATGAACAACTAGGTAAACCAGCAGCTAGTGATCTTCAGAGTGGTTACCTT
ACTGCCCCGGTCTTTTATGCTTTGGAGGAAAATCCACGTCTTAGTGAACTTATTAATGGTAAATTCTCCCAAAAAGATGA
TCTTGATCAAGCTCTATCTCTCGTAAGAGATTCAAGTGCGATTAAAAAATCAAGAGAATTAGCCGAACAATTTGCATCTG
AATCAAAAGATTCTATTTCTTGGTTGCCAGATTCACCATCAAAAACAGCTTTACTAGAATTACCTGAATTTGTTATTAGC
AGACTTTATTAA

Upstream 100 bases:

>100_bases
AATAAAGCAAAGCATTGGTTAGATGTATTTCCTGAAGTTAATCTTGTTTCACTGCAGAAGAAGGGCTGGGTCTCTTAATA
TCAAAAAGTAGAGCGGTTTT

Downstream 100 bases:

>100_bases
CTTAGTACTCATTCAATATTTGATCAATTTCTTTTAGATGACTGATTTGTCTTAAATTAATGTGTTGATCCAAATCTTCT
TTTTTCGGAAGTTCTTCACT

Product: polyprenyl synthetase; solanesyl diphosphate synthase (sds)

Products: diphosphate; geranylgeranyl diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTTATEILQPVELDLEALLLDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRALTSEKELPLKHRKLAQITEMI
HTASLVHDDVVDEADTRRGVETVHSRFDPRIAVLAGDFLFAQASWHLANLENLEVVKLLSRVIMDLAEGEIKQGLNRFDS
SQSFESYLEKSYCKTASLIANSSKAIGVLSDVDQESLNSLYFFGRQLGLAFQVVDDILDFTGNDEQLGKPAASDLQSGYL
TAPVFYALEENPRLSELINGKFSQKDDLDQALSLVRDSSAIKKSRELAEQFASESKDSISWLPDSPSKTALLELPEFVIS
RLY

Sequences:

>Translated_323_residues
MTTATEILQPVELDLEALLLDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRALTSEKELPLKHRKLAQITEMI
HTASLVHDDVVDEADTRRGVETVHSRFDPRIAVLAGDFLFAQASWHLANLENLEVVKLLSRVIMDLAEGEIKQGLNRFDS
SQSFESYLEKSYCKTASLIANSSKAIGVLSDVDQESLNSLYFFGRQLGLAFQVVDDILDFTGNDEQLGKPAASDLQSGYL
TAPVFYALEENPRLSELINGKFSQKDDLDQALSLVRDSSAIKKSRELAEQFASESKDSISWLPDSPSKTALLELPEFVIS
RLY
>Mature_322_residues
TTATEILQPVELDLEALLLDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRALTSEKELPLKHRKLAQITEMIH
TASLVHDDVVDEADTRRGVETVHSRFDPRIAVLAGDFLFAQASWHLANLENLEVVKLLSRVIMDLAEGEIKQGLNRFDSS
QSFESYLEKSYCKTASLIANSSKAIGVLSDVDQESLNSLYFFGRQLGLAFQVVDDILDFTGNDEQLGKPAASDLQSGYLT
APVFYALEENPRLSELINGKFSQKDDLDQALSLVRDSSAIKKSRELAEQFASESKDSISWLPDSPSKTALLELPEFVISR
LY

Specific function: Possible role in synthesis of the nonaprenyl side chain of plastoquinone or in synthesis of other prenyl chains such as undekaprenyl pyrophosphate [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=312, Percent_Identity=40.3846153846154, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI169808399, Length=231, Percent_Identity=30.7359307359307, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4758430, Length=290, Percent_Identity=23.1034482758621, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI83700220, Length=290, Percent_Identity=23.1034482758621, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1789578, Length=287, Percent_Identity=34.8432055749129, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1786623, Length=225, Percent_Identity=32.8888888888889, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17505681, Length=299, Percent_Identity=35.4515050167224, Blast_Score=188, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6319475, Length=298, Percent_Identity=37.5838926174497, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6325188, Length=304, Percent_Identity=23.0263157894737, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651612, Length=316, Percent_Identity=37.6582278481013, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21356309, Length=346, Percent_Identity=28.3236994219653, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR014120
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: 2.5.1.29

Molecular weight: Translated: 35672; Mature: 35541

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTATEILQPVELDLEALLLDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRAL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TSEKELPLKHRKLAQITEMIHTASLVHDDVVDEADTRRGVETVHSRFDPRIAVLAGDFLF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHH
AQASWHLANLENLEVVKLLSRVIMDLAEGEIKQGLNRFDSSQSFESYLEKSYCKTASLIA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NSSKAIGVLSDVDQESLNSLYFFGRQLGLAFQVVDDILDFTGNDEQLGKPAASDLQSGYL
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHCCCC
TAPVFYALEENPRLSELINGKFSQKDDLDQALSLVRDSSAIKKSRELAEQFASESKDSIS
HHHHHEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WLPDSPSKTALLELPEFVISRLY
CCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTATEILQPVELDLEALLLDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TSEKELPLKHRKLAQITEMIHTASLVHDDVVDEADTRRGVETVHSRFDPRIAVLAGDFLF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHH
AQASWHLANLENLEVVKLLSRVIMDLAEGEIKQGLNRFDSSQSFESYLEKSYCKTASLIA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NSSKAIGVLSDVDQESLNSLYFFGRQLGLAFQVVDDILDFTGNDEQLGKPAASDLQSGYL
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHCCCC
TAPVFYALEENPRLSELINGKFSQKDDLDQALSLVRDSSAIKKSRELAEQFASESKDSIS
HHHHHEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WLPDSPSKTALLELPEFVISRLY
CCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: trans,trans-farnesyl diphosphate; isopentenyl diphosphate

Specific reaction: trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]