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The map label for this gene is hisI [H]

Identifier: 124025345

GI number: 124025345

Start: 573986

End: 574627

Strand: Reverse

Name: hisI [H]

Synonym: NATL1_06341

Alternate gene names: 124025345

Gene position: 574627-573986 (Counterclockwise)

Preceding gene: 124025347

Following gene: 124025344

Centisome position: 30.82

GC content: 36.29

Gene sequence:

>642_bases
ATGTTTTTTATAGATAATCTTCATTTTGATCAAAACGGTTTGATCCCAGCCATAGCGCAAGATTGGATCGATGGCGCAGT
CTTAATGATGGCATGGATGAACAAAGAATCCATTACAAAAACATTAGAATCTGGTGAGGTTCATTATTGGAGTCGTTCAA
GGAAAGAACTTTGGCACAAAGGAAAAACGAGCGGACATTTTCAAAAATTGAAAGGAATTAGGACTGATTGCGATTCAGAT
ACAATACTTTTGTCAATTGAGCAAATTGGTTCAATCGCATGCCATACAGGGGAAAGAAGTTGTTTCTTTAAAGATTTAGA
AACAAATAAAGACGTTCTTCACCCTCCATCTAATGCTTGTAGTGAATTATTCAACGTCATAGAGAGTCGTAAGAGTAATC
CTGAGGAGGGAAGCTATACAAATACTCTTTTGAAGGAAGGCGATAATAAAATCCTAAAAAAGATAGGAGAAGAAACAGCC
GAATTTATTATGGCTTGTAAAGATAAAAATCCTATTTCAGTTGCTAATGAGGCTGCAGATCTACTTTTCCATATGCAGGT
TTCTCTAGCCAATCAAAACGTTTCCTGGGAAGAAGTTCTAAAAGTTCTAGTAAAAAGAAGAGGCGCTCCCAGAAGAAATT
AA

Upstream 100 bases:

>100_bases
AATGTAATATCTTTAATCGTCATAAAAAGATGAATAAAAAACCAATAGAGGATTAAATTTAAATAATTAAAGTTCAAAAG
CCTAATTGGCTTAATTAAAA

Downstream 100 bases:

>100_bases
TAGCCAAAGAAGCAACTCTTATATAATTTTTTTACTTATAAATAAGTTGCTTTGGTAGAAAGACAAAGAATTAAATTAAT
AAAAAGTCTTGAAAGAGAAA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MFFIDNLHFDQNGLIPAIAQDWIDGAVLMMAWMNKESITKTLESGEVHYWSRSRKELWHKGKTSGHFQKLKGIRTDCDSD
TILLSIEQIGSIACHTGERSCFFKDLETNKDVLHPPSNACSELFNVIESRKSNPEEGSYTNTLLKEGDNKILKKIGEETA
EFIMACKDKNPISVANEAADLLFHMQVSLANQNVSWEEVLKVLVKRRGAPRRN

Sequences:

>Translated_213_residues
MFFIDNLHFDQNGLIPAIAQDWIDGAVLMMAWMNKESITKTLESGEVHYWSRSRKELWHKGKTSGHFQKLKGIRTDCDSD
TILLSIEQIGSIACHTGERSCFFKDLETNKDVLHPPSNACSELFNVIESRKSNPEEGSYTNTLLKEGDNKILKKIGEETA
EFIMACKDKNPISVANEAADLLFHMQVSLANQNVSWEEVLKVLVKRRGAPRRN
>Mature_213_residues
MFFIDNLHFDQNGLIPAIAQDWIDGAVLMMAWMNKESITKTLESGEVHYWSRSRKELWHKGKTSGHFQKLKGIRTDCDSD
TILLSIEQIGSIACHTGERSCFFKDLETNKDVLHPPSNACSELFNVIESRKSNPEEGSYTNTLLKEGDNKILKKIGEETA
EFIMACKDKNPISVANEAADLLFHMQVSLANQNVSWEEVLKVLVKRRGAPRRN

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=38.974358974359, Blast_Score=136, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319819, Length=174, Percent_Identity=35.0574712643678, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 24169; Mature: 24169

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFIDNLHFDQNGLIPAIAQDWIDGAVLMMAWMNKESITKTLESGEVHYWSRSRKELWHK
CEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEHHHHHHHHHHC
GKTSGHFQKLKGIRTDCDSDTILLSIEQIGSIACHTGERSCFFKDLETNKDVLHPPSNAC
CCCCHHHHHHHCCCCCCCCCEEEEEHHHHCCCCCCCCCCCCEEHHCCCCCCCCCCCCHHH
SELFNVIESRKSNPEEGSYTNTLLKEGDNKILKKIGEETAEFIMACKDKNPISVANEAAD
HHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LLFHMQVSLANQNVSWEEVLKVLVKRRGAPRRN
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFFIDNLHFDQNGLIPAIAQDWIDGAVLMMAWMNKESITKTLESGEVHYWSRSRKELWHK
CEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEHHHHHHHHHHC
GKTSGHFQKLKGIRTDCDSDTILLSIEQIGSIACHTGERSCFFKDLETNKDVLHPPSNAC
CCCCHHHHHHHCCCCCCCCCEEEEEHHHHCCCCCCCCCCCCEEHHCCCCCCCCCCCCHHH
SELFNVIESRKSNPEEGSYTNTLLKEGDNKILKKIGEETAEFIMACKDKNPISVANEAAD
HHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LLFHMQVSLANQNVSWEEVLKVLVKRRGAPRRN
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]