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The map label for this gene is hisD [H]

Identifier: 124022143

GI number: 124022143

Start: 434047

End: 435375

Strand: Reverse

Name: hisD [H]

Synonym: P9303_04331

Alternate gene names: 124022143

Gene position: 435375-434047 (Counterclockwise)

Preceding gene: 124022148

Following gene: 124022137

Centisome position: 16.23

GC content: 57.41

Gene sequence:

>1329_bases
TTGACACAAAGCGGCCAGGCCGAGTCAGAGACTCCCTCAACCCTGATTCATTGTGTTCGGGATCGGCAACAAGCCAAGCT
TGAACTAGAGCGGCTGGCCAACCGCTCTACCGGCAATTCTCAAAAGCAAGCCATGGCGACGGTGGAGGACATCCTCGACA
CCGTTCGCAGCCAAGGGGACCAAGCCCTGATGACCTTGACCGAGCGCTTTGACGGTTTTCGTCCAGAGCCATTGACCGTA
GCTCCAGAAGAGTTGGAAGACGCCTGGCGAAAAACTCCCAAAAAACTTCAATCTGCTCTGGAGCTGGCCTATCGCCGTAT
CCAGGATTTCCATCAGCATCAACGACCGAATGACCTGATGGTGCAAGGCATCCACGGCGAACAATTGGGCCGCCGCTGGC
GCCCTGTACAAAAAGCCGGGATCTACATCCCAGGAGGCCGAGCTGCCTATCCGAGCACAGTACTGATGAATGCAGTCCCA
GCCCAAGTAGCCGGCGTGGAGCAGCTGGTGATGACTTCACCCGCTGGAAGGGATGGTCAGATCAACAGAACCGTTCTAGC
CGCCGCACACCTAGCAGGAATTCGTGAGGTCTTGCGTCTCGGTGGTGCCCAGGCCATCGCAGCCCTGGCCTTTGGCACTG
AAACTGTGCCAAAGGTCGATGTGATCAGCGGACCCGGCAATCTCTACGTCACCCTTGCGAAAAAGGCCGTCTACGGGCAA
GTGGGCATTGATTCTCTCGCAGGCCCAAGTGAGGTTTTAGTAATCGCCGACCAGAGTGCTCGTGCTGAGCAGGTGGCCGC
CGACCTACTGGCCCAATCAGAACACGATCCACTTGCTGCTGCAGTACTACTCACCACCGAAGCAAGCCTCGCCGAACAGC
TCCCATCCCATTTGGAGGCTCAGCTTAAGGGGCACCCTCGCGAGCAGATCTGCCGAGCCTCTTTAAGCAACTGGGGGCTG
GTAGTGATCTGTGACAACCTGGAAATATGCGCTCAACTCAGCGATCACTTCGCTCCTGAGCACTTGGAGTTATTGGTCGA
GCACCCGCACACCATTGCCGACCGCATCAAAAATGCCGGCGCCATCTTCATCGGCCCCTGGACCCCTGAAGCGGTAGGCG
ACTATCTAGCCGGACCAAACCACACACTACCGACATGCGGAACGGCCCGCTTCAGCGGCGCCCTGAGCGTGGAAACATTT
CTGCGGCACACCTCTCTGATCGAATTCAATCGATCAGCCCTTGAGGCCACTGCTAACGCCGTAAGGGAATTGGCCAGCAG
CGAAGGCTTGCACAGCCATGCTGAATCCGTGCGTATCCGCTTCGAATAA

Upstream 100 bases:

>100_bases
CAGTAACCCAGCACCAATTTTTTAGATGCCATTACAAGCGCTTTAAGACAAGCCAGAAGAGCAAGCCCTAACTTGATTTC
AGATATTCAGGTTGCAGACT

Downstream 100 bases:

>100_bases
CCCCTCTACTCACGGCGCTGTAGACGACGCACTCCCGCAACACCATCACTAATCTGGCCAACCAAAACTTCATCGGTGAG
ATTGACGAACAAACCGTTCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTQSGQAESETPSTLIHCVRDRQQAKLELERLANRSTGNSQKQAMATVEDILDTVRSQGDQALMTLTERFDGFRPEPLTV
APEELEDAWRKTPKKLQSALELAYRRIQDFHQHQRPNDLMVQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVP
AQVAGVEQLVMTSPAGRDGQINRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQ
VGIDSLAGPSEVLVIADQSARAEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEAQLKGHPREQICRASLSNWGL
VVICDNLEICAQLSDHFAPEHLELLVEHPHTIADRIKNAGAIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETF
LRHTSLIEFNRSALEATANAVRELASSEGLHSHAESVRIRFE

Sequences:

>Translated_442_residues
MTQSGQAESETPSTLIHCVRDRQQAKLELERLANRSTGNSQKQAMATVEDILDTVRSQGDQALMTLTERFDGFRPEPLTV
APEELEDAWRKTPKKLQSALELAYRRIQDFHQHQRPNDLMVQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVP
AQVAGVEQLVMTSPAGRDGQINRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQ
VGIDSLAGPSEVLVIADQSARAEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEAQLKGHPREQICRASLSNWGL
VVICDNLEICAQLSDHFAPEHLELLVEHPHTIADRIKNAGAIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETF
LRHTSLIEFNRSALEATANAVRELASSEGLHSHAESVRIRFE
>Mature_441_residues
TQSGQAESETPSTLIHCVRDRQQAKLELERLANRSTGNSQKQAMATVEDILDTVRSQGDQALMTLTERFDGFRPEPLTVA
PEELEDAWRKTPKKLQSALELAYRRIQDFHQHQRPNDLMVQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVPA
QVAGVEQLVMTSPAGRDGQINRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQV
GIDSLAGPSEVLVIADQSARAEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEAQLKGHPREQICRASLSNWGLV
VICDNLEICAQLSDHFAPEHLELLVEHPHTIADRIKNAGAIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETFL
RHTSLIEFNRSALEATANAVRELASSEGLHSHAESVRIRFE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=400, Percent_Identity=40.75, Blast_Score=292, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=446, Percent_Identity=37.6681614349776, Blast_Score=271, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47870; Mature: 47739

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00024 HEMOPEXIN ; PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSGQAESETPSTLIHCVRDRQQAKLELERLANRSTGNSQKQAMATVEDILDTVRSQGD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
QALMTLTERFDGFRPEPLTVAPEELEDAWRKTPKKLQSALELAYRRIQDFHQHQRPNDLM
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVPAQVAGVEQLVMTSPAGRDGQ
EECCCHHHHHHHCCCHHHCCEECCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
INRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQ
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEHHHHHCC
VGIDSLAGPSEVLVIADQSARAEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEA
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHEECCCHHHHHHHHHHHHH
QLKGHPREQICRASLSNWGLVVICDNLEICAQLSDHFAPEHLELLVEHPHTIADRIKNAG
HHCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCC
AIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETFLRHTSLIEFNRSALEATANA
EEEECCCCHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VRELASSEGLHSHAESVRIRFE
HHHHHHCCCHHHHHHCEEEECC
>Mature Secondary Structure 
TQSGQAESETPSTLIHCVRDRQQAKLELERLANRSTGNSQKQAMATVEDILDTVRSQGD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
QALMTLTERFDGFRPEPLTVAPEELEDAWRKTPKKLQSALELAYRRIQDFHQHQRPNDLM
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VQGIHGEQLGRRWRPVQKAGIYIPGGRAAYPSTVLMNAVPAQVAGVEQLVMTSPAGRDGQ
EECCCHHHHHHHCCCHHHCCEECCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
INRTVLAAAHLAGIREVLRLGGAQAIAALAFGTETVPKVDVISGPGNLYVTLAKKAVYGQ
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEHHHHHCC
VGIDSLAGPSEVLVIADQSARAEQVAADLLAQSEHDPLAAAVLLTTEASLAEQLPSHLEA
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHEECCCHHHHHHHHHHHHH
QLKGHPREQICRASLSNWGLVVICDNLEICAQLSDHFAPEHLELLVEHPHTIADRIKNAG
HHCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCC
AIFIGPWTPEAVGDYLAGPNHTLPTCGTARFSGALSVETFLRHTSLIEFNRSALEATANA
EEEECCCCHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VRELASSEGLHSHAESVRIRFE
HHHHHHCCCHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]