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The map label for this gene is groEL

Identifier: 124025217

GI number: 124025217

Start: 461078

End: 462769

Strand: Reverse

Name: groEL

Synonym: NATL1_05061

Alternate gene names: 124025217

Gene position: 462769-461078 (Counterclockwise)

Preceding gene: 124025219

Following gene: 124025211

Centisome position: 24.82

GC content: 40.01

Gene sequence:

>1692_bases
ATGGCAAAACTTCTAAGTTTTTCAGACGAATCTCGTGGTGCTCTCGAAAAAGGAGTAAACAATTTAGCCAACGCTCTAAA
AGTCACAATTGGACCTAAAGGTAGAAATGTTGTTATTGAAAAAAAATTTGGAGCTCCAGATATAGTTAATGATGGAGTAA
CTATTGCTAAGGAAATAGATCTTGAAGATCCATTTGAAAATATAGGAGCAAAGCTCATTGAACAGGTTGCATCAAAAACG
AAAGAAAAAGCTGGAGATGGAACAACTACTGCAACAGTTTTAGCTCAATTTATGGTTCAAGAGGGTTTGAGAAATACAGC
CGCTGGAGCAAGCCCAATCGAATTAAGAAGAGGAATGGAAAAGGCTGTAGCTCAAATAGTTGATGATCTAAAGAAAAAAA
GCAAATCAGTCAGTGGTGATGCTATAAAACAAGTTGCGACAGTAAGTGCCGGTGGAGACGAGGAAATAGGTTCCATGATT
GCAGATGCAATAGATAAAGTAAGTTTTGATGGAGTTATAACTGTTGAGGAATCCAAATCTCTAGCCACCGAATTAGATAT
CACTGAGGGAATGGCATTTGACAGAGGATATAGCTCTCCATATTTTGTGACAGATGAAGATCGATTAATTTGCGAATTTG
AAAATCCTTCAATCCTAATTACTGACAAAAAGATTTCATCAATTGCCGATCTCATTCCTGTTCTAGAAACAGTTCAAAAG
AACGGAACACCATTAATAATTCTTGCAGAAGAAGTAGAGGGTGAAGCATTAGCCACATTAGTAGTAAATAAAAATCGTGG
TGTTTTACAAGTAGCAGCTGTTAGAGCTCCATCATTTGGCGAGAGACGAAAAGCAGCTCTTGGAGATATTGCGGTATTAA
CTGGTGGCACATTAATAAGCGAAGACAAAGCAATGAGTCTTGAGAAAGTTCAAATTTCTGACCTAGGTCAAGCAAGAAGA
GTAACAATTACAAAAGACAGTACAACAATTGTCGCAAATGATAATCAAAACACCGAACTATCTAATCGCATTGCATCAAT
CAAGAGAGAACTTGACGAAACAGACTCTGAGTACGATCAAGAGAAGTTAAATGAGAGAATAGCTAAACTTGCTGGGGGTG
TAGCTGTAATTAAAGTCGGAGCTCCAACTGAAACTGAGTTAAAAAACAGAAAGCTCAGAATTGAGGATGCTCTGAATGCA
ACTCGTGCAGCCATTGAAGAAGGTATTGTTGCAGGTGGTGGAACAACTCTTTTAGAACTGAGTGAAGGGCTTGGAGATTT
AGCTAAAAAGCTAGAGGGTGATCAGAAGACTGGAGTTGAAATTATAAAAAGAGCATTGACTGCTCCAACAAAACAGATAG
CGATAAATGCTGGATTTAACGGAGATGTTGTTGTTTCAGATATCAAGCGTTTAGGCAAAGGCTTCAATGCACAAACTGGA
GAGTACGTGGATTTGCTTGAAGCAGGAATCTTAGATGCTTCAAAAGTAATACGACTTGCTCTTCAAGATGCTGTATCAAT
TGCCTCACTGCTCATAACTACTGAAGTTGTTATTGCTGACAAACCTGAGCCCCCATCAGCGCCAGGAGCTGAAGGTGGAG
ATCCAATGGGCGGAATGGGCGGAATGGGCGGTATGGGCGGTATGGGCGGTATGGGCGGTATGGGCGGTATGGGAATGCCT
GGAATGATGTAA

Upstream 100 bases:

>100_bases
ATTGGGAATAATTTGTGAATTACAATTCGGCTTTCCCCACTTATTTAGCCTCCCCTAATGTGTGTTTCCTGTGGGAGATT
AAGATTAATTCAAATCAAAT

Downstream 100 bases:

>100_bases
GAAAATAAAAAATTCTACAATCTCAAATTAAAGAATTAGAAATTAGTAAAAACTAATTTAGAACTTATTATCTCAACAAC
CACTTCTTGAGATAACTATA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MAKLLSFSDESRGALEKGVNNLANALKVTIGPKGRNVVIEKKFGAPDIVNDGVTIAKEIDLEDPFENIGAKLIEQVASKT
KEKAGDGTTTATVLAQFMVQEGLRNTAAGASPIELRRGMEKAVAQIVDDLKKKSKSVSGDAIKQVATVSAGGDEEIGSMI
ADAIDKVSFDGVITVEESKSLATELDITEGMAFDRGYSSPYFVTDEDRLICEFENPSILITDKKISSIADLIPVLETVQK
NGTPLIILAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGERRKAALGDIAVLTGGTLISEDKAMSLEKVQISDLGQARR
VTITKDSTTIVANDNQNTELSNRIASIKRELDETDSEYDQEKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNA
TRAAIEEGIVAGGGTTLLELSEGLGDLAKKLEGDQKTGVEIIKRALTAPTKQIAINAGFNGDVVVSDIKRLGKGFNAQTG
EYVDLLEAGILDASKVIRLALQDAVSIASLLITTEVVIADKPEPPSAPGAEGGDPMGGMGGMGGMGGMGGMGGMGGMGMP
GMM

Sequences:

>Translated_563_residues
MAKLLSFSDESRGALEKGVNNLANALKVTIGPKGRNVVIEKKFGAPDIVNDGVTIAKEIDLEDPFENIGAKLIEQVASKT
KEKAGDGTTTATVLAQFMVQEGLRNTAAGASPIELRRGMEKAVAQIVDDLKKKSKSVSGDAIKQVATVSAGGDEEIGSMI
ADAIDKVSFDGVITVEESKSLATELDITEGMAFDRGYSSPYFVTDEDRLICEFENPSILITDKKISSIADLIPVLETVQK
NGTPLIILAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGERRKAALGDIAVLTGGTLISEDKAMSLEKVQISDLGQARR
VTITKDSTTIVANDNQNTELSNRIASIKRELDETDSEYDQEKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNA
TRAAIEEGIVAGGGTTLLELSEGLGDLAKKLEGDQKTGVEIIKRALTAPTKQIAINAGFNGDVVVSDIKRLGKGFNAQTG
EYVDLLEAGILDASKVIRLALQDAVSIASLLITTEVVIADKPEPPSAPGAEGGDPMGGMGGMGGMGGMGGMGGMGGMGMP
GMM
>Mature_562_residues
AKLLSFSDESRGALEKGVNNLANALKVTIGPKGRNVVIEKKFGAPDIVNDGVTIAKEIDLEDPFENIGAKLIEQVASKTK
EKAGDGTTTATVLAQFMVQEGLRNTAAGASPIELRRGMEKAVAQIVDDLKKKSKSVSGDAIKQVATVSAGGDEEIGSMIA
DAIDKVSFDGVITVEESKSLATELDITEGMAFDRGYSSPYFVTDEDRLICEFENPSILITDKKISSIADLIPVLETVQKN
GTPLIILAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGERRKAALGDIAVLTGGTLISEDKAMSLEKVQISDLGQARRV
TITKDSTTIVANDNQNTELSNRIASIKRELDETDSEYDQEKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNAT
RAAIEEGIVAGGGTTLLELSEGLGDLAKKLEGDQKTGVEIIKRALTAPTKQIAINAGFNGDVVVSDIKRLGKGFNAQTGE
YVDLLEAGILDASKVIRLALQDAVSIASLLITTEVVIADKPEPPSAPGAEGGDPMGGMGGMGGMGGMGGMGGMGGMGMPG
MM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=532, Percent_Identity=48.6842105263158, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI31542947, Length=532, Percent_Identity=48.6842105263158, Blast_Score=483, Evalue=1e-136,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=54.2533081285444, Blast_Score=551, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=47.5378787878788, Blast_Score=466, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI193210679, Length=223, Percent_Identity=43.9461883408072, Blast_Score=174, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=49.1428571428571, Blast_Score=482, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24641193, Length=533, Percent_Identity=48.780487804878, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24641191, Length=533, Percent_Identity=48.780487804878, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=46.7680608365019, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=46.7680608365019, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=46.7680608365019, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17864606, Length=524, Percent_Identity=44.8473282442748, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24584129, Length=548, Percent_Identity=36.8613138686131, Blast_Score=291, Evalue=6e-79,
Organism=Drosophila melanogaster, GI19921262, Length=548, Percent_Identity=36.8613138686131, Blast_Score=291, Evalue=6e-79,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_PROM1 (A2C0Q8)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014333.1
- ProteinModelPortal:   A2C0Q8
- SMR:   A2C0Q8
- STRING:   A2C0Q8
- GeneID:   4780924
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_05061
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   GASPIEL
- ProtClustDB:   PRK12849
- BioCyc:   PMAR167555:NATL1_05061-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 59053; Mature: 58922

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLSFSDESRGALEKGVNNLANALKVTIGPKGRNVVIEKKFGAPDIVNDGVTIAKEID
CCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEECC
LEDPFENIGAKLIEQVASKTKEKAGDGTTTATVLAQFMVQEGLRNTAAGASPIELRRGME
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KAVAQIVDDLKKKSKSVSGDAIKQVATVSAGGDEEIGSMIADAIDKVSFDGVITVEESKS
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
LATELDITEGMAFDRGYSSPYFVTDEDRLICEFENPSILITDKKISSIADLIPVLETVQK
HHHHCCHHCCCCCCCCCCCCEEEECCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHHHC
NGTPLIILAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGERRKAALGDIAVLTGGTLIS
CCCEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHCCEEEEECCEEEC
EDKAMSLEKVQISDLGQARRVTITKDSTTIVANDNQNTELSNRIASIKRELDETDSEYDQ
CCCCCCHHHEEHHCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHH
EKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNATRAAIEEGIVAGGGTTLLEL
HHHHHHHHHHHCCEEEEEECCCCHHHHHCCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHH
SEGLGDLAKKLEGDQKTGVEIIKRALTAPTKQIAINAGFNGDVVVSDIKRLGKGFNAQTG
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCC
EYVDLLEAGILDASKVIRLALQDAVSIASLLITTEVVIADKPEPPSAPGAEGGDPMGGMG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCC
GMGGMGGMGGMGGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKLLSFSDESRGALEKGVNNLANALKVTIGPKGRNVVIEKKFGAPDIVNDGVTIAKEID
CCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEECC
LEDPFENIGAKLIEQVASKTKEKAGDGTTTATVLAQFMVQEGLRNTAAGASPIELRRGME
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KAVAQIVDDLKKKSKSVSGDAIKQVATVSAGGDEEIGSMIADAIDKVSFDGVITVEESKS
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
LATELDITEGMAFDRGYSSPYFVTDEDRLICEFENPSILITDKKISSIADLIPVLETVQK
HHHHCCHHCCCCCCCCCCCCEEEECCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHHHC
NGTPLIILAEEVEGEALATLVVNKNRGVLQVAAVRAPSFGERRKAALGDIAVLTGGTLIS
CCCEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHCCEEEEECCEEEC
EDKAMSLEKVQISDLGQARRVTITKDSTTIVANDNQNTELSNRIASIKRELDETDSEYDQ
CCCCCCHHHEEHHCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHH
EKLNERIAKLAGGVAVIKVGAPTETELKNRKLRIEDALNATRAAIEEGIVAGGGTTLLEL
HHHHHHHHHHHCCEEEEEECCCCHHHHHCCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHH
SEGLGDLAKKLEGDQKTGVEIIKRALTAPTKQIAINAGFNGDVVVSDIKRLGKGFNAQTG
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCC
EYVDLLEAGILDASKVIRLALQDAVSIASLLITTEVVIADKPEPPSAPGAEGGDPMGGMG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCC
GMGGMGGMGGMGGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA