Click here to switch to the map view.

The map label for this gene is malY [C]

Identifier: 121638175

GI number: 121638175

Start: 2542421

End: 2543644

Strand: Direct

Name: malY [C]

Synonym: BCG_2310

Alternate gene names: 121638175

Gene position: 2542421-2543644 (Clockwise)

Preceding gene: 121638173

Following gene: 121638176

Centisome position: 58.12

GC content: 64.79

Gene sequence:

>1224_bases
GTGATACCTAACCCACTCGAGGAGCTAACGCTCGAGCAACTGCGAAGCCAACGCACGAGCATGAAGTGGCGTGCGCACCC
AGCCGACGTCTTGCCGTTGTGGGTCGCGGAGATGGACGTGAAGCTTCCGCCGACGGTGGCCGATGCCCTCCGTAGAGCTA
TCGACGACGGCGACACCGGATATCCCTATGGAACGGAGTATGCCGAAGCCGTCCGCGAATTCGCTTGCCAACGTTGGCAA
TGGCACGACCTGGAAGTGAGCCGCACGGCCATCGTTCCCGACGTCATGCTCGGCATCGTCGAAGTGCTGCGTCTGATCAC
CGACCGCGGTGACCCTGTGATCGTCAACTCCCCGGTATATGCGCCGTTCTACGCTTTCGTGTCGCATGACGGCCGCCGAG
TGATCCCAGCGCCGCTGCGGGGAGACGGCCGGATCGATTTGGACGCGCTGCAGGAAGCGTTCTCGAGCGCGCGTGCTTCA
AGCGGCTCGAGCGGCAACGTCGCCTACCTCCTGTGCAATCCGCACAACCCGACGGGGTCGGTGCACACCGCCGACGAACT
GCGCGGCATCGCGGAACGCGCCCAACGGTTCGGTGTCCGGGTGGTGTCCGACGAGATTCATGCCCCTCTTATCCCGTCCG
GGGCACGGTTTACGCCCTATCTGAGCGTCCCCGGTGCGGAAAACGCATTCGCACTAATGTCGGCTTCCAAGGCGTGGAAT
CTCGGCGGACTCAAGGCAGCCCTGGCCATTGCCGGTCGCGAGGCGGCGGCCGACCTCGCTCGGATGCCCGAGGAGGTCGG
TCACGGCCCCAGCCACCTGGGTGTCATCGCGCACACCGCGGCGTTCAGGACTGGTGGCAACTGGCTCGACGCGCTGCTGC
GCGGTCTGGACCACAATCGAACGTTGCTAGGCGCTCTGGTCGACGAGCATCTTCCCGGGGTGCAATACCGATGGCCGCAG
GGTACTTACCTGGCGTGGCTGGATTGCCGAGAACTCGGCTTCGATGACGCGGCTAGCGACGAGATGACCGAAGGCCTGGC
GGTGGTGTCAGATCTGTCCGGGCCAGCCCGCTGGTTCCTCGACCACGCGCGGGTTGCGCTCAGTTCTGGTCACGTCTTCG
GGATTGGCGGTGCCGGGCATGTGCGCATCAACTTCGCGACCTCCCGAGCCATTCTCATCGAGGCGGTATCGCGGATGAGC
CGGTCACTACTCGAGCGCCGGTAG

Upstream 100 bases:

>100_bases
GTGCAAGCGTGATTGGTCGATAGCCCCGGTCGGGCTATGTTCCCCGGTGTGGCTAGACCAGTTGACCGGTGCGGGACGCG
GATACGGCTAGTCTGCCGGA

Downstream 100 bases:

>100_bases
CGCGTCCAGAGAACCGCTAGCGCCAACACGATCACCTCGGGTGACGGTCTTGTCCGCTCGGCGGCCCTTCAGTGCCCAGC
CAATGCGGCCGACCCCGCGG

Product: putative aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MIPNPLEELTLEQLRSQRTSMKWRAHPADVLPLWVAEMDVKLPPTVADALRRAIDDGDTGYPYGTEYAEAVREFACQRWQ
WHDLEVSRTAIVPDVMLGIVEVLRLITDRGDPVIVNSPVYAPFYAFVSHDGRRVIPAPLRGDGRIDLDALQEAFSSARAS
SGSSGNVAYLLCNPHNPTGSVHTADELRGIAERAQRFGVRVVSDEIHAPLIPSGARFTPYLSVPGAENAFALMSASKAWN
LGGLKAALAIAGREAAADLARMPEEVGHGPSHLGVIAHTAAFRTGGNWLDALLRGLDHNRTLLGALVDEHLPGVQYRWPQ
GTYLAWLDCRELGFDDAASDEMTEGLAVVSDLSGPARWFLDHARVALSSGHVFGIGGAGHVRINFATSRAILIEAVSRMS
RSLLERR

Sequences:

>Translated_407_residues
MIPNPLEELTLEQLRSQRTSMKWRAHPADVLPLWVAEMDVKLPPTVADALRRAIDDGDTGYPYGTEYAEAVREFACQRWQ
WHDLEVSRTAIVPDVMLGIVEVLRLITDRGDPVIVNSPVYAPFYAFVSHDGRRVIPAPLRGDGRIDLDALQEAFSSARAS
SGSSGNVAYLLCNPHNPTGSVHTADELRGIAERAQRFGVRVVSDEIHAPLIPSGARFTPYLSVPGAENAFALMSASKAWN
LGGLKAALAIAGREAAADLARMPEEVGHGPSHLGVIAHTAAFRTGGNWLDALLRGLDHNRTLLGALVDEHLPGVQYRWPQ
GTYLAWLDCRELGFDDAASDEMTEGLAVVSDLSGPARWFLDHARVALSSGHVFGIGGAGHVRINFATSRAILIEAVSRMS
RSLLERR
>Mature_407_residues
MIPNPLEELTLEQLRSQRTSMKWRAHPADVLPLWVAEMDVKLPPTVADALRRAIDDGDTGYPYGTEYAEAVREFACQRWQ
WHDLEVSRTAIVPDVMLGIVEVLRLITDRGDPVIVNSPVYAPFYAFVSHDGRRVIPAPLRGDGRIDLDALQEAFSSARAS
SGSSGNVAYLLCNPHNPTGSVHTADELRGIAERAQRFGVRVVSDEIHAPLIPSGARFTPYLSVPGAENAFALMSASKAWN
LGGLKAALAIAGREAAADLARMPEEVGHGPSHLGVIAHTAAFRTGGNWLDALLRGLDHNRTLLGALVDEHLPGVQYRWPQ
GTYLAWLDCRELGFDDAASDEMTEGLAVVSDLSGPARWFLDHARVALSSGHVFGIGGAGHVRINFATSRAILIEAVSRMS
RSLLERR

Specific function: Acts As A Beta-Cystathionase And As A Repressor Of The Maltose Regulon. [C]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily

Homologues:

Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=30.5128205128205, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1788722, Length=384, Percent_Identity=22.1354166666667, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CBL_MYCBO (P63503)

Other databases:

- EMBL:   BX248342
- RefSeq:   NP_855965.1
- ProteinModelPortal:   P63503
- SMR:   P63503
- EnsemblBacteria:   EBMYCT00000017651
- GeneID:   1090409
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2316
- GeneTree:   EBGT00070000032189
- HOGENOM:   HBG681988
- OMA:   LANPLRE
- ProtClustDB:   CLSK872043
- BioCyc:   MBOV233413:MB2316-MONOMER
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.4.1.8

Molecular weight: Translated: 44284; Mature: 44284

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNPLEELTLEQLRSQRTSMKWRAHPADVLPLWVAEMDVKLPPTVADALRRAIDDGDTG
CCCCCHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
YPYGTEYAEAVREFACQRWQWHDLEVSRTAIVPDVMLGIVEVLRLITDRGDPVIVNSPVY
CCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
APFYAFVSHDGRRVIPAPLRGDGRIDLDALQEAFSSARASSGSSGNVAYLLCNPHNPTGS
HHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
VHTADELRGIAERAQRFGVRVVSDEIHAPLIPSGARFTPYLSVPGAENAFALMSASKAWN
CCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCC
LGGLKAALAIAGREAAADLARMPEEVGHGPSHLGVIAHTAAFRTGGNWLDALLRGLDHNR
CCCHHHHHHHHCHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCH
TLLGALVDEHLPGVQYRWPQGTYLAWLDCRELGFDDAASDEMTEGLAVVSDLSGPARWFL
HHHHHHHHHHCCCCEEECCCCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHH
DHARVALSSGHVFGIGGAGHVRINFATSRAILIEAVSRMSRSLLERR
HHHHHHEECCCEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIPNPLEELTLEQLRSQRTSMKWRAHPADVLPLWVAEMDVKLPPTVADALRRAIDDGDTG
CCCCCHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
YPYGTEYAEAVREFACQRWQWHDLEVSRTAIVPDVMLGIVEVLRLITDRGDPVIVNSPVY
CCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
APFYAFVSHDGRRVIPAPLRGDGRIDLDALQEAFSSARASSGSSGNVAYLLCNPHNPTGS
HHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
VHTADELRGIAERAQRFGVRVVSDEIHAPLIPSGARFTPYLSVPGAENAFALMSASKAWN
CCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCC
LGGLKAALAIAGREAAADLARMPEEVGHGPSHLGVIAHTAAFRTGGNWLDALLRGLDHNR
CCCHHHHHHHHCHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCH
TLLGALVDEHLPGVQYRWPQGTYLAWLDCRELGFDDAASDEMTEGLAVVSDLSGPARWFL
HHHHHHHHHHCCCCEEECCCCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHH
DHARVALSSGHVFGIGGAGHVRINFATSRAILIEAVSRMSRSLLERR
HHHHHHEECCCEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972