Click here to switch to the map view.

The map label for this gene is secA2

Identifier: 121637724

GI number: 121637724

Start: 2067468

End: 2069894

Strand: Direct

Name: secA2

Synonym: BCG_1856

Alternate gene names: 121637724

Gene position: 2067468-2069894 (Clockwise)

Preceding gene: 121637723

Following gene: 121637725

Centisome position: 47.26

GC content: 64.32

Gene sequence:

>2427_bases
GTGAACGTGCACGGTTGTCCACGAATTGCGGCCTGTCGGTGTACAGACACGCACCCTCGCGGCCGGCCGGCATTCGCGTA
CCGTTGGTTTGTGCCCAAGACCACCCGCGCTCAACCCGGCCGGCTGAGCAGCCGATTCTGGCGATTGCTCGGCGCCAGCA
CCGAAAAGAACCGGAGCCGCTCCCTGGCGGATGTAACCGCTTCGGCAGAATACGACAAGGAAGCTGCCGATCTGTCCGAC
GAGAAGCTGCGTAAGGCGGCAGGCCTGCTCAACCTCGACGACCTCGCGGAGTCCGCCGATATCCCGCAGTTTCTCGCGAT
TGCCCGGGAAGCCGCCGAGCGGAGGACCGGGCTGCGACCATTTGATGTGCAGTTGCTTGGCGCGTTGCGCATGCTCGCCG
GAGACGTGATCGAGATGGCCACCGGTGAGGGCAAAACCCTTGCCGGGGCGATCGCGGCCGCCGGTTATGCGCTGGCCGGC
CGGCACGTGCACGTCGTGACGATTAACGATTACCTGGCCCGCCGCGATGCGGAGTGGATGGGCCCGCTGCTGGACGCGAT
GGGCCTGACGGTCGGCTGGATCACCGCGGACTCGACCCCTGACGAGCGCCGGACCGCATATGACCGTGATGTCACCTATG
CCTCGGTCAACGAGATTGGCTTCGATGTACTGCGCGATCAGTTGGTGACTGATGTCAATGACCTGGTATCGCCCAATCCA
GACGTGGCTCTCATCGACGAAGCCGACTCCGTGCTGGTCGACGAGGCGCTGGTGCCCCTGGTGCTGGCCGGAACCACACA
TCGTGAGACGCCGCGGCTGGAGATCATCCGGCTGGTCGCTGAGCTTGTTGGCGACAAGGACGCCGACGAGTACTTTGCCA
CCGATTCCGATAACCGCAATGTCCACTTGACCGAGCACGGGGCACGCAAAGTCGAGAAAGCGCTCGGTGGCATCGACCTG
TACTCCGAGGAGCACGTCGGCACCACACTGACTGAGGTCAATGTCGCGCTGCACGCGCATGTGCTCCTGCAACGCGACGT
GCACTACATCGTCCGCGACGACGCGGTGCACCTGATCAACGCGTCGCGTGGCCGTATCGCGCAACTGCAGCGCTGGCCGG
ACGGGTTGCAAGCTGCGGTCGAGGCCAAGGAAGGTATCGAGACCACGGAAACTGGGGAAGTGCTCGACACCATCACGGTG
CAGGCCCTGATCAACCGGTATGCGACTGTGTGCGGAATGACGGGAACCGCGCTGGCCGCCGGTGAGCAGCTACGGCAGTT
CTACCAGCTCGGTGTCTCACCGATACCACCGAACAAGCCAAACATCCGCGAGGACGAGGCCGACCGGGTCTACATCACCA
CTGCAGCCAAGAACGACGGGATCGTCGAGCACATCACCGAGGTGCACCAGAGGGGGCAGCCTGTGCTGGTCGGTACCCGC
GACGTGGCCGAATCCGAGGAACTGCACGAACGCCTGGTGCGCCGCGGTGTGCCCGCCGTGGTGCTCAACGCGAAGAACGA
CGCCGAGGAGGCCCGGGTCATCGCCGAGGCCGGCAAATACGGCGCGGTCACGGTGTCAACTCAAATGGCCGGGCGCGGCA
CCGACATCAGGCTCGGCGGGTCCGACGAAGCTGACCACGACAGGGTCGCGGAATTGGGCGGCCTGCACGTGGTCGGCACT
GGCCGTCACCACACCGAGCGGCTAGACAACCAGCTGCGCGGTCGGGCCGGGCGCCAGGGAGATCCCGGGTCGTCGGTGTT
TTTCTCAAGCTGGGAAGACGATGTCGTTGCGGCCAACCTCGACCACAACAAGCTGCCGATGGCAACCGACGAAAATGGCC
GGATTGTCAGCCCGAGGACGGGTAGTCTGCTCGACCATGCCCAGCGCGTTGCCGAGGGCCGGTTATTGGATGTGCACGCC
AACACGTGGCGCTACAACCAGCTGATCGCCCAGCAGCGCGCCATCATCGTCGAACGGCGTAACACGTTGTTGCGCACCGT
AACCGCGCGTGAGGAACTCGCCGAACTGGCGCCTAAGCGGTACGAGGAGCTGTCCGACAAAGTATCCGAGGAACGCCTCG
AGACGATTTGTCGGCAGATCATGCTGTATCACCTCGACCGTGGCTGGGCCGATCACCTGGCGTATCTGGCCGACATCCGG
GAGAGCATCCATCTACGCGCGCTGGGCCGGCAGAACCCACTCGACGAGTTTCACCGGATGGCTGTGGACGCGTTCGCGTC
GCTGGCCGCCGACGCCATCGAGGCGGCTCAACAGACGTTCGAAACCGCGAACGTCCTTGACCACGAGCCGGGGCTGGACC
TGTCCAAACTGGCCCGGCCGACGTCGACATGGACCTACATGGTCAATGACAACCCACTGTCCGATGACACGCTTTCTGCC
CTCAGTCTGCCCGGGGTGTTCCGCTGA

Upstream 100 bases:

>100_bases
GGGCCTTTGCCAGTGGCCTGCCCGCTGTGGTCAACGTGCTCACCGACCCAAGCGTGGCTTATCCACGCCGATCCAACCTG
GCTTGACGTCCAGCCGGGCC

Downstream 100 bases:

>100_bases
TCTGCCCAGCGTAAGCGCCGAGCGTAACGCCACTGCGAAATTTCGGGCAGAAAATCGCAGTGGCGTTACGCTCGCGGCTA
GGGGTGCCCCCACAGCCCGC

Product: preprotein translocase subunit SecA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 808; Mature: 808

Protein sequence:

>808_residues
MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSRFWRLLGASTEKNRSRSLADVTASAEYDKEAADLSD
EKLRKAAGLLNLDDLAESADIPQFLAIAREAAERRTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAG
RHVHVVTINDYLARRDAEWMGPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFDVLRDQLVTDVNDLVSPNP
DVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAELVGDKDADEYFATDSDNRNVHLTEHGARKVEKALGGIDL
YSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLINASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITV
QALINRYATVCGMTGTALAAGEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKNDGIVEHITEVHQRGQPVLVGTR
DVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEAGKYGAVTVSTQMAGRGTDIRLGGSDEADHDRVAELGGLHVVGT
GRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANLDHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRLLDVHA
NTWRYNQLIAQQRAIIVERRNTLLRTVTAREELAELAPKRYEELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIR
ESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARPTSTWTYMVNDNPLSDDTLSA
LSLPGVFR

Sequences:

>Translated_808_residues
MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSRFWRLLGASTEKNRSRSLADVTASAEYDKEAADLSD
EKLRKAAGLLNLDDLAESADIPQFLAIAREAAERRTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAG
RHVHVVTINDYLARRDAEWMGPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFDVLRDQLVTDVNDLVSPNP
DVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAELVGDKDADEYFATDSDNRNVHLTEHGARKVEKALGGIDL
YSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLINASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITV
QALINRYATVCGMTGTALAAGEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKNDGIVEHITEVHQRGQPVLVGTR
DVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEAGKYGAVTVSTQMAGRGTDIRLGGSDEADHDRVAELGGLHVVGT
GRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANLDHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRLLDVHA
NTWRYNQLIAQQRAIIVERRNTLLRTVTAREELAELAPKRYEELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIR
ESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARPTSTWTYMVNDNPLSDDTLSA
LSLPGVFR
>Mature_808_residues
MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSRFWRLLGASTEKNRSRSLADVTASAEYDKEAADLSD
EKLRKAAGLLNLDDLAESADIPQFLAIAREAAERRTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAG
RHVHVVTINDYLARRDAEWMGPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFDVLRDQLVTDVNDLVSPNP
DVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAELVGDKDADEYFATDSDNRNVHLTEHGARKVEKALGGIDL
YSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLINASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITV
QALINRYATVCGMTGTALAAGEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKNDGIVEHITEVHQRGQPVLVGTR
DVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEAGKYGAVTVSTQMAGRGTDIRLGGSDEADHDRVAELGGLHVVGT
GRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANLDHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRLLDVHA
NTWRYNQLIAQQRAIIVERRNTLLRTVTAREELAELAPKRYEELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIR
ESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARPTSTWTYMVNDNPLSDDTLSA
LSLPGVFR

Specific function: Part of the Sec protein translocase complex. Interacts with the secYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular mo

COG id: COG0653

COG function: function code U; Preprotein translocase subunit SecA (ATPase, RNA helicase)

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Note=Distribution is 50-50 (By similarity)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secA family

Homologues:

Organism=Escherichia coli, GI1786287, Length=813, Percent_Identity=35.7933579335793, Blast_Score=421, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECA2_MYCBO (P66786)

Other databases:

- EMBL:   BX248340
- RefSeq:   NP_855504.1
- ProteinModelPortal:   P66786
- SMR:   P66786
- EnsemblBacteria:   EBMYCT00000016516
- GeneID:   1092972
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1852
- GeneTree:   EBGT00050000016775
- HOGENOM:   HBG284200
- OMA:   QRVTEGQ
- ProtClustDB:   PRK12326
- BioCyc:   MBOV233413:MB1852-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01382
- InterPro:   IPR000185
- InterPro:   IPR020937
- InterPro:   IPR011115
- InterPro:   IPR014018
- InterPro:   IPR011130
- InterPro:   IPR011116
- Gene3D:   G3DSA:1.10.3060.10
- PRINTS:   PR00906
- SMART:   SM00957
- SMART:   SM00958

Pfam domain/function: PF07517 SecA_DEAD; PF01043 SecA_PP_bind; PF07516 SecA_SW; SSF81767 SecA_PP_bd; SSF81886 SecA_SW

EC number: NA

Molecular weight: Translated: 88953; Mature: 88953

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01312 SECA; PS51196 SECA_MOTOR_DEAD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSRFWRLLGASTEKNRSR
CCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
SLADVTASAEYDKEAADLSDEKLRKAAGLLNLDDLAESADIPQFLAIAREAAERRTGLRP
HHHHHHHCCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
FDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHVHVVTINDYLARRDAEWM
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHCCHHHH
GPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFDVLRDQLVTDVNDLVSPNP
HHHHHHHCCEEEEEECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
DVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAELVGDKDADEYFATDSDNRN
CEEEECCCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCE
VHLTEHGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLIN
EEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHEEEECCCEEEEE
ASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYATVCGMTGTALAA
CCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
GEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKNDGIVEHITEVHQRGQPVLVGTR
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEECC
DVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEAGKYGAVTVSTQMAGRGTDIRLGG
CHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECC
SDEADHDRVAELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANL
CCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCEEEECC
DHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVERR
CCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHH
NTLLRTVTAREELAELAPKRYEELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIR
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARP
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC
TSTWTYMVNDNPLSDDTLSALSLPGVFR
CCCEEEEECCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSSRFWRLLGASTEKNRSR
CCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
SLADVTASAEYDKEAADLSDEKLRKAAGLLNLDDLAESADIPQFLAIAREAAERRTGLRP
HHHHHHHCCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
FDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHVHVVTINDYLARRDAEWM
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHCCHHHH
GPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNEIGFDVLRDQLVTDVNDLVSPNP
HHHHHHHCCEEEEEECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
DVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIRLVAELVGDKDADEYFATDSDNRN
CEEEECCCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCE
VHLTEHGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLIN
EEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHEEEECCCEEEEE
ASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYATVCGMTGTALAA
CCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
GEQLRQFYQLGVSPIPPNKPNIREDEADRVYITTAAKNDGIVEHITEVHQRGQPVLVGTR
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEECC
DVAESEELHERLVRRGVPAVVLNAKNDAEEARVIAEAGKYGAVTVSTQMAGRGTDIRLGG
CHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECC
SDEADHDRVAELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANL
CCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCEEEECC
DHNKLPMATDENGRIVSPRTGSLLDHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVERR
CCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHH
NTLLRTVTAREELAELAPKRYEELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIR
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ESIHLRALGRQNPLDEFHRMAVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARP
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC
TSTWTYMVNDNPLSDDTLSALSLPGVFR
CCCEEEEECCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972