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The map label for this gene is bioF1 [C]

Identifier: 121637491

GI number: 121637491

Start: 1791196

End: 1792356

Strand: Direct

Name: bioF1 [C]

Synonym: BCG_1622

Alternate gene names: 121637491

Gene position: 1791196-1792356 (Clockwise)

Preceding gene: 121637490

Following gene: 121637492

Centisome position: 40.95

GC content: 72.44

Gene sequence:

>1161_bases
ATGAAAGCCGCCACGCAGGCACGGATCGACGATTCACCGTTGGCCTGGTTGGACGCGGTGCAGCGGCAGCGCCACGAGGC
CGGACTGCGGCGCTGCCTGCGGCCGCGTCCCGCGGTCGCCACCGAGCTGGACTTGGCCTCCAACGACTATCTCGGTCTGT
CCCGACATCCCGCCGTCATCGACGGCGGCGTCCAGGCGCTGCGGATCTGGGGCGCCGGCGCCACCGGGTCGCGCCTGGTT
ACCGGCGACACCAAGCTGCACCAGCAATTCGAGGCCGAGCTCGCCGAGTTCGTCGGCGCTGCCGCGGGATTGCTGTTCTC
CTCTGGCTACACGGCCAACCTGGGCGCCGTGGTCGGCCTGTCCGGCCCGGGTTCCCTGCTGGTGTCCGACGCCCGTTCGC
ATGCGTCGTTGGTGGATGCCTGTCGGCTGTCGCGGGCGCGGGTTGTGGTGACGCCGCACCGCGACGTCGACGCCGTGGAC
GCCGCGCTGCGATCGCGCGACGAGCAGCGCGCCGTCGTCGTCACCGACTCGGTGTTCAGCGCCGACGGCTCGCTGGCGCC
GGTTCGGGAGTTGCTTGAGGTCTGCCGGCGTCATGGTGCGCTGCTTCTGGTGGACGAGGCGCACGGCCTGGGTGTGCGTG
GCGGCGGACGCGGGCTGCTCTACGAGTTAGGTCTAGCGGGTGCGCCCGACGTGGTGATGACCACCACGCTGTCCAAGGCG
CTGGGCAGCCAGGGTGGTGTGGTGCTCGGGCCGACGCCGGTGCGGGCCCATCTGATCGATGCTGCCCGGCCGTTCATCTT
CGACACCGGTCTGGCGCCGGCGGCGGTGGGTGCCGCACGGGCCGCGCTGCGCGTCTTGCAGGCCGAGCCGTGGCGACCGC
AGGCGGTGCTCAACCACGCTGGTGAACTTGCGCGGATGTGCGGTGTGGCTGCGGTGCCGGACTCGGCGATGGTGTCGGTG
ATCCTGGGCGAGCCGGAGTCGGCAGTGGCCGCCGCGGCGGCCTGCCTGGACGCCGGGGTCAAGGTGGGCTGCTTCCGGCC
GCCGACGGTGCCCGCGGGTACGTCGCGGCTGCGGCTGACCGCGCGCGCATCGCTGAACGCCGGCGAGCTCGAGCTGGCCC
GGCGGGTGCTGACGGATGTTCTCGCCGTGGCGCGCCGTTGA

Upstream 100 bases:

>100_bases
ACCTGGTCTACGCCATGCCGCCCTATATCTGCACACCGGCCGAGATCACGCAGATCACCTCGGCGATGGTCGAGGTCGCA
CGGCTCGTAGGCTCACTGCC

Downstream 100 bases:

>100_bases
CGATCCTGGTCGTCACCGGGACCGGCACGGGGGTCGGCAAGACGGTCGTCTGCGCGGCGCTGGCGTCGGCCGCACGTCAG
GCCGGCATCGACGTGGCGGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLV
TGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVD
AALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKA
LGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSV
ILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR

Sequences:

>Translated_386_residues
MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLV
TGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVD
AALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKA
LGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSV
ILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR
>Mature_386_residues
MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLV
TGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVD
AALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKA
LGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSV
ILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=328, Percent_Identity=35.0609756097561, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI284448556, Length=328, Percent_Identity=35.0609756097561, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI83977442, Length=328, Percent_Identity=33.5365853658537, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI83977444, Length=328, Percent_Identity=33.5365853658537, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI83977440, Length=328, Percent_Identity=33.5365853658537, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI4502025, Length=250, Percent_Identity=35.2, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI40316939, Length=250, Percent_Identity=35.2, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI4758668, Length=289, Percent_Identity=25.2595155709343, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI119220554, Length=233, Percent_Identity=27.0386266094421, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI5454084, Length=260, Percent_Identity=23.0769230769231, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1786993, Length=345, Percent_Identity=35.9420289855072, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1790046, Length=325, Percent_Identity=30.7692307692308, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=331, Percent_Identity=33.2326283987915, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI32566772, Length=259, Percent_Identity=25.4826254826255, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=270, Percent_Identity=25.1851851851852, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71982617, Length=270, Percent_Identity=25.1851851851852, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17560914, Length=290, Percent_Identity=23.1034482758621, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560912, Length=290, Percent_Identity=23.1034482758621, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=386, Percent_Identity=28.4974093264249, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=279, Percent_Identity=26.8817204301075, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320267, Length=406, Percent_Identity=22.6600985221675, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24662918, Length=344, Percent_Identity=30.2325581395349, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=31.5186246418338, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17136286, Length=260, Percent_Identity=25, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653280, Length=260, Percent_Identity=23.0769230769231, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24653276, Length=260, Percent_Identity=23.0769230769231, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24653278, Length=260, Percent_Identity=23.0769230769231, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_MYCBO (P0A4X5)

Other databases:

- EMBL:   AF041819
- EMBL:   BX248339
- RefSeq:   NP_855248.1
- ProteinModelPortal:   P0A4X5
- SMR:   P0A4X5
- EnsemblBacteria:   EBMYCT00000017885
- GeneID:   1092481
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1596
- GeneTree:   EBGT00050000015340
- HOGENOM:   HBG649839
- OMA:   KDYASND
- ProtClustDB:   PRK05958
- BioCyc:   MBOV233413:MB1596-MONOMER
- BRENDA:   2.3.1.47
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 40028; Mature: 40028

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 31-31 BINDING 134-134 BINDING 180-180 BINDING 349-349

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEE
DGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGL
CCCCEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
SGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAALRSRDEQRAVVVTDSVFS
CCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECCHHC
ADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKA
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHH
LGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHA
HCCCCCEEECCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLT
HHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEE
ARASLNAGELELARRVLTDVLAVARR
EECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCEE
DGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGL
CCCCEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
SGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAALRSRDEQRAVVVTDSVFS
CCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECCHHC
ADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKA
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHH
LGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHA
HCCCCCEEECCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLT
HHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEE
ARASLNAGELELARRVLTDVLAVARR
EECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972