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The map label for this gene is pks17 [H]

Identifier: 121637571

GI number: 121637571

Start: 1891776

End: 1893284

Strand: Direct

Name: pks17 [H]

Synonym: BCG_1702

Alternate gene names: 121637571

Gene position: 1891776-1893284 (Clockwise)

Preceding gene: 121637570

Following gene: 121637572

Centisome position: 43.25

GC content: 62.96

Gene sequence:

>1509_bases
ATGGAGGCCGGACCGCAGCGGATTGCGCAGATGCTGGCCGAGTTAGTCGAGTTGTTCAAAACTGAAGCGCTGCATCGGCT
TCCAGTCAAGTCATGGGATGTGCGGCACGCTCGGGAGGCGTATCGGTTCTTGAGCCAGGCGCGCCATGTCGGCAAAGTGG
TGCTGACCATGCCGGACGCGTGGGCCGCGGGCACGGTGCTGATCACCGGTGGCACTGGGATGGCAGGTTCTGCGGTGGCG
CGTCATCTGGTGAGTCGATACGGGGTGCGGCAGGTGGTGTTGGCCAGTCGTGCTGGTGAGCACACGGAGAGCGTCGCAGC
ATTGGTGGACGAGCTCGGCTCGGCCGGCGCCCGAGTGCAGGTGGTGTCTTGCGATGTGGCCGATCGTGATGCGGTGGCGG
GTTTGGTGGCAAGCCAACCAGATCTGACTGCAGTGTTTCATGCGGCTGGGGTTCTTGACGATGCGGTAATCACCGGATTG
ACGCCGGAGCGGGTGGATAAGGTATTGCGGGCCAAGGTCGATGGGGCCTGGAATTTGCATGAGCTCACCCGGCACCTGGA
TGTGTCAGCGTTTGTGTTGTTTTCGTCGATGGCCGGGATTGTGGGTGCGCCGGGCCAGGCCAATTATGCTGCAGCGAACG
CGTTTTTGGACGGGTTGGCGGCCTATCGGCGATCACGTGGACTGGCCGCGTTGTCGGTGGCGTGGGGATTGTGGGAGCAG
GCTTCGGCGATGACCGAGCATTTAGGCGAGCGGGATCGGGTCCGGATGAGTCGGGTTGGACTGGCGCCGTTGCCTACCAA
CCAGGCGATGGGATTCCTGGATGCCGCGTTGCTGGCGGATCGGCCCGTGGTGGTGGCTGCTCGGCTGGATCGTGCCGCGC
TGGCCGGTGCCGAGCTGCCGGCACTATTTAGCCAGTTGGTTGCCGGTCCGATCCGACGGATCATCGACGGCGCCGATGAG
GTGTCGGGGTCGGGATTGGCGTCGCGGCTGCACGGGCTGACTCCCGAGCAGCGGCACCGCGAACTCACCGAGTTAGTATG
TAGCAACGCCGCGATCGTGTTGGGGCATTCCGGCACTGAGATCGACGCGCACAAGGCATTCCAGGATCTCGGGTTTGATT
CGCTGACAGCGGTGGAGCTGCGCAACCGGCTCAAGACTGCGACCGGGTTGACCTTGCCACCGACCTTGATCTTTGACTAC
CCCACGGCCGCCGAGTTGGCCGAACACCTCGACATCCAGCTGGCGAACGCCCCTGCCGTCACGGTCGACCAACCCAACCC
GTCGACTCGTTTCAACGAGGTCACCCGCGAACTACAAGCATTGCTCGACCAACCCAACTGGAACCCCGACGACAAAACGC
GCCTGATCAAGCGATTGCAAGCGATTTTGACCGATTGCACCGCTCCACCGGCCAGCTCCGGCCCGTCTACCACCCATGAC
GACGAGGACATCACCACCGCCACTGAAAGCCAGCTTTTTGCCATCCTCGACGACGAACTTGGACCTTAG

Upstream 100 bases:

>100_bases
CGCGAGGCGGTCGCTTCATCGAGATGGGCAAAACCGAGTTCGGGACGCCCAGGTCGTTGCCCAGGACCATCCTGGGGTGG
CCTACCGGGCTTTCGACTTG

Downstream 100 bases:

>100_bases
CGCACGTGCAACCGACAGGCATCGCAATCATCGGGCTGGCATGCAGGTTTCCCACCGTCGTCAGCCCCGGCGACCTCTGG
GACCTGTTGCGCGACGGGCG

Product: putative polyketide synthase pks17

Products: NA

Alternate protein names: 6-deoxyerythronolide B synthase II; DEBS 2; ORF 2 [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFLSQARHVGKVVLTMPDAWAAGTVLITGGTGMAGSAVA
RHLVSRYGVRQVVLASRAGEHTESVAALVDELGSAGARVQVVSCDVADRDAVAGLVASQPDLTAVFHAAGVLDDAVITGL
TPERVDKVLRAKVDGAWNLHELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDGLAAYRRSRGLAALSVAWGLWEQ
ASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAALLADRPVVVAARLDRAALAGAELPALFSQLVAGPIRRIIDGADE
VSGSGLASRLHGLTPEQRHRELTELVCSNAAIVLGHSGTEIDAHKAFQDLGFDSLTAVELRNRLKTATGLTLPPTLIFDY
PTAAELAEHLDIQLANAPAVTVDQPNPSTRFNEVTRELQALLDQPNWNPDDKTRLIKRLQAILTDCTAPPASSGPSTTHD
DEDITTATESQLFAILDDELGP

Sequences:

>Translated_502_residues
MEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFLSQARHVGKVVLTMPDAWAAGTVLITGGTGMAGSAVA
RHLVSRYGVRQVVLASRAGEHTESVAALVDELGSAGARVQVVSCDVADRDAVAGLVASQPDLTAVFHAAGVLDDAVITGL
TPERVDKVLRAKVDGAWNLHELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDGLAAYRRSRGLAALSVAWGLWEQ
ASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAALLADRPVVVAARLDRAALAGAELPALFSQLVAGPIRRIIDGADE
VSGSGLASRLHGLTPEQRHRELTELVCSNAAIVLGHSGTEIDAHKAFQDLGFDSLTAVELRNRLKTATGLTLPPTLIFDY
PTAAELAEHLDIQLANAPAVTVDQPNPSTRFNEVTRELQALLDQPNWNPDDKTRLIKRLQAILTDCTAPPASSGPSTTHD
DEDITTATESQLFAILDDELGP
>Mature_502_residues
MEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFLSQARHVGKVVLTMPDAWAAGTVLITGGTGMAGSAVA
RHLVSRYGVRQVVLASRAGEHTESVAALVDELGSAGARVQVVSCDVADRDAVAGLVASQPDLTAVFHAAGVLDDAVITGL
TPERVDKVLRAKVDGAWNLHELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDGLAAYRRSRGLAALSVAWGLWEQ
ASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAALLADRPVVVAARLDRAALAGAELPALFSQLVAGPIRRIIDGADE
VSGSGLASRLHGLTPEQRHRELTELVCSNAAIVLGHSGTEIDAHKAFQDLGFDSLTAVELRNRLKTATGLTLPPTLIFDY
PTAAELAEHLDIQLANAPAVTVDQPNPSTRFNEVTRELQALLDQPNWNPDDKTRLIKRLQAILTDCTAPPASSGPSTTHD
DEDITTATESQLFAILDDELGP

Specific function: Unknown

COG id: COG3321

COG function: function code Q; Polyketide synthase modules and related proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI41872631, Length=385, Percent_Identity=27.012987012987, Blast_Score=100, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI212642053, Length=408, Percent_Identity=25.2450980392157, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=324, Percent_Identity=23.4567901234568, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24581345, Length=278, Percent_Identity=26.978417266187, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI221330659, Length=350, Percent_Identity=26, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19920632, Length=350, Percent_Identity=26, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR002198
- InterPro:   IPR015357
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR020806
- InterPro:   IPR015083
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00106 adh_short; PF00107 ADH_zinc_N; PF08990 Docking; PF09277 Erythro-docking; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF00550 PP-binding [H]

EC number: =2.3.1.94 [H]

Molecular weight: Translated: 53525; Mature: 53525

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFLSQARHVGKVVLTMPDA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCC
WAAGTVLITGGTGMAGSAVARHLVSRYGVRQVVLASRAGEHTESVAALVDELGSAGARVQ
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEE
VVSCDVADRDAVAGLVASQPDLTAVFHAAGVLDDAVITGLTPERVDKVLRAKVDGAWNLH
EEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHH
ELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDGLAAYRRSRGLAALSVAWGLWEQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAALLADRPVVVAARLDRAALAGAELP
HHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCHHH
ALFSQLVAGPIRRIIDGADEVSGSGLASRLHGLTPEQRHRELTELVCSNAAIVLGHSGTE
HHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCC
IDAHKAFQDLGFDSLTAVELRNRLKTATGLTLPPTLIFDYPTAAELAEHLDIQLANAPAV
CHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHCCEEEECCCEE
TVDQPNPSTRFNEVTRELQALLDQPNWNPDDKTRLIKRLQAILTDCTAPPASSGPSTTHD
EECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DEDITTATESQLFAILDDELGP
CCCCCHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFLSQARHVGKVVLTMPDA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCC
WAAGTVLITGGTGMAGSAVARHLVSRYGVRQVVLASRAGEHTESVAALVDELGSAGARVQ
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEE
VVSCDVADRDAVAGLVASQPDLTAVFHAAGVLDDAVITGLTPERVDKVLRAKVDGAWNLH
EEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHH
ELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDGLAAYRRSRGLAALSVAWGLWEQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAALLADRPVVVAARLDRAALAGAELP
HHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCHHH
ALFSQLVAGPIRRIIDGADEVSGSGLASRLHGLTPEQRHRELTELVCSNAAIVLGHSGTE
HHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCC
IDAHKAFQDLGFDSLTAVELRNRLKTATGLTLPPTLIFDYPTAAELAEHLDIQLANAPAV
CHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHCCEEEECCCEE
TVDQPNPSTRFNEVTRELQALLDQPNWNPDDKTRLIKRLQAILTDCTAPPASSGPSTTHD
EECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DEDITTATESQLFAILDDELGP
CCCCCHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2024119; 1740151 [H]