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The map label for this gene is map [C]

Identifier: 124025244

GI number: 124025244

Start: 482878

End: 483717

Strand: Direct

Name: map [C]

Synonym: NATL1_05331

Alternate gene names: 124025244

Gene position: 482878-483717 (Clockwise)

Preceding gene: 124025239

Following gene: 124025246

Centisome position: 25.9

GC content: 35.36

Gene sequence:

>840_bases
ATGAATCTTTTCTCTGATCTTCTTTCTTCTGAAAACTCAAAAATCCCCATAAATAATGGCCCTGTAATTAAACAAAGGAG
AGGAGTTGAAATTAAGTCTTCAAGAGAGATAGCAATTATGCGTAAATCCAGCAAAATAGTTGCAACTGTATTGAGTGAAA
TTAGAGACTTAGTTAAACCTGGAATGTCTACATTAGATCTAGATAACTATGCTGAAAAACGAATAAGAGATCATGATGCA
AAGCCAAGCTTCAAAGGATATCATGGCTTTCCAGGTAGTATATGTTCAAGCATAAATAACGAAGTTGTTCATGGAATACC
AAGTAAGAAGAAAATTATTAATGATGGAGATTTGCTAAAAGTAGATACGGGTGCTTTTTATAATGGTTACCATGGAGATA
GCTGTATAACTATATGCGTAGGTAATACCTCAGATAAAGCAAACGAATTGAGTAGAGTCGCTAGAGAAGCTTTGATGCTT
GGAATAAAACAAATTAGGCCACAAAATAAACTTCTTGATATTGCAGGTGCAATAGAAGATTATGTGAAAGCTAATGGTTT
TAGTGTCGTCGAAGATTACACTGGGCATGGAGTAGGTAGAAACCTTCACGAAGAGCCTTCGGTGTTTAATTTCAGAACTA
ATGATTTACCAAATGTCACTCTAAGAGAGGGTATGACTATTGCAGTGGAACCTATAATTAATCTTGGGTCAAAACACTGT
AAGACACTGAGAGATGGATGGACAGTCATTACAAAAGATGGAAATCTATCTGCTCAATGGGAACATACTGTTTTGGTCAC
AAAAAATGGTTGTGAGATATTAACTGATAGAGGTGATTGA

Upstream 100 bases:

>100_bases
ATTTTTTAAATGAAACTGTCCCTCTTCATTTGATAGTTTATCTATTATTAGATCATCAATAAAGATGCAAATTTTGAGGT
TTTTACTTTTTTACTAAACA

Downstream 100 bases:

>100_bases
TTTTATTTTAAAGGGGTGGTATTTGAGTAGATTTTATTTATAAATCTTGAATAGAATATTCTAATTAATTCAACGAATGG
CATTATCAAATGTGTTATGG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MNLFSDLLSSENSKIPINNGPVIKQRRGVEIKSSREIAIMRKSSKIVATVLSEIRDLVKPGMSTLDLDNYAEKRIRDHDA
KPSFKGYHGFPGSICSSINNEVVHGIPSKKKIINDGDLLKVDTGAFYNGYHGDSCITICVGNTSDKANELSRVAREALML
GIKQIRPQNKLLDIAGAIEDYVKANGFSVVEDYTGHGVGRNLHEEPSVFNFRTNDLPNVTLREGMTIAVEPIINLGSKHC
KTLRDGWTVITKDGNLSAQWEHTVLVTKNGCEILTDRGD

Sequences:

>Translated_279_residues
MNLFSDLLSSENSKIPINNGPVIKQRRGVEIKSSREIAIMRKSSKIVATVLSEIRDLVKPGMSTLDLDNYAEKRIRDHDA
KPSFKGYHGFPGSICSSINNEVVHGIPSKKKIINDGDLLKVDTGAFYNGYHGDSCITICVGNTSDKANELSRVAREALML
GIKQIRPQNKLLDIAGAIEDYVKANGFSVVEDYTGHGVGRNLHEEPSVFNFRTNDLPNVTLREGMTIAVEPIINLGSKHC
KTLRDGWTVITKDGNLSAQWEHTVLVTKNGCEILTDRGD
>Mature_279_residues
MNLFSDLLSSENSKIPINNGPVIKQRRGVEIKSSREIAIMRKSSKIVATVLSEIRDLVKPGMSTLDLDNYAEKRIRDHDA
KPSFKGYHGFPGSICSSINNEVVHGIPSKKKIINDGDLLKVDTGAFYNGYHGDSCITICVGNTSDKANELSRVAREALML
GIKQIRPQNKLLDIAGAIEDYVKANGFSVVEDYTGHGVGRNLHEEPSVFNFRTNDLPNVTLREGMTIAVEPIINLGSKHC
KTLRDGWTVITKDGNLSAQWEHTVLVTKNGCEILTDRGD

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=258, Percent_Identity=36.4341085271318, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=37.5, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI1786364, Length=253, Percent_Identity=43.8735177865613, Blast_Score=231, Evalue=4e-62,
Organism=Escherichia coli, GI1788728, Length=275, Percent_Identity=26.1818181818182, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789275, Length=175, Percent_Identity=26.8571428571429, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=255, Percent_Identity=36.8627450980392, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6323273, Length=265, Percent_Identity=37.3584905660377, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21355531, Length=253, Percent_Identity=38.7351778656126, Blast_Score=180, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=38.6178861788618, Blast_Score=180, Evalue=8e-46,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 30748; Mature: 30748

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFSDLLSSENSKIPINNGPVIKQRRGVEIKSSREIAIMRKSSKIVATVLSEIRDLVKP
CCHHHHHHCCCCCEECCCCCCCEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHC
GMSTLDLDNYAEKRIRDHDAKPSFKGYHGFPGSICSSINNEVVHGIPSKKKIINDGDLLK
CCCEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCHHEECCCCCCCCCCCCCEEE
VDTGAFYNGYHGDSCITICVGNTSDKANELSRVAREALMLGIKQIRPQNKLLDIAGAIED
EECCCEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YVKANGFSVVEDYTGHGVGRNLHEEPSVFNFRTNDLPNVTLREGMTIAVEPIINLGSKHC
HHHCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEHHCCCEEEEHHHHHCCHHHH
KTLRDGWTVITKDGNLSAQWEHTVLVTKNGCEILTDRGD
HHHHCCCEEEEECCCCCEEEEEEEEEECCCCEEECCCCC
>Mature Secondary Structure
MNLFSDLLSSENSKIPINNGPVIKQRRGVEIKSSREIAIMRKSSKIVATVLSEIRDLVKP
CCHHHHHHCCCCCEECCCCCCCEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHC
GMSTLDLDNYAEKRIRDHDAKPSFKGYHGFPGSICSSINNEVVHGIPSKKKIINDGDLLK
CCCEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCHHEECCCCCCCCCCCCCEEE
VDTGAFYNGYHGDSCITICVGNTSDKANELSRVAREALMLGIKQIRPQNKLLDIAGAIED
EECCCEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YVKANGFSVVEDYTGHGVGRNLHEEPSVFNFRTNDLPNVTLREGMTIAVEPIINLGSKHC
HHHCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEHHCCCEEEEHHHHHCCHHHH
KTLRDGWTVITKDGNLSAQWEHTVLVTKNGCEILTDRGD
HHHHCCCEEEEECCCCCEEEEEEEEEECCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]