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The map label for this gene is fadE35 [H]

Identifier: 121639714

GI number: 121639714

Start: 4223488

End: 4225269

Strand: Direct

Name: fadE35 [H]

Synonym: BCG_3859

Alternate gene names: 121639714

Gene position: 4223488-4225269 (Clockwise)

Preceding gene: 121639713

Following gene: 121639715

Centisome position: 96.55

GC content: 66.61

Gene sequence:

>1782_bases
ATGCCCGAGTACGACCTAGAGGCCGTGGACAAGCTGCCCTTCTCGACCCCTGAAAAGGCGCAGCGCTACCAAACGGAAAA
CTATCGCGGGGCCATGGGCCTCAACTGGTACCTCACGGATCCGACCCTGCAGTTCATCATGGCCTATTACCTACGACCCG
ATGAATTGGCGTTCGCAGAACCCCATCTGACCCGCATTGGTGAGCTGACGGGCGGGCCAGTGACGCGTTGGGCCGAGGAA
ACCGACCGCAACCCCCCGCGGCTCGAACGCTACGACCGGTGGGGGCATGACATCAGCCGGGTAGTGCTGCCGGAATCGTT
CATCCAATCCAAGCGCGCCGTCATCGAGGCGCGACAAGCCGTGCGCGACGACGCGGCACGGGCCGGCGTCAAGCCGTCGC
TGGCACTCTTCGCCGCCGACTATCTGCTCAACCAGGCCGATATCGGTATGGCTTGCGCGCTCGCCACTGGCGGCAACATG
GTCCGGTCGCTGGTGACTGCCTACGCGCCACCCGATGTGCGCGAATTCGTCCTAGGCAAACTCAATTCCGGCGAGTGGGA
CGGCGAGGCCGCGCAGCTGCTGACGGAGCGTGCGGGCGGCTCCGATCTGGGAGCTCTGGAGACGACGGCCACCCGCAGCG
GCGACGTGTGGCTGCTGAACGGCTTCAAGTGGTTTGCGTCCAACTGCGCCGGGGAGGCGTTCGTGGTGTTGGCCAAGCCC
GAGGGGGCGCCTGACTCGACTCGAGGTGTGGCCACCTTCCTCGTGCTACGGACGCGCCGTGACGGTTCCCGCAACGGCGT
GCGTATCCGTCGGCTGAAGGACAAGCTCGGCACCCGCTCTGTCGCCTCCGGTGAAATCGAGTTCGTCGACGCCGAAGCCT
TTCTGTTGTCCGGCGAACCGAGCGCTGACGCGGGCCCGTCCGACGGCAAGGGACTCACCCGCATGATGGAGCTGACCAAC
AGATTGCGGTTGGGCACCGCCTCGTTCGCCCTCGGCAACGCGCGCCGCGCGCTGGTCGAATCGCTGTGCTACGCCGGGCA
GCGGCGGGCATTCGGTGGGGCGCTCATCGACAAGCCGCTGATGCGCCGCAAGCTGGCCGAAATGGTCGTTGATGTGGAAG
CCGCGCTGGCGATGGTGTTCGACGGCTTCGGAGCGGCGAACCACCGCCAGCCCAGATGCCTGCCGCAACGTATCGCGGTG
CCGGTCACCAAGCTTAAGACTTGCCGGCTCGGGATCACCGTGGCATCGGATGCGATCGAGATCCACGGCGGCAATGGCTA
CATCGAGACCTGGCCGGTGGCCCGGTTGCTGCGTGACGCGCAAGTCAACACGATCTGGGAGGGCCCCGACAACATCCTGT
GTCTGGATGTGCGGCGCGGGATCGAGCAGACGCGCGCTCACGAGACACTGTTGGCGCGGCTGCGCGATGCGGTGTCGGTG
TCCGACGATGACGACACCACGCGGCTGGTCTCGCGCCGCATTGAGGACCTCGACGCGGCGATCACCGCTTGGACCAAACT
CGACAGGCAGCTGGCCGAGGCGCGGCTGTTCCCGCTGGCCCAATTCATGGGCGACGTCTACGCCGGCGCGTTGCTCACCG
AGCAGGCCGCCTGGGAACGGGCAACCCGCGGCACCGACCGCAAGGCACTCGTCGCCCGCCTGTACGCGCGCCGGTATCTC
GCCGACCAAGGCCCGCTGCGCGGTATCGACGCAGATTGCGATGAGGCGCTGCAGCGTTTCGACGAACTCGTGGCGGGCGC
GTTCACTGCCGAGCAGACGTAA

Upstream 100 bases:

>100_bases
GGCCAGGTCTTCGCCCTCTGATCCGTTAGCGGTAGCGCCCCGTTCGACGATCGCTGCCTAGAGCTAGACATATATAAAAC
CTATGCAATAGGGTCGCGGC

Downstream 100 bases:

>100_bases
AAGCCCCCAATTCGTGGCTCTTCTGACACTTCCGTGGGTGAGTTTGTGTCCTGAGTAGGCGCACGTCGTTGTGGCTTAAG
GTTTCTGGCTTGTCAAGGAT

Product: putative acyl-CoA dehydrogenase fadE35

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MPEYDLEAVDKLPFSTPEKAQRYQTENYRGAMGLNWYLTDPTLQFIMAYYLRPDELAFAEPHLTRIGELTGGPVTRWAEE
TDRNPPRLERYDRWGHDISRVVLPESFIQSKRAVIEARQAVRDDAARAGVKPSLALFAADYLLNQADIGMACALATGGNM
VRSLVTAYAPPDVREFVLGKLNSGEWDGEAAQLLTERAGGSDLGALETTATRSGDVWLLNGFKWFASNCAGEAFVVLAKP
EGAPDSTRGVATFLVLRTRRDGSRNGVRIRRLKDKLGTRSVASGEIEFVDAEAFLLSGEPSADAGPSDGKGLTRMMELTN
RLRLGTASFALGNARRALVESLCYAGQRRAFGGALIDKPLMRRKLAEMVVDVEAALAMVFDGFGAANHRQPRCLPQRIAV
PVTKLKTCRLGITVASDAIEIHGGNGYIETWPVARLLRDAQVNTIWEGPDNILCLDVRRGIEQTRAHETLLARLRDAVSV
SDDDDTTRLVSRRIEDLDAAITAWTKLDRQLAEARLFPLAQFMGDVYAGALLTEQAAWERATRGTDRKALVARLYARRYL
ADQGPLRGIDADCDEALQRFDELVAGAFTAEQT

Sequences:

>Translated_593_residues
MPEYDLEAVDKLPFSTPEKAQRYQTENYRGAMGLNWYLTDPTLQFIMAYYLRPDELAFAEPHLTRIGELTGGPVTRWAEE
TDRNPPRLERYDRWGHDISRVVLPESFIQSKRAVIEARQAVRDDAARAGVKPSLALFAADYLLNQADIGMACALATGGNM
VRSLVTAYAPPDVREFVLGKLNSGEWDGEAAQLLTERAGGSDLGALETTATRSGDVWLLNGFKWFASNCAGEAFVVLAKP
EGAPDSTRGVATFLVLRTRRDGSRNGVRIRRLKDKLGTRSVASGEIEFVDAEAFLLSGEPSADAGPSDGKGLTRMMELTN
RLRLGTASFALGNARRALVESLCYAGQRRAFGGALIDKPLMRRKLAEMVVDVEAALAMVFDGFGAANHRQPRCLPQRIAV
PVTKLKTCRLGITVASDAIEIHGGNGYIETWPVARLLRDAQVNTIWEGPDNILCLDVRRGIEQTRAHETLLARLRDAVSV
SDDDDTTRLVSRRIEDLDAAITAWTKLDRQLAEARLFPLAQFMGDVYAGALLTEQAAWERATRGTDRKALVARLYARRYL
ADQGPLRGIDADCDEALQRFDELVAGAFTAEQT
>Mature_592_residues
PEYDLEAVDKLPFSTPEKAQRYQTENYRGAMGLNWYLTDPTLQFIMAYYLRPDELAFAEPHLTRIGELTGGPVTRWAEET
DRNPPRLERYDRWGHDISRVVLPESFIQSKRAVIEARQAVRDDAARAGVKPSLALFAADYLLNQADIGMACALATGGNMV
RSLVTAYAPPDVREFVLGKLNSGEWDGEAAQLLTERAGGSDLGALETTATRSGDVWLLNGFKWFASNCAGEAFVVLAKPE
GAPDSTRGVATFLVLRTRRDGSRNGVRIRRLKDKLGTRSVASGEIEFVDAEAFLLSGEPSADAGPSDGKGLTRMMELTNR
LRLGTASFALGNARRALVESLCYAGQRRAFGGALIDKPLMRRKLAEMVVDVEAALAMVFDGFGAANHRQPRCLPQRIAVP
VTKLKTCRLGITVASDAIEIHGGNGYIETWPVARLLRDAQVNTIWEGPDNILCLDVRRGIEQTRAHETLLARLRDAVSVS
DDDDTTRLVSRRIEDLDAAITAWTKLDRQLAEARLFPLAQFMGDVYAGALLTEQAAWERATRGTDRKALVARLYARRYLA
DQGPLRGIDADCDEALQRFDELVAGAFTAEQT

