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The map label for this gene is bioA

Identifier: 121637490

GI number: 121637490

Start: 1789886

End: 1791199

Strand: Direct

Name: bioA

Synonym: BCG_1621

Alternate gene names: 121637490

Gene position: 1789886-1791199 (Clockwise)

Preceding gene: 121637482

Following gene: 121637491

Centisome position: 40.92

GC content: 69.63

Gene sequence:

>1314_bases
ATGGCTGCGGCGACTGGCGGGTTGACGCCCGAGCAGATCATCGCGGTCGATGGCGCCCATCTGTGGCACCCTTACAGCTC
CATCGGCAGGGAAGCCGTGTCGCCGGTGGTGGCCGTCGCCGCCCACGGAGCGTGGTTGACGCTGATTCGCGACGGCCAGC
CGATCGAGGTGCTCGACGCGATGAGCTCCTGGTGGACCGCGATCCACGGGCACGGCCACCCCGCTCTGGACCAGGCGTTA
ACCACCCAGTTGCGGGTGATGAACCACGTCATGTTCGGGGGGCTGACTCACGAGCCGGCGGCCCGGCTGGCGAAGCTGCT
GGTCGACATCACCCCGGCGGGTCTCGACACGGTGTTCTTCAGCGACTCCGGCTCGGTGTCGGTGGAAGTCGCGGCCAAGA
TGGCGCTGCAGTACTGGCGCGGCCGCGGCCTGCCCGGCAAGCGACGGCTCATGACCTGGCGCGGCGGCTATCACGGCGAC
ACCTTCCTGGCTATGAGCATCTGCGACCCGCACGGCGGCATGCACTCGCTGTGGACCGACGTCCTGGCCGCCCAAGTGTT
CGCGCCACAAGTGCCACGGGACTACGATCCCGCCTACAGCGCGGCGTTCGAGGCGCAGCTGGCGCAGCACGCCGGCGAGC
TGGCCGCGGTGGTCGTGGAGCCGGTCGTGCAGGGTGCGGGCGGTATGCGTTTTCACGACCCGCGCTATCTGCACGACCTG
CGGGACATCTGCCGCCGTTACGAGGTGCTGCTGATCTTCGATGAGATCGCCACCGGCTTCGGCCGCACCGGCGCGTTGTT
CGCCGCCGACCACGCCGGGGTGAGCCCGGACATCATGTGTGTCGGCAAGGCGCTCACCGGCGGCTACCTCAGCTTGGCCG
CCACCTTGTGCACCGCCGACGTCGCGCACACCATCAGCGCCGGTGCGGCCGGGGCGCTGATGCACGGCCCCACCTTCATG
GCCAATCCGCTGGCCTGTGCGGTCTCGGTGGCCAGTGTGGAGCTGCTGCTCGGCCAGGACTGGCGCACGCGCATCACCGA
ACTGGCCGCCGGGCTGACCGCCGGCCTGGATACCGCCCGGGCGCTGCCCGCCGTCACCGATGTGCGGGTGTGCGGCGCGA
TCGGCGTCATCGAATGCGACCGACCGGTCGACCTGGCCGTCGCGACTCCCGCGGCGCTGGATCGAGGCGTGTGGCTGCGC
CCGTTTCGCAACCTGGTCTACGCCATGCCGCCCTATATCTGCACACCGGCCGAGATCACGCAGATCACCTCGGCGATGGT
CGAGGTCGCACGGCTCGTAGGCTCACTGCCATGA

Upstream 100 bases:

>100_bases
CTGATTCGGCGGTGCCATGCATGCATGCTCCCCGATGGCAGAGGTTTTGGCGACCGTTACTGGGATGGGCCGTGGCGTGG
CTGCATTACCCTCGATCTCC

Downstream 100 bases:

>100_bases
AAGCCGCCACGCAGGCACGGATCGACGATTCACCGTTGGCCTGGTTGGACGCGGTGCAGCGGCAGCGCCACGAGGCCGGA
CTGCGGCGCTGCCTGCGGCC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQAL
TTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGD
TFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDL
RDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTADVAHTISAGAAGALMHGPTFM
ANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLR
PFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP

Sequences:

>Translated_437_residues
MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQAL
TTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGD
TFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDL
RDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTADVAHTISAGAAGALMHGPTFM
ANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLR
PFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP
>Mature_436_residues
AAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQALT
TQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDT
FLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDLR
DICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTADVAHTISAGAAGALMHGPTFMA
NPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLRP
FRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=28.743961352657, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI284507298, Length=307, Percent_Identity=30.6188925081433, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI13994255, Length=391, Percent_Identity=26.8542199488491, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI37574042, Length=419, Percent_Identity=23.6276849642005, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=23.8845144356955, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=24.8210023866348, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI226442705, Length=432, Percent_Identity=21.9907407407407, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=50.9569377990431, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1789759, Length=288, Percent_Identity=36.1111111111111, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788044, Length=305, Percent_Identity=36.0655737704918, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI145693181, Length=343, Percent_Identity=32.3615160349854, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1789016, Length=384, Percent_Identity=28.3854166666667, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787560, Length=353, Percent_Identity=27.7620396600567, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786349, Length=362, Percent_Identity=30.3867403314917, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=418, Percent_Identity=26.3157894736842, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=234, Percent_Identity=32.4786324786325, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=23.6658932714617, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17541228, Length=407, Percent_Identity=25.3071253071253, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=466, Percent_Identity=39.6995708154506, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6323470, Length=396, Percent_Identity=29.7979797979798, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=328, Percent_Identity=25.3048780487805, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=27.1634615384615, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI161085790, Length=469, Percent_Identity=26.4392324093817, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=26.5116279069767, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356575, Length=393, Percent_Identity=23.4096692111959, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOA_MYCBO (P0A4X7)

Other databases:

- EMBL:   AF041819
- EMBL:   BX248339
- RefSeq:   NP_855247.1
- ProteinModelPortal:   P0A4X7
- SMR:   P0A4X7
- EnsemblBacteria:   EBMYCT00000016253
- GeneID:   1092480
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1595
- GeneTree:   EBGT00050000015339
- HOGENOM:   HBG725944
- OMA:   GMVVAFE
- ProtClustDB:   PRK05964
- BioCyc:   MBOV233413:MB1595-MONOMER
- BRENDA:   2.6.1.62
- GO:   GO:0005737
- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF8
- TIGRFAMs:   TIGR00508

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.62

Molecular weight: Translated: 46320; Mature: 46189

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 25-25 BINDING 254-254 BINDING 283-283 BINDING 316-316 BINDING 318-318 BINDING 400-400

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIRDGQPIEVLDA
CCCCCCCCCHHHEEEECCCHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHH
MSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFF
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEE
SDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDTFLAMSICDPHGGMHSLWTD
CCCCCEEHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHH
VLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
RDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTAD
HHHHHHHEEEEEEHHHHCCCCCCCCEEEECCCCCCCCEEEECHHHCCHHHHHHHHHHHHH
VAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTAR
HHHHHHCCCCCHHHCCCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHH
ALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLRPFRNLVYAMPPYICTPAEIT
HCCCHHHHHHHCCCCEEECCCCCCEEEECHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHH
QITSAMVEVARLVGSLP
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIRDGQPIEVLDA
CCCCCCCCHHHEEEECCCHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHH
MSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFF
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEE
SDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDTFLAMSICDPHGGMHSLWTD
CCCCCEEHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHH
VLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
RDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTAD
HHHHHHHEEEEEEHHHHCCCCCCCCEEEECCCCCCCCEEEECHHHCCHHHHHHHHHHHHH
VAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTAR
HHHHHHCCCCCHHHCCCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHH
ALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLRPFRNLVYAMPPYICTPAEIT
HCCCHHHHHHHCCCCEEECCCCCCEEEECHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHH
QITSAMVEVARLVGSLP
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972