Click here to switch to the map view.

The map label for this gene is guaB [C]

Identifier: 123968700

GI number: 123968700

Start: 978590

End: 979753

Strand: Reverse

Name: guaB [C]

Synonym: A9601_11671

Alternate gene names: 123968700

Gene position: 979753-978590 (Counterclockwise)

Preceding gene: 123968703

Following gene: 123968699

Centisome position: 58.67

GC content: 38.83

Gene sequence:

>1164_bases
GTGAATATTGAACTTGGTCTAAATAAAAAAGTCAGAAGGGCTTATGGCATTGATGAAATAGCTTTAGTCCCTGGTAATAG
AACTCTTGATTATGATTTAACTGATCCTTCTTGGTCAATAGGTGATATCAAAAGAGAAGTTCCGATCGTAGCTAGTGCTA
TGGACAGTGTTGTGGATGTTGATACGGCTGTAGAACTCACGAAATTAGGTTGTCTAGGGGTTATTAATATGGAGGGCATA
CAGACAAGATATGAAAACCCTGATGAAATATTAAACCAAATAGCATCAGTCGGGAAGAATGATTTTGTTCCGTTAATGCA
GAAGATTTACAGTGAACCAGTCAAGGAGGAATTGATTTTACAAAGAATAAATGAGGTCAAAGAAGGAGGAGGCATCGCTG
CTTTTAGTGGGACTCCACAAGCCGCTATTAGGTTTAAAGAAATACTTAATAATTCCAAAATAGATTTATTTTTTCTTCAA
GGAACAGTTGTTTCAACTGAACATCTTGGTATGGAAGGTAAGGAAACCTTAAATATTAAAGATCTCTGCCAATCTATGAA
TGCCCCAGTTGTAGCCGGAAATTGTGTTACTTATGAAGTTGCAAAACTTCTCATGGACTCTGGAGTTGCAGGATTAATGG
TTGGGATAGGACCTGGAGCGGCATGTACATCAAGAGGAGTATTAGGAATTGGAATCCCTCAAGCAACTGCAATTGCTGAT
TGTAGTGCGGCAAGAAATGATTACTTTAAAGAAACTGGTCGTTATGTTCCTATTATTGGTGATGGAGGAATTGTGACGGG
CGGAGATATCTGTAAATGTTTAGCATGTGGATCAGATGCTGTAATGATTGGATCCCCAGTAGCTAAATCCTCAAACGCTC
CAGGTAAAGGATTTCACTGGGGTATGGCTACTCCAAGTCCAGTATTGCCAAGGGGTACAAGAATTGAAGTTGGTTCTACA
GGATCCTTAGAAAGGATAATTAAAGGCCCTGCCTTACTTGATGATGGGACACATAACTTATTAGGAGCCATTAGAACATC
AATGAGTACTCTTGGAGCAAAAAATATTAAAGAAATGCAAAAAGTTGAAATAGTTATCGCACCATCTCTTCTTACAGAGG
GTAAGGTTTATCAAAAAGCTCAGCAGCTTGGGATGGGTAAGTAA

Upstream 100 bases:

>100_bases
CATTTACACACAAATCAAAATAAAACCTTTTGTTTTTGAACAAATCTTGGCTTATTACCCCTTTAGTTGTTAATTTAATC
AAAATAAAGAGTAAATTATC

Downstream 100 bases:

>100_bases
TTCATTAAGAACAAAATTATAAAACCTTAGTTAATTAAATATTAAATTGAAAAATATTCTAATTAGGAGCTATTATGAAA
TGATGGGGGAAACCCCATAC

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNIELGLNKKVRRAYGIDEIALVPGNRTLDYDLTDPSWSIGDIKREVPIVASAMDSVVDVDTAVELTKLGCLGVINMEGI
QTRYENPDEILNQIASVGKNDFVPLMQKIYSEPVKEELILQRINEVKEGGGIAAFSGTPQAAIRFKEILNNSKIDLFFLQ
GTVVSTEHLGMEGKETLNIKDLCQSMNAPVVAGNCVTYEVAKLLMDSGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
CSAARNDYFKETGRYVPIIGDGGIVTGGDICKCLACGSDAVMIGSPVAKSSNAPGKGFHWGMATPSPVLPRGTRIEVGST
GSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQKVEIVIAPSLLTEGKVYQKAQQLGMGK

Sequences:

>Translated_387_residues
MNIELGLNKKVRRAYGIDEIALVPGNRTLDYDLTDPSWSIGDIKREVPIVASAMDSVVDVDTAVELTKLGCLGVINMEGI
QTRYENPDEILNQIASVGKNDFVPLMQKIYSEPVKEELILQRINEVKEGGGIAAFSGTPQAAIRFKEILNNSKIDLFFLQ
GTVVSTEHLGMEGKETLNIKDLCQSMNAPVVAGNCVTYEVAKLLMDSGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
CSAARNDYFKETGRYVPIIGDGGIVTGGDICKCLACGSDAVMIGSPVAKSSNAPGKGFHWGMATPSPVLPRGTRIEVGST
GSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQKVEIVIAPSLLTEGKVYQKAQQLGMGK
>Mature_387_residues
MNIELGLNKKVRRAYGIDEIALVPGNRTLDYDLTDPSWSIGDIKREVPIVASAMDSVVDVDTAVELTKLGCLGVINMEGI
QTRYENPDEILNQIASVGKNDFVPLMQKIYSEPVKEELILQRINEVKEGGGIAAFSGTPQAAIRFKEILNNSKIDLFFLQ
GTVVSTEHLGMEGKETLNIKDLCQSMNAPVVAGNCVTYEVAKLLMDSGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
CSAARNDYFKETGRYVPIIGDGGIVTGGDICKCLACGSDAVMIGSPVAKSSNAPGKGFHWGMATPSPVLPRGTRIEVGST
GSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQKVEIVIAPSLLTEGKVYQKAQQLGMGK

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. [C

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=384, Percent_Identity=25.5208333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI50541952, Length=384, Percent_Identity=25.5208333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI50541948, Length=384, Percent_Identity=25.5208333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI50541956, Length=384, Percent_Identity=25.5208333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI66933016, Length=112, Percent_Identity=45.5357142857143, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI217035150, Length=109, Percent_Identity=44.954128440367, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI217035152, Length=109, Percent_Identity=44.954128440367, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI34328930, Length=109, Percent_Identity=44.954128440367, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI217035146, Length=109, Percent_Identity=44.954128440367, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI217035148, Length=109, Percent_Identity=44.954128440367, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI34328928, Length=109, Percent_Identity=44.954128440367, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156616279, Length=109, Percent_Identity=44.954128440367, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156104880, Length=197, Percent_Identity=28.9340101522843, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786293, Length=263, Percent_Identity=27.3764258555133, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788855, Length=204, Percent_Identity=32.3529411764706, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994385, Length=142, Percent_Identity=37.3239436619718, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994389, Length=142, Percent_Identity=37.3239436619718, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560440, Length=187, Percent_Identity=31.0160427807487, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322012, Length=110, Percent_Identity=38.1818181818182, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323585, Length=110, Percent_Identity=36.3636363636364, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323464, Length=110, Percent_Identity=35.4545454545455, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571163, Length=168, Percent_Identity=36.3095238095238, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641071, Length=168, Percent_Identity=36.3095238095238, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641073, Length=168, Percent_Identity=36.3095238095238, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 40980; Mature: 40980

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIELGLNKKVRRAYGIDEIALVPGNRTLDYDLTDPSWSIGDIKREVPIVASAMDSVVDV
CCEECCCCHHHHHHCCCCCEEEECCCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHH
DTAVELTKLGCLGVINMEGIQTRYENPDEILNQIASVGKNDFVPLMQKIYSEPVKEELIL
HHHHHHHHHCEEEEEECCCHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHH
QRINEVKEGGGIAAFSGTPQAAIRFKEILNNSKIDLFFLQGTVVSTEHLGMEGKETLNIK
HHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEECEEEEHHHCCCCCCCCCCHH
DLCQSMNAPVVAGNCVTYEVAKLLMDSGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
HHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CSAARNDYFKETGRYVPIIGDGGIVTGGDICKCLACGSDAVMIGSPVAKSSNAPGKGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEC
GMATPSPVLPRGTRIEVGSTGSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQ
CCCCCCCCCCCCCEEEECCCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHCHHHHHHHH
KVEIVIAPSLLTEGKVYQKAQQLGMGK
HEEEEEECCHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNIELGLNKKVRRAYGIDEIALVPGNRTLDYDLTDPSWSIGDIKREVPIVASAMDSVVDV
CCEECCCCHHHHHHCCCCCEEEECCCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHH
DTAVELTKLGCLGVINMEGIQTRYENPDEILNQIASVGKNDFVPLMQKIYSEPVKEELIL
HHHHHHHHHCEEEEEECCCHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHH
QRINEVKEGGGIAAFSGTPQAAIRFKEILNNSKIDLFFLQGTVVSTEHLGMEGKETLNIK
HHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEECEEEEHHHCCCCCCCCCCHH
DLCQSMNAPVVAGNCVTYEVAKLLMDSGVAGLMVGIGPGAACTSRGVLGIGIPQATAIAD
HHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CSAARNDYFKETGRYVPIIGDGGIVTGGDICKCLACGSDAVMIGSPVAKSSNAPGKGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEC
GMATPSPVLPRGTRIEVGSTGSLERIIKGPALLDDGTHNLLGAIRTSMSTLGAKNIKEMQ
CCCCCCCCCCCCCEEEECCCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHCHHHHHHHH
KVEIVIAPSLLTEGKVYQKAQQLGMGK
HEEEEEECCHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA