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The map label for this gene is argE [C]

Identifier: 121638023

GI number: 121638023

Start: 2380386

End: 2381732

Strand: Reverse

Name: argE [C]

Synonym: BCG_2158c

Alternate gene names: 121638023

Gene position: 2381732-2380386 (Counterclockwise)

Preceding gene: 121638024

Following gene: 121638022

Centisome position: 54.45

GC content: 65.11

Gene sequence:

>1347_bases
GTGACAGATGAGACCGGGGCTTCAAGCGACCACAGCGATGATGTCGCCCAGGTCGTCAGCAGGCTAATCCGGTTCGATAC
CACCAACAGTGGCGAACCCGGGACCACCAAGGGTGAGGCCGAGTGCGCACGCTGGGTCGCCGAGCAGCTCGCCGAAGTCG
GCTACCAACCTGAATACGTTGAATCCGGTGCGCCCGGCCGCGGCAACGTGTTCGCCCGGCTGGCGGGCGCCGATAGTTCT
CGCGGCGCGCTGCTGATCCACGGGCATCTCGATGTGGTGCCGGCTGAACCGGCCGAATGGAGTGTGCACCCGTTTTCCGG
CGCCATCGAAGACGGCTACGTCTGGGGTCGTGGCGCGGTCGACATGAAGGACATGGTGGGCATGATGATTGTGGTTGCCC
GCCACCTTCGTCAGGCCGCTATCGTGCCGCCACGGGATCTGGTGTTCGCGTTCGTTGCCGACGAGGAGCACGGCGGCAAG
TACGGGTCGCACTGGCTGGTCGACAATAGGCCCGATCTGTTCGACGGCATCACCGAGGCAATCGGTGAAGTCGGCGGTTT
CTCGCTAACCGTGCCCCGGCACGATGGTGGCGAACGTCGCCTGTACCTGATTGAAACCGCCGAGAAGGGCATCCAGTGGA
TGCGGCTGACGGCACGCGGCCGGGCTGGGCACGGCTCGATGGTGCACGACCAGAACGCGGTCACCGCCGTTTGTGAGGCG
GTCGCTCGCCTAGGGCGCCACCAGTTTCCGCTGGTCTGCACTGACACCGTCGCCCAGTTCTTGGCCGTAGTCGGAGAGGA
GACCGGACTGGCCTTCGACCTTGACTCGCCGGACCTGGCCGGGACGATCGACAAGCTTGGCCCGATGGCCCGCATGTTGA
AGGCAGTGCTACATGACACCGCGAACCCTACGATGCTCAAGGCCGGATACAAGGCCAACGTCGTCCCGGCGACCGCGGAG
GCAGTTGTGGACTGCCGCGTGCTTCCGGGTCGCCGGGCGGCGTTCGAGGCCGAAGTCGACGCGCTGATCGGACCCGACGT
GACCCGGGAGTGGGTCAGCGATCTGCCATCATATGAGACCACCTTCGACGGTGATCTGGTCGCCGCCATGAACGCCGCGG
TGTTGGCGGTCGACCCAGACGGTCGCACGGTGCCGTACATGCTGTCCGGTGGAACGGACGCGAAGGCGTTCGCGCGCTTG
GGTATTCGGTGCTTTGGCTTCAGCCCGCTGCGCTTGCCGCCGGACTTGGATTTCACCTCGTTGTTCCACGGCGTCGACGA
GCGGGTACCCATCGATGGGTTGCGGTTCGGCACCGAGGTGCTAACGCACTTGCTGACACACTGCTAG

Upstream 100 bases:

>100_bases
CAATCAGCCCACGTAAGCAAATCCAGCTCGGCGACGACGCGGGCCCGGCGCGCCAGGGGCGATCGGCTCGCCAGGGTTAC
GAGTGGTAGGAAAGGTGACT

Downstream 100 bases:

>100_bases
TCGAAAACGAGGCTAGTCGCAACGTCGATCACACGAGAGGACTGACCATGACAACTTCACCCGACCCGTATGCCGCGCTG
CCCAAGCTGCCGTCCTTCAG

Product: hypothetical protein

Products: Acetate; Ornithine [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPEYVESGAPGRGNVFARLAGADSS
RGALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGGK
YGSHWLVDNRPDLFDGITEAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVCEA
VARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPATAE
AVVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSYETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFARL
GIRCFGFSPLRLPPDLDFTSLFHGVDERVPIDGLRFGTEVLTHLLTHC

Sequences:

>Translated_448_residues
MTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPEYVESGAPGRGNVFARLAGADSS
RGALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGGK
YGSHWLVDNRPDLFDGITEAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVCEA
VARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPATAE
AVVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSYETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFARL
GIRCFGFSPLRLPPDLDFTSLFHGVDERVPIDGLRFGTEVLTHLLTHC
>Mature_447_residues
TDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPEYVESGAPGRGNVFARLAGADSSR
GALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGGKY
GSHWLVDNRPDLFDGITEAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVCEAV
ARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPATAEA
VVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSYETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFARLG
IRCFGFSPLRLPPDLDFTSLFHGVDERVPIDGLRFGTEVLTHLLTHC

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=440, Percent_Identity=26.3636363636364, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4501901, Length=389, Percent_Identity=26.7352185089974, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24649206, Length=416, Percent_Identity=25.2403846153846, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24649202, Length=413, Percent_Identity=24.9394673123487, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24649204, Length=413, Percent_Identity=24.9394673123487, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24649210, Length=414, Percent_Identity=24.8792270531401, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24649212, Length=425, Percent_Identity=25.1764705882353, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24649208, Length=389, Percent_Identity=25.1928020565553, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356353, Length=387, Percent_Identity=24.5478036175711, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 48143; Mature: 48012

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPEYV
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
ESGAPGRGNVFARLAGADSSRGALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAV
CCCCCCCCCEEEEEECCCCCCCEEEEECCEEEECCCCCCCEECCCCCCCCCCEEECCCCC
DMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGGKYGSHWLVDNRPDLFDGITEA
CHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHH
IGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVCEA
HHHCCCEEEEECCCCCCCEEEEEEECHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHH
VARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLHDT
HHHHCCCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
ANPTMLKAGYKANVVPATAEAVVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSYET
CCCCEEECCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCC
TFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFARLGIRCFGFSPLRLPPDLDFTS
CCCCCHHEECCCEEEEECCCCCEECEEEECCCCHHHHHHHCEEEECCCCCCCCCCCCHHH
LFHGVDERVPIDGLRFGTEVLTHLLTHC
HHHCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECARWVAEQLAEVGYQPEYV
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
ESGAPGRGNVFARLAGADSSRGALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAV
CCCCCCCCCEEEEEECCCCCCCEEEEECCEEEECCCCCCCEECCCCCCCCCCEEECCCCC
DMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGGKYGSHWLVDNRPDLFDGITEA
CHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHH
IGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGSMVHDQNAVTAVCEA
HHHCCCEEEEECCCCCCCEEEEEEECHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHH
VARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLAGTIDKLGPMARMLKAVLHDT
HHHHCCCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
ANPTMLKAGYKANVVPATAEAVVDCRVLPGRRAAFEAEVDALIGPDVTREWVSDLPSYET
CCCCEEECCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCC
TFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGTDAKAFARLGIRCFGFSPLRLPPDLDFTS
CCCCCHHEECCCEEEEECCCCCEECEEEECCCCHHHHHHHCEEEECCCCCCCCCCCCHHH
LFHGVDERVPIDGLRFGTEVLTHLLTHC
HHHCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]