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The map label for this gene is purC

Identifier: 124022258

GI number: 124022258

Start: 530835

End: 531563

Strand: Direct

Name: purC

Synonym: P9303_05481

Alternate gene names: 124022258

Gene position: 530835-531563 (Clockwise)

Preceding gene: 124022257

Following gene: 124022259

Centisome position: 19.79

GC content: 54.46

Gene sequence:

>729_bases
ATGACGCCAGATCACGGCCCTCTGCTCTATGAGGGCAAGGCCAAAAGAGTATTCGCTGCGGATCAGCCCGATTGTGTGTT
GGTGGAGTTCAAGAATGACGCCACGGCGTTTAATGCACTCAAACGGGCTGAACTCGAGGGCAAGGGGCGACTGAACTGTC
AGATCTCGGCACGACTGTTCGAGATGCTTGAGCGAGAGGGTGTGCCCACCCACTACCTCGGCCTGGCCGCCGAAACCTGG
ATGCTTGTTCAGCATGTTGATGTGATTCCCCTGGAGGTTGTGATTCGCAACGTGGCGACTGGATCGCTTTGTCAACAAAC
GCCGATTGCGGCCGGTACTGAGCTTTCGCCCGCTTTGTTGGATCTCTATTACAAGGACGACAATTTGGGTGATCCCCTGC
TGAGCGAATCAAGGCTGCAGCTGCTTGGATTGATCAGTTCGCAGCAGCGTTTAGAGATCGAACAGTTGGCACGTCGAGTG
AATCAGCTGTTGCTGTCTTTTTTTGAGAGCTTGGACCTGTTGTTGGTGGACTTCAAGCTCGAACTTGGACTCAACGGTGC
CGGCACTCTGCTGGTGGCTGATGAAATCAGTCCTGATACCTGCAGGCTTTGGGACCATCGAAATAGTGATCCCCAGGCCC
GCATTTTGGATAAGGATCGCTTCCGCCAGGACCTTGGTGGAGTGATTGAAGCCTACGGGGAGATCCTCAAACGGGTCCAA
GGGGTGTGA

Upstream 100 bases:

>100_bases
TTCTAGAGCAGGAGCTGCGCTCGCCCCGTCAGCCTGGCGGCCATGCTGCTGTTGAAGCGCATCAAAGTGCGCCTCCTGTT
TCAGTTCCATCAGAATTCAA

Downstream 100 bases:

>100_bases
GCTAATCCCTTCAACTGCAGGTAATGTCAGCGCACATTTGGCGGCTTTGTAGCCGGATTCCTATCACCCATGGCCAGCTT
CCTATCTAGCGGACCCTCGG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTPDHGPLLYEGKAKRVFAADQPDCVLVEFKNDATAFNALKRAELEGKGRLNCQISARLFEMLEREGVPTHYLGLAAETW
MLVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALLDLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRV
NQLLLSFFESLDLLLVDFKLELGLNGAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQ
GV

Sequences:

>Translated_242_residues
MTPDHGPLLYEGKAKRVFAADQPDCVLVEFKNDATAFNALKRAELEGKGRLNCQISARLFEMLEREGVPTHYLGLAAETW
MLVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALLDLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRV
NQLLLSFFESLDLLLVDFKLELGLNGAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQ
GV
>Mature_241_residues
TPDHGPLLYEGKAKRVFAADQPDCVLVEFKNDATAFNALKRAELEGKGRLNCQISARLFEMLEREGVPTHYLGLAAETWM
LVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALLDLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRVN
QLLLSFFESLDLLLVDFKLELGLNGAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQG
V

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=226, Percent_Identity=31.4159292035398, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI5453539, Length=226, Percent_Identity=31.4159292035398, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI119220559, Length=233, Percent_Identity=30.0429184549356, Blast_Score=101, Evalue=7e-22,
Organism=Escherichia coli, GI1788820, Length=231, Percent_Identity=38.961038961039, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17531275, Length=236, Percent_Identity=32.2033898305085, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI18860083, Length=244, Percent_Identity=28.6885245901639, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583917, Length=249, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_PROM3 (A2C740)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016565.1
- ProteinModelPortal:   A2C740
- SMR:   A2C740
- STRING:   A2C740
- GeneID:   4775922
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_05481
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26995; Mature: 26864

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDHGPLLYEGKAKRVFAADQPDCVLVEFKNDATAFNALKRAELEGKGRLNCQISARLF
CCCCCCCEEECCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEHHHHHH
EMLEREGVPTHYLGLAAETWMLVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHH
DLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRVNQLLLSFFESLDLLLVDFKL
EEEECCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEE
ELGLNGAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQ
EECCCCCCEEEEEECCCCCCEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHC
GV
CC
>Mature Secondary Structure 
TPDHGPLLYEGKAKRVFAADQPDCVLVEFKNDATAFNALKRAELEGKGRLNCQISARLF
CCCCCCEEECCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEHHHHHH
EMLEREGVPTHYLGLAAETWMLVQHVDVIPLEVVIRNVATGSLCQQTPIAAGTELSPALL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHH
DLYYKDDNLGDPLLSESRLQLLGLISSQQRLEIEQLARRVNQLLLSFFESLDLLLVDFKL
EEEECCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEE
ELGLNGAGTLLVADEISPDTCRLWDHRNSDPQARILDKDRFRQDLGGVIEAYGEILKRVQ
EECCCCCCEEEEEECCCCCCEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHC
GV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA