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The map label for this gene is PPE29

Identifier: 121637702

GI number: 121637702

Start: 2043003

End: 2044274

Strand: Direct

Name: PPE29

Synonym: BCG_1833

Alternate gene names: 121637702

Gene position: 2043003-2044274 (Clockwise)

Preceding gene: 121637701

Following gene: 121637703

Centisome position: 46.7

GC content: 66.59

Gene sequence:

>1272_bases
ATGGATTTCGGGTTGTTACCGCCGGAGATCAACTCAGGCAGGATGTATACGGGGCCGGGGCCGGGGCCCATGCTGGCCGC
CGCGACAGCCTGGGACGGGCTGGCTGTTGAGCTGCACGCAACAGCGGCTGGCTACGCCTCGGAGCTATCGGCTTTGACCG
GGGCATGGAGCGGTCCTTCGTCGACGTCCATGGCATCTGCAGCCGCACCCTATGTGGCATGGATGAGCGCCACCGCAGTG
CATGCCGAGCTGGCGGGCGCGCAAGCCAGGTTGGCGATAGCTGCCTATGAAGCTGCGTTCGCTGCCACCGTGCCTCCGCC
GGTGATCGCCGCTAATCGTGCCCAACTGATGGTGTTGATCGCGACGAACATCTTCGGGCAGAACACGCCGGCGATCATGA
TGACTGAGGCCCAATACATGGAAATGTGGGCGCAGGATGCCGCCGCGATGTACGGGTACGCCGGCTCGTCAGCGACCGCC
TCGCGAATGACAGCGTTCACTGAGCCGCCGCAAACCACTAACCATGGTCAGTTGGGGGCCCAGTCCTCCGCCGTCGCACA
AACCGCCGCCACCGCGGCCGGCGGCAACCTGCAATCGGCATTCCCGCAGCTGCTCTCCGCGGTTCCCCGCGCCCTGCAAG
GCCTGGCATTGCCGACCGCATCACAGTCGGCATCGGCGACGCCGCAGTGGGTTACCGACCTGGGGAACCTGTCCACCTTC
CTGGGCGGGGCGGTCACCGGCCCGTACACCTTTCCCGGGGTATTGCCTCCCTCCGGGGTGCCATACCTGTTAGGCATTCA
GAGCGTCTTGGTAACCCAAAACGGGCAGGGGGTAAGCGCCTTGCTTGGCAAGATCGGGGGGAAACCAATCACCGGAGCGT
TGGCTCCGCTGGCCGAATTTGCTTTGCATACACCAATTTTGGGTTCGGAGGGCTTGGGTGGTGGATCGGTTTCCGCGGGT
ATTGGCCGGGCAGGCTTGGTCGGAAAGCTATCGGTGCCTCAGGGCTGGACGGTGGCCGCCCCGGAGATCCCATCGCCGGC
GGCGGCGTTGCAGGCGACGCGCCTGGCCGCCGCGCCGATTGCGGCTACCGACGGCGCGGGTGCGTTGCTCGGTGGCATGG
CGCTGTCGGGCTTGGCTGGCCGCGCTGCCGCCGGTTCTACCGGCCACCCCATCGGCAGCGCCGCAGCACCCGCCGTCGGT
GCCGCTGCCGCTGCCGTCGAGGACCTGGCCACCGAAGCCAACATCTTCGTGATACCGGCCATGGACGACTAG

Upstream 100 bases:

>100_bases
GAACACGGGTGATTTGTCACTACGGGCCGCTGCGGTTCCTGCGCTGCCAGGGGGCCGCGAGTGCGATTCCGGCGAGCCAC
GCGATTAGGGATTAAGCGAA

Downstream 100 bases:

>100_bases
CGCCATGTCACGGGAGAGAAGGTTGTCGACACTTTTGCGACCAGCGCCGGTTCGGTATGTGGCCACCGGGGCTGCCAATG
GGGTTACGGCCCGTTAAGGA

Product: PPE family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAGYASELSALTGAWSGPSSTSMASAAAPYVAWMSATAV
HAELAGAQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTEAQYMEMWAQDAAAMYGYAGSSATA
SRMTAFTEPPQTTNHGQLGAQSSAVAQTAATAAGGNLQSAFPQLLSAVPRALQGLALPTASQSASATPQWVTDLGNLSTF
LGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQGVSALLGKIGGKPITGALAPLAEFALHTPILGSEGLGGGSVSAG
IGRAGLVGKLSVPQGWTVAAPEIPSPAAALQATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHPIGSAAAPAVG
AAAAAVEDLATEANIFVIPAMDD

Sequences:

>Translated_423_residues
MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAGYASELSALTGAWSGPSSTSMASAAAPYVAWMSATAV
HAELAGAQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTEAQYMEMWAQDAAAMYGYAGSSATA
SRMTAFTEPPQTTNHGQLGAQSSAVAQTAATAAGGNLQSAFPQLLSAVPRALQGLALPTASQSASATPQWVTDLGNLSTF
LGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQGVSALLGKIGGKPITGALAPLAEFALHTPILGSEGLGGGSVSAG
IGRAGLVGKLSVPQGWTVAAPEIPSPAAALQATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHPIGSAAAPAVG
AAAAAVEDLATEANIFVIPAMDD
>Mature_423_residues
MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAGYASELSALTGAWSGPSSTSMASAAAPYVAWMSATAV
HAELAGAQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTEAQYMEMWAQDAAAMYGYAGSSATA
SRMTAFTEPPQTTNHGQLGAQSSAVAQTAATAAGGNLQSAFPQLLSAVPRALQGLALPTASQSASATPQWVTDLGNLSTF
LGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQGVSALLGKIGGKPITGALAPLAEFALHTPILGSEGLGGGSVSAG
IGRAGLVGKLSVPQGWTVAAPEIPSPAAALQATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHPIGSAAAPAVG
AAAAAVEDLATEANIFVIPAMDD

Specific function: Could be required for host endothelial-cell invasion and/or intracellular survival

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPE29_MYCTU (Q7D7X9)

Other databases:

- EMBL:   BX842577
- EMBL:   AE000516
- PIR:   B70931
- RefSeq:   NP_336308.1
- RefSeq:   YP_177840.1
- HSSP:   Q79FE1
- ProteinModelPortal:   Q7D7X9
- SMR:   Q7D7X9
- EnsemblBacteria:   EBMYCT00000003302
- EnsemblBacteria:   EBMYCT00000070498
- GeneID:   885491
- GeneID:   925146
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1850
- KEGG:   mtu:Rv1801
- TIGR:   MT1850
- TubercuList:   Rv1801
- GeneTree:   EBGT00050000014887
- HOGENOM:   HBG572308
- OMA:   PANWASA
- ProtClustDB:   CLSK799843
- InterPro:   IPR022171
- InterPro:   IPR000030

Pfam domain/function: PF12484 PE_PPE_C; PF00823 PPE

EC number: NA

Molecular weight: Translated: 41477; Mature: 41477

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAGYASELSALTGAWSGPS
CCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCEEEEEEECHHHHHHHHHHHHCCCCCCC
STSMASAAAPYVAWMSATAVHAELAGAQARLAIAAYEAAFAATVPPPVIAANRAQLMVLI
CCCHHHHHCHHHHHHHHHHHHHHHCCCHHEEEEEEHHHHHHCCCCCCCEECCCCEEEEEE
ATNIFGQNTPAIMMTEAQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGA
EEHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCCCCCCCCCCC
QSSAVAQTAATAAGGNLQSAFPQLLSAVPRALQGLALPTASQSASATPQWVTDLGNLSTF
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQGVSALLGKIGGKPITGALAPLAEF
HCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHH
ALHTPILGSEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAAPEIPSPAAALQATRLAAAPI
HHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHHHCCC
AATDGAGALLGGMALSGLAGRAAAGSTGHPIGSAAAPAVGAAAAAVEDLATEANIFVIPA
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHCCCCEEEEEC
MDD
CCC
>Mature Secondary Structure
MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAGYASELSALTGAWSGPS
CCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCEEEEEEECHHHHHHHHHHHHCCCCCCC
STSMASAAAPYVAWMSATAVHAELAGAQARLAIAAYEAAFAATVPPPVIAANRAQLMVLI
CCCHHHHHCHHHHHHHHHHHHHHHCCCHHEEEEEEHHHHHHCCCCCCCEECCCCEEEEEE
ATNIFGQNTPAIMMTEAQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGA
EEHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECCCCCCCCCCCCCC
QSSAVAQTAATAAGGNLQSAFPQLLSAVPRALQGLALPTASQSASATPQWVTDLGNLSTF
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQGVSALLGKIGGKPITGALAPLAEF
HCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHH
ALHTPILGSEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAAPEIPSPAAALQATRLAAAPI
HHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHHHCCC
AATDGAGALLGGMALSGLAGRAAAGSTGHPIGSAAAPAVGAAAAAVEDLATEANIFVIPA
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHCCCCEEEEEC
MDD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036