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The map label for this gene is ilvG

Identifier: 121637723

GI number: 121637723

Start: 2065810

End: 2067453

Strand: Direct

Name: ilvG

Synonym: BCG_1855

Alternate gene names: 121637723

Gene position: 2065810-2067453 (Clockwise)

Preceding gene: 121637720

Following gene: 121637724

Centisome position: 47.22

GC content: 67.82

Gene sequence:

>1644_bases
ATGAGCACCGACACCGCCCCGGCCCAGACCATGCATGCTGGCCGGCTTATCGCGCGCCGACTTAAAGCCAGTGGTATCGA
CACGGTCTTCACGTTGTCGGGCGGCCACCTGTTTTCCATCTACGACGGCTGCCGTGAGGAGGGCATCCGCCTGATCGACA
CCCGCCACGAACAAACCGCCGCCTTTGCCGCCGAAGGCTGGTCGAAGGTGACCAGGGTGCCGGGCGTGGCCGCGCTCACC
GCGGGGCCGGGGATCACCAACGGGATGAGCGCGATGGCGGCGGCCCAGCAGAACCAGTCACCACTGGTGGTGCTCGGCGG
CCGGGCGCCGGCGCTGCGCTGGGGTATGGGCTCCCTGCAGGAGATCGATCACGTGCCGTTTGTGGCGCCGGTGGCCCGCT
TCGCCGCTACAGCGCAGTCAGCCGAGAACGCGGGCCTGCTGGTCGATCAGGCGTTGCAGGCGGCGGTGAGTGCGCCGTCG
GGTGTGGCATTCGTCGACTTCCCGATGGATCACGCGTTCTCCATGTCCTCAGACAATGGCCGCCCCGGCGCGCTCACCGA
GCTACCGGCCGGTCCCACCCCAGCCGGCGACGCCCTGGACCGGGCGGCGGGCCTGCTTTCGACGGCCCAGCGTCCGGTCA
TCATGGCAGGTACCAACGTCTGGTGGGGCCATGCGGAGGCGGCATTGCTGCGTCTTGTCGAGGAACGGCACATTCCGGTG
CTGATGAACGGGATGGCGCGCGGCGTGGTGCCCGCCGATCACCGGTTGGCCTTCTCACGGGCGCGGTCAAAAGCGCTGGG
GGAGGCTGATGTCGCGCTGATCGTCGGTGTGCCGATGGATTTCCGTCTGGGCTTCGGTGGGGTATTCGGGTCGACAACGC
AGCTCATCGTGGCAGACCGCGTCGAACCCGCACGCGAACATCCGCGACCAGTCGCGGCGGGGCTCTATGGGGATCTGACC
GCCACCCTTTCGGCGCTGGCCGGATCTGGCGGCACCGACCACCAGGGCTGGATCGAGGAGCTCGCGACGGCCGAGACCAT
GGCGCGTGATCTCGAGAAGGCCGAGCTGGTCGATGACCGGATCCCATTGCATCCGATGCGGGTGTACGCCGAGCTGGCCG
CGCTGCTGGAGCGGGATGCTCTAGTCGTTATCGATGCGGGCGATTTCGGGTCGTACGCCGGCCGGATGATCGACAGCTAT
CTGCCAGGCTGTTGGCTGGACAGCGGTCCGTTTGGCTGCCTGGGGTCGGGTCCCGGCTACGCCCTGGCTGCCAAACTGGC
GCGGCCGCAGCGCCAGGTCGTGCTCTTGCAGGGCGACGGCGCGTTCGGGTTCAGCGGCATGGAATGGGACACGCTGGTTC
GGCACAACGTGGCGGTCGTGTCAGTGATCGGCAACAACGGCATCTGGGGTTTGGAGAAGCACCCGATGGAAGCGTTGTAC
GGCTATTCGGTGGTGGCCGAACTGCGCCCGGGAACCCGCTACGACGAGGTGGTGCGCGCACTGGGCGGCCACGGCGAGCT
GGTGTCGGTGCCCGCTGAACTTCGGCCGGCGCTGGAACGGGCCTTTGCCAGTGGCCTGCCCGCTGTGGTCAACGTGCTCA
CCGACCCAAGCGTGGCTTATCCACGCCGATCCAACCTGGCTTGA

Upstream 100 bases:

>100_bases
GATGGACGGCTTAAACAATTTCGGGCCCAAGGTCGACGTCTCCTCACAAACAGAAATCCTTCGGGCGAAGGTACCCGAAG
GTTGTCGATAGGCTGCCGAT

Downstream 100 bases:

>100_bases
CGTCCAGCCGGGCCGTGAACGTGCACGGTTGTCCACGAATTGCGGCCTGTCGGTGTACAGACACGCACCCTCGCGGCCGG
CCGGCATTCGCGTACCGTTG

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVTRVPGVAALT
AGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPS
GVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV
LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLT
ATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSY
LPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY
GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA

Sequences:

>Translated_547_residues
MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVTRVPGVAALT
AGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPS
GVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV
LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLT
ATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSY
LPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY
GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA
>Mature_546_residues
STDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVTRVPGVAALTA
GPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSG
VAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVL
MNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTA
TLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYL
PGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYG
YSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family

Homologues:

Organism=Homo sapiens, GI21361361, Length=580, Percent_Identity=32.7586206896552, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=27.7777777777778, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1788716, Length=556, Percent_Identity=30.5755395683453, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87081685, Length=539, Percent_Identity=26.9016697588126, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1790104, Length=550, Percent_Identity=25.0909090909091, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786717, Length=548, Percent_Identity=26.4598540145985, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787096, Length=542, Percent_Identity=24.5387453874539, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17542570, Length=573, Percent_Identity=31.7626527050611, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17531299, Length=546, Percent_Identity=29.6703296703297, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17531301, Length=546, Percent_Identity=29.6703296703297, Blast_Score=181, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320816, Length=560, Percent_Identity=27.6785714285714, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6323755, Length=565, Percent_Identity=23.716814159292, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI19922626, Length=556, Percent_Identity=30.5755395683453, Blast_Score=238, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVG_MYCBO (P66947)

Other databases:

- EMBL:   BX248340
- RefSeq:   NP_855503.1
- ProteinModelPortal:   P66947
- SMR:   P66947
- EnsemblBacteria:   EBMYCT00000016155
- GeneID:   1092971
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1851
- GeneTree:   EBGT00050000014643
- HOGENOM:   HBG323037
- OMA:   QSWIREL
- ProtClustDB:   PRK05858
- BioCyc:   MBOV233413:MB1851-MONOMER
- BRENDA:   2.2.1.6
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N

EC number: =2.2.1.6

Molecular weight: Translated: 57521; Mature: 57390

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00187 TPP_ENZYMES

Important sites: BINDING 57-57 BINDING 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHCCCEEEECCCHHHH
AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ
HHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHCCCCCHH
EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG
HHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCCC
RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCEECCHHHHHHHHHHHHCCCCE
LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR
EECCHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCCCCEEEEEECC
VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR
CCHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY
CCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCH
ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY
HHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHH
GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY
HHHHEEECCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PRRSNLA
CCCCCCC
>Mature Secondary Structure 
STDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHCCCEEEECCCHHHH
AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ
HHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHCCCCCHH
EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG
HHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCCC
RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCEECCHHHHHHHHHHHHCCCCE
LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR
EECCHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCCCCEEEEEECC
VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR
CCHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY
CCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCH
ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY
HHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHH
GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY
HHHHEEECCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PRRSNLA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972