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The map label for this gene is pyrG

Identifier: 121637606

GI number: 121637606

Start: 1929047

End: 1930807

Strand: Direct

Name: pyrG

Synonym: BCG_1737

Alternate gene names: 121637606

Gene position: 1929047-1930807 (Clockwise)

Preceding gene: 121637605

Following gene: 121637607

Centisome position: 44.1

GC content: 62.41

Gene sequence:

>1761_bases
GTGCGAAAGCACCCGCAAACCGCTACCAAGCACCTCTTCGTCAGCGGCGGCGTTGCTTCCTCGCTCGGCAAGGGACTGAC
CGCCAGCAGCCTAGGACAATTGTTGACGGCTCGTGGGTTACACGTCACGATGCAAAAGCTCGACCCGTACCTCAACGTCG
ACCCGGGTACCATGAACCCGTTCCAGCACGGCGAGGTCTTCGTGACCGAGGACGGTGCCGAAACCGATCTCGACGTCGGC
CACTACGAACGGTTCCTCGATCGCAATTTGCCCGGCTCAGCGAATGTGACTACCGGGCAGGTGTATTCAACGGTGATCGC
GAAGGAGCGCCGCGGCGAATACCTGGGCGACACCGTGCAGGTGATCCCCCATATCACCGACGAGATAAAACGGCGCATCC
TGGCGATGGCCCAACCGGACGCCGACGGTAACCGCCCGGACGTGGTCATCACCGAAATCGGGGGCACTGTCGGCGATATC
GAGTCACAGCCCTTCCTGGAGGCAGCGCGGCAAGTCCGGCACTATCTCGGCCGGGAGGACGTGTTTTTTCTGCACGTGTC
GCTGGTGCCCTACCTGGCGCCGTCGGGTGAGCTCAAAACCAAGCCAACACAGCACTCGGTGGCCGCACTGCGCAGCATTG
GGATTACCCCGGACGCGTTGATCCTGCGCTGCGACCGCGACGTTCCCGAAGCGCTGAAAAACAAGATTGCGTTGATGTGT
GACGTCGATATCGACGGCGTTATCTCCACCCCGGACGCGCCCTCCATCTACGACATACCCAAGGTATTGCACCGCGAGGA
GCTCGATGCGTTCGTGGTGCGCCGACTCAATCTGCCGTTCCGCGACGTCGATTGGACCGAATGGGACGACCTGCTGCGCC
GGGTTCACGAACCACATGAGACAGTGCGAATTGCTTTGGTGGGCAAGTACGTCGAATTATCCGACGCTTACCTCTCGGTT
GCCGAGGCATTGCGTGCCGGCGGATTCAAGCACCGGGCCAAGGTCGAGATCTGTTGGGTGGCATCCGACGGTTGTGAAAC
GACCAGTGGTGCCGCGGCGGCGCTCGGCGATGTGCATGGGGTGCTCATTCCGGGCGGATTCGGCATCAGGGGCATCGAGG
GCAAGATCGGCGCCATTGCATACGCGCGGGCGCGCGGGTTGCCGGTGTTGGGGCTGTGCCTCGGTTTGCAGTGCATTGTG
ATCGAGGCCGCGCGATCGGTCGGTCTCACCAACGCCAATTCGGCCGAATTTGATCCCGACACACCAGATCCCGTTATCGC
CACGATGCCCGATCAAGAAGAAATCGTGGCCGGCGAGGCGGATCTGGGCGGTACCATGCGTCTCGGGTCCTACCCCGCCG
TGTTGGAGCCGGATTCGGTTGTTGCCCAGGCATACCAAACTACCCAGGTGTCCGAGCGGCATCGCCACCGGTACGAGGTC
AACAACGCGTACCGAGACAAGATCGCCGAAAGCGGCCTGAGGTTTTCCGGGACGTCACCTGACGGACACTTGGTAGAGTT
CGTCGAGTATCCGCCGGATCGGCATCCGTTCGTTGTCGGCACCCAGGCCCACCCCGAGTTGAAGAGCCGACCCACCCGGC
CGCACCCACTGTTTGTCGCATTCGTCGGGGCAGCCATCGATTACAAGGCGGGTGAGTTGCTGCCTGTCGAGATCCCCGAG
ATCCCCGAGCACACACCCAACGGTAGCTCCCATCGGGACGGCGTGGGCCAGCCGCTACCGGAACCTGCGTCTCGTGGCTG
A

Upstream 100 bases:

>100_bases
GATGTTAGGGTGGGTTTCCGTGGGTCGGCAGGCCCAGCAAGGCCAGAGAAATCTTGGCAGCGTCAAGAACAGCCCTGCCC
GTCTTCACGGAGGTCGCTCA

Downstream 100 bases:

>100_bases
GCATGATTTCGAGACGATATCGTCGGAAACCTTGCATACGGGAGCCATTTTCGCATTACGTCGGGACCAGGTGCGGATGC
CTGGTGGGGGTATTGTGACG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVG
HYERFLDRNLPGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKRRILAMAQPDADGNRPDVVITEIGGTVGDI
ESQPFLEAARQVRHYLGREDVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
DVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFRDVDWTEWDDLLRRVHEPHETVRIALVGKYVELSDAYLSV
AEALRAGGFKHRAKVEICWVASDGCETTSGAAAALGDVHGVLIPGGFGIRGIEGKIGAIAYARARGLPVLGLCLGLQCIV
IEAARSVGLTNANSAEFDPDTPDPVIATMPDQEEIVAGEADLGGTMRLGSYPAVLEPDSVVAQAYQTTQVSERHRHRYEV
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDRHPFVVGTQAHPELKSRPTRPHPLFVAFVGAAIDYKAGELLPVEIPE
IPEHTPNGSSHRDGVGQPLPEPASRG

Sequences:

>Translated_586_residues
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVG
HYERFLDRNLPGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKRRILAMAQPDADGNRPDVVITEIGGTVGDI
ESQPFLEAARQVRHYLGREDVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
DVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFRDVDWTEWDDLLRRVHEPHETVRIALVGKYVELSDAYLSV
AEALRAGGFKHRAKVEICWVASDGCETTSGAAAALGDVHGVLIPGGFGIRGIEGKIGAIAYARARGLPVLGLCLGLQCIV
IEAARSVGLTNANSAEFDPDTPDPVIATMPDQEEIVAGEADLGGTMRLGSYPAVLEPDSVVAQAYQTTQVSERHRHRYEV
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDRHPFVVGTQAHPELKSRPTRPHPLFVAFVGAAIDYKAGELLPVEIPE
IPEHTPNGSSHRDGVGQPLPEPASRG
>Mature_586_residues
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVG
HYERFLDRNLPGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKRRILAMAQPDADGNRPDVVITEIGGTVGDI
ESQPFLEAARQVRHYLGREDVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
DVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFRDVDWTEWDDLLRRVHEPHETVRIALVGKYVELSDAYLSV
AEALRAGGFKHRAKVEICWVASDGCETTSGAAAALGDVHGVLIPGGFGIRGIEGKIGAIAYARARGLPVLGLCLGLQCIV
IEAARSVGLTNANSAEFDPDTPDPVIATMPDQEEIVAGEADLGGTMRLGSYPAVLEPDSVVAQAYQTTQVSERHRHRYEV
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDRHPFVVGTQAHPELKSRPTRPHPLFVAFVGAAIDYKAGELLPVEIPE
IPEHTPNGSSHRDGVGQPLPEPASRG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=554, Percent_Identity=44.9458483754513, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI28559085, Length=553, Percent_Identity=42.6763110307414, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI28559083, Length=553, Percent_Identity=42.6763110307414, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI221316689, Length=553, Percent_Identity=42.6763110307414, Blast_Score=449, Evalue=1e-126,
Organism=Escherichia coli, GI1789142, Length=549, Percent_Identity=51.7304189435337, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25148299, Length=603, Percent_Identity=37.6451077943615, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=42.5795053003534, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319432, Length=566, Percent_Identity=42.0494699646643, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24664469, Length=555, Percent_Identity=44.6846846846847, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI21357815, Length=500, Percent_Identity=43.6, Blast_Score=387, Evalue=1e-107,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_MYCBO (P0A5U3)

Other databases:

- EMBL:   U88301
- EMBL:   BX248339
- RefSeq:   NP_855378.1
- ProteinModelPortal:   P0A5U3
- SMR:   P0A5U3
- EnsemblBacteria:   EBMYCT00000015358
- GeneID:   1092675
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1725
- GeneTree:   EBGT00050000016104
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   MBOV233413:MB1725-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 63636; Mature: 63636

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 393-393 ACT_SITE 524-524 ACT_SITE 526-526

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQKLDPYLNVDPGTMNP
CCCCCCCHHHEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEHHHCCCCEECCCCCCCC
FQHGEVFVTEDGAETDLDVGHYERFLDRNLPGSANVTTGQVYSTVIAKERRGEYLGDTVQ
CCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHH
VIPHITDEIKRRILAMAQPDADGNRPDVVITEIGGTVGDIESQPFLEAARQVRHYLGRED
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC
VFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
EEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCEEEEE
DVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFRDVDWTEWDDLLRRVHEPHE
ECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCC
TVRIALVGKYVELSDAYLSVAEALRAGGFKHRAKVEICWVASDGCETTSGAAAALGDVHG
EEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCE
VLIPGGFGIRGIEGKIGAIAYARARGLPVLGLCLGLQCIVIEAARSVGLTNANSAEFDPD
EEECCCCCCCCCCCCHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TPDPVIATMPDQEEIVAGEADLGGTMRLGSYPAVLEPDSVVAQAYQTTQVSERHRHRYEV
CCCCEEEECCCHHHEEECCCCCCCEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHH
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDRHPFVVGTQAHPELKSRPTRPHPLFVA
HHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCCCEEEECCCCCHHHCCCCCCCCEEEE
FVGAAIDYKAGELLPVEIPEIPEHTPNGSSHRDGVGQPLPEPASRG
EECHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQKLDPYLNVDPGTMNP
CCCCCCCHHHEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEHHHCCCCEECCCCCCCC
FQHGEVFVTEDGAETDLDVGHYERFLDRNLPGSANVTTGQVYSTVIAKERRGEYLGDTVQ
CCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHH
VIPHITDEIKRRILAMAQPDADGNRPDVVITEIGGTVGDIESQPFLEAARQVRHYLGRED
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC
VFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMC
EEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCEEEEE
DVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFRDVDWTEWDDLLRRVHEPHE
ECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCC
TVRIALVGKYVELSDAYLSVAEALRAGGFKHRAKVEICWVASDGCETTSGAAAALGDVHG
EEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCE
VLIPGGFGIRGIEGKIGAIAYARARGLPVLGLCLGLQCIVIEAARSVGLTNANSAEFDPD
EEECCCCCCCCCCCCHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TPDPVIATMPDQEEIVAGEADLGGTMRLGSYPAVLEPDSVVAQAYQTTQVSERHRHRYEV
CCCCEEEECCCHHHEEECCCCCCCEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHH
NNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDRHPFVVGTQAHPELKSRPTRPHPLFVA
HHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCCCEEEECCCCCHHHCCCCCCCCEEEE
FVGAAIDYKAGELLPVEIPEIPEHTPNGSSHRDGVGQPLPEPASRG
EECHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9415801; 12788972