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The map label for this gene is dcm [H]

Identifier: 123967970

GI number: 123967970

Start: 373751

End: 375847

Strand: Reverse

Name: dcm [H]

Synonym: A9601_04331

Alternate gene names: 123967970

Gene position: 375847-373751 (Counterclockwise)

Preceding gene: 123967971

Following gene: 123967963

Centisome position: 22.51

GC content: 33.81

Gene sequence:

>2097_bases
ATGATTCATAAAAATGCAGTAGGGAAAAGTGATCCACACAGATTAAGTCCTGTAAGAGGGCCTTCATCAGAACTTGAGGC
ACATGTAGATTCATGCAGTTTTGATGAACTTCCTGAATATGCAGCAAAAGTTCGATCTATAAAAAAAGAACCTTATTTTG
CTGTTGACCTTTTTTCAGGTGCCGGTGGTTTAAGCCTTGGACTGCATCGTGCAAATTTTGATGTAATCCTGGCCTGCGAT
ATCAGAAACGATTCAATAATGACTCACAGACATCACTTTGGTGGATGTTCATATGAATGTGATTTAAGCAAAAGAAAAGT
TATTAATGAAATTTCAGAACAACTTAATAAGTGTGGAGAAATATCACTTATTGCAGGTGGACCACCATGTCAGCCTTTCT
CCCGAAATATCAAATGGAGAAAACACAACGAAGAAGTTTCTGCTCAACATCAGGAACTAAATGAAGATAGAAGAGAATTA
TGGGAATCATTTATTTCGATAGTGGAACAGGTTAAACCAAAAGCTTTTCTCATGGAGAATGTTACTGATATTGCGCAGAC
AGGTGAGCAGGAAATATATAGATCAATCATTAATAGAGCTGAGAAAGCTGGCTATCGCATAAATCCTAAATTGATTTATG
CATGGCAATATGGAGTACCCCAACTAAGGCCAAGATTATTTATTTCCGGAACAAAAATAAATGAATGCGCTCCTATGAAA
TGGCCAAAGCCAAAATATGATTCTCTCGAAGAGGCAGTCACCTTAGACGAAGCGATTTCAGATCTCCCTCCACTTAAAGG
AGGATGGGATGAAAAGTGGGATGAAAAATACAGCTATGAAGGACCGAAAAACGATTATCAGAAATTAATGAGGAATTGGT
TGGATATTGATGACGAGATGATTCATGATCATCTGATAAGAAAAGTAAGGGAAGATGATCTTGAGACATTTAAATTAATG
CGATCAACCGGGATCAAATATTCCCAATTATCAGAAGAGCAAAGAAGATATTCAGTTACGAGCAAAGCTTTCAGAGAAGG
TAAGCAAGTAAAACAAAATCAGAAAATGAGTTTTGGTGATAAATATAATATCCTCAAACCTAATGAACCATGTCTGACAA
TAACTGCGCATATGTCAAAAGATGGTTATTGGTATATTCACCCTCACCAGAATAGAACCCTATCAGTTAGAGAAGCGGCA
AGAGTTCAGTCTTTCCCAGATGGTTTCAATTTTTATGGAGGGCCTTCAAATAGATTCCACCAGATTGGAGAAGCCGTTGC
ACCAATTGTTGCTTTTGAACTCGGCAAATCTTTCATGAAATCAATTAAAAATGAGAAAGAATTTACTCAACCTGATGTAG
TGCCCAAACTTAGAGAAAATCTTATTAACTGGTATGAATCAAATAAAAAAGAAGTTGAACTTATATGGACAAAAAAAAGG
GAAGGAAGAAAAATAATTCCAAGTAATATAAGGGCATGGAATGCATGTCTTGGAAATTTACTACCAGAGACTTTCAAAAA
AAATACTAAAGAAAAAAATAAACCTGCAATCTTAGGAGATAAAGATCTTGAAAACAGGAAGAAAGAAACCTATCAAAGAT
TAAAAAACTTTTGGCCTACCCCTGAGATTTTTCTGCAAGATAAAGCTAGAAAAATGAAAATAAAAAGTTTTAGCCTTGAA
AAATATATCCCTTCATTAGAACTGTTTGCTGAAGAACTTATAAAAGATGAAATCGATTGGAGTGAAATCGCAAGAAAAGA
ATATGATTTGTTTTCCAGGAATTCGGTAAGAGGTGCATTAGCTACTGTTGGATTAACCACAGAGATAAAACAATCAATAT
TTATTAGCAGAATTATTTCTCAGATCATGGATATTGATCATGAAATTTTAAAATTCAGCAATATGAATAGAGATATACAT
ATAGGTCATTTATTAGAAATGGATAAAGATGGTATAGGCTATTGCGCTCTTTTAGCTTTATCAAAAAAAGATAATAAAGA
AAAAATAATTGAGAAAATAAATACAGAAGATCTAGAAATAAATAATATTGAAAAAATATCTCAAGTTTATTCAAAAGAAT
TTAGAGATGTCTCATAA

Upstream 100 bases:

>100_bases
CGATAAGAAAACTAAATTCCCTTGGAGGTTCAATATGTCTTGATCTTTTAAGTGAAGAACAACTCCAGCAGTTAATTGAT
ACTCAGAGTGAAGAGGTCGC

Downstream 100 bases:

>100_bases
ATAGGAAATTTAAAAATCTATAAATTTTTTAATTCTAAAATTTCACTTTCTTTTAATTCAAAAACTTTTGCAATTAATTC
TTTCAATTCTATATCTTCCA

Product: DNA-cytosine methyltransferase

Products: NA

Alternate protein names: M.AgeI; Cytosine-specific methyltransferase AgeI [H]

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MIHKNAVGKSDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSGAGGLSLGLHRANFDVILACD
IRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGEISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRREL
WESFISIVEQVKPKAFLMENVTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
WPKPKYDSLEEAVTLDEAISDLPPLKGGWDEKWDEKYSYEGPKNDYQKLMRNWLDIDDEMIHDHLIRKVREDDLETFKLM
RSTGIKYSQLSEEQRRYSVTSKAFREGKQVKQNQKMSFGDKYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAA
RVQSFPDGFNFYGGPSNRFHQIGEAVAPIVAFELGKSFMKSIKNEKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
EGRKIIPSNIRAWNACLGNLLPETFKKNTKEKNKPAILGDKDLENRKKETYQRLKNFWPTPEIFLQDKARKMKIKSFSLE
KYIPSLELFAEELIKDEIDWSEIARKEYDLFSRNSVRGALATVGLTTEIKQSIFISRIISQIMDIDHEILKFSNMNRDIH
IGHLLEMDKDGIGYCALLALSKKDNKEKIIEKINTEDLEINNIEKISQVYSKEFRDVS

Sequences:

>Translated_698_residues
MIHKNAVGKSDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSGAGGLSLGLHRANFDVILACD
IRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGEISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRREL
WESFISIVEQVKPKAFLMENVTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
WPKPKYDSLEEAVTLDEAISDLPPLKGGWDEKWDEKYSYEGPKNDYQKLMRNWLDIDDEMIHDHLIRKVREDDLETFKLM
RSTGIKYSQLSEEQRRYSVTSKAFREGKQVKQNQKMSFGDKYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAA
RVQSFPDGFNFYGGPSNRFHQIGEAVAPIVAFELGKSFMKSIKNEKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
EGRKIIPSNIRAWNACLGNLLPETFKKNTKEKNKPAILGDKDLENRKKETYQRLKNFWPTPEIFLQDKARKMKIKSFSLE
KYIPSLELFAEELIKDEIDWSEIARKEYDLFSRNSVRGALATVGLTTEIKQSIFISRIISQIMDIDHEILKFSNMNRDIH
IGHLLEMDKDGIGYCALLALSKKDNKEKIIEKINTEDLEINNIEKISQVYSKEFRDVS
>Mature_698_residues
MIHKNAVGKSDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSGAGGLSLGLHRANFDVILACD
IRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGEISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRREL
WESFISIVEQVKPKAFLMENVTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
WPKPKYDSLEEAVTLDEAISDLPPLKGGWDEKWDEKYSYEGPKNDYQKLMRNWLDIDDEMIHDHLIRKVREDDLETFKLM
RSTGIKYSQLSEEQRRYSVTSKAFREGKQVKQNQKMSFGDKYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAA
RVQSFPDGFNFYGGPSNRFHQIGEAVAPIVAFELGKSFMKSIKNEKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
EGRKIIPSNIRAWNACLGNLLPETFKKNTKEKNKPAILGDKDLENRKKETYQRLKNFWPTPEIFLQDKARKMKIKSFSLE
KYIPSLELFAEELIKDEIDWSEIARKEYDLFSRNSVRGALATVGLTTEIKQSIFISRIISQIMDIDHEILKFSNMNRDIH
IGHLLEMDKDGIGYCALLALSKKDNKEKIIEKINTEDLEINNIEKISQVYSKEFRDVS

Specific function: This methylase recognizes the double-stranded sequence ACCGGT, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the AgeI endonuclease [H]

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4503351, Length=466, Percent_Identity=24.0343347639485, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI195927037, Length=466, Percent_Identity=24.0343347639485, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018117
- InterPro:   IPR001525 [H]

Pfam domain/function: PF00145 DNA_methylase [H]

EC number: =2.1.1.37 [H]

Molecular weight: Translated: 80995; Mature: 80995

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00094 C5_MTASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHKNAVGKSDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
AGGLSLGLHRANFDVILACDIRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGE
CCCCEEEEEECCCCEEEEEECCCCCEEEEHHHCCCCCEECCCHHHHHHHHHHHHHHCCCC
ISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRRELWESFISIVEQVKPKAFLMEN
EEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
HHHHHHCCHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
WPKPKYDSLEEAVTLDEAISDLPPLKGGWDEKWDEKYSYEGPKNDYQKLMRNWLDIDDEM
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
IHDHLIRKVREDDLETFKLMRSTGIKYSQLSEEQRRYSVTSKAFREGKQVKQNQKMSFGD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAARVQSFPDGFNFYGGPSNRFH
CCCCCCCCCCEEEEEEEECCCCEEEEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCHHHH
QIGEAVAPIVAFELGKSFMKSIKNEKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCC
EGRKIIPSNIRAWNACLGNLLPETFKKNTKEKNKPAILGDKDLENRKKETYQRLKNFWPT
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCC
PEIFLQDKARKMKIKSFSLEKYIPSLELFAEELIKDEIDWSEIARKEYDLFSRNSVRGAL
CHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHH
ATVGLTTEIKQSIFISRIISQIMDIDHEILKFSNMNRDIHIGHLLEMDKDGIGYCALLAL
HHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCEEEHHHHHCCCCCCCEEEEEEE
SKKDNKEKIIEKINTEDLEINNIEKISQVYSKEFRDVS
CCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIHKNAVGKSDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
AGGLSLGLHRANFDVILACDIRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGE
CCCCEEEEEECCCCEEEEEECCCCCEEEEHHHCCCCCEECCCHHHHHHHHHHHHHHCCCC
ISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRRELWESFISIVEQVKPKAFLMEN
EEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
HHHHHHCCHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
WPKPKYDSLEEAVTLDEAISDLPPLKGGWDEKWDEKYSYEGPKNDYQKLMRNWLDIDDEM
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
IHDHLIRKVREDDLETFKLMRSTGIKYSQLSEEQRRYSVTSKAFREGKQVKQNQKMSFGD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAARVQSFPDGFNFYGGPSNRFH
CCCCCCCCCCEEEEEEEECCCCEEEEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCHHHH
QIGEAVAPIVAFELGKSFMKSIKNEKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCC
EGRKIIPSNIRAWNACLGNLLPETFKKNTKEKNKPAILGDKDLENRKKETYQRLKNFWPT
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCC
PEIFLQDKARKMKIKSFSLEKYIPSLELFAEELIKDEIDWSEIARKEYDLFSRNSVRGAL
CHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHH
ATVGLTTEIKQSIFISRIISQIMDIDHEILKFSNMNRDIHIGHLLEMDKDGIGYCALLAL
HHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCEEEHHHHHCCCCCCCEEEEEEE
SKKDNKEKIIEKINTEDLEINNIEKISQVYSKEFRDVS
CCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8901102 [H]