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The map label for this gene is ribA1 [H]

Identifier: 121637845

GI number: 121637845

Start: 2194766

End: 2195827

Strand: Direct

Name: ribA1 [H]

Synonym: BCG_1979

Alternate gene names: 121637845

Gene position: 2194766-2195827 (Clockwise)

Preceding gene: 121637844

Following gene: 121637846

Centisome position: 50.17

GC content: 69.02

Gene sequence:

>1062_bases
ATGAAGACGACCGATGTGCGGGTACGTCGTGCGATCACGGCGATGGCGGGCGGTCACGCCGTGGTCCTGACCGGCGACCC
CAATGGCGATGGCTATCTCGTCTTCGCCGCCCAGGCCGCGACGCCGCGGCTGGTTGCCTTTGCGGTCCGGCACACCTCGG
GTTATTTGCGCGTCGCGCTGCCGGGCGCCGAATGCGAGCGACTGCACCTGCCGCCCATGTGTGACCGAGACACCACGCAT
TGCGTGTCGGTCGACGTTCGCGGCACCGGCACCGGAATCTCGGCGAGCGATCGCGCCTGGACCATCGCGGCACTGGCTTC
GGCCACCTCCGTCGCCGCCGATTTCCAACGTCCGGGCCATGTGGTGCCCGTGCAGGCGCAAGCCGACGGTGTGCTGGGTC
GGCGGGGACCCGCCGAGGCGGCCGTCGACCTGGCCCGCCTGGCGGAACGGCGGCCGGCCGCCGCGCTCTGCGAGATCGTC
TCGCCCGATAATCCCGTCCAGATGGCGCACCACGCCGAGTCGGTCGAATTCGCCGTCGAACACGGACTGGCCATGGTCTC
GATCGGGGAGCTGGTGGCGTATCGCCGGCGGATCGAGCCCCAGGTGGTCCGGTTTACGGCAGCGACGCTGCCCACCTGGG
CCGGCGCCTCGCGTGTCATCGGCTTTCGTGACGTTTACGACCTCGGCGAGCATTTGGCGGTCATCGTGGGTGCGGTCGGT
GCCGGGGTGCCCGTGCCGCTGCACGTCCACATCGAGTGCCTGACGGGCGACGTGTTCGGCTCGACGGCGTGCCGCTGCGG
CGAGGAACTCAACGGCGCGCTGGCGAGGATGTCGGCTCAGGGCAGCGGCGTGGTCTTGTATCTGCGTCCGCCCGGACCCG
CGCAAGCGTGCGGCTTGTTCGCCCGGGGCGATGCGGCGACCGATGTCATGCCGGAGACCGTGACATGGATCCTGCGCGAT
CTTGGGGTGTATGCGATCCGACTTTCCGATGATGTGCCAGGATTTGGGCTTGTCATGTTCGGGGCGATCCGAGAAGCCAG
CACGTTGGCGGCCGCAGGTTGA

Upstream 100 bases:

>100_bases
ATCACCTGATCGCCCTGCTGGAGATCTGCGCGGTGCGCGCCGATCCCGAGACACCGCCGCTGGTGTTTCACGGTAGCCGG
TTCCGCCGGTTGGAGTCTCG

Downstream 100 bases:

>100_bases
ACCATCCAGACCTGGCCGGCAAGGTCGCGATCGTTACTGGGGCGGGCGCCGGAATCGGTCTGGCGGTTGCCCGGCGACTC
GCCGACGAGGGCTGCCATGT

Product: putative riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II)

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLVAFAVRHTSGYLRVALPGAECERLHLPPMCDRDTTH
CVSVDVRGTGTGISASDRAWTIAALASATSVAADFQRPGHVVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIV
SPDNPVQMAHHAESVEFAVEHGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASRVIGFRDVYDLGEHLAVIVGAVG
AGVPVPLHVHIECLTGDVFGSTACRCGEELNGALARMSAQGSGVVLYLRPPGPAQACGLFARGDAATDVMPETVTWILRD
LGVYAIRLSDDVPGFGLVMFGAIREASTLAAAG

Sequences:

>Translated_353_residues
MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLVAFAVRHTSGYLRVALPGAECERLHLPPMCDRDTTH
CVSVDVRGTGTGISASDRAWTIAALASATSVAADFQRPGHVVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIV
SPDNPVQMAHHAESVEFAVEHGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASRVIGFRDVYDLGEHLAVIVGAVG
AGVPVPLHVHIECLTGDVFGSTACRCGEELNGALARMSAQGSGVVLYLRPPGPAQACGLFARGDAATDVMPETVTWILRD
LGVYAIRLSDDVPGFGLVMFGAIREASTLAAAG
>Mature_353_residues
MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLVAFAVRHTSGYLRVALPGAECERLHLPPMCDRDTTH
CVSVDVRGTGTGISASDRAWTIAALASATSVAADFQRPGHVVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIV
SPDNPVQMAHHAESVEFAVEHGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASRVIGFRDVYDLGEHLAVIVGAVG
AGVPVPLHVHIECLTGDVFGSTACRCGEELNGALARMSAQGSGVVLYLRPPGPAQACGLFARGDAATDVMPETVTWILRD
LGVYAIRLSDDVPGFGLVMFGAIREASTLAAAG

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=36.8686868686869, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1787533, Length=92, Percent_Identity=38.0434782608696, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=35.2941176470588, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 36870; Mature: 36870

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLVAFAVRHTSGYLRVAL
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEEE
PGAECERLHLPPMCDRDTTHCVSVDVRGTGTGISASDRAWTIAALASATSVAADFQRPGH
CCCCCCEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCC
VVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIVSPDNPVQMAHHAESVEFAVE
EEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
HGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASRVIGFRDVYDLGEHLAVIVGAVG
CCCCEEHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHC
AGVPVPLHVHIECLTGDVFGSTACRCGEELNGALARMSAQGSGVVLYLRPPGPAQACGLF
CCCCEEEEEEEEEEECCCCCCHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCEE
ARGDAATDVMPETVTWILRDLGVYAIRLSDDVPGFGLVMFGAIREASTLAAAG
ECCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLVAFAVRHTSGYLRVAL
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEEE
PGAECERLHLPPMCDRDTTHCVSVDVRGTGTGISASDRAWTIAALASATSVAADFQRPGH
CCCCCCEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCC
VVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIVSPDNPVQMAHHAESVEFAVE
EEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
HGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASRVIGFRDVYDLGEHLAVIVGAVG
CCCCEEHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHC
AGVPVPLHVHIECLTGDVFGSTACRCGEELNGALARMSAQGSGVVLYLRPPGPAQACGLF
CCCCEEEEEEEEEEECCCCCCHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCEE
ARGDAATDVMPETVTWILRDLGVYAIRLSDDVPGFGLVMFGAIREASTLAAAG
ECCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA