| Definition | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome. |
|---|---|
| Accession | NC_008769 |
| Length | 4,374,522 |
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The map label for this gene is lytC [H]
Identifier: 121639826
GI number: 121639826
Start: 4366182
End: 4367402
Strand: Direct
Name: lytC [H]
Synonym: BCG_3973
Alternate gene names: 121639826
Gene position: 4366182-4367402 (Clockwise)
Preceding gene: 121639825
Following gene: NA
Centisome position: 99.81
GC content: 62.82
Gene sequence:
>1221_bases ATGCCGAGCCCGCGCCGCGAAGACGGCGATGCGCTGCGCTGTGGCGACCGCAGTGCGGCCGTCACCGAGATCCGGGCTGC GCTGACCGCGTTAGGGATGCTGGATCATCAGGAAGAAGACCTGACGACGGGCCGTAACGTCGCCCTTGAGTTGTTCGACG CGCAGCTCGACCAGGCGGTCCGTGCCTTCCAACAGCATCGCGGCCTGCTGGTGGACGGCATCGTCGGTGAGGCCACCTAC CGCGCGTTGAAAGAAGCCTCCTACCGGCTCGGGGCCCGCACGCTGTACCACCAATTCGGCGCCCCGCTCTACGGGGACGA CGTCGCTACACTGCAGGCCCGGCTGCAGGATCTTGGTTTCTACACCGGGCTGGTCGACGGTCATTTCGGGTTGCAGACCC ACAATGCGTTGATGTCCTATCAGCGTGAGTACGGACTTGCCGCAGACGGTATCTGCGGCCCAGAAACGTTGCGCTCCTTG TACTTTCTAAGTTCGCGAGTCAGCGGTGGCTCGCCACATGCGATTCGCGAAGAAGAGCTGGTCCGCAGCTCGGGGCCGAA GCTGTCTGGCAAACGGATCATCATTGATCCCGGTCGCGGCGGCGTGGACCACGGACTTATCGCGCAAGGTCCGGCTGGGC CCATCAGCGAAGCAGACTTGTTGTGGGACTTGGCAAGTCGGCTCGAAGGACGGATGGCAGCTATCGGTATGGAGACCCAC CTGTCCCGTCCGACCAACCGTAGTCCGTCCGACGCAGAGCGTGCCGCCACCGCCAACGCCGTTGGCGCAGACCTGATGAT CAGCCTGCGCTGCGAGACCCAGACCAGTCTCGCGGCCAACGGCGTGGCTTCCTTTCACTTCGGCAACTCGCACGGCTCGG TGTCTACCATCGGCCGCAATCTTGCCGATTTCATTCAACGAGAAGTGGTGGCGCGCACCGGTTTACGGGATTGCCGTGTG CATGGTCGAACGTGGGATCTGTTGCGGCTGACCAGGATGCCGACCGTTCAGGTCGATATCGGCTACATCACCAACCCCCA CGATCGTGGGATGCTGGTCTCAACGCAGACGCGCGATGCCATCGCCGAAGGCATTCTCGCCGCGGTCAAACGGCTGTATC TGTTAGGCAAGAACGATCGGCCCACCGGCACATTCACTTTCGCCGAGTTGCTGGCCCACGAACTGTCTGTCGAGCGAGCG GGTAGACTCGGCGGTTCTTAA
Upstream 100 bases:
>100_bases TTAGCCTGGGGTTTTCCCGAAATCGGCAAGGATCTGCGACAATACCGGTTGGCTGGTCCGCATTGTCAACGATGTGAGCT AATCCCGGAGGGCCCTTGGT
Downstream 100 bases:
>100_bases GCCCAGTGGCCGCGTGGGGTTTACGACGTGTTGCCGGCCGTCGACCCCGCTGCTATCGGCTCTTGCAGTCGAGCATTCTC CAGCAAGCGTTCAAGAGCGG
Product: putative hydrolase
Products: NA
Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]
Number of amino acids: Translated: 406; Mature: 405
Protein sequence:
>406_residues MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATY RALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSL YFLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETH LSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRV HGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERA GRLGGS
Sequences:
>Translated_406_residues MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATY RALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSL YFLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETH LSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRV HGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERA GRLGGS >Mature_405_residues PSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATYR ALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSLY FLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETHL SRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRVH GRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERAG RLGGS
Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich
COG id: COG0860
COG function: function code M; N-acetylmuramoyl-L-alanine amidase
Gene ontology:
Cell location: Secreted, cell wall [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR007253 - InterPro: IPR002508 [H]
Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]
EC number: =3.5.1.28 [H]
Molecular weight: Translated: 43912; Mature: 43781
Theoretical pI: Translated: 6.85; Mature: 6.85
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAV CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH RAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGF HHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH YTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSLYFLSSRVSGGSPHAIREEEL HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH VRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETH HHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHEECHHHH LSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRN CCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHCCCEEEEECCCCCCHHHHHHH LADFIQREVVARTGLRDCRVHGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDA HHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHCCCEEEEEECEEECCCCCCEEEECCHHHH IAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERAGRLGGS HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC >Mature Secondary Structure PSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAV CCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH RAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGF HHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH YTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSLYFLSSRVSGGSPHAIREEEL HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH VRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETH HHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHEECHHHH LSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRN CCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHCCCEEEEECCCCCCHHHHHHH LADFIQREVVARTGLRDCRVHGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDA HHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHCCCEEEEEECEEECCCCCCEEEECCHHHH IAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERAGRLGGS HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1357079; 1682302; 9384377 [H]