Click here to switch to the map view.

The map label for this gene is gsk [C]

Identifier: 124025274

GI number: 124025274

Start: 509322

End: 510329

Strand: Reverse

Name: gsk [C]

Synonym: NATL1_05631

Alternate gene names: 124025274

Gene position: 510329-509322 (Counterclockwise)

Preceding gene: 124025275

Following gene: 124025271

Centisome position: 27.37

GC content: 37.1

Gene sequence:

>1008_bases
ATGACTAATGAAACAAACGCCGCTTCGCTAGACATAGTAGGTATTGGGAACGCAATTGTAGACGTATTAACAACAATAGA
TGATTCCTTTCTAAAGAAGCTATCTTTCGACAAAGGTTCAATGACCTTGATTGATGAAAACAAAGCCAAAGAACTTTATG
AAATGACTACTAACAGAATTCAAAAGTCAGGAGGTTCAGTTGCCAATTCATTAGCATGTGTTGCACAGCTAGGTGGAAAG
GCAGCCTTTATTGGAAGAGTAAGAGATGACAAGCTAGGAGAAATCTTTACAGAGGAAATATCAACGACTGGGACCATTTT
CAAGACCCCTCCATCATCCGTTGGCCCCTCGACTGCTAGATGCATAATTTTTGTCACTCCAGATGCTCAGAGAACTATGT
GCACTTATCTGGGCGCTTCAGTTCTCTTAGAACCTAAGGATATCGACCTCTCACTAGTCAAGGAAGCAAAAATACTTTAT
TTAGAGGGATACCTATGGGATAACCCAGCTGCTAAAAATGCATTTATTAAAGCGGCAGAAATAGCTAAAAATGCAGGTCG
AAAAGTTGCTTTATCCCTTTCTGATTCATTTTGTGTTAGCAGACACCGCGAGAGTTTTATAAAACTAGTTGACGATCATA
TAGATATATTATTTGCCAATGAAGATGAAATAACAAATTTGTATGAGACCTCTTCTCTAAGTAAAGCTCTTGAAAAATTG
AAAAAAAAATGTGATCTTGCGGCAATCACAATTGGTGAAAAAGGATCAATTCTAATTTCAAATGGCAAAGAAATAAAAAT
AGATCCTTTCATTCTTGGGAAGGCTGTTGATACTACGGGTGCTGGAGATCTTTATGCTGGAGCTTTTTTAAAAGGGTATG
CAGATGGCCTAAAGCCAGAATTATCTGCAAAAATTGGATCTATTTGTGCAGGACAGATAGTTACAGAATTAGGATCTCGC
TCCAATACTGATCTTTTAAATTTGATCAATTCATATTTAGAAAACTAA

Upstream 100 bases:

>100_bases
AAACAATTGTTATTGAAGATCCTATTCACGGACCCAAAAGAGCTCTTTTGAATTCTTAAAAAACAAACAATTGTTCTTTT
ATGATTTTTAAACAAACTTG

Downstream 100 bases:

>100_bases
GGATTGAAAGCTTAAATAGAATTCATCCAATGATGATAATTTTTATTAGCTGAAACGCGAAAATAAATTATTTCTGGTAT
TTCATAGCTATGCAATTCAG

Product: carbohydrate kinase

Products: ADP; H+; IMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTNETNAASLDIVGIGNAIVDVLTTIDDSFLKKLSFDKGSMTLIDENKAKELYEMTTNRIQKSGGSVANSLACVAQLGGK
AAFIGRVRDDKLGEIFTEEISTTGTIFKTPPSSVGPSTARCIIFVTPDAQRTMCTYLGASVLLEPKDIDLSLVKEAKILY
LEGYLWDNPAAKNAFIKAAEIAKNAGRKVALSLSDSFCVSRHRESFIKLVDDHIDILFANEDEITNLYETSSLSKALEKL
KKKCDLAAITIGEKGSILISNGKEIKIDPFILGKAVDTTGAGDLYAGAFLKGYADGLKPELSAKIGSICAGQIVTELGSR
SNTDLLNLINSYLEN

Sequences:

>Translated_335_residues
MTNETNAASLDIVGIGNAIVDVLTTIDDSFLKKLSFDKGSMTLIDENKAKELYEMTTNRIQKSGGSVANSLACVAQLGGK
AAFIGRVRDDKLGEIFTEEISTTGTIFKTPPSSVGPSTARCIIFVTPDAQRTMCTYLGASVLLEPKDIDLSLVKEAKILY
LEGYLWDNPAAKNAFIKAAEIAKNAGRKVALSLSDSFCVSRHRESFIKLVDDHIDILFANEDEITNLYETSSLSKALEKL
KKKCDLAAITIGEKGSILISNGKEIKIDPFILGKAVDTTGAGDLYAGAFLKGYADGLKPELSAKIGSICAGQIVTELGSR
SNTDLLNLINSYLEN
>Mature_334_residues
TNETNAASLDIVGIGNAIVDVLTTIDDSFLKKLSFDKGSMTLIDENKAKELYEMTTNRIQKSGGSVANSLACVAQLGGKA
AFIGRVRDDKLGEIFTEEISTTGTIFKTPPSSVGPSTARCIIFVTPDAQRTMCTYLGASVLLEPKDIDLSLVKEAKILYL
EGYLWDNPAAKNAFIKAAEIAKNAGRKVALSLSDSFCVSRHRESFIKLVDDHIDILFANEDEITNLYETSSLSKALEKLK
KKCDLAAITIGEKGSILISNGKEIKIDPFILGKAVDTTGAGDLYAGAFLKGYADGLKPELSAKIGSICAGQIVTELGSRS
NTDLLNLINSYLEN

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family [H]

Homologues:

Organism=Homo sapiens, GI32484973, Length=307, Percent_Identity=26.3843648208469, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI32484975, Length=307, Percent_Identity=26.3843648208469, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1786684, Length=264, Percent_Identity=25.7575757575758, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17541820, Length=331, Percent_Identity=25.3776435045317, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322565, Length=331, Percent_Identity=23.5649546827795, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571668, Length=331, Percent_Identity=22.3564954682779, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356339, Length=335, Percent_Identity=26.2686567164179, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24663633, Length=335, Percent_Identity=26.2686567164179, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355521, Length=337, Percent_Identity=23.7388724035608, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: 2.7.1.73 [C]

Molecular weight: Translated: 35994; Mature: 35862

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNETNAASLDIVGIGNAIVDVLTTIDDSFLKKLSFDKGSMTLIDENKAKELYEMTTNRI
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHH
QKSGGSVANSLACVAQLGGKAAFIGRVRDDKLGEIFTEEISTTGTIFKTPPSSVGPSTAR
HHCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCE
CIIFVTPDAQRTMCTYLGASVLLEPKDIDLSLVKEAKILYLEGYLWDNPAAKNAFIKAAE
EEEEECCCCHHHHHHHHCHHEEECCCCCCHHEECCCEEEEEEEEEECCCCCCHHHHHHHH
IAKNAGRKVALSLSDSFCVSRHRESFIKLVDDHIDILFANEDEITNLYETSSLSKALEKL
HHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHH
KKKCDLAAITIGEKGSILISNGKEIKIDPFILGKAVDTTGAGDLYAGAFLKGYADGLKPE
HHHCCEEEEEECCCCCEEEECCCEEEECCEEECCCCCCCCCCCHHHHHHHHHHHCCCCHH
LSAKIGSICAGQIVTELGSRSNTDLLNLINSYLEN
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TNETNAASLDIVGIGNAIVDVLTTIDDSFLKKLSFDKGSMTLIDENKAKELYEMTTNRI
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHH
QKSGGSVANSLACVAQLGGKAAFIGRVRDDKLGEIFTEEISTTGTIFKTPPSSVGPSTAR
HHCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCE
CIIFVTPDAQRTMCTYLGASVLLEPKDIDLSLVKEAKILYLEGYLWDNPAAKNAFIKAAE
EEEEECCCCHHHHHHHHCHHEEECCCCCCHHEECCCEEEEEEEEEECCCCCCHHHHHHHH
IAKNAGRKVALSLSDSFCVSRHRESFIKLVDDHIDILFANEDEITNLYETSSLSKALEKL
HHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHH
KKKCDLAAITIGEKGSILISNGKEIKIDPFILGKAVDTTGAGDLYAGAFLKGYADGLKPE
HHHCCEEEEEECCCCCEEEECCCEEEECCEEECCCCCCCCCCCHHHHHHHHHHHCCCCHH
LSAKIGSICAGQIVTELGSRSNTDLLNLINSYLEN
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; Inosine [C]

Specific reaction: ATP + Inosine --> ADP + H+ + IMP [C]

General reaction: Phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]