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The map label for this gene is pbpB [H]

Identifier: 121638045

GI number: 121638045

Start: 2404936

End: 2406975

Strand: Reverse

Name: pbpB [H]

Synonym: BCG_2180c

Alternate gene names: 121638045

Gene position: 2406975-2404936 (Counterclockwise)

Preceding gene: 121638046

Following gene: 121638044

Centisome position: 55.02

GC content: 65.93

Gene sequence:

>2040_bases
GTGAGCCGCGCCGCCCCCAGGCGGGCCAGTCAGTCGCAGTCGACGCGACCGGCGCGCGGTTTGCGCCGGCCACCGGGAGC
CCAGGAGGTTGGGCAACGCAAACGGCCCGGCAAAACGCAGAAAGCCCGGCAAGCCCAGGAAGCCACGAAATCCCGCCCTG
CGACACGGTCAGACGTCGCACCCGCGGGTCGCTCGACTCGTGCGAGGCGCACCCGGCAGGTGGTGGACGTCGGGACGCGC
GGTGCGTCGTTCGTCTTTCGGCATCGGACCGGAAACGCGGTCATCTTGGTGTTGATGTTGGTCGCGGCAACACAATTGTT
CTTTCTGCAGGTATCACATGCCGCGGGCCTGCGTGCGCAGGCGGCCGGCCAACTCAAGGTCACCGACGTCCAGCCAGCGG
CTCGCGGCAGCATCGTCGACCGCAACAATGACCGGCTCGCGTTCACCATCGAGGCGCGTGCCCTGACGTTCCAGCCGAAG
CGGATTCGGCGGCAATTGGAAGAGGCCAGGAAGAAGACGTCGGCTGCACCCGACCCGCAGCAGCGCCTGCGCGATATCGC
CCAGGAGGTCGCCGGCAAGCTGAACAACAAGCCAGATGCCGCGGCCGTGCTGAAGAAGCTGCAAAGCGACGAGACCTTCG
TCTACTTGGCGCGTGCGGTCGACCCGGCTGTCGCCAGCGCGATCTGCGCGAAGTATCCCGAGGTCGGTGCGGAAAGACAG
GATCTGCGTCAGTACCCGGGTGGGTCGCTGGCGGCAAACGTCGTCGGTGGCATCGACTGGGATGGTCATGGGCTGCTGGG
TCTGGAGGACTCCCTGGATGCGGTGCTGGCCGGAACCGACGGATCGGTCACCTACGACCGTGGGTCAGACGGCGTCGTCA
TCCCCGGCAGCTACCGGAATCGGCACAAGGCGGTCCACGGTTCCACCGTCGTGCTCACCCTCGACAACGACATCCAGTTC
TACGTGCAGCAGCAGGTGCAGCAGGCCAAGAACCTATCGGGGGCTCACAACGTCTCGGCCGTCGTCCTGGACGCCAAGAC
CGGCGAGGTGCTCGCGATGGCCAACGACAACACCTTCGACCCGTCGCAAGACATCGGGCGCCAGGGCGACAAGCAGTTGG
GCAACCCGGCGGTGTCGTCGCCCTTCGAGCCGGGCTCGGTGAACAAGATCGTCGCCGCGTCCGCGGTCATCGAGCACGGG
TTGAGCAGCCCCGACGAGGTGCTACAGGTGCCTGGCTCGATCCAGATGGGCGGTGTTACCGTGCATGACGCTTGGGAGCA
CGGCGTGATGCCCTATACCACCACGGGGGTGTTCGGAAAGTCCTCCAACGTCGGCACGCTGATGCTTTCCCAACGTGTCG
GACCGGAACGCTATTACGATATGCTCCGCAAGTTCGGGTTGGGACAGCGCACCGGCGTGGGCCTGCCCGGTGAGAGCGCC
GGACTGGTGCCGCCAATCGACCAGTGGTCGGGCAGTACGTTCGCTAATCTTCCTATTGGCCAAGGTCTTTCGATGACTTT
GCTGCAGATGACCGGCATGTACCAGGCCATCGCCAACGATGGAGTGCGGGTACCCCCACGCATTATCAAGGCCACCGTCG
CACCCGACGGCAGCCGGACCGAAGAACCGCGCCCCGACGACATTCGCGTGGTGTCGGCGCAGACCGCCCAGACCGTGCGC
CAGATGCTGCGTGCCGTGGTGCAACGCGATCCGATGGGCTACCAGCAGGGTACCGGGCCGACGGCCGGGGTGCCCGGCTA
TCAGATGGCCGGCAAGACCGGTACCGCGCAGCAGATCAACCCTGGCTGCGGCTGCTACTTCGACGACGTGTATTGGATCA
CCTTCGCCGGAATCGCCACTGCCGACAATCCCCGCTACGTGATCGGCATCATGTTGGACAACCCGGCGCGCAACTCCGAC
GGCGCGCCTGGGCACTCGGCCGCCCCGCTGTTCCACAACATCGCGGGCTGGCTGATGCAGCGCGAAAACGTCCCGCTGTC
ACCCGATCCCGGGCCTCCTTTGGTCTTGCAGGCCACCTAG

Upstream 100 bases:

>100_bases
GGTCGCAACCCATGGTGGCACCACCCGCTCCAGTGCCGGCCAACGGCGAACAGTTCGGTCCCGTCACGGCGCCGGTGCCA
ACGGCGCCGGGGGCTCCCAG

Downstream 100 bases:

>100_bases
GGCGGCGGCGCCGGTAACGGCGCGCGCCGGTTCGTTTCGGCTCCAACAACTTTTGCGCAACATGCGCGCGCTGACGATCG
GGTTGGCGGAAGCGCTTTTA

Product: putative penicillin-binding membrane protein pbpB

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTR
GASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPK
RIRRQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQ
DLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQF
YVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHG
LSSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESA
GLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVR
QMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSD
GAPGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT

Sequences:

>Translated_679_residues
MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTR
GASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPK
RIRRQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQ
DLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQF
YVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHG
LSSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESA
GLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVR
QMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSD
GAPGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT
>Mature_678_residues
SRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTRG
ASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKR
IRRQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQD
LRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQFY
VQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHGL
SSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESAG
LVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVRQ
MLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSDG
APGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=593, Percent_Identity=28.8364249578415, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI1786854, Length=579, Percent_Identity=23.6614853195164, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 72538; Mature: 72407

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVA
CCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
PAGRSTRARRTRQVVDVGTRGASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQ
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKRIRRQLEEARKKTSAAPDPQ
CCCCEEEEECCCCCCCCEEECCCCEEEEEEEEEEEEECHHHHHHHHHHHHHHCCCCCCHH
QRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEHHHCHHHHHHHHHHCCCCCCCHH
DLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRN
HHHHCCCCCEEHHHHCCCCCCCCCEECCCCCCCEEEECCCCCEEEECCCCCEEECCCCCC
RHKAVHGSTVVLTLDNDIQFYVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFD
CCCEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCC
PSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHGLSSPDEVLQVPGSIQMGGVT
CHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCEE
VHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESA
EECCHHCCCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
GLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRT
CCCCCHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCCC
EEPRPDDIRVVSAQTAQTVRQMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQIN
CCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCC
PGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSDGAPGHSAAPLFHNIAGWLMQ
CCCCEEECCEEEEEEECEEECCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
RENVPLSPDPGPPLVLQAT
CCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVA
CCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
PAGRSTRARRTRQVVDVGTRGASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQ
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKRIRRQLEEARKKTSAAPDPQ
CCCCEEEEECCCCCCCCEEECCCCEEEEEEEEEEEEECHHHHHHHHHHHHHHCCCCCCHH
QRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEHHHCHHHHHHHHHHCCCCCCCHH
DLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRN
HHHHCCCCCEEHHHHCCCCCCCCCEECCCCCCCEEEECCCCCEEEECCCCCEEECCCCCC
RHKAVHGSTVVLTLDNDIQFYVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFD
CCCEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCC
PSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHGLSSPDEVLQVPGSIQMGGVT
CHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCEE
VHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESA
EECCHHCCCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
GLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRT
CCCCCHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCCC
EEPRPDDIRVVSAQTAQTVRQMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQIN
CCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCC
PGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSDGAPGHSAAPLFHNIAGWLMQ
CCCCEEECCEEEEEEECEEECCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
RENVPLSPDPGPPLVLQAT
CCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]