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The map label for this gene is cyoB [H]

Identifier: 124025210

GI number: 124025210

Start: 453952

End: 455592

Strand: Reverse

Name: cyoB [H]

Synonym: NATL1_04991

Alternate gene names: 124025210

Gene position: 455592-453952 (Counterclockwise)

Preceding gene: 124025211

Following gene: 124025209

Centisome position: 24.43

GC content: 39.49

Gene sequence:

>1641_bases
ATGACTATTTCACTCAAACCAAACAACTCTTCTCCAGAAAAACTTCAACCAACAGGATGGCTCAAATATCTGAGTTTTAG
TCTTGATCACAAAGTCATAGGACTTCAATATTTAGTTTGTGGTTTCTTGTTTTATTTAATTGGAGGATCTTTAGCTGGAG
CAATAAGAGTAGAACTGATCAGTCCCCTCTCAGATTTTATGCCTAGAGAGGTTTACAACCAGGTTTTAACTCTCCACGGC
ACAATCATGATTTTCTTATGGATCGTGCCTGTAGTAAATGGTGCCTTTGGAAACTACTTAATACCCTTTTATGTTGGGGC
TAGGGACATGGCTTTCCCAAGGCTGAATGCAGTTGCTTTTTGGCTAATACCTCCCTCTGGCTTAATGTTGATAACAAGTT
ATTTCATAAACGGAGCCGCACAATCAGGGTGGACAGCTTACCCACCTTTAAGCATTACGACTCCAGCCGCTGGGCAAATC
ATTTGGATATTAAGTGTCTTGCTTTTGGGTGGGAGCTCAATTTTTGGTGGCATTAATTTCATCGCCACCATCCTCAAGCT
AAGGAGACCTGGTCTTAAATTAATGCAATTACCTATGTATTGCTGGGCAATGCTTGGCACGAGTATTCTTGTAGTTCTAT
CAACTCCTGTTCTCGCTGGTACTCTAATACTGCTGAGCTTTGACATAGTTGCTCATACCGGTTTCTTCAACCCAAGTCTT
GGTGGGAATGTAATCGTTTATCAACATCTTTTTTGGTTTTACTCGCATCCTGCTGTTTATATCATGGTCTTACCTGCCTT
TGGTTTAGTCAGTGAAATACTTCCAATCCATAGTAGAAAACCACTTTTTGGCTATACAACTATGGTCTTCTCAATTATGG
GAATAGTTGTGTTGGGTCTAGTTGTTTGGGCTCATCATATGTTTACAAGCGGTACTCCTCCTTGGATGCGCTTATTTTTT
ACAATCGCTACTGCATTTATAGCTGTTCCCACAGGTATTAAATTTTTTAATTGGGTTGCGACCTTATGGGGAGGAAAAAT
ATCACTTAATGCTGCAATGTTATTTTCCTGCGGATTTATTATTAACTTTGTTTTAGGTGGAATAACGGGAGTTGCCCTAG
CGCAAGTACCTTTTGATGTTCATGTACACGACACTTATTTTGTTGTTGCCCATTTTCATTACATAGTTTATGGCGGTTCT
GTCTTTGTTATCTTCTCCTCGATTTATCACTGGTTCCCAAAATTTACTGGAAAAATGCTCAATGAAAATCTTGGAAGATT
CCACTTTATAATTACTTTTATAGGCTTTAATCTTTGTTTTGCTCCTCAACATTGGCTAGGTTTAAACGGAATGCCTCGAC
GAGTTGCCGAATACGATCCACAATTTCAGTTAATCAATCAAATTAGTAGTGTAGGTGCATTATTAATGGCTTTAAGTACT
TTACCTTTCTTATGGAATATTCTTCAAAGCATCCTCTTTGGGGAAGAGGCTGGTGATAACCCTTGGAATGCACTAACTCC
TGAGTGGTTAACAAGTTCTCCTCCTCCTGTTGAGAATTGGGACGGAGAAGCCCCACTAGTTCTTGAACCTTATGGTTATG
GAGAAAAAGATTCAAATGAGACTCAGGAGGCAATCAGATGA

Upstream 100 bases:

>100_bases
GGTCCTTATCATGGTGGGATGAGATCAAACGTAATAGTTGATGAACAAGAAGACTTTGATACTTGGTTAAAAGAAAACTC
TAAAGAATCAATATAAGTTC

Downstream 100 bases:

>100_bases
CATCAATAGTTCCAAAAGAGCAATCCTCAGGAAGCAAGAATGAGCTCTCAGCTGAAGAACATGAAGATTTTCGTTTGTTT
GGCTTAATAGCTTTTTTAAT

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTISLKPNNSSPEKLQPTGWLKYLSFSLDHKVIGLQYLVCGFLFYLIGGSLAGAIRVELISPLSDFMPREVYNQVLTLHG
TIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWLIPPSGLMLITSYFINGAAQSGWTAYPPLSITTPAAGQI
IWILSVLLLGGSSIFGGINFIATILKLRRPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLILLSFDIVAHTGFFNPSL
GGNVIVYQHLFWFYSHPAVYIMVLPAFGLVSEILPIHSRKPLFGYTTMVFSIMGIVVLGLVVWAHHMFTSGTPPWMRLFF
TIATAFIAVPTGIKFFNWVATLWGGKISLNAAMLFSCGFIINFVLGGITGVALAQVPFDVHVHDTYFVVAHFHYIVYGGS
VFVIFSSIYHWFPKFTGKMLNENLGRFHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQLINQISSVGALLMALST
LPFLWNILQSILFGEEAGDNPWNALTPEWLTSSPPPVENWDGEAPLVLEPYGYGEKDSNETQEAIR

Sequences:

>Translated_546_residues
MTISLKPNNSSPEKLQPTGWLKYLSFSLDHKVIGLQYLVCGFLFYLIGGSLAGAIRVELISPLSDFMPREVYNQVLTLHG
TIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWLIPPSGLMLITSYFINGAAQSGWTAYPPLSITTPAAGQI
IWILSVLLLGGSSIFGGINFIATILKLRRPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLILLSFDIVAHTGFFNPSL
GGNVIVYQHLFWFYSHPAVYIMVLPAFGLVSEILPIHSRKPLFGYTTMVFSIMGIVVLGLVVWAHHMFTSGTPPWMRLFF
TIATAFIAVPTGIKFFNWVATLWGGKISLNAAMLFSCGFIINFVLGGITGVALAQVPFDVHVHDTYFVVAHFHYIVYGGS
VFVIFSSIYHWFPKFTGKMLNENLGRFHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQLINQISSVGALLMALST
LPFLWNILQSILFGEEAGDNPWNALTPEWLTSSPPPVENWDGEAPLVLEPYGYGEKDSNETQEAIR
>Mature_545_residues
TISLKPNNSSPEKLQPTGWLKYLSFSLDHKVIGLQYLVCGFLFYLIGGSLAGAIRVELISPLSDFMPREVYNQVLTLHGT
IMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWLIPPSGLMLITSYFINGAAQSGWTAYPPLSITTPAAGQII
WILSVLLLGGSSIFGGINFIATILKLRRPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLILLSFDIVAHTGFFNPSLG
GNVIVYQHLFWFYSHPAVYIMVLPAFGLVSEILPIHSRKPLFGYTTMVFSIMGIVVLGLVVWAHHMFTSGTPPWMRLFFT
IATAFIAVPTGIKFFNWVATLWGGKISLNAAMLFSCGFIINFVLGGITGVALAQVPFDVHVHDTYFVVAHFHYIVYGGSV
FVIFSSIYHWFPKFTGKMLNENLGRFHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQLINQISSVGALLMALSTL
PFLWNILQSILFGEEAGDNPWNALTPEWLTSSPPPVENWDGEAPLVLEPYGYGEKDSNETQEAIR

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=507, Percent_Identity=43.3925049309665, Blast_Score=383, Evalue=1e-106,
Organism=Escherichia coli, GI1786634, Length=536, Percent_Identity=40.2985074626866, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6226519, Length=525, Percent_Identity=38.2857142857143, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6226524, Length=318, Percent_Identity=39.622641509434, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6226523, Length=246, Percent_Identity=35.7723577235772, Blast_Score=144, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 60634; Mature: 60503

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISLKPNNSSPEKLQPTGWLKYLSFSLDHKVIGLQYLVCGFLFYLIGGSLAGAIRVELI
CEEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SPLSDFMPREVYNQVLTLHGTIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEE
WLIPPSGLMLITSYFINGAAQSGWTAYPPLSITTPAAGQIIWILSVLLLGGSSIFGGINF
EEECCCCHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCHHHHHHHH
IATILKLRRPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLILLSFDIVAHTGFFNPSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCC
GGNVIVYQHLFWFYSHPAVYIMVLPAFGLVSEILPIHSRKPLFGYTTMVFSIMGIVVLGL
CCCEEHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
VVWAHHMFTSGTPPWMRLFFTIATAFIAVPTGIKFFNWVATLWGGKISLNAAMLFSCGFI
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHH
INFVLGGITGVALAQVPFDVHVHDTYFVVAHFHYIVYGGSVFVIFSSIYHWFPKFTGKML
HHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NENLGRFHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQLINQISSVGALLMALST
HCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
LPFLWNILQSILFGEEAGDNPWNALTPEWLTSSPPPVENWDGEAPLVLEPYGYGEKDSNE
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCH
TQEAIR
HHHHCC
>Mature Secondary Structure 
TISLKPNNSSPEKLQPTGWLKYLSFSLDHKVIGLQYLVCGFLFYLIGGSLAGAIRVELI
EEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SPLSDFMPREVYNQVLTLHGTIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEE
WLIPPSGLMLITSYFINGAAQSGWTAYPPLSITTPAAGQIIWILSVLLLGGSSIFGGINF
EEECCCCHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCHHHHHHHH
IATILKLRRPGLKLMQLPMYCWAMLGTSILVVLSTPVLAGTLILLSFDIVAHTGFFNPSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCC
GGNVIVYQHLFWFYSHPAVYIMVLPAFGLVSEILPIHSRKPLFGYTTMVFSIMGIVVLGL
CCCEEHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
VVWAHHMFTSGTPPWMRLFFTIATAFIAVPTGIKFFNWVATLWGGKISLNAAMLFSCGFI
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHH
INFVLGGITGVALAQVPFDVHVHDTYFVVAHFHYIVYGGSVFVIFSSIYHWFPKFTGKML
HHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NENLGRFHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQLINQISSVGALLMALST
HCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
LPFLWNILQSILFGEEAGDNPWNALTPEWLTSSPPPVENWDGEAPLVLEPYGYGEKDSNE
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCH
TQEAIR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8387368; 8905231 [H]