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The map label for this gene is menB [H]

Identifier: 124025375

GI number: 124025375

Start: 610013

End: 610906

Strand: Direct

Name: menB [H]

Synonym: NATL1_06641

Alternate gene names: 124025375

Gene position: 610013-610906 (Clockwise)

Preceding gene: 124025374

Following gene: 124025376

Centisome position: 32.71

GC content: 39.82

Gene sequence:

>894_bases
ATGACTTTAAAACCTATTACTCCTAACAATATGTCTAGAAGAGTTCTCCCTGGGGAAATTATTACCTCATGGGTTTCTGT
TGGTGAATACAAAGATATCTTGCTTGATAAAAGTCCAGAAGGAATTGCTCGTGTTGCGATAAATCGTCCTGAGAAAAGAA
ATGCTTTTCGACCTCAAACAATTTCAGAACTTTGTGATGCATTTATTAGAATAAGAGAAGATCCAAAAATTGGAGTCGTT
TTATTTACAGGCGTAGGGCCTTCCAAAGATGGAAAGTTCGCTTTTTGTTCTGGCGGAGATCAGGCTATACGCGGAAGTGG
AGGATACCTTGGAGATGATGGAATTCCGCGTTTAAATGTTCTTGATTTACAACGTATAATTCGGAGCCTTCCTAAAGTAG
TTATTGCACTTGTCCCTGGTTTCGCTATAGGGGGAGGACATGTTTTACATTTAATTTGTGATCTGAGCTTGGCTGCAGAT
AATGCAATGTTCGGACAAACAGGACCTAAAGTTGGGAGCTTTGATGCAGGGTTTGGTTCCAGTTATTTAGCAAGGGTTGT
AGGTCAAAAAAAGGCTAGAGAAATTTGGTTCCTATGCAGGAAATATGGAGCGAAGGAAGCATTGGATATGGGGCTAATAA
ATGCAATCTCACCAATTAATTTACTCGAGTCAGAAGGTGTTAAATGGGCGAGGGAAATACTTCAAAACAGTCCAACAGCT
ATAAAGTGTTTGAAATTTTCTTTTAATGCTGATACAGATGGATTAGCAGGTATCCAAGAGCTAGCTGGCCAGGCAACACA
TCTTTTTTATACGACTGATGAGTCAAAGGAGGGAAGAAATGCTTTCATGGAGAAAAGGGATCCTGATTTCTCCGAATCAA
AATGGCTTCCATGA

Upstream 100 bases:

>100_bases
AACTCTATTGAAGATCATAGATTGAGAGTAAATTTAAGTGATGACCTAAAAAAAACATTATCTGAGAATTTATCAAGTTT
TGACTAGATTTAATTAAAAA

Downstream 100 bases:

>100_bases
TTTTATTTGGTTTATCCAAAAAATAAATCTTTCTTTTTCATGAATTAAATGCGAATACTTTTTGCTGCTGCTGAATGCGC
CCCAATGATAAAGGTTGGAG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTLKPITPNNMSRRVLPGEIITSWVSVGEYKDILLDKSPEGIARVAINRPEKRNAFRPQTISELCDAFIRIREDPKIGVV
LFTGVGPSKDGKFAFCSGGDQAIRGSGGYLGDDGIPRLNVLDLQRIIRSLPKVVIALVPGFAIGGGHVLHLICDLSLAAD
NAMFGQTGPKVGSFDAGFGSSYLARVVGQKKAREIWFLCRKYGAKEALDMGLINAISPINLLESEGVKWAREILQNSPTA
IKCLKFSFNADTDGLAGIQELAGQATHLFYTTDESKEGRNAFMEKRDPDFSESKWLP

Sequences:

