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The map label for this gene is folK [H]

Identifier: 124025080

GI number: 124025080

Start: 339802

End: 340383

Strand: Reverse

Name: folK [H]

Synonym: NATL1_03671

Alternate gene names: 124025080

Gene position: 340383-339802 (Counterclockwise)

Preceding gene: 124025082

Following gene: 124025079

Centisome position: 18.25

GC content: 37.29

Gene sequence:

>582_bases
ATGACTTATGCAAAACAAAAACCAGAATTGAAACTCGTCATCTCAATAGGCTCAAATATCCCTGGCATTCTTGGAGACCC
CATAAGAACAATCGCTGCTATGAGGCCGCATATAGAAAAAAGCGTAATCGAGTGGAATATTGCTTTAAATCATCCAAAAA
TAGACTCTCAAAATTTTGATAAGTCTTTATCTTTTCAATGGGCTCCTCTATTTGAGACTGATCCTTTAGGGGGGCCAATT
GACCAACCAAGATTCATTAATACCGTACTTGTTGTGGAGGGAGAGGGTTTTGCCTCAGTAACCCCAAATGAAAAAGCAGC
TAAATGCTTAATGAAAAAATTTTTAGAATTAGAAAAAATTGCAGGCAGGGAAAGAGAAAATACAGAGATTATTTGGGGGC
CAAGATCTTTGGATATTGACTTCATTTCTTGGGGAGGACTACAAATAAATACTGACACTTTGATTTTGCCTCATCCAAGA
TTAAGTGAAAGGAACTTTGTTTTAATTCCCCTTGCAGAAGTTTTATCAAAGACCCAAGGGAAACCGACACGAATCAGTTC
TCAAAATATTTGGCCTGAATAA

Upstream 100 bases:

>100_bases
CAATGTCTTTTGAAGTCGAAGACATATTGTTATTGTTCAATCCACTGGAAACCATGGGTTGGATCAACAAGCAAATTTTT
AAAAGTCTTTTAATATTCGC

Downstream 100 bases:

>100_bases
AACTCGTAACCAAAATCACCAACCTTTTCTAAAAAAATCAGCCATCCTATAAGGATAGAAAAAAAAGCATGGCAATTCCA
GGACCTGAACCCTCAGAAAT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTYAKQKPELKLVISIGSNIPGILGDPIRTIAAMRPHIEKSVIEWNIALNHPKIDSQNFDKSLSFQWAPLFETDPLGGPI
DQPRFINTVLVVEGEGFASVTPNEKAAKCLMKKFLELEKIAGRERENTEIIWGPRSLDIDFISWGGLQINTDTLILPHPR
LSERNFVLIPLAEVLSKTQGKPTRISSQNIWPE

Sequences:

>Translated_193_residues
MTYAKQKPELKLVISIGSNIPGILGDPIRTIAAMRPHIEKSVIEWNIALNHPKIDSQNFDKSLSFQWAPLFETDPLGGPI
DQPRFINTVLVVEGEGFASVTPNEKAAKCLMKKFLELEKIAGRERENTEIIWGPRSLDIDFISWGGLQINTDTLILPHPR
LSERNFVLIPLAEVLSKTQGKPTRISSQNIWPE
>Mature_192_residues
TYAKQKPELKLVISIGSNIPGILGDPIRTIAAMRPHIEKSVIEWNIALNHPKIDSQNFDKSLSFQWAPLFETDPLGGPID
QPRFINTVLVVEGEGFASVTPNEKAAKCLMKKFLELEKIAGRERENTEIIWGPRSLDIDFISWGGLQINTDTLILPHPRL
SERNFVLIPLAEVLSKTQGKPTRISSQNIWPE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=105, Percent_Identity=36.1904761904762, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 21690; Mature: 21559

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYAKQKPELKLVISIGSNIPGILGDPIRTIAAMRPHIEKSVIEWNIALNHPKIDSQNFD
CCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCC
KSLSFQWAPLFETDPLGGPIDQPRFINTVLVVEGEGFASVTPNEKAAKCLMKKFLELEKI
CCCCEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
AGRERENTEIIWGPRSLDIDFISWGGLQINTDTLILPHPRLSERNFVLIPLAEVLSKTQG
CCCCCCCCEEEECCCCCCEEEEEECCEEECCCEEEECCCCCCCCCEEEEEHHHHHHHCCC
KPTRISSQNIWPE
CCCEECCCCCCCC
>Mature Secondary Structure 
TYAKQKPELKLVISIGSNIPGILGDPIRTIAAMRPHIEKSVIEWNIALNHPKIDSQNFD
CCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCC
KSLSFQWAPLFETDPLGGPIDQPRFINTVLVVEGEGFASVTPNEKAAKCLMKKFLELEKI
CCCCEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
AGRERENTEIIWGPRSLDIDFISWGGLQINTDTLILPHPRLSERNFVLIPLAEVLSKTQG
CCCCCCCCEEEECCCCCCEEEEEECCEEECCCEEEECCCCCCCCCEEEEEHHHHHHHCCC
KPTRISSQNIWPE
CCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]