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The map label for this gene is mutM

Identifier: 124025133

GI number: 124025133

Start: 391064

End: 391912

Strand: Reverse

Name: mutM

Synonym: NATL1_04201

Alternate gene names: 124025133

Gene position: 391912-391064 (Counterclockwise)

Preceding gene: 124025134

Following gene: 124025132

Centisome position: 21.02

GC content: 32.74

Gene sequence:

>849_bases
TTGCCAGAATTACCTGAAGTTGAGACAGTTAGGAAAGGACTTGAGAAACTTTTAAATGATTTTTATATTGAAAGAATAGA
AGTGTTAAAAGAGCGTTCAATAGCAAGTAATGGAGGGTCAAAAAGTTTCATAGATAATGTTAAAAATAGTTATTTGGGTA
ATTGGGAAAGAAGAGGTAAATATTTAATAGGATCCCTACTTACAAAAGAAAAATTTAGTAAAGGTTTTTTAGTTGTTCAC
TTAAGAATGACAGGCCAATTTAAATTACTTGAGAAAGAAGTTTTAGCATGCAAGCATACGAGAGTGAGATTTTTTGAGGA
GAGAGGGAGAGAACTCCGTTTTATAGATATTAGAAATTTCGGACAAATGTGGCACGTGCCTTCGTCAAGATCAGTTCCAG
AGATAGTATCTGGAATTAAAAGATTAGGCCCAGAGCCATTTAGTGATGATTTTAATAGTCACTATTTAGAAGAATATTTG
AAGAAAAAAACTCGCTCAATTAAATCTGCTTTATTAGATCAAAGAACTGTTGCTGGGGTTGGGAATATATATGCAGATGA
AACATTATTTGATGCAGGGATTAATCCAAAAACAGAAAGTAGAAATTTAAAAAGTAATGAATTAAAAAGACTTTGCAATA
GTCTGATCAAAATCTTAAATATAAGTATTGGAGAAGGAGGCACTACTTTTAGTGACTTTAGAGATTTAGAGGGGGGCAAT
GGAAATTATGGAGGACAAGCCTTGGTATACAGAAGAAGTGGTAAAAATTGTAAAAAATGTGGAGAAAAGATATTGCGAGA
AAAAATCTGTGGAAGGAGCACACACTGGTGTCCTAATTGCCAAAAATAA

Upstream 100 bases:

>100_bases
GTGATTTCAAAGCTTTTAGCGGTGTTGATGGTGGAGCCAATACCAGTCAATTTTCAGTAAAAGAATTAGAAGCTGCAGCA
AGCTAGTACTATTAATACTT

Downstream 100 bases:

>100_bases
TTTGTCATTAAAAAAGGGTCCCTAAAGACCCTTTTTTAAAATATTTTACCTGGCATCGAGCTATTTTCTCAGGGGGCAAC
CCCCCAAATATCGTCGCCGC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MPELPEVETVRKGLEKLLNDFYIERIEVLKERSIASNGGSKSFIDNVKNSYLGNWERRGKYLIGSLLTKEKFSKGFLVVH
LRMTGQFKLLEKEVLACKHTRVRFFEERGRELRFIDIRNFGQMWHVPSSRSVPEIVSGIKRLGPEPFSDDFNSHYLEEYL
KKKTRSIKSALLDQRTVAGVGNIYADETLFDAGINPKTESRNLKSNELKRLCNSLIKILNISIGEGGTTFSDFRDLEGGN
GNYGGQALVYRRSGKNCKKCGEKILREKICGRSTHWCPNCQK

Sequences:

>Translated_282_residues
MPELPEVETVRKGLEKLLNDFYIERIEVLKERSIASNGGSKSFIDNVKNSYLGNWERRGKYLIGSLLTKEKFSKGFLVVH
LRMTGQFKLLEKEVLACKHTRVRFFEERGRELRFIDIRNFGQMWHVPSSRSVPEIVSGIKRLGPEPFSDDFNSHYLEEYL
KKKTRSIKSALLDQRTVAGVGNIYADETLFDAGINPKTESRNLKSNELKRLCNSLIKILNISIGEGGTTFSDFRDLEGGN
GNYGGQALVYRRSGKNCKKCGEKILREKICGRSTHWCPNCQK
>Mature_281_residues
PELPEVETVRKGLEKLLNDFYIERIEVLKERSIASNGGSKSFIDNVKNSYLGNWERRGKYLIGSLLTKEKFSKGFLVVHL
RMTGQFKLLEKEVLACKHTRVRFFEERGRELRFIDIRNFGQMWHVPSSRSVPEIVSGIKRLGPEPFSDDFNSHYLEEYLK
KKTRSIKSALLDQRTVAGVGNIYADETLFDAGINPKTESRNLKSNELKRLCNSLIKILNISIGEGGTTFSDFRDLEGGNG
NYGGQALVYRRSGKNCKKCGEKILREKICGRSTHWCPNCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=287, Percent_Identity=35.8885017421603, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1786932, Length=148, Percent_Identity=26.3513513513513, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_PROM1 (A2C0H4)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014249.1
- ProteinModelPortal:   A2C0H4
- SMR:   A2C0H4
- STRING:   A2C0H4
- GeneID:   4780860
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_04201
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK13945
- BioCyc:   PMAR167555:NATL1_04201-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 32248; Mature: 32117

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 272-272 BINDING 99-99 BINDING 118-118 BINDING 163-163

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRKGLEKLLNDFYIERIEVLKERSIASNGGSKSFIDNVKNSYLGNWERRGK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHH
YLIGSLLTKEKFSKGFLVVHLRMTGQFKLLEKEVLACKHTRVRFFEERGRELRFIDIRNF
HHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
GQMWHVPSSRSVPEIVSGIKRLGPEPFSDDFNSHYLEEYLKKKTRSIKSALLDQRTVAGV
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GNIYADETLFDAGINPKTESRNLKSNELKRLCNSLIKILNISIGEGGTTFSDFRDLEGGN
CCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCC
GNYGGQALVYRRSGKNCKKCGEKILREKICGRSTHWCPNCQK
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRKGLEKLLNDFYIERIEVLKERSIASNGGSKSFIDNVKNSYLGNWERRGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHH
YLIGSLLTKEKFSKGFLVVHLRMTGQFKLLEKEVLACKHTRVRFFEERGRELRFIDIRNF
HHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
GQMWHVPSSRSVPEIVSGIKRLGPEPFSDDFNSHYLEEYLKKKTRSIKSALLDQRTVAGV
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GNIYADETLFDAGINPKTESRNLKSNELKRLCNSLIKILNISIGEGGTTFSDFRDLEGGN
CCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCC
GNYGGQALVYRRSGKNCKKCGEKILREKICGRSTHWCPNCQK
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA