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The map label for this gene is fumC [H]

Identifier: 124022172

GI number: 124022172

Start: 464902

End: 466299

Strand: Reverse

Name: fumC [H]

Synonym: P9303_04621

Alternate gene names: 124022172

Gene position: 466299-464902 (Counterclockwise)

Preceding gene: 124022173

Following gene: 124022171

Centisome position: 17.38

GC content: 54.36

Gene sequence:

>1398_bases
ATGGCTGACCTGATGCGTATCGAACACGACAGCATGGGCACTGTTGAGGTGCCCGCTGGGGTTCTCTGGGGTGCACAAAC
CCAGCGATCGCTCCTTAACTTCGCCATCAGCACAGACCGCATGCCAGTCGAACTGATCCATGCCTTGGCATTGATCAAAC
AGGCTGCCGCCAGCGTGAACTGTCGCCTGGGTGTTCTCGATGAAATCCAGCGGGATCAAATTATCAAGGCCGCCTCTGCT
GTTGCATCCGGTCTCCATGACGATCAGTTTCCACTGAGGGTCTGGCAGACCGGTAGCGGTACCCACACAAACATGAATGT
CAACGAGGTGATTAGCAACCTGGCGTCTCAGGCAAACGACGAACCTCTAGGTAGCCATAGCCCGGTGCATCCAAACGATC
ATGTCAATCGATCCCAGTCCACCAATGACGCCTTCCCTACAGCTATACATATCGCCGCAGTCCACGGGATCACTAAAAAC
TTGCTGCCTGAACTGGAGCGATTGATCGCAGCCTTTGCCCGAAAAAGCAATGCCTGGAGTGACATCATCAAAATCGGTCG
CACTCATCTACAGGACGCCGTACCTCTCACCCTTGGTCAGGAGGCCTCTGCGTGGCGGGATCAAATTGCCTCAGCCCATA
GTCGTATTCAGTCAAGCCTGATAGAGCTCTACCCTCTGCCGCTTGGAGGCACCGCCGTGGGGACTGGCCTCAACGCCCCA
GCTCGCTTCGGGCAAGAAACAGCTGCGCAACTTGCCAGCATCACAGGCCTGCCATTCAGCTCAGCTAAAAACAAGTTCGC
CGTGATGGCGAGCCATGACGGGTTAGTGAATGCAATGGCTCAGTTGCGCATGTTGGCGGTTGCCCTATTCAAGATCTCCA
ATGATCTGCGCCTACTGGCCTGTGGCCCAAGGGCCGGCCTGGCAGAGCTGCATCTACCTGAGAATGAGCCGGGAAGCTCG
ATCATGCCTGGGAAAGTCAACCCCTCTCAATGCGAGGCCATGGCCATGGTCTGTTTACAAGTCATCGGGCTTGATTCAGC
CGTGACCATGGCAGGTGGTAGTGGTCATCTCCAAATGAACGTCTACAAACCCCTGATTGGCTTCAACCTGCTTCACAGCA
TTGAATTGCTACATGACGCCTGCCGCAATTACCGGCTGGCAATGGTGCAAGGGATTGAACCAAACCGAATCAAGATCCAG
CATGATCTAGAGCAATCGCTGATGCTAGTAACAGCTTTAACCCCAGAAATCGGTTACGACAAAGCCAGTGAGATTGCCCA
CCTCGCCCATGAGAAGGGATTCAGCCTGCGTGAAGCAGCACTAACACTCGGCTATGTGAGCAAAGAAGACTTCGATCGCA
TTGTTAATCCGGCATTGATGACATCTGCTCGGCTGTGA

Upstream 100 bases:

>100_bases
AGACTTTTTACCATCATTGAATGGGTTCTAAAGCGCTCTCAAACCCCATAAAACAAGTGAAGATCAATGTGATCTGCTTC
TGCCCCTTGCCGAAAACTTG

Downstream 100 bases:

>100_bases
CCCCCCGATGACATCAAATCCTGGCGAATCAAGAAGCATCCAGAGCCAGAGTTCCGCACAGCAACGAATCAGCAATCTTC
ATGGTCAAGCCCAGCGCGCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MADLMRIEHDSMGTVEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASVNCRLGVLDEIQRDQIIKAASA
VASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQANDEPLGSHSPVHPNDHVNRSQSTNDAFPTAIHIAAVHGITKN
LLPELERLIAAFARKSNAWSDIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNAP
ARFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLLACGPRAGLAELHLPENEPGSS
IMPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQMNVYKPLIGFNLLHSIELLHDACRNYRLAMVQGIEPNRIKIQ
HDLEQSLMLVTALTPEIGYDKASEIAHLAHEKGFSLREAALTLGYVSKEDFDRIVNPALMTSARL

Sequences:

>Translated_465_residues
MADLMRIEHDSMGTVEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASVNCRLGVLDEIQRDQIIKAASA
VASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQANDEPLGSHSPVHPNDHVNRSQSTNDAFPTAIHIAAVHGITKN
LLPELERLIAAFARKSNAWSDIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNAP
ARFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLLACGPRAGLAELHLPENEPGSS
IMPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQMNVYKPLIGFNLLHSIELLHDACRNYRLAMVQGIEPNRIKIQ
HDLEQSLMLVTALTPEIGYDKASEIAHLAHEKGFSLREAALTLGYVSKEDFDRIVNPALMTSARL
>Mature_464_residues
ADLMRIEHDSMGTVEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASVNCRLGVLDEIQRDQIIKAASAV
ASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQANDEPLGSHSPVHPNDHVNRSQSTNDAFPTAIHIAAVHGITKNL
LPELERLIAAFARKSNAWSDIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNAPA
RFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLLACGPRAGLAELHLPENEPGSSI
MPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQMNVYKPLIGFNLLHSIELLHDACRNYRLAMVQGIEPNRIKIQH
DLEQSLMLVTALTPEIGYDKASEIAHLAHEKGFSLREAALTLGYVSKEDFDRIVNPALMTSARL

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=458, Percent_Identity=53.7117903930131, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI266458395, Length=62, Percent_Identity=54.8387096774194, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=53.3622559652928, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI87082375, Length=457, Percent_Identity=39.8249452954048, Blast_Score=321, Evalue=6e-89,
Organism=Escherichia coli, GI1790398, Length=307, Percent_Identity=26.3843648208469, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=52.1834061135371, Blast_Score=467, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI32565146, Length=323, Percent_Identity=51.702786377709, Blast_Score=333, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=51.5151515151515, Blast_Score=455, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24640179, Length=459, Percent_Identity=52.9411764705882, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=52.9411764705882, Blast_Score=480, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24662684, Length=459, Percent_Identity=51.19825708061, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=51.0869565217391, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24583245, Length=459, Percent_Identity=47.7124183006536, Blast_Score=437, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50072; Mature: 49941

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLMRIEHDSMGTVEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASVN
CCCCCEECCCCCCCEECCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
CRLGVLDEIQRDQIIKAASAVASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQAND
CEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
EPLGSHSPVHPNDHVNRSQSTNDAFPTAIHIAAVHGITKNLLPELERLIAAFARKSNAWS
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNAP
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCC
ARFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLLA
HHCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
CGPRAGLAELHLPENEPGSSIMPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQMN
ECCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEE
VYKPLIGFNLLHSIELLHDACRNYRLAMVQGIEPNRIKIQHDLEQSLMLVTALTPEIGYD
EHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHCCCCCCC
KASEIAHLAHEKGFSLREAALTLGYVSKEDFDRIVNPALMTSARL
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure 
ADLMRIEHDSMGTVEVPAGVLWGAQTQRSLLNFAISTDRMPVELIHALALIKQAAASVN
CCCCEECCCCCCCEECCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
CRLGVLDEIQRDQIIKAASAVASGLHDDQFPLRVWQTGSGTHTNMNVNEVISNLASQAND
CEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
EPLGSHSPVHPNDHVNRSQSTNDAFPTAIHIAAVHGITKNLLPELERLIAAFARKSNAWS
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DIIKIGRTHLQDAVPLTLGQEASAWRDQIASAHSRIQSSLIELYPLPLGGTAVGTGLNAP
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCC
ARFGQETAAQLASITGLPFSSAKNKFAVMASHDGLVNAMAQLRMLAVALFKISNDLRLLA
HHCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
CGPRAGLAELHLPENEPGSSIMPGKVNPSQCEAMAMVCLQVIGLDSAVTMAGGSGHLQMN
ECCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEE
VYKPLIGFNLLHSIELLHDACRNYRLAMVQGIEPNRIKIQHDLEQSLMLVTALTPEIGYD
EHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHCCCCCCC
KASEIAHLAHEKGFSLREAALTLGYVSKEDFDRIVNPALMTSARL
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]