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The map label for this gene is cmtR

Identifier: 121637878

GI number: 121637878

Start: 2216283

End: 2216639

Strand: Reverse

Name: cmtR

Synonym: BCG_2011c

Alternate gene names: 121637878

Gene position: 2216639-2216283 (Counterclockwise)

Preceding gene: 121637882

Following gene: 121637877

Centisome position: 50.67

GC content: 65.55

Gene sequence:

>357_bases
ATGCTGACGTGTGAGATGCGGGAATCGGCCCTGGCTCGACTCGGCCGGGCTCTGGCTGATCCGACGCGGTGCCGGATTCT
GGTGGCGTTGCTGGATGGCGTTTGCTATCCCGGCCAGCTAGCTGCGCACCTCGGGTTGACCCGATCGAATGTGTCCAACC
ATCTGTCGTGTTTGCGGGGCTGCGGGCTGGTAGTCGCAACCTATGAGGGCCGGCAGGTTCGGTATGCGCTGGCCGACAGT
CACCTGGCGCGAGCCTTGGGCGAGTTGGTCCAGGTCGTTCTCGCGGTGGATACCGACCAACCCTGTGTCGCCGAGCGCGC
CGCGTCCGGGGAGGCGGTCGAGATGACAGGTAGCTGA

Upstream 100 bases:

>100_bases
CTCTGCGGCCGGAAGCTTGTGACGCGCGCCGATCATATCTGCTATGGATGTACAATTCAGCTCTTGCTGTTATACCAGTA
TATGGTGTACTATTTGATCT

Downstream 100 bases:

>100_bases
GCAGCAGACGACACGACTTGTGGTTACAGGACAAAGCAAAGGAGAACTGACCGTGGTTACGCATGAGCTATTGGTTAAGG
CGGCCGGGGCGGTGCTCACC

Product: putative transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MLTCEMRESALARLGRALADPTRCRILVALLDGVCYPGQLAAHLGLTRSNVSNHLSCLRGCGLVVATYEGRQVRYALADS
HLARALGELVQVVLAVDTDQPCVAERAASGEAVEMTGS

Sequences:

>Translated_118_residues
MLTCEMRESALARLGRALADPTRCRILVALLDGVCYPGQLAAHLGLTRSNVSNHLSCLRGCGLVVATYEGRQVRYALADS
HLARALGELVQVVLAVDTDQPCVAERAASGEAVEMTGS
>Mature_118_residues
MLTCEMRESALARLGRALADPTRCRILVALLDGVCYPGQLAAHLGLTRSNVSNHLSCLRGCGLVVATYEGRQVRYALADS
HLARALGELVQVVLAVDTDQPCVAERAASGEAVEMTGS

Specific function: Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CMTR_MYCBO (P67732)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855667.1
- ProteinModelPortal:   P67732
- SMR:   P67732
- EnsemblBacteria:   EBMYCT00000016843
- GeneID:   1093783
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2017c
- GeneTree:   EBGT00050000015474
- HOGENOM:   HBG742701
- OMA:   RYEIADP
- ProtClustDB:   CLSK791546
- BioCyc:   MBOV233413:MB2017C-MONOMER
- GO:   GO:0005622
- InterPro:   IPR001845
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00778
- SMART:   SM00418

Pfam domain/function: PF01022 HTH_5

EC number: NA

Molecular weight: Translated: 12496; Mature: 12496

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00846 HTH_ARSR_1; PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTCEMRESALARLGRALADPTRCRILVALLDGVCYPGQLAAHLGLTRSNVSNHLSCLRG
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
CGLVVATYEGRQVRYALADSHLARALGELVQVVLAVDTDQPCVAERAASGEAVEMTGS
CCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCC
>Mature Secondary Structure
MLTCEMRESALARLGRALADPTRCRILVALLDGVCYPGQLAAHLGLTRSNVSNHLSCLRG
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
CGLVVATYEGRQVRYALADSHLARALGELVQVVLAVDTDQPCVAERAASGEAVEMTGS
CCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972