>Translated_297_residues
MTLKPITPNNMSRRVLPGEIITSWVSVGEYKDILLDKSPEGIARVAINRPEKRNAFRPQTISELCDAFIRIREDPKIGVV
LFTGVGPSKDGKFAFCSGGDQAIRGSGGYLGDDGIPRLNVLDLQRIIRSLPKVVIALVPGFAIGGGHVLHLICDLSLAAD
NAMFGQTGPKVGSFDAGFGSSYLARVVGQKKAREIWFLCRKYGAKEALDMGLINAISPINLLESEGVKWAREILQNSPTA
IKCLKFSFNADTDGLAGIQELAGQATHLFYTTDESKEGRNAFMEKRDPDFSESKWLP
>Mature_296_residues
TLKPITPNNMSRRVLPGEIITSWVSVGEYKDILLDKSPEGIARVAINRPEKRNAFRPQTISELCDAFIRIREDPKIGVVL
FTGVGPSKDGKFAFCSGGDQAIRGSGGYLGDDGIPRLNVLDLQRIIRSLPKVVIALVPGFAIGGGHVLHLICDLSLAADN
AMFGQTGPKVGSFDAGFGSSYLARVVGQKKAREIWFLCRKYGAKEALDMGLINAISPINLLESEGVKWAREILQNSPTAI
KCLKFSFNADTDGLAGIQELAGQATHLFYTTDESKEGRNAFMEKRDPDFSESKWLP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=263, Percent_Identity=30.4182509505703, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI31542718, Length=256, Percent_Identity=28.125, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI70995211, Length=244, Percent_Identity=27.4590163934426, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4502327, Length=265, Percent_Identity=29.0566037735849, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI213417737, Length=223, Percent_Identity=26.9058295964126, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI157694516, Length=223, Percent_Identity=26.9058295964126, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788597, Length=278, Percent_Identity=60.431654676259, Blast_Score=352, Evalue=1e-98,
Organism=Escherichia coli, GI1787659, Length=252, Percent_Identity=27.7777777777778, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI221142681, Length=264, Percent_Identity=29.9242424242424, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082183, Length=258, Percent_Identity=27.1317829457364, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787660, Length=264, Percent_Identity=27.6515151515151, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=260, Percent_Identity=31.1538461538462, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=266, Percent_Identity=29.6992481203008, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540714, Length=214, Percent_Identity=29.9065420560748, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17549921, Length=222, Percent_Identity=28.3783783783784, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=191, Percent_Identity=30.3664921465969, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=259, Percent_Identity=29.7297297297297, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129971, Length=266, Percent_Identity=29.6992481203008, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653477, Length=266, Percent_Identity=29.6992481203008, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653139, Length=293, Percent_Identity=26.962457337884, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357171, Length=214, Percent_Identity=30.3738317757009, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24654903, Length=207, Percent_Identity=29.4685990338164, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650670, Length=196, Percent_Identity=29.0816326530612, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 32387; Mature: 32255

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKPITPNNMSRRVLPGEIITSWVSVGEYKDILLDKSPEGIARVAINRPEKRNAFRPQT
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEEEEECCCHHCCCCCCHH
ISELCDAFIRIREDPKIGVVLFTGVGPSKDGKFAFCSGGDQAIRGSGGYLGDDGIPRLNV
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCCHH
LDLQRIIRSLPKVVIALVPGFAIGGGHVLHLICDLSLAADNAMFGQTGPKVGSFDAGFGS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
SYLARVVGQKKAREIWFLCRKYGAKEALDMGLINAISPINLLESEGVKWAREILQNSPTA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCCE
IKCLKFSFNADTDGLAGIQELAGQATHLFYTTDESKEGRNAFMEKRDPDFSESKWLP
EEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TLKPITPNNMSRRVLPGEIITSWVSVGEYKDILLDKSPEGIARVAINRPEKRNAFRPQT
CCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEEEEECCCHHCCCCCCHH
ISELCDAFIRIREDPKIGVVLFTGVGPSKDGKFAFCSGGDQAIRGSGGYLGDDGIPRLNV
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCCHH
LDLQRIIRSLPKVVIALVPGFAIGGGHVLHLICDLSLAADNAMFGQTGPKVGSFDAGFGS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
SYLARVVGQKKAREIWFLCRKYGAKEALDMGLINAISPINLLESEGVKWAREILQNSPTA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCCE
IKCLKFSFNADTDGLAGIQELAGQATHLFYTTDESKEGRNAFMEKRDPDFSESKWLP
EEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]