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The map label for this gene is apt [H]

Identifier: 124023104

GI number: 124023104

Start: 1195987

End: 1196568

Strand: Reverse

Name: apt [H]

Synonym: P9303_13991

Alternate gene names: 124023104

Gene position: 1196568-1195987 (Counterclockwise)

Preceding gene: 124023108

Following gene: 124023101

Centisome position: 44.6

GC content: 51.72

Gene sequence:

>582_bases
GTGGTTGTTGCATTGACCATGGCTGCGATGATGCCAGGCCTAAGGCCCCTGCGTCACCACTCCTTGGATCTTCGCCACCT
CATTCAAGACATACCAGACTTTCCAAAACCTGGAATTCTCTTTCGGGACATCAGTCCCCTGCTGCGTGATCCCGATGGCT
GGGGTGAAGTGATGCGACAGCTAGGAGATCTCTGCACAGAATTCAAACCCGATTTAATTGTCGGAATCGAATCACGTGGA
TTCATTGTGGGAACAGCTTTAGCAACGAATCGGAAAATCGGCTTTGTTCCGGTTAGGAAGCCTGGCAAATTGCCTGGTGA
TGTTCTTGGCATCGACTATTCCCTGGAGTACGGCAGCGATCGGCTCGAGATTCATGCGGATGCTCTGCAAGGTCATCCCC
GTGTCTTAATGGTGGACGACCTTCTGGCGACTGGAGGAACTGCAAAAGCCACAGTCGAGTTAATCGAGCAGGCTGGTGGT
GATCTGGTGGGATGTGGTTTTGTGATCGAATTAGCCGCTCTCGGCGGGCGTCAGCAACTTCCAGTTGAGATACCAGTGAA
ATCACTGATTATCTACTCCTGA

Upstream 100 bases:

>100_bases
ACGCTCAAGTCCTCTCCTGCCAAGAATGGTGTTGTTCTGCACGCCGCTCTGCTTTTGCTCAAAGGGTTTCTGTGGCTGAA
CAGTTGATGAAGGGTCTGAA

Downstream 100 bases:

>100_bases
TCATTTTCCCAATCGAGAACCTGCTGATACTGAGTCAAGCTGAGTAAACCGAAACTCCAAAGCACGACCGGCAGAGGTGC
TTGCTCAAGTTCTGCCTGAC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MVVALTMAAMMPGLRPLRHHSLDLRHLIQDIPDFPKPGILFRDISPLLRDPDGWGEVMRQLGDLCTEFKPDLIVGIESRG
FIVGTALATNRKIGFVPVRKPGKLPGDVLGIDYSLEYGSDRLEIHADALQGHPRVLMVDDLLATGGTAKATVELIEQAGG
DLVGCGFVIELAALGGRQQLPVEIPVKSLIIYS

Sequences:

>Translated_193_residues
MVVALTMAAMMPGLRPLRHHSLDLRHLIQDIPDFPKPGILFRDISPLLRDPDGWGEVMRQLGDLCTEFKPDLIVGIESRG
FIVGTALATNRKIGFVPVRKPGKLPGDVLGIDYSLEYGSDRLEIHADALQGHPRVLMVDDLLATGGTAKATVELIEQAGG
DLVGCGFVIELAALGGRQQLPVEIPVKSLIIYS
>Mature_193_residues
MVVALTMAAMMPGLRPLRHHSLDLRHLIQDIPDFPKPGILFRDISPLLRDPDGWGEVMRQLGDLCTEFKPDLIVGIESRG
FIVGTALATNRKIGFVPVRKPGKLPGDVLGIDYSLEYGSDRLEIHADALQGHPRVLMVDDLLATGGTAKATVELIEQAGG
DLVGCGFVIELAALGGRQQLPVEIPVKSLIIYS

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=172, Percent_Identity=44.7674418604651, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI71773201, Length=124, Percent_Identity=49.1935483870968, Blast_Score=107, Evalue=5e-24,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=49.0445859872611, Blast_Score=151, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17509087, Length=168, Percent_Identity=44.6428571428571, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=175, Percent_Identity=42.2857142857143, Blast_Score=122, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=169, Percent_Identity=33.1360946745562, Blast_Score=85, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136334, Length=171, Percent_Identity=43.2748538011696, Blast_Score=123, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20895; Mature: 20895

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVALTMAAMMPGLRPLRHHSLDLRHLIQDIPDFPKPGILFRDISPLLRDPDGWGEVMRQ
CEEEEEHHHHCCCCCHHHHCCCCHHHHHHHCCCCCCCCEEHHCCCHHHCCCCCHHHHHHH
LGDLCTEFKPDLIVGIESRGFIVGTALATNRKIGFVPVRKPGKLPGDVLGIDYSLEYGSD
HHHHHHHCCCCEEEEECCCCEEEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCC
RLEIHADALQGHPRVLMVDDLLATGGTAKATVELIEQAGGDLVGCGFVIELAALGGRQQL
EEEEEEHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCC
PVEIPVKSLIIYS
CEEECHHEEEEEC
>Mature Secondary Structure
MVVALTMAAMMPGLRPLRHHSLDLRHLIQDIPDFPKPGILFRDISPLLRDPDGWGEVMRQ
CEEEEEHHHHCCCCCHHHHCCCCHHHHHHHCCCCCCCCEEHHCCCHHHCCCCCHHHHHHH
LGDLCTEFKPDLIVGIESRGFIVGTALATNRKIGFVPVRKPGKLPGDVLGIDYSLEYGSD
HHHHHHHCCCCEEEEECCCCEEEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCC
RLEIHADALQGHPRVLMVDDLLATGGTAKATVELIEQAGGDLVGCGFVIELAALGGRQQL
EEEEEEHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCC
PVEIPVKSLIIYS
CEEECHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA