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The map label for this gene is mtnP [H]

Identifier: 124025093

GI number: 124025093

Start: 349706

End: 350638

Strand: Reverse

Name: mtnP [H]

Synonym: NATL1_03801

Alternate gene names: 124025093

Gene position: 350638-349706 (Counterclockwise)

Preceding gene: 124025095

Following gene: 124025087

Centisome position: 18.8

GC content: 35.8

Gene sequence:

>933_bases
ATGATCACTGAACATGATTTTTTGAATATTTCTGGAACACAATCAGATGCCTACGATTTCAAACAAGCAAGATTAGGAAT
TATTGGCGGAAGCGGACTATATAGGATAGAAAATCTTAAAGACATAGTCGAGTTAAGCTTAGACACTCCCTATGGGAAAC
CATCTAATAAGTTACTAATAGGCAATCTATTTGGAATTGAGATTGTTTTTCTTGCTCGCCACGGAGAGAAACATACTTTA
AATCCAAGTGAAATTCCATACAAAGCAAATATCTGGGCTATGCGCTCTCTAAATGTTAGATGGTTGATATCCGCATCAGC
GGTGGGATCATTAAAAGAAAATATCAAACCTTGCGACATTGTTATTCCTGATCAATTTATTGATCGCACTCATCAAAGGC
CATTGACTTTTTTCAACAATGGAGTTGTAGCGCACATAAGCATGGCAAATCCATTTTGCGACATTCTTTCTCAAATACTT
TCGAAAGAAATAGAAAAACTTTTAACAAAAGACAAAAAAATGCATATTGGAGGAACATATCTTGCTATGGAGGGACCAGC
CTTTTCAACAAGAGCAGAATCAAACTTATACAGAGATTGGGGATGCTCAATAATAGGTATGACAAACCATACTGAAGCTA
GATTGGCAAAAGAAGCTGAAATCGCATATTCCAGCCTATCAATGGTTACTGATTATGATTGCTGGAACCAAAATTGCGAA
AATGTATCTGTAGAAATGGTCATTGAAAATCTTCAGGAAAATGCAAATTTTGCAAAATCAATAATTTCTGCTGTTGCTAA
AAGAGTCTCATCATTAAGGCCGCCAAGCTCTTTTCACAGTGCATTAAAAGATGCCTTAGTCACCCCAGAAGAGCATGTTC
CAGAAAAGACTAAAAGCAAGATCAAATTATTTACAGATAAATATTGGCTTTAA

Upstream 100 bases:

>100_bases
TATTAACTAAAGTAATCATTCCAGCAGGCTTCAATTTTGGATTCATTGCCCACTGGAGCAACACAAGGGCATGAGTATGA
CCACCACCAGCTAGAACGAG

Downstream 100 bases:

>100_bases
AAAAAACAACCGACACATTAAGTGTCGGTTGTTTTTTTTATTTCAATTAAAATAGTATTTATCTAGTTGAAACTAACCAG
CGTTACCAATACCAGTGTAT

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MITEHDFLNISGTQSDAYDFKQARLGIIGGSGLYRIENLKDIVELSLDTPYGKPSNKLLIGNLFGIEIVFLARHGEKHTL
NPSEIPYKANIWAMRSLNVRWLISASAVGSLKENIKPCDIVIPDQFIDRTHQRPLTFFNNGVVAHISMANPFCDILSQIL
SKEIEKLLTKDKKMHIGGTYLAMEGPAFSTRAESNLYRDWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQNCE
NVSVEMVIENLQENANFAKSIISAVAKRVSSLRPPSSFHSALKDALVTPEEHVPEKTKSKIKLFTDKYWL

Sequences:

>Translated_310_residues
MITEHDFLNISGTQSDAYDFKQARLGIIGGSGLYRIENLKDIVELSLDTPYGKPSNKLLIGNLFGIEIVFLARHGEKHTL
NPSEIPYKANIWAMRSLNVRWLISASAVGSLKENIKPCDIVIPDQFIDRTHQRPLTFFNNGVVAHISMANPFCDILSQIL
SKEIEKLLTKDKKMHIGGTYLAMEGPAFSTRAESNLYRDWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQNCE
NVSVEMVIENLQENANFAKSIISAVAKRVSSLRPPSSFHSALKDALVTPEEHVPEKTKSKIKLFTDKYWL
>Mature_310_residues
MITEHDFLNISGTQSDAYDFKQARLGIIGGSGLYRIENLKDIVELSLDTPYGKPSNKLLIGNLFGIEIVFLARHGEKHTL
NPSEIPYKANIWAMRSLNVRWLISASAVGSLKENIKPCDIVIPDQFIDRTHQRPLTFFNNGVVAHISMANPFCDILSQIL
SKEIEKLLTKDKKMHIGGTYLAMEGPAFSTRAESNLYRDWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQNCE
NVSVEMVIENLQENANFAKSIISAVAKRVSSLRPPSSFHSALKDALVTPEEHVPEKTKSKIKLFTDKYWL

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=275, Percent_Identity=44, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71980569, Length=290, Percent_Identity=34.8275862068965, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323045, Length=307, Percent_Identity=37.1335504885993, Blast_Score=189, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20130079, Length=252, Percent_Identity=40.8730158730159, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI221459247, Length=248, Percent_Identity=35.0806451612903, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 34811; Mature: 34811

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITEHDFLNISGTQSDAYDFKQARLGIIGGSGLYRIENLKDIVELSLDTPYGKPSNKLLI
CCCCCCEEEECCCCCHHHHHHHHEEEEECCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEE
GNLFGIEIVFLARHGEKHTLNPSEIPYKANIWAMRSLNVRWLISASAVGSLKENIKPCDI
EEECCEEEEEEEECCCCCCCCCCCCCEECCEEEEEECCEEEEEEHHHHHHHHHCCCCCEE
VIPDQFIDRTHQRPLTFFNNGVVAHISMANPFCDILSQILSKEIEKLLTKDKKMHIGGTY
ECCHHHHHHHCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEECCEEE
LAMEGPAFSTRAESNLYRDWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQNCE
EEECCCCCCCHHHCCCCHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
NVSVEMVIENLQENANFAKSIISAVAKRVSSLRPPSSFHSALKDALVTPEEHVPEKTKSK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHCCCHHHHH
IKLFTDKYWL
EEEECCCCCC
>Mature Secondary Structure
MITEHDFLNISGTQSDAYDFKQARLGIIGGSGLYRIENLKDIVELSLDTPYGKPSNKLLI
CCCCCCEEEECCCCCHHHHHHHHEEEEECCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEE
GNLFGIEIVFLARHGEKHTLNPSEIPYKANIWAMRSLNVRWLISASAVGSLKENIKPCDI
EEECCEEEEEEEECCCCCCCCCCCCCEECCEEEEEECCEEEEEEHHHHHHHHHCCCCCEE
VIPDQFIDRTHQRPLTFFNNGVVAHISMANPFCDILSQILSKEIEKLLTKDKKMHIGGTY
ECCHHHHHHHCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEECCEEE
LAMEGPAFSTRAESNLYRDWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQNCE
EEECCCCCCCHHHCCCCHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
NVSVEMVIENLQENANFAKSIISAVAKRVSSLRPPSSFHSALKDALVTPEEHVPEKTKSK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHCCCHHHHH
IKLFTDKYWL
EEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA