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The map label for this gene is trxC_1

Identifier: 121639825

GI number: 121639825

Start: 4365722

End: 4366072

Strand: Direct

Name: trxC_1

Synonym: BCG_3972

Alternate gene names: 121639825

Gene position: 4365722-4366072 (Clockwise)

Preceding gene: 121639824

Following gene: 121639826

Centisome position: 99.8

GC content: 58.97

Gene sequence:

>351_bases
ATGACCGATTCCGAGAAGTCCGCCACCATCAAAGTTACCGACGCATCCTTTGCCACCGACGTGCTATCCAGCAACAAGCC
TGTGCTGGTTGACTTTTGGGCGACATGGTGTGGACCTTGCAAGATGGTAGCGCCCGTTCTCGAGGAAATCGCCACCGAGC
GCGCAACAGACCTCACCGTCGCCAAGCTCGACGTGGACACCAACCCGGAGACCGCCCGCAACTTCCAGGTCGTCTCGATC
CCTACCCTGATCTTGTTCAAGGACGGCCAGCCGGTGAAACGAATCGTTGGCGCCAAGGGTAAGGCTGCGTTGCTGCGCGA
GCTCTCAGACGTGGTTCCCAACCTCAACTAG

Upstream 100 bases:

>100_bases
GCAGTGGCTGCGCCGCGGCTATCGACGCCGAGCGCTGGCTCGCCGAGCACGCAGCAACCGGAGAAGCTGACAGTACCGAC
GCATTGATAGGAGCACAACG

Downstream 100 bases:

>100_bases
CCCCCGCGGTTAGCCTGGGGTTTTCCCGAAATCGGCAAGGATCTGCGACAATACCGGTTGGCTGGTCCGCATTGTCAACG
ATGTGAGCTAATCCCGGAGG

Product: thioredoxin trxC

Products: NA

Alternate protein names: Trx; MPT46

Number of amino acids: Translated: 116; Mature: 115

Protein sequence:

>116_residues
MTDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVAPVLEEIATERATDLTVAKLDVDTNPETARNFQVVSI
PTLILFKDGQPVKRIVGAKGKAALLRELSDVVPNLN

Sequences:

>Translated_116_residues
MTDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVAPVLEEIATERATDLTVAKLDVDTNPETARNFQVVSI
PTLILFKDGQPVKRIVGAKGKAALLRELSDVVPNLN
>Mature_115_residues
TDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVAPVLEEIATERATDLTVAKLDVDTNPETARNFQVVSIP
TLILFKDGQPVKRIVGAKGKAALLRELSDVVPNLN

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=36.0824742268041, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=54.4554455445545, Blast_Score=114, Evalue=2e-27,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=40.4761904761905, Blast_Score=81, Evalue=2e-17,
Organism=Escherichia coli, GI87081747, Length=91, Percent_Identity=35.1648351648352, Blast_Score=63, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=38.2716049382716, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17569137, Length=91, Percent_Identity=37.3626373626374, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=91, Percent_Identity=37.3626373626374, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=91, Percent_Identity=37.3626373626374, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=73, Percent_Identity=38.3561643835616, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=70, Percent_Identity=42.8571428571429, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=89, Percent_Identity=37.0786516853933, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=79, Percent_Identity=31.6455696202532, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=70, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=81, Percent_Identity=39.5061728395062, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=70, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=74, Percent_Identity=36.4864864864865, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=74, Percent_Identity=36.4864864864865, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=76, Percent_Identity=52.6315789473684, Blast_Score=88, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323072, Length=77, Percent_Identity=46.7532467532467, Blast_Score=81, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=96, Percent_Identity=36.4583333333333, Blast_Score=80, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573567, Length=115, Percent_Identity=36.5217391304348, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=43.0379746835443, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=43.0379746835443, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24664269, Length=76, Percent_Identity=42.1052631578947, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24639826, Length=88, Percent_Identity=38.6363636363636, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21358065, Length=93, Percent_Identity=39.7849462365591, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639068, Length=81, Percent_Identity=34.5679012345679, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_MYCBO (P0A617)

Other databases:

- EMBL:   BX248347
- RefSeq:   NP_857580.1
- ProteinModelPortal:   P0A617
- SMR:   P0A617
- EnsemblBacteria:   EBMYCT00000015686
- GeneID:   1093957
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3945
- GeneTree:   EBGT00050000014620
- HOGENOM:   HBG493509
- OMA:   TLMLFKG
- ProtClustDB:   CLSK792810
- BioCyc:   MBOV233413:MB3945-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 12545; Mature: 12413

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVAPVLEEIATERATDLTV
CCCCCCCCEEEEECCHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCCCEEE
AKLDVDTNPETARNFQVVSIPTLILFKDGQPVKRIVGAKGKAALLRELSDVVPNLN
EEEECCCCCCCCCCEEEEEECEEEEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVAPVLEEIATERATDLTV
CCCCCCCEEEEECCHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCCCEEE
AKLDVDTNPETARNFQVVSIPTLILFKDGQPVKRIVGAKGKAALLRELSDVVPNLN
EEEECCCCCCCCCCEEEEEECEEEEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972