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The map label for this gene is gmk [H]

Identifier: 124025233

GI number: 124025233

Start: 475386

End: 475946

Strand: Direct

Name: gmk [H]

Synonym: NATL1_05221

Alternate gene names: 124025233

Gene position: 475386-475946 (Clockwise)

Preceding gene: 124025229

Following gene: 124025236

Centisome position: 25.49

GC content: 33.69

Gene sequence:

>561_bases
ATGTCTTCTTTAGGAAATCTTACTGTTCTTACTGGCCCAAGCGGGGTGGGTAAAGGAACAATTGTTAGGAAAATCCTTGA
AAGTCATAGTGATGTATGGCTTTCTATTTCTGCTACTACTCGTCAGCCAAGATCTGGAGAAATTGAGGGAGAGCATTACT
TCTTCTTAGAGAAAAAAAAATTTCAAGAAATAATTGATAAAGATGGTTTCCTAGAGTGGGCTTCATTCTCTAATAATTTT
TATGGAACTCCAAAAAAAATAGTTAAAGAAAAAATTGAAAAGGGAACAAATGTCCTTCTTGAAATTGAATTAGAGGGTGC
TCGACAAATTCGAAAGTCTTTTCCGGAGGCATTTCAAATATTTTTAGCACCACCAAATTTATATGAACTTGAAAAAAGAA
TTAGAGGAAGAGGAACTGAAACAGAAGAATCTATTAGAGATCGTTTGTCCATAGCTGAAAAAGAACTTATTGCCCAAAAA
GAGTTTGACGCTGTAGTTATTAATGAAGATATAGAAAAAGCCTTCAAGGAAATTGAAGGCTTTATGGGATTAAAACTTTA
A

Upstream 100 bases:

>100_bases
AAGTCCATTATTTGAATTGGAACTTTGTTCATCTATCATCCTTTTAAATTCATAAATAATGCAATTAAGCTTTGCTAGGC
AAATCAGATAGGATTTATTT

Downstream 100 bases:

>100_bases
TTTAATTAATAATGTCTTTTTTTTAAAAAGACATTGGGTGGAAAAGTAAGTCTGGTACGAATCTATTGAATTCAACGATA
ATACCTGCTGTGAGAGTGAT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MSSLGNLTVLTGPSGVGKGTIVRKILESHSDVWLSISATTRQPRSGEIEGEHYFFLEKKKFQEIIDKDGFLEWASFSNNF
YGTPKKIVKEKIEKGTNVLLEIELEGARQIRKSFPEAFQIFLAPPNLYELEKRIRGRGTETEESIRDRLSIAEKELIAQK
EFDAVVINEDIEKAFKEIEGFMGLKL

Sequences:

>Translated_186_residues
MSSLGNLTVLTGPSGVGKGTIVRKILESHSDVWLSISATTRQPRSGEIEGEHYFFLEKKKFQEIIDKDGFLEWASFSNNF
YGTPKKIVKEKIEKGTNVLLEIELEGARQIRKSFPEAFQIFLAPPNLYELEKRIRGRGTETEESIRDRLSIAEKELIAQK
EFDAVVINEDIEKAFKEIEGFMGLKL
>Mature_185_residues
SSLGNLTVLTGPSGVGKGTIVRKILESHSDVWLSISATTRQPRSGEIEGEHYFFLEKKKFQEIIDKDGFLEWASFSNNFY
GTPKKIVKEKIEKGTNVLLEIELEGARQIRKSFPEAFQIFLAPPNLYELEKRIRGRGTETEESIRDRLSIAEKELIAQKE
FDAVVINEDIEKAFKEIEGFMGLKL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=39.4285714285714, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=39.4285714285714, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI226874831, Length=176, Percent_Identity=39.2045454545455, Blast_Score=137, Evalue=5e-33,
Organism=Homo sapiens, GI38570142, Length=173, Percent_Identity=27.7456647398844, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI186700629, Length=176, Percent_Identity=25.5681818181818, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI186972120, Length=176, Percent_Identity=25.5681818181818, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI186700627, Length=176, Percent_Identity=25.5681818181818, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI111154074, Length=171, Percent_Identity=28.0701754385965, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI14780902, Length=183, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI21361598, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4505237, Length=181, Percent_Identity=25.414364640884, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI262118255, Length=181, Percent_Identity=25.414364640884, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI262118259, Length=181, Percent_Identity=25.414364640884, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI262118263, Length=181, Percent_Identity=25.414364640884, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790080, Length=177, Percent_Identity=39.5480225988701, Blast_Score=163, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI193203132, Length=174, Percent_Identity=46.551724137931, Blast_Score=156, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17508835, Length=174, Percent_Identity=46.551724137931, Blast_Score=155, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17557440, Length=178, Percent_Identity=31.4606741573034, Blast_Score=90, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71988048, Length=175, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71988041, Length=175, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320662, Length=179, Percent_Identity=41.8994413407821, Blast_Score=153, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21356141, Length=178, Percent_Identity=41.5730337078652, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI161077626, Length=172, Percent_Identity=25, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554489, Length=172, Percent_Identity=25, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24640542, Length=172, Percent_Identity=25, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI116007136, Length=172, Percent_Identity=25, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45554481, Length=172, Percent_Identity=25, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI85724806, Length=172, Percent_Identity=25, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45551002, Length=206, Percent_Identity=26.2135922330097, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85816106, Length=206, Percent_Identity=25.7281553398058, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85816281, Length=206, Percent_Identity=25.7281553398058, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221330166, Length=183, Percent_Identity=26.2295081967213, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221330162, Length=183, Percent_Identity=25.6830601092896, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221330164, Length=183, Percent_Identity=25.6830601092896, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21170; Mature: 21038

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLGNLTVLTGPSGVGKGTIVRKILESHSDVWLSISATTRQPRSGEIEGEHYFFLEKKK
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEECHHH
FQEIIDKDGFLEWASFSNNFYGTPKKIVKEKIEKGTNVLLEIELEGARQIRKSFPEAFQI
HHHHHCCCCCEEHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECHHHHHHHHCHHHHEE
FLAPPNLYELEKRIRGRGTETEESIRDRLSIAEKELIAQKEFDAVVINEDIEKAFKEIEG
EECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
FMGLKL
HCCCCC
>Mature Secondary Structure 
SSLGNLTVLTGPSGVGKGTIVRKILESHSDVWLSISATTRQPRSGEIEGEHYFFLEKKK
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEECHHH
FQEIIDKDGFLEWASFSNNFYGTPKKIVKEKIEKGTNVLLEIELEGARQIRKSFPEAFQI
HHHHHCCCCCEEHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECHHHHHHHHCHHHHEE
FLAPPNLYELEKRIRGRGTETEESIRDRLSIAEKELIAQKEFDAVVINEDIEKAFKEIEG
EECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
FMGLKL
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA