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The map label for this gene is purL

Identifier: 124021717

GI number: 124021717

Start: 2209

End: 4593

Strand: Direct

Name: purL

Synonym: P9303_00021

Alternate gene names: 124021717

Gene position: 2209-4593 (Clockwise)

Preceding gene: 124021716

Following gene: 124021718

Centisome position: 0.08

GC content: 46.08

Gene sequence:

>2385_bases
TTGAGAGTTGATTATGACGTGGCTGCGGCTTTACGTCATGAAGGTCTCAAACCAGATGATTACGACGAGATTTGTCGTCG
TCTCCAACGTGCACCTAACCGAGTTGAGCTGGGCATGTTTGGTGTGATGTGGTCTGAACACTGTTGTTATCGCAATTCAA
GGCCTTTACTCAGCAGCTTTCCTACAACTGGTCATCGGATTTTGGTTGGTCCTGGAGAAAATGCTGGTGTCGTGGATTTA
GGAGATGGACAGAGTTTGGCTTTCAAAATTGAAAGCCACAATCATCCTTCTGCATTGGAACCTTTTCAAGGAGCTGCTAC
AGGTGTTGGCGGAATTTTGAGAGATATTTTTACTATGGGTGCAAGGCCTATTGCGCTTCTTAATGCTTTGCGTTTTGGAC
CTCTTGAAGATGAACGTAATGTTGGTCTTATCGAGGGGGTCGTTGAAGGTATTGCTCATTACGGCAATTGTGTGGGAGTT
CCTACCGTTGGTGGTGAGGTGGCGTTTGATTCCAGTTATTCCGGTAATCCGTTAGTTAATGCAATGGCTCTAGGGCTGAT
GGAAACAGACGAGATTGTCTGTTCTGGGGCTCATGGTGTTGGTTATCCGGTGGTTTATGTCGGTAGTACAACTGGTCGTG
ATGGCATGGGTGGTGCCAGTTTTGCTAGTGCAGAGCTAACAAAAGCTTCTCTGGATGATCGTCCTGCGGTTCAGGTTGGT
GATCCATTTTTGGAAAAAGGTTTAATCGAAGCTTGTCTTGAAGCTTTTAAGAGTGGCGATGTTGTTGCTGCTCAGGACAT
GGGTGCCGCTGGTCTTACCTGCAGCTGTTCGGAGATGGCTGCTAAGGGTGGTCTTGGTATTGAACTTGATCTTGATCGAG
TTCCTGCTCGTGAGCTTGGGATGACTCCATATGAGTTTTTACTCTCGGAATCTCAAGAGAGAATGCTTTTTGTGGTGAAG
CCTGGACAAGAGCAATCTTTGATGGAGAGATTTATCCGTTGGGGGTTGCAAGCAGCAATTGTTGGTTGCGTTCTTGAAAA
GAAGGTGGTTCGTGTTTTGCAAAAAGGTGAAGTTGTTGCTGAGGTGCCTGCTAATGCGTTAGCTGATGATACTCCAATTG
ATCGACATGAATTAGTTAGTGATCCTCCGCTAGAGATTCAAGCTAAATGGGATTGGCAGGAGGATCTATTACCAGTTGTT
GGTTTAAAAGGGATCAATTTAAATTCACAATCTCATTTTGGTAGTAATTTATCATGGGATGAAATTCTTTTAAAGTTACT
TGATGACCCTACGATTGCTTCAAAACGTTGGGTTTTTCGTCAATATGATCATCAGGTTCAAGCCAATACAGTTTCAGCTC
CAGGAGTTTCTGATGCTGCTGTTGTGAGATTACGTCCACAGCAAGGTGAAGGCTCTGTAGATGAGGTGAACCGGGGAGTT
GCGGCAGTTGTTGATTGTCCTAATCGATGGGTTTTTCTTGATCCAGAACGTGGTGCTATCGCCGCTGTCGCAGAAGCGGC
CCGTAATCTTAGTTGTGTAGGTGCGGAGCCTTTGGCTGTCACGGACAATCTAAATTTTCCTTCTCCGGAAACGCCTACTG
GTTATTGGCAATTGGCTTTAGCTTGTCGTGGTCTTTCTAAGGCTTGTAAGAGCTTGTCAACACCAGTAACTGGAGGAAAT
GTTTCTCTATATAATGAGACTCGCTTAGCTGATGGAGAAATACAACCTATTCACCCAACACCAGTTGTTGGAATGGTTGG
GTTAGTTCATGATCTTGCAAATGTGTGTGGTCAGGCTTGGCTTGAGCCTGGTGATTTGATTTGGCTTTTAGGCGTGCCTA
TCGATACAACAGTTGCGGTTGATCCTCGCGTTAGCCTTGCGGGTAGTAGTTATCTTGAATGTATTCATGGTTTAGTTACT
GGTAGGCCTCCGGAGATTGATCTGAAACTTGAGTGTTTAGTTCAATCTTTCCTACGCAATTCTATTACCGAGGGATTTGT
TCGCTCTGCTCATGATCTAAGTGATGGAGGTCTTGCAGTTGCAGTTGCTGAGTGCTGTATCGCTGGAAACTTGGGTGCAC
ATCTTGAGTTACCATCCAGCGATGCTCGATTGGATCGGTTGTTATTTGCGGAAGGTGGTTCACGCATCTTGGTGAGTGTT
CCGTCGACGCAGGCTGTTGCCTGGCAAAAGGTTTTAAATCAGGCAAAGACCGCATCCCCTGGCGCAGTGTTTGATCAGTA
CCTTGGTGTTGTTACGGCTGATGAGGAGTTGCTGATCACTCAGGCTGGCAATCGCTTGGTTCAACTTCCTTTGAATCAGC
TGAGGGAGTGCTTTGAGCAGGCAATCCCTCGTCGTATGGGCTTGGATCTCTCTTCAAGCGTCTGA

Upstream 100 bases:

>100_bases
TCCGGACGGTAGAGGCGATGGTCAGGATGATCCTTGGGTTTGAGCTTTATAAGTAAAACTGGGAAGAGATGAGTCAGATC
TCGTGTGTGAGGGCCCCGAT

Downstream 100 bases:

>100_bases
GTTGAGCTTTAGTGCAAAATGTCTTCCTTGGCTTATGCATTTGAGGAGTTGAGCTTCACATGTGCGGCATTGTTGGCATT
GTTTCTACTGCGCTGGTCAA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 794; Mature: 794

Protein sequence:

>794_residues
MRVDYDVAAALRHEGLKPDDYDEICRRLQRAPNRVELGMFGVMWSEHCCYRNSRPLLSSFPTTGHRILVGPGENAGVVDL
GDGQSLAFKIESHNHPSALEPFQGAATGVGGILRDIFTMGARPIALLNALRFGPLEDERNVGLIEGVVEGIAHYGNCVGV
PTVGGEVAFDSSYSGNPLVNAMALGLMETDEIVCSGAHGVGYPVVYVGSTTGRDGMGGASFASAELTKASLDDRPAVQVG
DPFLEKGLIEACLEAFKSGDVVAAQDMGAAGLTCSCSEMAAKGGLGIELDLDRVPARELGMTPYEFLLSESQERMLFVVK
PGQEQSLMERFIRWGLQAAIVGCVLEKKVVRVLQKGEVVAEVPANALADDTPIDRHELVSDPPLEIQAKWDWQEDLLPVV
GLKGINLNSQSHFGSNLSWDEILLKLLDDPTIASKRWVFRQYDHQVQANTVSAPGVSDAAVVRLRPQQGEGSVDEVNRGV
AAVVDCPNRWVFLDPERGAIAAVAEAARNLSCVGAEPLAVTDNLNFPSPETPTGYWQLALACRGLSKACKSLSTPVTGGN
VSLYNETRLADGEIQPIHPTPVVGMVGLVHDLANVCGQAWLEPGDLIWLLGVPIDTTVAVDPRVSLAGSSYLECIHGLVT
GRPPEIDLKLECLVQSFLRNSITEGFVRSAHDLSDGGLAVAVAECCIAGNLGAHLELPSSDARLDRLLFAEGGSRILVSV
PSTQAVAWQKVLNQAKTASPGAVFDQYLGVVTADEELLITQAGNRLVQLPLNQLRECFEQAIPRRMGLDLSSSV

Sequences:

>Translated_794_residues
MRVDYDVAAALRHEGLKPDDYDEICRRLQRAPNRVELGMFGVMWSEHCCYRNSRPLLSSFPTTGHRILVGPGENAGVVDL
GDGQSLAFKIESHNHPSALEPFQGAATGVGGILRDIFTMGARPIALLNALRFGPLEDERNVGLIEGVVEGIAHYGNCVGV
PTVGGEVAFDSSYSGNPLVNAMALGLMETDEIVCSGAHGVGYPVVYVGSTTGRDGMGGASFASAELTKASLDDRPAVQVG
DPFLEKGLIEACLEAFKSGDVVAAQDMGAAGLTCSCSEMAAKGGLGIELDLDRVPARELGMTPYEFLLSESQERMLFVVK
PGQEQSLMERFIRWGLQAAIVGCVLEKKVVRVLQKGEVVAEVPANALADDTPIDRHELVSDPPLEIQAKWDWQEDLLPVV
GLKGINLNSQSHFGSNLSWDEILLKLLDDPTIASKRWVFRQYDHQVQANTVSAPGVSDAAVVRLRPQQGEGSVDEVNRGV
AAVVDCPNRWVFLDPERGAIAAVAEAARNLSCVGAEPLAVTDNLNFPSPETPTGYWQLALACRGLSKACKSLSTPVTGGN
VSLYNETRLADGEIQPIHPTPVVGMVGLVHDLANVCGQAWLEPGDLIWLLGVPIDTTVAVDPRVSLAGSSYLECIHGLVT
GRPPEIDLKLECLVQSFLRNSITEGFVRSAHDLSDGGLAVAVAECCIAGNLGAHLELPSSDARLDRLLFAEGGSRILVSV
PSTQAVAWQKVLNQAKTASPGAVFDQYLGVVTADEELLITQAGNRLVQLPLNQLRECFEQAIPRRMGLDLSSSV
>Mature_794_residues
MRVDYDVAAALRHEGLKPDDYDEICRRLQRAPNRVELGMFGVMWSEHCCYRNSRPLLSSFPTTGHRILVGPGENAGVVDL
GDGQSLAFKIESHNHPSALEPFQGAATGVGGILRDIFTMGARPIALLNALRFGPLEDERNVGLIEGVVEGIAHYGNCVGV
PTVGGEVAFDSSYSGNPLVNAMALGLMETDEIVCSGAHGVGYPVVYVGSTTGRDGMGGASFASAELTKASLDDRPAVQVG
DPFLEKGLIEACLEAFKSGDVVAAQDMGAAGLTCSCSEMAAKGGLGIELDLDRVPARELGMTPYEFLLSESQERMLFVVK
PGQEQSLMERFIRWGLQAAIVGCVLEKKVVRVLQKGEVVAEVPANALADDTPIDRHELVSDPPLEIQAKWDWQEDLLPVV
GLKGINLNSQSHFGSNLSWDEILLKLLDDPTIASKRWVFRQYDHQVQANTVSAPGVSDAAVVRLRPQQGEGSVDEVNRGV
AAVVDCPNRWVFLDPERGAIAAVAEAARNLSCVGAEPLAVTDNLNFPSPETPTGYWQLALACRGLSKACKSLSTPVTGGN
VSLYNETRLADGEIQPIHPTPVVGMVGLVHDLANVCGQAWLEPGDLIWLLGVPIDTTVAVDPRVSLAGSSYLECIHGLVT
GRPPEIDLKLECLVQSFLRNSITEGFVRSAHDLSDGGLAVAVAECCIAGNLGAHLELPSSDARLDRLLFAEGGSRILVSV
PSTQAVAWQKVLNQAKTASPGAVFDQYLGVVTADEELLITQAGNRLVQLPLNQLRECFEQAIPRRMGLDLSSSV

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=766, Percent_Identity=25.065274151436, Blast_Score=113, Evalue=8e-25,
Organism=Escherichia coli, GI48994899, Length=389, Percent_Identity=27.2493573264781, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321498, Length=815, Percent_Identity=22.5766871165644, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_PROM3 (A2C5J9)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016024.1
- ProteinModelPortal:   A2C5J9
- SMR:   A2C5J9
- STRING:   A2C5J9
- GeneID:   4778993
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_00021
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 84886; Mature: 84886

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVDYDVAAALRHEGLKPDDYDEICRRLQRAPNRVELGMFGVMWSEHCCYRNSRPLLSSF
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCHHHCC
PTTGHRILVGPGENAGVVDLGDGQSLAFKIESHNHPSALEPFQGAATGVGGILRDIFTMG
CCCCCEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
ARPIALLNALRFGPLEDERNVGLIEGVVEGIAHYGNCVGVPTVGGEVAFDSSYSGNPLVN
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCHHHH
AMALGLMETDEIVCSGAHGVGYPVVYVGSTTGRDGMGGASFASAELTKASLDDRPAVQVG
HHHHCCCCCCHHEEECCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCEECC
DPFLEKGLIEACLEAFKSGDVVAAQDMGAAGLTCSCSEMAAKGGLGIELDLDRVPARELG
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEECHHHHHHCCCCCEEEECCCCCHHHHC
MTPYEFLLSESQERMLFVVKPGQEQSLMERFIRWGLQAAIVGCVLEKKVVRVLQKGEVVA
CCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
EVPANALADDTPIDRHELVSDPPLEIQAKWDWQEDLLPVVGLKGINLNSQSHFGSNLSWD
ECCCHHHCCCCCCCHHHHCCCCCCEEEEECCCHHCCHHHHCCCCCCCCCCCCCCCCCCHH
EILLKLLDDPTIASKRWVFRQYDHQVQANTVSAPGVSDAAVVRLRPQQGEGSVDEVNRGV
HHHHHHHCCCCCCHHHHHHHHHCCEEECCEECCCCCCCEEEEEEECCCCCCCHHHHCCCE
AAVVDCPNRWVFLDPERGAIAAVAEAARNLSCVGAEPLAVTDNLNFPSPETPTGYWQLAL
EEEEECCCCEEEECCCCCHHHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCHHHHHHH
ACRGLSKACKSLSTPVTGGNVSLYNETRLADGEIQPIHPTPVVGMVGLVHDLANVCGQAW
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LEPGDLIWLLGVPIDTTVAVDPRVSLAGSSYLECIHGLVTGRPPEIDLKLECLVQSFLRN
CCCCCEEEEEECCCCCEEEECCCEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
SITEGFVRSAHDLSDGGLAVAVAECCIAGNLGAHLELPSSDARLDRLLFAEGGSRILVSV
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHEECCCCEEEEEC
PSTQAVAWQKVLNQAKTASPGAVFDQYLGVVTADEELLITQAGNRLVQLPLNQLRECFEQ
CCCHHHHHHHHHHHHCCCCCCHHHHHHHCEEECCCEEEEEECCCEEEECCHHHHHHHHHH
AIPRRMGLDLSSSV
HHHHHHCCCHHCCC
>Mature Secondary Structure
MRVDYDVAAALRHEGLKPDDYDEICRRLQRAPNRVELGMFGVMWSEHCCYRNSRPLLSSF
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCHHHCC
PTTGHRILVGPGENAGVVDLGDGQSLAFKIESHNHPSALEPFQGAATGVGGILRDIFTMG
CCCCCEEEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
ARPIALLNALRFGPLEDERNVGLIEGVVEGIAHYGNCVGVPTVGGEVAFDSSYSGNPLVN
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCHHHH
AMALGLMETDEIVCSGAHGVGYPVVYVGSTTGRDGMGGASFASAELTKASLDDRPAVQVG
HHHHCCCCCCHHEEECCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCEECC
DPFLEKGLIEACLEAFKSGDVVAAQDMGAAGLTCSCSEMAAKGGLGIELDLDRVPARELG
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEECHHHHHHCCCCCEEEECCCCCHHHHC
MTPYEFLLSESQERMLFVVKPGQEQSLMERFIRWGLQAAIVGCVLEKKVVRVLQKGEVVA
CCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
EVPANALADDTPIDRHELVSDPPLEIQAKWDWQEDLLPVVGLKGINLNSQSHFGSNLSWD
ECCCHHHCCCCCCCHHHHCCCCCCEEEEECCCHHCCHHHHCCCCCCCCCCCCCCCCCCHH
EILLKLLDDPTIASKRWVFRQYDHQVQANTVSAPGVSDAAVVRLRPQQGEGSVDEVNRGV
HHHHHHHCCCCCCHHHHHHHHHCCEEECCEECCCCCCCEEEEEEECCCCCCCHHHHCCCE
AAVVDCPNRWVFLDPERGAIAAVAEAARNLSCVGAEPLAVTDNLNFPSPETPTGYWQLAL
EEEEECCCCEEEECCCCCHHHHHHHHHHCCEECCCCCEEEECCCCCCCCCCCCHHHHHHH
ACRGLSKACKSLSTPVTGGNVSLYNETRLADGEIQPIHPTPVVGMVGLVHDLANVCGQAW
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LEPGDLIWLLGVPIDTTVAVDPRVSLAGSSYLECIHGLVTGRPPEIDLKLECLVQSFLRN
CCCCCEEEEEECCCCCEEEECCCEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
SITEGFVRSAHDLSDGGLAVAVAECCIAGNLGAHLELPSSDARLDRLLFAEGGSRILVSV
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHEECCCCEEEEEC
PSTQAVAWQKVLNQAKTASPGAVFDQYLGVVTADEELLITQAGNRLVQLPLNQLRECFEQ
CCCHHHHHHHHHHHHCCCCCCHHHHHHHCEEECCCEEEEEECCCEEEECCHHHHHHHHHH
AIPRRMGLDLSSSV
HHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA