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The map label for this gene is prlC [H]

Identifier: 124025360

GI number: 124025360

Start: 592451

End: 594562

Strand: Reverse

Name: prlC [H]

Synonym: NATL1_06491

Alternate gene names: 124025360

Gene position: 594562-592451 (Counterclockwise)

Preceding gene: 124025361

Following gene: 124025355

Centisome position: 31.88

GC content: 37.41

Gene sequence:

>2112_bases
ATGACTTCAATAAAGCCAACAGCTCTATTAAAAGGTGAAGGACTTCCTGATTACGATAAAATCACCCCTAACGAGATCAC
GGAAAATATACCCAAGCTTATAAAAGAACTAAATGAAAAATTAGACAAACTAGAAGTACAACTCGAAAAACAATTACAAA
CCAAAAGCTCACTTAGTTGGGGTGATGTAATGCCTCAGCTTTATGAAATAGGTGAAAAGCTTAGGTGGAGTTGGGGGGTT
GTAAGTCATCTGAATGCTGTATGCAATTCCACTAAACTTCGTGAGGTTCATTCAAATCAGCAACCTACAATCGTTAGGTT
TAGCAATCAGCTCGCTCAAAACGAGGTCATTTTTAAGGCGCTCTTAAATTTAAAAGAGCATGGAAATATAAAGGACGAAA
CACAAATAAGAATACTTGAGACAGAACTCATAACCATGAAAAACAAAGGAATCGGTCTAGAAGCTGATGAAAAAACACTC
TTTAATTCTCGTAGTGAGAGACTAGCCGAATTGTCAACGACATTTAGTAACAACGTATTAGATGCTACTAAGAATTGGAG
CCTTTTATTAAAAAACAAATCAGAAGTCGAGGGGCTTCCTGAAAGAGCACTTGAAACATTGGCTCTTGCGGCAAAGGAAG
CTGGTGACAAAGATGAAGAAGGTAATAACCCGTCATCATCAATTGGACCATGGAGAGTTGGGTTGGATTTGCCTAGGTAC
ATTCCTTTTCAAACCTATGCAAAAAATAGACGTATTAGAGAGAAAGTCTACAGAGCTTTTGTAAGTAGAGCTAGCGATGG
AAAGATTAATAATAAAAAAATAATTGAAGAAATTCTAGAGCTCAGAAACAAACAGGCAAAACTATTAGGATATAAAAACT
GGTGTGAAATTAGTTTAGCCACAAAGATGGCGGATAATGAAGAAGCTGTTGAGATGTTACTAGAAGAATTACGATTAGCT
GCAATACCTCATGCCGAAAAAGAAGTAATACATCTTCGTGAGTGTGCCAAAAGAAATGGAGAAAACGAAGATTTTGAGCT
ATCTCCATGGGATATAAGTTTTTGGTCTGAAGTTCTTCGCAAAGAGAAATACGATCTTGACCAAGAGAAACTCAGGCCAT
GGTTTCCTCTAGATCAAGTTCTTGATGGTCTATTCAATCTGTGCAAAAGACTTTTTGAAATTGACATTGAAGAAGCAATT
AATACAGCTCCTTTATGGCATGAAGATGTTCGTTTCTTCAACGTTAAAAATATAGATGGCCAGAAAATTGCATCTTTCTA
TCTAGATCCATTCAGTCGTCCTGCGACAAAAAGAGGAGGTGCATGGATGGATGAATGTTTGTGCAGAAATCAAAAAACAA
AAGATGATATTGTTCTCCCAGTAGCCTATTTAGTCTGCAATCAAACTCCTCCAATTGCAGACAAACCCAGTCTTATGAGT
TTCGAAGAAGTAGAAACTCTCTTTCATGAATTTGGGCATGGACTACAACATATGCTGACAACTATAAATTACCCTCAAGC
AGCCGGTATTAATAACGTCGAATGGGATGCTGTCGAATTAGCAAGCCAATTCATGGAAAATTGGTGCTTGGAGGATCAAA
CAATTTCTGAAATAGCAATACATTGGAAGACGAAAGAACCATTACCAGAATCTGAAATCAATAAATTAAGGCAAAGCAGA
ACATTTAATTCTGGGCTAGCGACTTTAAGGCAAATACATTTTGCTCTTACTGATCTAAAACTCCATAGTCAATGGAATAA
AGATTTAGAAATTTCCCCAGATGAGTTGCGACGAGAAATTGCAAAAAATACAACAGTAATGGATCCTATTCCAGAAGATC
AATTTCTCTGTGCCTTCAGTCATATTTTTGCTGGTGGCTATGCTGCTGGATACTACTCTTACAAATGGGCTGAGGTACTC
AGTTCTGACGCCTTTGCCGCTTTTGAAGAGGCAGGCCTTGCTAATCAGGATGAAGTAAGAAAGATTGGTAAAAAATATCG
AGATTCAATTCTTAGTCTTGGTGGTAGTCGTTCACCCAATAAGGTTTTCAAACAATTTAGAGGAAGACTTCCCTCTACTG
AAGCACTAATAAGACATAGTGGTCTTAATTAG

Upstream 100 bases:

>100_bases
AGAATAGCTATTGATTTATATGAGGTATCAACAAATGCTCTCGCACAATCATTAATTACCAATAACCTTGTACCAATCAG
TTAGTTTTTGAATCTTAAAA

Downstream 100 bases:

>100_bases
CTATTTTTAAAAATCTTTTTGACCAAAATATCAAGAGAACTAGAATTTGTTATCAATTCTTTATGTGTCAACACAGGTAA
GTGATAAGACTCACCAATAG

Product: M3 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MTSIKPTALLKGEGLPDYDKITPNEITENIPKLIKELNEKLDKLEVQLEKQLQTKSSLSWGDVMPQLYEIGEKLRWSWGV
VSHLNAVCNSTKLREVHSNQQPTIVRFSNQLAQNEVIFKALLNLKEHGNIKDETQIRILETELITMKNKGIGLEADEKTL
FNSRSERLAELSTTFSNNVLDATKNWSLLLKNKSEVEGLPERALETLALAAKEAGDKDEEGNNPSSSIGPWRVGLDLPRY
IPFQTYAKNRRIREKVYRAFVSRASDGKINNKKIIEEILELRNKQAKLLGYKNWCEISLATKMADNEEAVEMLLEELRLA
AIPHAEKEVIHLRECAKRNGENEDFELSPWDISFWSEVLRKEKYDLDQEKLRPWFPLDQVLDGLFNLCKRLFEIDIEEAI
NTAPLWHEDVRFFNVKNIDGQKIASFYLDPFSRPATKRGGAWMDECLCRNQKTKDDIVLPVAYLVCNQTPPIADKPSLMS
FEEVETLFHEFGHGLQHMLTTINYPQAAGINNVEWDAVELASQFMENWCLEDQTISEIAIHWKTKEPLPESEINKLRQSR
TFNSGLATLRQIHFALTDLKLHSQWNKDLEISPDELRREIAKNTTVMDPIPEDQFLCAFSHIFAGGYAAGYYSYKWAEVL
SSDAFAAFEEAGLANQDEVRKIGKKYRDSILSLGGSRSPNKVFKQFRGRLPSTEALIRHSGLN

Sequences:

>Translated_703_residues
MTSIKPTALLKGEGLPDYDKITPNEITENIPKLIKELNEKLDKLEVQLEKQLQTKSSLSWGDVMPQLYEIGEKLRWSWGV
VSHLNAVCNSTKLREVHSNQQPTIVRFSNQLAQNEVIFKALLNLKEHGNIKDETQIRILETELITMKNKGIGLEADEKTL
FNSRSERLAELSTTFSNNVLDATKNWSLLLKNKSEVEGLPERALETLALAAKEAGDKDEEGNNPSSSIGPWRVGLDLPRY
IPFQTYAKNRRIREKVYRAFVSRASDGKINNKKIIEEILELRNKQAKLLGYKNWCEISLATKMADNEEAVEMLLEELRLA
AIPHAEKEVIHLRECAKRNGENEDFELSPWDISFWSEVLRKEKYDLDQEKLRPWFPLDQVLDGLFNLCKRLFEIDIEEAI
NTAPLWHEDVRFFNVKNIDGQKIASFYLDPFSRPATKRGGAWMDECLCRNQKTKDDIVLPVAYLVCNQTPPIADKPSLMS
FEEVETLFHEFGHGLQHMLTTINYPQAAGINNVEWDAVELASQFMENWCLEDQTISEIAIHWKTKEPLPESEINKLRQSR
TFNSGLATLRQIHFALTDLKLHSQWNKDLEISPDELRREIAKNTTVMDPIPEDQFLCAFSHIFAGGYAAGYYSYKWAEVL
SSDAFAAFEEAGLANQDEVRKIGKKYRDSILSLGGSRSPNKVFKQFRGRLPSTEALIRHSGLN
>Mature_702_residues
TSIKPTALLKGEGLPDYDKITPNEITENIPKLIKELNEKLDKLEVQLEKQLQTKSSLSWGDVMPQLYEIGEKLRWSWGVV
SHLNAVCNSTKLREVHSNQQPTIVRFSNQLAQNEVIFKALLNLKEHGNIKDETQIRILETELITMKNKGIGLEADEKTLF
NSRSERLAELSTTFSNNVLDATKNWSLLLKNKSEVEGLPERALETLALAAKEAGDKDEEGNNPSSSIGPWRVGLDLPRYI
PFQTYAKNRRIREKVYRAFVSRASDGKINNKKIIEEILELRNKQAKLLGYKNWCEISLATKMADNEEAVEMLLEELRLAA
IPHAEKEVIHLRECAKRNGENEDFELSPWDISFWSEVLRKEKYDLDQEKLRPWFPLDQVLDGLFNLCKRLFEIDIEEAIN
TAPLWHEDVRFFNVKNIDGQKIASFYLDPFSRPATKRGGAWMDECLCRNQKTKDDIVLPVAYLVCNQTPPIADKPSLMSF
EEVETLFHEFGHGLQHMLTTINYPQAAGINNVEWDAVELASQFMENWCLEDQTISEIAIHWKTKEPLPESEINKLRQSRT
FNSGLATLRQIHFALTDLKLHSQWNKDLEISPDELRREIAKNTTVMDPIPEDQFLCAFSHIFAGGYAAGYYSYKWAEVLS
SDAFAAFEEAGLANQDEVRKIGKKYRDSILSLGGSRSPNKVFKQFRGRLPSTEALIRHSGLN

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=694, Percent_Identity=27.9538904899135, Blast_Score=246, Evalue=6e-65,
Organism=Homo sapiens, GI14149738, Length=630, Percent_Identity=29.2063492063492, Blast_Score=232, Evalue=9e-61,
Organism=Homo sapiens, GI156105687, Length=457, Percent_Identity=28.0087527352298, Blast_Score=156, Evalue=6e-38,
Organism=Escherichia coli, GI1789913, Length=695, Percent_Identity=39.568345323741, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI1787819, Length=645, Percent_Identity=30.077519379845, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71999758, Length=598, Percent_Identity=24.4147157190635, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32565901, Length=515, Percent_Identity=23.3009708737864, Blast_Score=93, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319793, Length=528, Percent_Identity=30.1136363636364, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6322715, Length=476, Percent_Identity=25.4201680672269, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356111, Length=707, Percent_Identity=27.5813295615276, Blast_Score=251, Evalue=2e-66,
Organism=Drosophila melanogaster, GI20129717, Length=454, Percent_Identity=23.568281938326, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 80513; Mature: 80382

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIKPTALLKGEGLPDYDKITPNEITENIPKLIKELNEKLDKLEVQLEKQLQTKSSLSW
CCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
GDVMPQLYEIGEKLRWSWGVVSHLNAVCNSTKLREVHSNQQPTIVRFSNQLAQNEVIFKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHH
LLNLKEHGNIKDETQIRILETELITMKNKGIGLEADEKTLFNSRSERLAELSTTFSNNVL
HHHHHHCCCCCCCCEEEEEEHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
DATKNWSLLLKNKSEVEGLPERALETLALAAKEAGDKDEEGNNPSSSIGPWRVGLDLPRY
CCCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCC
IPFQTYAKNRRIREKVYRAFVSRASDGKINNKKIIEEILELRNKQAKLLGYKNWCEISLA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCHHEEEHH
TKMADNEEAVEMLLEELRLAAIPHAEKEVIHLRECAKRNGENEDFELSPWDISFWSEVLR
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
KEKYDLDQEKLRPWFPLDQVLDGLFNLCKRLFEIDIEEAINTAPLWHEDVRFFNVKNIDG
HHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCHHCCCEEEECCCCH
QKIASFYLDPFSRPATKRGGAWMDECLCRNQKTKDDIVLPVAYLVCNQTPPIADKPSLMS
HHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
FEEVETLFHEFGHGLQHMLTTINYPQAAGINNVEWDAVELASQFMENWCLEDQTISEIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHE
HWKTKEPLPESEINKLRQSRTFNSGLATLRQIHFALTDLKLHSQWNKDLEISPDELRREI
EECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AKNTTVMDPIPEDQFLCAFSHIFAGGYAAGYYSYKWAEVLSSDAFAAFEEAGLANQDEVR
HHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHH
KIGKKYRDSILSLGGSRSPNKVFKQFRGRLPSTEALIRHSGLN
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TSIKPTALLKGEGLPDYDKITPNEITENIPKLIKELNEKLDKLEVQLEKQLQTKSSLSW
CCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
GDVMPQLYEIGEKLRWSWGVVSHLNAVCNSTKLREVHSNQQPTIVRFSNQLAQNEVIFKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHH
LLNLKEHGNIKDETQIRILETELITMKNKGIGLEADEKTLFNSRSERLAELSTTFSNNVL
HHHHHHCCCCCCCCEEEEEEHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
DATKNWSLLLKNKSEVEGLPERALETLALAAKEAGDKDEEGNNPSSSIGPWRVGLDLPRY
CCCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCC
IPFQTYAKNRRIREKVYRAFVSRASDGKINNKKIIEEILELRNKQAKLLGYKNWCEISLA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCHHEEEHH
TKMADNEEAVEMLLEELRLAAIPHAEKEVIHLRECAKRNGENEDFELSPWDISFWSEVLR
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
KEKYDLDQEKLRPWFPLDQVLDGLFNLCKRLFEIDIEEAINTAPLWHEDVRFFNVKNIDG
HHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCHHCCCEEEECCCCH
QKIASFYLDPFSRPATKRGGAWMDECLCRNQKTKDDIVLPVAYLVCNQTPPIADKPSLMS
HHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
FEEVETLFHEFGHGLQHMLTTINYPQAAGINNVEWDAVELASQFMENWCLEDQTISEIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHE
HWKTKEPLPESEINKLRQSRTFNSGLATLRQIHFALTDLKLHSQWNKDLEISPDELRREI
EECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AKNTTVMDPIPEDQFLCAFSHIFAGGYAAGYYSYKWAEVLSSDAFAAFEEAGLANQDEVR
HHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHH
KIGKKYRDSILSLGGSRSPNKVFKQFRGRLPSTEALIRHSGLN
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]