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The map label for this gene is ald [H]

Identifier: 124022198

GI number: 124022198

Start: 483092

End: 484231

Strand: Reverse

Name: ald [H]

Synonym: P9303_04881

Alternate gene names: 124022198

Gene position: 484231-483092 (Counterclockwise)

Preceding gene: 124022199

Following gene: 124022195

Centisome position: 18.05

GC content: 60.61

Gene sequence:

>1140_bases
ATGGACTCCTCTATTCTTTCGGCCCCAATAGCCAGCATCGGGGTACCGACCGAAATTAAAGCCGATGAGCTGAGAGTGGC
ACTTACTCCTGACGGGGTGAAAGAACTGGTCAACAAGGGGCTAGAAGTAAGGGTTCAGGCTGGTGCCGGGGCTGGAGCGG
GCATTGGTGATGAGGCCTTCGCTGATGCCGGTGCCAAGCTTGTCAACCGCGAGGAGGCCTGGGCAGCCCATCTCGTCGTG
AAGGTGAAGGAGCCTCAGGAAGAGGAGTTCTGTCTACTCAGGCAAGACATGGTGCTCTTCACTTACCTACACCTGGCCGC
CTACCCAAAGGTGGGTGAAGCCCTGCTCAATGCTGGCACCACCGGCGTGGGTTACGAAACGGTGCAACTAGAAAACGGCA
GCCTGCCGCTACTGGCACCAATGAGCGAAATCGCCGGCCGTCTAGCCGCACAAGTGGGCGCCCATTTGCTCGAACGACCT
CATGGCGGACGCGGCGTGCTGATCGGAGGCTGCACCGGCGTGCAACCGGCCCGGGTGGTCGTGTTGGGCGCTGGCACCGT
GGGCTGGAATGCGGCCAGGCTGGCCGCCGCCATGGATGCCGAAGTGATGTTGCTAGACCGCTCACCTGAACGGTTGCGTA
GCCTTGAGACAAGCCGCCGCGGCAGGCTGATTAGCGTTGTCAACAGCCGTGGCCTGCTGGAGCGACTCATCCCCACTGCA
GACCTTTTGATCGGTGCCGTCCTGACGCCCGGAGGTCGAGCACCCACCCTCGTCGATGAAGAGATGGTGAAACAAATGAA
GCCCAATTCAGTGATCGTGGATGTAGCGATCGATCAGGGAGGTTGTGTGGCCACCAGCCAAGAAACCACCCACACCCATC
CCACCGTGACCATCCACGGCGTCCAGCACTACGCCGTCGGCAACATGCCAGGTGCGGTGCCTTTTACCTCCACTGAAGCC
CTGGTGAGCGTGACCCTGCCCTACATCCTTGGCATTGCCGGGCGGGGCCTTGAGGAGGCCGTCACCGAACGTCCCGAACT
TCTTTCCGGCCTCAACACAATTCAAGGCTCCGTTTGTCATCCGGGTGTCGCCAAGGCCCTAGGACTACCACCAAGGCACC
CAATGGCATGCTTACGCTAA

Upstream 100 bases:

>100_bases
TTGGCAGCGGCTGGCGGCTACCGATCGCCGCCGAATAATCACCACAAAACCTGGTCAGGCTGCCCTGATGTCGCCAACCT
AAAAGAAGTCATTGGCGTCC

Downstream 100 bases:

>100_bases
ACAGCCTTCACCACAAAACCAGCTCTCAAAAACACCGCTTCGCAACGCTTTTGCTCAGCATCACGACAGTGGCGTATCAG
AGCTAGATGAGATCTCACTC

Product: alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MDSSILSAPIASIGVPTEIKADELRVALTPDGVKELVNKGLEVRVQAGAGAGAGIGDEAFADAGAKLVNREEAWAAHLVV
KVKEPQEEEFCLLRQDMVLFTYLHLAAYPKVGEALLNAGTTGVGYETVQLENGSLPLLAPMSEIAGRLAAQVGAHLLERP
HGGRGVLIGGCTGVQPARVVVLGAGTVGWNAARLAAAMDAEVMLLDRSPERLRSLETSRRGRLISVVNSRGLLERLIPTA
DLLIGAVLTPGGRAPTLVDEEMVKQMKPNSVIVDVAIDQGGCVATSQETTHTHPTVTIHGVQHYAVGNMPGAVPFTSTEA
LVSVTLPYILGIAGRGLEEAVTERPELLSGLNTIQGSVCHPGVAKALGLPPRHPMACLR

Sequences:

