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The map label for this gene is hisC2

Identifier: 121639688

GI number: 121639688

Start: 4189536

End: 4190597

Strand: Direct

Name: hisC2

Synonym: BCG_3833

Alternate gene names: 121639688

Gene position: 4189536-4190597 (Clockwise)

Preceding gene: 121639683

Following gene: 121639691

Centisome position: 95.77

GC content: 67.61

Gene sequence:

>1062_bases
GTGACCGCCCGCCTGCGACCCGAGCTGGCTGGGCTGCCGGTTTATGTGCCCGGCAAAACGGTGCCGGGCGCCATCAAGCT
GGCCAGCAACGAAACCGTGTTCGGCCCGCTGCCCAGCGTCCGTGCCGCCATCGACCGGGCTACCGACACGGTCAACCGCT
ACCCCGACAACGGCTGCGTGCAGCTCAAGGCCGCGCTGGCCCGGCATCTTGGCCCGGACTTCGCTCCCGAGCACGTCGCC
GTCGGTTGCGGCTCGGTCAGCCTCTGCCAGCAACTCGTTCAGGTCACCGCCTCGGTTGGTGACGAAGTGGTCTTCGGCTG
GCGCAGCTTTGAGCTCTATCCACCACAGGTCCGGGTCGCCGGCGCTATCCCCATCCAGGTGCCGTTGACCGACCACACGT
TCGACCTCTACGCCATGCTCGCCGCGGTCACCGACCGCACCCGGCTGATCTTCGTGTGCAACCCCAACAATCCGACCTCC
ACCGTCGTCGGTCCGGACGCGCTGGCCCGCTTCGTCGAGGCGGTTCCGGCGCACATCCTGATCGCCATCGACGAGGCGTA
TGTGGAGTACATCCGGGACGGCATGCGGCCCGACAGCTTAGGCCTGGTTCGCGCACACAACAATGTCGTTGTGCTGCGTA
CGTTTTCGAAAGCGTACGGCCTGGCGGGGTTGCGGATCGGCTACGCGATCGGCCACCCCGACGTCATAACCGCGCTGGAC
AAGGTCTACGTGCCATTTACCGTGTCGAGTATCGGGCAGGCCGCGGCCATCGCGTCCCTGGACGCCGCCGACGAGCTGCT
GGCCCGTACCGACACCGTGGTTGCCGAGCGCGCCCGCGTCAGCGCCGAGTTGCGTGCTGCCGGGTTCACGCTGCCGCCAT
CGCAGGCCAACTTTGTCTGGCTTCCGCTGGGATCCCGCACCCAAGACTTCGTGGAGCAGGCCGCCGATGCACGCATCGTG
GTCCGCCCGTACGGCACGGATGGCGTTCGGGTCACCGTCGCCGCACCAGAGGAGAACGACGCGTTCCTGCGGTTCGCCCG
CCGCTGGCGGAGCGACCAATGA

Upstream 100 bases:

>100_bases
TTCGGCCGCTCTGGCACGCCTCCATGGACTTCCCGAGAGTACCCGGACTCCCCGAGCCGCCGGAGGCCTAGCGTACACAG
CCGCCACATATGCTGTCGAC

Downstream 100 bases:

>100_bases
GCGTGGCCCGTAAGAAAATTCGACGCCCACGCTCGAGCGTCACGGCTATCTGGCCGGGTTGCGGCCGGTGAACGCGATCA
GCCGCTCCAGCGCCCCGCCA

Product: putative aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIDRATDTVNRYPDNGCVQLKAALARHLGPDFAPEHVA
VGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVAGAIPIQVPLTDHTFDLYAMLAAVTDRTRLIFVCNPNNPTS
TVVGPDALARFVEAVPAHILIAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALD
KVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARVSAELRAAGFTLPPSQANFVWLPLGSRTQDFVEQAADARIV
VRPYGTDGVRVTVAAPEENDAFLRFARRWRSDQ

Sequences:

>Translated_353_residues
MTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIDRATDTVNRYPDNGCVQLKAALARHLGPDFAPEHVA
VGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVAGAIPIQVPLTDHTFDLYAMLAAVTDRTRLIFVCNPNNPTS
TVVGPDALARFVEAVPAHILIAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALD
KVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARVSAELRAAGFTLPPSQANFVWLPLGSRTQDFVEQAADARIV
VRPYGTDGVRVTVAAPEENDAFLRFARRWRSDQ
>Mature_352_residues
TARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIDRATDTVNRYPDNGCVQLKAALARHLGPDFAPEHVAV
GCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVAGAIPIQVPLTDHTFDLYAMLAAVTDRTRLIFVCNPNNPTST
VVGPDALARFVEAVPAHILIAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALDK
VYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARVSAELRAAGFTLPPSQANFVWLPLGSRTQDFVEQAADARIVV
RPYGTDGVRVTVAAPEENDAFLRFARRWRSDQ

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Escherichia coli, GI1788332, Length=307, Percent_Identity=27.3615635179153, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786816, Length=264, Percent_Identity=24.6212121212121, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788722, Length=267, Percent_Identity=26.2172284644195, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788627, Length=195, Percent_Identity=27.6923076923077, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994472, Length=171, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=171, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=22.9551451187335, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PATR_MYCBO (Q7TVQ0)

Other databases:

- EMBL:   BX248347
- RefSeq:   NP_857437.1
- ProteinModelPortal:   Q7TVQ0
- SMR:   Q7TVQ0
- EnsemblBacteria:   EBMYCT00000014823
- GeneID:   1093367
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3800
- GeneTree:   EBGT00070000031717
- HOGENOM:   HBG646350
- OMA:   ENTLIVI
- ProtClustDB:   PRK03321
- BioCyc:   MBOV233413:MB3800-MONOMER
- HAMAP:   MF_01513
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.9

Molecular weight: Translated: 38010; Mature: 37879

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIDRATDTVNRYPDNGCV
CCCCCCCHHCCCCEEECCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHCCCCCCHH
QLKAALARHLGPDFAPEHVAVGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVA
HHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCEEEE
GAIPIQVPLTDHTFDLYAMLAAVTDRTRLIFVCNPNNPTSTVVGPDALARFVEAVPAHIL
EEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECHHHHHHHHHHCCCEEE
IAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALD
EEEHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECHHHHCCCCEEEEEEECCCHHHHHHH
KVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARVSAELRAAGFTLPPSQANFVW
HEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LPLGSRTQDFVEQAADARIVVRPYGTDGVRVTVAAPEENDAFLRFARRWRSDQ
EECCCCHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIDRATDTVNRYPDNGCV
CCCCCCHHCCCCEEECCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHCCCCCCHH
QLKAALARHLGPDFAPEHVAVGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVA
HHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCEEEE
GAIPIQVPLTDHTFDLYAMLAAVTDRTRLIFVCNPNNPTSTVVGPDALARFVEAVPAHIL
EEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECHHHHHHHHHHCCCEEE
IAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALD
EEEHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECHHHHCCCCEEEEEEECCCHHHHHHH
KVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARVSAELRAAGFTLPPSQANFVW
HEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LPLGSRTQDFVEQAADARIVVRPYGTDGVRVTVAAPEENDAFLRFARRWRSDQ
EECCCCHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972