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The map label for this gene is nadA

Identifier: 121637501

GI number: 121637501

Start: 1800003

End: 1801052

Strand: Direct

Name: nadA

Synonym: BCG_1632

Alternate gene names: 121637501

Gene position: 1800003-1801052 (Clockwise)

Preceding gene: 121637498

Following gene: 121637502

Centisome position: 41.15

GC content: 65.81

Gene sequence:

>1050_bases
ATGACTGTGCTGAATCGCACGGACACGCTCGTGGATGAACTGACTGCCGACATCACCAACACACCGCTCGGCTACGGCGG
GGTTGACGGTGACGAACGGTGGGCCGCCGAGATTCGCCGTCTGGCGCATTTGCGCGGGGCCACCGTCCTGGCGCACAACT
ACCAGCTGCCCGCGATCCAGGACGTTGCCGACCACGTCGGGGATTCGCTGGCGCTATCGCGGGTGGCCGCCGAGGCACCG
GAGGACACCATCGTGTTCTGCGGAGTGCACTTCATGGCCGAGACCGCCAAAATTCTCAGCCCGCACAAAACCGTGCTGAT
CCCGGATCAGCGGGCCGGCTGTTCGCTGGCCGATTCGATCACCCCCGACGAGCTGCGCGCCTGGAAGGACGAGCATCCCG
GCGCCGTCGTCGTTTCCTACGTCAACACCACGGCGGCCGTCAAGGCGCTCACCGACATCTGCTGCACCTCGTCAAACGCC
GTCGACGTGGTCGCATCCATCGATCCCGACCGCGAGGTGTTGTTCTGTCCGGACCAATTCCTCGGTGCACACGTGCGCCG
GGTGACCGGCCGCAAGAACCTGCATGTGTGGGCCGGCGAATGCCACGTACACGCCGGGATCAACGGCGACGAGCTCGCTG
ACCAGGCCCGCGCACATCCCGATGCCGAACTGTTCGTGCATCCGGAGTGTGGTTGCGCAACCTCGGCGCTATACCTCGCC
GGCGAAGGAGCATTCCCAGCCGAGCGGGTAAAGATCTTGTCCACCGGCGGCATGCTCGAAGCGGCGCACACGACGCGCGC
CCGCCAGGTGCTGGTCGCCACCGAGGTCGGCATGTTGCACCAGCTTCGCCGGGCGGCACCGGAAGTCGACTTTCGCGCGG
TCAACGACCGCGCCTCATGCAAGTACATGAAGATGATCACCCCCGCGGCCCTGTTGCGCTGCCTGGTAGAGGGTGCCGAC
GAAGTCCATGTCGATCCGGGAATCGCCGCCAGTGGGCGTCGCAGCGTGCAGCGGATGATCGAAATCGGCCATCCCGGCGG
TGGCGAATGA

Upstream 100 bases:

>100_bases
GCACTTGAAAGACGACGGCCAGCACTTCGTGGGCGGTGCTACCATGGGCCATGTTTTCGATTATAAGTCGAAAACCTGTT
GGAGCGCGGAAGGGGCGGCA

Downstream 100 bases:

>100_bases
TGGCCGGTCCCGCTTGGCGGGATGCGGCCGATGTTGTCGTGATCGGCACGGGCGTTGCCGGGCTGGCGGCGGCATTGGCC
GCCGATCGCGCCGGGCGCAG

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MTVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLRGATVLAHNYQLPAIQDVADHVGDSLALSRVAAEAP
EDTIVFCGVHFMAETAKILSPHKTVLIPDQRAGCSLADSITPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNA
VDVVASIDPDREVLFCPDQFLGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARAHPDAELFVHPECGCATSALYLA
GEGAFPAERVKILSTGGMLEAAHTTRARQVLVATEVGMLHQLRRAAPEVDFRAVNDRASCKYMKMITPAALLRCLVEGAD
EVHVDPGIAASGRRSVQRMIEIGHPGGGE

Sequences:

>Translated_349_residues
MTVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLRGATVLAHNYQLPAIQDVADHVGDSLALSRVAAEAP
EDTIVFCGVHFMAETAKILSPHKTVLIPDQRAGCSLADSITPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNA
VDVVASIDPDREVLFCPDQFLGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARAHPDAELFVHPECGCATSALYLA
GEGAFPAERVKILSTGGMLEAAHTTRARQVLVATEVGMLHQLRRAAPEVDFRAVNDRASCKYMKMITPAALLRCLVEGAD
EVHVDPGIAASGRRSVQRMIEIGHPGGGE
>Mature_348_residues
TVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLRGATVLAHNYQLPAIQDVADHVGDSLALSRVAAEAPE
DTIVFCGVHFMAETAKILSPHKTVLIPDQRAGCSLADSITPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNAV
DVVASIDPDREVLFCPDQFLGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARAHPDAELFVHPECGCATSALYLAG
EGAFPAERVKILSTGGMLEAAHTTRARQVLVATEVGMLHQLRRAAPEVDFRAVNDRASCKYMKMITPAALLRCLVEGADE
VHVDPGIAASGRRSVQRMIEIGHPGGGE

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=359, Percent_Identity=32.8690807799443, Blast_Score=164, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_MYCBO (P65498)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855273.1
- ProteinModelPortal:   P65498
- SMR:   P65498
- EnsemblBacteria:   EBMYCT00000016426
- GeneID:   1092509
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1620
- GeneTree:   EBGT00050000016402
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- ProtClustDB:   PRK09375
- BioCyc:   MBOV233413:MB1620-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 37409; Mature: 37278

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 69-69 BINDING 140-140 BINDING 157-157 BINDING 227-227 BINDING 255-255

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLRGATVLAHNYQLPAIQ
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHH
DVADHVGDSLALSRVAAEAPEDTIVFCGVHFMAETAKILSPHKTVLIPDQRAGCSLADSI
HHHHHCCCHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
TPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNAVDVVASIDPDREVLFCPDQF
CHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCHHH
LGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARAHPDAELFVHPECGCATSALYLA
HHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEE
GEGAFPAERVKILSTGGMLEAAHTTRARQVLVATEVGMLHQLRRAAPEVDFRAVNDRASC
CCCCCCHHHEEEEECCCCEEHHHHHHHHEEEEHHHHHHHHHHHHHCCCCCEEECCCCCCC
KYMKMITPAALLRCLVEGADEVHVDPGIAASGRRSVQRMIEIGHPGGGE
HHHHHHCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLRGATVLAHNYQLPAIQ
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHH
DVADHVGDSLALSRVAAEAPEDTIVFCGVHFMAETAKILSPHKTVLIPDQRAGCSLADSI
HHHHHCCCHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
TPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNAVDVVASIDPDREVLFCPDQF
CHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCHHH
LGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARAHPDAELFVHPECGCATSALYLA
HHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEE
GEGAFPAERVKILSTGGMLEAAHTTRARQVLVATEVGMLHQLRRAAPEVDFRAVNDRASC
CCCCCCHHHEEEEECCCCEEHHHHHHHHEEEEHHHHHHHHHHHHHCCCCCEEECCCCCCC
KYMKMITPAALLRCLVEGADEVHVDPGIAASGRRSVQRMIEIGHPGGGE
HHHHHHCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972