>Translated_379_residues
MDSSILSAPIASIGVPTEIKADELRVALTPDGVKELVNKGLEVRVQAGAGAGAGIGDEAFADAGAKLVNREEAWAAHLVV
KVKEPQEEEFCLLRQDMVLFTYLHLAAYPKVGEALLNAGTTGVGYETVQLENGSLPLLAPMSEIAGRLAAQVGAHLLERP
HGGRGVLIGGCTGVQPARVVVLGAGTVGWNAARLAAAMDAEVMLLDRSPERLRSLETSRRGRLISVVNSRGLLERLIPTA
DLLIGAVLTPGGRAPTLVDEEMVKQMKPNSVIVDVAIDQGGCVATSQETTHTHPTVTIHGVQHYAVGNMPGAVPFTSTEA
LVSVTLPYILGIAGRGLEEAVTERPELLSGLNTIQGSVCHPGVAKALGLPPRHPMACLR
>Mature_379_residues
MDSSILSAPIASIGVPTEIKADELRVALTPDGVKELVNKGLEVRVQAGAGAGAGIGDEAFADAGAKLVNREEAWAAHLVV
KVKEPQEEEFCLLRQDMVLFTYLHLAAYPKVGEALLNAGTTGVGYETVQLENGSLPLLAPMSEIAGRLAAQVGAHLLERP
HGGRGVLIGGCTGVQPARVVVLGAGTVGWNAARLAAAMDAEVMLLDRSPERLRSLETSRRGRLISVVNSRGLLERLIPTA
DLLIGAVLTPGGRAPTLVDEEMVKQMKPNSVIVDVAIDQGGCVATSQETTHTHPTVTIHGVQHYAVGNMPGAVPFTSTEA
LVSVTLPYILGIAGRGLEEAVTERPELLSGLNTIQGSVCHPGVAKALGLPPRHPMACLR

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=332, Percent_Identity=29.5180722891566, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI122939153, Length=332, Percent_Identity=29.5180722891566, Blast_Score=115, Evalue=9e-26,
Organism=Escherichia coli, GI1787887, Length=329, Percent_Identity=30.0911854103343, Blast_Score=124, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17550456, Length=360, Percent_Identity=27.7777777777778, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39629; Mature: 39629

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSILSAPIASIGVPTEIKADELRVALTPDGVKELVNKGLEVRVQAGAGAGAGIGDEAF
CCCCHHHCCHHHCCCCCCCCCCCEEEEECCHHHHHHHCCCCEEEEEECCCCCCCCCCHHH
ADAGAKLVNREEAWAAHLVVKVKEPQEEEFCLLRQDMVLFTYLHLAAYPKVGEALLNAGT
HHHHHHHHCHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
TGVGYETVQLENGSLPLLAPMSEIAGRLAAQVGAHLLERPHGGRGVLIGGCTGVQPARVV
CCCCEEEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEE
VLGAGTVGWNAARLAAAMDAEVMLLDRSPERLRSLETSRRGRLISVVNSRGLLERLIPTA
EEECCCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHCCHH
DLLIGAVLTPGGRAPTLVDEEMVKQMKPNSVIVDVAIDQGGCVATSQETTHTHPTVTIHG
HHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCCCEEEEEC
VQHYAVGNMPGAVPFTSTEALVSVTLPYILGIAGRGLEEAVTERPELLSGLNTIQGSVCH
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHCCCCCC
PGVAKALGLPPRHPMACLR
CCHHHHCCCCCCCCHHHCC
>Mature Secondary Structure
MDSSILSAPIASIGVPTEIKADELRVALTPDGVKELVNKGLEVRVQAGAGAGAGIGDEAF
CCCCHHHCCHHHCCCCCCCCCCCEEEEECCHHHHHHHCCCCEEEEEECCCCCCCCCCHHH
ADAGAKLVNREEAWAAHLVVKVKEPQEEEFCLLRQDMVLFTYLHLAAYPKVGEALLNAGT
HHHHHHHHCHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
TGVGYETVQLENGSLPLLAPMSEIAGRLAAQVGAHLLERPHGGRGVLIGGCTGVQPARVV
CCCCEEEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEE
VLGAGTVGWNAARLAAAMDAEVMLLDRSPERLRSLETSRRGRLISVVNSRGLLERLIPTA
EEECCCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHCCHH
DLLIGAVLTPGGRAPTLVDEEMVKQMKPNSVIVDVAIDQGGCVATSQETTHTHPTVTIHG
HHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCCCEEEEEC
VQHYAVGNMPGAVPFTSTEALVSVTLPYILGIAGRGLEEAVTERPELLSGLNTIQGSVCH
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHCCCCCC
PGVAKALGLPPRHPMACLR
CCHHHHCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]