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The map label for this gene is trpC [H]

Identifier: 121637518

GI number: 121637518

Start: 1815487

End: 1816305

Strand: Direct

Name: trpC [H]

Synonym: BCG_1649

Alternate gene names: 121637518

Gene position: 1815487-1816305 (Clockwise)

Preceding gene: 121637517

Following gene: 121637519

Centisome position: 41.5

GC content: 66.3

Gene sequence:

>819_bases
ATGAGTCCGGCAACCGTGCTCGACTCCATCCTCGAGGGAGTCCGGGCCGACGTTGCCGCGCGTGAAGCCTCGGTGAGCCT
GTCGGAGATCAAGGCTGCCGCCGCTGCGGCGCCGCCGCCGCTCGACGTGATGGCCGCCCTACGCGAGCCCGGCATCGGCG
TCATCGCTGAGGTCAAGCGCGCTAGTCCTTCGGCAGGCGCATTGGCGACCATCGCCGACCCGGCAAAGCTGGCCCAGGCC
TACCAGGATGGCGGTGCCCGGATCGTCAGCGTGGTGACTGAGCAGCGGCGTTTTCAGGGATCGCTCGACGACCTCGACGC
GGTGCGGGCCTCGGTTTCGATTCCGGTGCTGCGCAAGGACTTTGTGGTGCAGCCGTACCAGATTCATGAGGCGCGTGCGC
ACGGCGCCGACATGTTGTTGCTCATCGTCGCCGCATTGGAGCAGTCGGTGTTGGTGTCGATGTTGGACCGCACCGAATCG
TTGGGTATGACAGCACTCGTCGAGGTCCATACCGAGCAGGAAGCCGACCGAGCGCTGAAGGCCGGGGCCAAGGTGATTGG
CGTTAACGCCCGCGACCTCATGACGCTGGACGTGGACCGGGATTGCTTCGCGCGAATAGCTCCTGGTTTGCCGAGCAGTG
TGATCAGGATTGCTGAATCCGGCGTGCGTGGCACCGCTGACCTGCTGGCGTACGCCGGCGCGGGCGCTGACGCGGTGTTG
GTAGGCGAAGGTCTGGTCACCAGCGGCGACCCACGTGCCGCGGTTGCCGATCTGGTTACCGCGGGCACCCATCCGTCCTG
TCCGAAACCGGCTCGCTAG

Upstream 100 bases:

>100_bases
AGGGGCGGTGACGGACCGCGCGCTGACGGTCGCTACCCTTCATGGACGTCGTCGAAATTGACGAGCGCGTGTGGGTGACA
GTGGGAAGGGAACGGCAGGC

Downstream 100 bases:

>100_bases
CCGTCGATGAGCCGCTTGCATCTTGAGCCTCGGTGATGACAGATCTATCCACCCCGGATCTTCCGCGCATGAGTGCTGCC
ATCGCCGAACCGACCAGTCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGALATIADPAKLAQA
YQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTES
LGMTALVEVHTEQEADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLAYAGAGADAVL
VGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR

Sequences:

>Translated_272_residues
MSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGALATIADPAKLAQA
YQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTES
LGMTALVEVHTEQEADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLAYAGAGADAVL
VGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR
>Mature_271_residues
SPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGALATIADPAKLAQAY
QDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESL
GMTALVEVHTEQEADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLAYAGAGADAVLV
GEGLVTSGDPRAAVADLVTAGTHPSCPKPAR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=251, Percent_Identity=35.0597609561753, Blast_Score=129, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322638, Length=232, Percent_Identity=40.5172413793103, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28023; Mature: 27892

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKR
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHH
ASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKD
CCCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHH
FVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESLGMTALVEVHTEQEADRALK
HCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHH
AGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLAYAGAGADAVL
CCCEEEECCCHHEEEEECCHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
VGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR
ECCCCEECCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKR
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHH
ASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKD
CCCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHH
FVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESLGMTALVEVHTEQEADRALK
HCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHH
AGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLAYAGAGADAVL
CCCEEEECCCHHEEEEECCHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
VGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR
ECCCCEECCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA