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The map label for this gene is echA21 [H]

Identifier: 121639691

GI number: 121639691

Start: 4191252

End: 4192076

Strand: Direct

Name: echA21 [H]

Synonym: BCG_3836

Alternate gene names: 121639691

Gene position: 4191252-4192076 (Clockwise)

Preceding gene: 121639688

Following gene: 121639692

Centisome position: 95.81

GC content: 65.94

Gene sequence:

>825_bases
ATGGGCGAAACCTACGAATCCGTCACCGTCGAAACCAAGGACCAGGTCGCGCAGGTGACGCTGATCGGGCCGGGCAAGGG
CAACGCGATGGGGCCCGCATTCTGGTCGGAGATGCCCGAGGTGTTCCATGCCCTGGACGCCGACCGTGAGGTGCGGGCCA
TCGTCATCACCGGATCGGGCAAGAACTTCAGCTACGGCCTGGACGTACCGGCCATGGGCGGAATGTTCGCCCCGTTGATC
GCCGACGGCGCGCTGGCCCGCCCACGCACGGACTTCCACACCGAAATACTGCGCATGCAGAAGGCGATCAACGCCGTCGC
CGACTGCCGCACCCCCACGATCGCGGCCGTCCAGGGTTGGTGCATCGGCGGCGCCGTCGACCTGATCTCCGCGGTCGACA
TCCGGTATGCCAGCGCCGACGCGAAGTTCTCGGTGCGCGAGGTCAAGCTAGCGATTGTTGCCGACATGGGCAGCCTGGCG
CGCCTTCCACTAATCCTGAGCGACGGCCATCTACGAGAACTCGCGCTGACCGGCAAAAATATCGACGCGGCCCGCGCCGA
GAAGATCGGCCTGGTCAACGACGTCTACGATGACGCCGACCAGACGCTGGCCGCGGCCCACGCGACTGCCGCCGAGATCG
CCGCCAACCCACCTTTGGCGGTCTACGGCATCAAGGACGTTCTCGACCAACAACGCACGTCCGCCGTCTCGGAGAACCTG
CGCTATGTCGCCGCCTGGAACGCCGCGTTTCTGCCGTCCAAGGACCTCACCGAAGGTATTTCCGCGACGTTCGCCAAGCG
CCCGCCCCAGTTCACCGGCGAGTAG

Upstream 100 bases:

>100_bases
ACCTGCAGCGCGGCTTCCGCGCACGCCAGCTCGTCGGTCGGTGGGGAATCTGGTCCGGGTCGCGATTCAGGCGGCATACT
GGCCACGCTACGGTCTGGGC

Downstream 100 bases:

>100_bases
ACCCGGCGACCATGCGCGCTGGCGACGGCAAGATCCGTGTCCCGGCCGACCTAGACGCCGTCACGGCAACCGGCGAAGAG
GACCACTCCGAAATCGACGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MGETYESVTVETKDQVAQVTLIGPGKGNAMGPAFWSEMPEVFHALDADREVRAIVITGSGKNFSYGLDVPAMGGMFAPLI
ADGALARPRTDFHTEILRMQKAINAVADCRTPTIAAVQGWCIGGAVDLISAVDIRYASADAKFSVREVKLAIVADMGSLA
RLPLILSDGHLRELALTGKNIDAARAEKIGLVNDVYDDADQTLAAAHATAAEIAANPPLAVYGIKDVLDQQRTSAVSENL
RYVAAWNAAFLPSKDLTEGISATFAKRPPQFTGE

Sequences:

>Translated_274_residues
MGETYESVTVETKDQVAQVTLIGPGKGNAMGPAFWSEMPEVFHALDADREVRAIVITGSGKNFSYGLDVPAMGGMFAPLI
ADGALARPRTDFHTEILRMQKAINAVADCRTPTIAAVQGWCIGGAVDLISAVDIRYASADAKFSVREVKLAIVADMGSLA
RLPLILSDGHLRELALTGKNIDAARAEKIGLVNDVYDDADQTLAAAHATAAEIAANPPLAVYGIKDVLDQQRTSAVSENL
RYVAAWNAAFLPSKDLTEGISATFAKRPPQFTGE
>Mature_273_residues
GETYESVTVETKDQVAQVTLIGPGKGNAMGPAFWSEMPEVFHALDADREVRAIVITGSGKNFSYGLDVPAMGGMFAPLIA
DGALARPRTDFHTEILRMQKAINAVADCRTPTIAAVQGWCIGGAVDLISAVDIRYASADAKFSVREVKLAIVADMGSLAR
LPLILSDGHLRELALTGKNIDAARAEKIGLVNDVYDDADQTLAAAHATAAEIAANPPLAVYGIKDVLDQQRTSAVSENLR
YVAAWNAAFLPSKDLTEGISATFAKRPPQFTGE

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=264, Percent_Identity=41.2878787878788, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI4502327, Length=251, Percent_Identity=27.8884462151394, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI194097323, Length=273, Percent_Identity=24.9084249084249, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI157694516, Length=238, Percent_Identity=21.8487394957983, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI213417737, Length=238, Percent_Identity=21.8487394957983, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI221142681, Length=280, Percent_Identity=31.7857142857143, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787659, Length=266, Percent_Identity=28.9473684210526, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787660, Length=270, Percent_Identity=27.4074074074074, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082183, Length=281, Percent_Identity=28.4697508896797, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788682, Length=212, Percent_Identity=29.7169811320755, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790281, Length=183, Percent_Identity=26.775956284153, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788597, Length=276, Percent_Identity=26.4492753623188, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534483, Length=278, Percent_Identity=33.8129496402878, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17536985, Length=267, Percent_Identity=32.9588014981273, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17554946, Length=263, Percent_Identity=29.6577946768061, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=260, Percent_Identity=28.4615384615385, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17558304, Length=173, Percent_Identity=32.9479768786127, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17540714, Length=178, Percent_Identity=29.7752808988764, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=245, Percent_Identity=24.4897959183673, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=253, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920382, Length=265, Percent_Identity=35.4716981132075, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI20129971, Length=260, Percent_Identity=31.9230769230769, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653477, Length=260, Percent_Identity=31.9230769230769, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653139, Length=275, Percent_Identity=30.1818181818182, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29101; Mature: 28970

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGETYESVTVETKDQVAQVTLIGPGKGNAMGPAFWSEMPEVFHALDADREVRAIVITGSG
CCCCCCEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECC
KNFSYGLDVPAMGGMFAPLIADGALARPRTDFHTEILRMQKAINAVADCRTPTIAAVQGW
CCEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCE
CIGGAVDLISAVDIRYASADAKFSVREVKLAIVADMGSLARLPLILSDGHLRELALTGKN
EHHHHHHHHHHHHEEEECCCCCEEHHHEEEEEEECCCCHHHCCEEECCCCEEEEEECCCC
IDAARAEKIGLVNDVYDDADQTLAAAHATAAEIAANPPLAVYGIKDVLDQQRTSAVSENL
CCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCC
RYVAAWNAAFLPSKDLTEGISATFAKRPPQFTGE
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GETYESVTVETKDQVAQVTLIGPGKGNAMGPAFWSEMPEVFHALDADREVRAIVITGSG
CCCCCEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECC
KNFSYGLDVPAMGGMFAPLIADGALARPRTDFHTEILRMQKAINAVADCRTPTIAAVQGW
CCEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCE
CIGGAVDLISAVDIRYASADAKFSVREVKLAIVADMGSLARLPLILSDGHLRELALTGKN
EHHHHHHHHHHHHEEEECCCCCEEHHHEEEEEEECCCCHHHCCEEECCCCEEEEEECCCC
IDAARAEKIGLVNDVYDDADQTLAAAHATAAEIAANPPLAVYGIKDVLDQQRTSAVSENL
CCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCC
RYVAAWNAAFLPSKDLTEGISATFAKRPPQFTGE
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]