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=264, Percent_Identity=32.1969696969697, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4501857, Length=303, Percent_Identity=26.7326732673267, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226958412, Length=281, Percent_Identity=29.1814946619217, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI226958414, Length=281, Percent_Identity=29.1814946619217, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI187960098, Length=274, Percent_Identity=28.1021897810219, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4557231, Length=274, Percent_Identity=28.1021897810219, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4501859, Length=321, Percent_Identity=25.2336448598131, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI21361497, Length=331, Percent_Identity=29.0030211480363, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI7656849, Length=276, Percent_Identity=26.8115942028986, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI4557235, Length=323, Percent_Identity=26.9349845201238, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI76496475, Length=323, Percent_Identity=26.9349845201238, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4503943, Length=327, Percent_Identity=27.217125382263, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI7669494, Length=308, Percent_Identity=26.9480519480519, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082384, Length=406, Percent_Identity=33.0049261083744, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI87081958, Length=340, Percent_Identity=27.0588235294118, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786223, Length=269, Percent_Identity=27.1375464684015, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=571, Percent_Identity=26.7950963222417, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI86563383, Length=571, Percent_Identity=26.7950963222417, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17508101, Length=261, Percent_Identity=31.8007662835249, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17506239, Length=311, Percent_Identity=25.7234726688103, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17569725, Length=273, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17533517, Length=303, Percent_Identity=26.4026402640264, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17570075, Length=288, Percent_Identity=28.4722222222222, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17538396, Length=329, Percent_Identity=29.1793313069909, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17534899, Length=286, Percent_Identity=26.2237762237762, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71990804, Length=199, Percent_Identity=30.1507537688442, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17534353, Length=322, Percent_Identity=24.223602484472, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71985184, Length=273, Percent_Identity=25.2747252747253, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71982178, Length=218, Percent_Identity=28.4403669724771, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32563615, Length=196, Percent_Identity=29.0816326530612, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551932, Length=263, Percent_Identity=26.2357414448669, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355753, Length=309, Percent_Identity=28.8025889967638, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24666513, Length=327, Percent_Identity=25.0764525993884, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24660351, Length=276, Percent_Identity=28.2608695652174, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356377, Length=264, Percent_Identity=29.5454545454545, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281363737, Length=335, Percent_Identity=25.3731343283582, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646207, Length=260, Percent_Identity=28.4615384615385, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 65323; Mature: 65192

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEYDLEAVDKLPFSTPEKAQRYQTENYRGAMGLNWYLTDPTLQFIMAYYLRPDELAFAE
CCCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCC
PHLTRIGELTGGPVTRWAEETDRNPPRLERYDRWGHDISRVVLPESFIQSKRAVIEARQA
CHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
VRDDAARAGVKPSLALFAADYLLNQADIGMACALATGGNMVRSLVTAYAPPDVREFVLGK
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHC
LNSGEWDGEAAQLLTERAGGSDLGALETTATRSGDVWLLNGFKWFASNCAGEAFVVLAKP
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHHHCCCCCCEEEEEECC
EGAPDSTRGVATFLVLRTRRDGSRNGVRIRRLKDKLGTRSVASGEIEFVDAEAFLLSGEP
CCCCCCHHHHHHHHEEEECCCCCCCCEEHHHHHHHHCCCCCCCCCEEEEECEEEEECCCC
SADAGPSDGKGLTRMMELTNRLRLGTASFALGNARRALVESLCYAGQRRAFGGALIDKPL
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MRRKLAEMVVDVEAALAMVFDGFGAANHRQPRCLPQRIAVPVTKLKTCRLGITVASDAIE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCHHHHHHEEEEEEEECCEEE
IHGGNGYIETWPVARLLRDAQVNTIWEGPDNILCLDVRRGIEQTRAHETLLARLRDAVSV
EECCCCCEECCHHHHHHHHCCCCEEECCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHCCC
SDDDDTTRLVSRRIEDLDAAITAWTKLDRQLAEARLFPLAQFMGDVYAGALLTEQAAWER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATRGTDRKALVARLYARRYLADQGPLRGIDADCDEALQRFDELVAGAFTAEQT
HHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PEYDLEAVDKLPFSTPEKAQRYQTENYRGAMGLNWYLTDPTLQFIMAYYLRPDELAFAE
CCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCC
PHLTRIGELTGGPVTRWAEETDRNPPRLERYDRWGHDISRVVLPESFIQSKRAVIEARQA
CHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
VRDDAARAGVKPSLALFAADYLLNQADIGMACALATGGNMVRSLVTAYAPPDVREFVLGK
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHC
LNSGEWDGEAAQLLTERAGGSDLGALETTATRSGDVWLLNGFKWFASNCAGEAFVVLAKP
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHHHCCCCCCEEEEEECC
EGAPDSTRGVATFLVLRTRRDGSRNGVRIRRLKDKLGTRSVASGEIEFVDAEAFLLSGEP
CCCCCCHHHHHHHHEEEECCCCCCCCEEHHHHHHHHCCCCCCCCCEEEEECEEEEECCCC
SADAGPSDGKGLTRMMELTNRLRLGTASFALGNARRALVESLCYAGQRRAFGGALIDKPL
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MRRKLAEMVVDVEAALAMVFDGFGAANHRQPRCLPQRIAVPVTKLKTCRLGITVASDAIE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCHHHHHHEEEEEEEECCEEE
IHGGNGYIETWPVARLLRDAQVNTIWEGPDNILCLDVRRGIEQTRAHETLLARLRDAVSV
EECCCCCEECCHHHHHHHHCCCCEEECCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHCCC
SDDDDTTRLVSRRIEDLDAAITAWTKLDRQLAEARLFPLAQFMGDVYAGALLTEQAAWER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATRGTDRKALVARLYARRYLADQGPLRGIDADCDEALQRFDELVAGAFTAEQT
HHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]