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The map label for this gene is mutA

Identifier: 121637424

GI number: 121637424

Start: 1707230

End: 1709077

Strand: Direct

Name: mutA

Synonym: BCG_1555

Alternate gene names: 121637424

Gene position: 1707230-1709077 (Clockwise)

Preceding gene: 121637422

Following gene: 121637425

Centisome position: 39.03

GC content: 70.29

Gene sequence:

>1848_bases
GTGTCCATTGATGTACCCGAGCGTGCCGACCTAGAACAGGTTCGCGGGCGCTGGCGCAACGCGGTTGCCGGTGTGCTGTC
CAAGAGCAACCGTACCGACTCAGCACAACTCGGCGATCACCCCGAGCGGCTGCTGGATACCCAGACCGCTGACGGGTTCG
CCATCCGGGCCCTCTACACCGCGTTCGACGAGCTCCCGGAGCCGCCGTTGCCGGGCCAGTGGCCCTTTGTGCGCGGCGGA
GACCCGCTGCGCGACGTGCATTCCGGCTGGAAGGTCGCCGAGGCGTTTCCCGCCAACGGTGCGACGGCCGACACCAACGC
GGCGGTGCTGGCCGCGCTCGGCGAGGGGGTCAGCGCGCTGCTGATCCGGGTGGGGGAGTCGGGTGTGGCGCCTGACCGGC
TCACGGCGCTGCTGTCCGGGGTGTATCTGAACCTGGCGCCGGTCATCCTCGACGCCGGCGCCGACTACCGCCCGGCCTGC
GACGTCATGCTGGCGCTGGTCGCCCAGCTCGATCCCGGCCAGCGCGACACCCTGTCGATCGACCTGGGCGCCGACCCGCT
GACGGCGTCGCTGCGCGATCGTCCCGCCCCGCCGATCGAGGAGGTCGTCGCGGTCGCATCCCGGGCGGCCGGCGAACGTG
GGCTTCGTGCGATCACCGTCGACGGACCGGCCTTCCACAACCTGGGCGCGACCGCGGCCACCGAACTCGCGGCCACCGTC
GCGGCCGCGGTGGCCTACCTGCGGGTGCTCACCGAATCCGGGCTCGTGGTGAGTGACGCGCTGCGGCAGATCAGCTTCCG
GCTCGCCGCCGACGACGACCAGTTCATGACGCTGGCCAAGATGCGGGCTCTACGTCAACTGTGGGCGCGGGTCGCCGAGG
TCGTGGGCGACCCGGGTGGCGGCGCGGCCGTCGTGCACGCGGAGACGTCGCTACCGATGATGACCCAGCGTGATCCGTGG
GTGAACATGCTGCGCTGCACGCTGGCGGCCTTCGGCGCCGGTGTCGGTGGCGCGGACACCGTGCTGGTGCACCCGTTCGA
CGTGGCGATTCCCGGCGGCTTTCCCGGCACGGCGGCCGGCTTTGCGCGCCGGATCGCTCGCAACACCCAACTGCTGCTTT
TAGAAGAGTCGCATGTCGGCAGGGTGCTCGATCCCGCCGGCGGGTCGTGGTTCGTCGAAGAGCTCACCGACCGGCTGGCT
CGGCGCGCCTGGCAGCGTTTCCAGGCCATCGAGGCCCGTGGCGGCTTCGTCGAGGCCCACGACTTCCTGGCCGGCCAGAT
CGCCGAGTGCGCCGCCCGCCGCGCCGACGACATCGCCCATCGGCGCCTGGCGATCACCGGCGTCAACGAATACCCGAACC
TGGGCGAACCCGCGCTGCCGCCCGGTGATCCGACATCGCCGGTGCGCCGCTACGCTGCCGGATTCGAAGCATTGCGCGAT
CGATCCGATCACCACCTAGCCCGCACTGGCGCACGGCCGCGGGTGCTGTTGCTGCCGTTGGGTCCGCTGGCCGAGCACAA
CATCCGGACGACCTTCGCCACCAACCTGCTGGCGTCCGGCGGCATCGAGGCGATCGACCCGGGAACGGTTGATGCGGGCA
CCGTCGGGAATGCCGTTGCCGATGCCGGTTCGCCCAGCGTTGCCGTGATCTGCGGCACCGATGCGCGCTACCGGGACGAG
GTTGCCGACATTGTGCAAGCGGCCCGAGCCGCCGGTGTTTCGAGGGTGTACCTCGCGGGTCCCGAGAAGGCGTTGGGAGA
TGCCGCACACCGGCCCGACGAGTTTTTGACCGCGAAAATCAATGTGGTGCAAGCCTTGTCGAATCTGCTGACGCGGTTGG
GGGCCTAG

Upstream 100 bases:

>100_bases
TCTATATGGGCGTCCCGATCAACTAGCCTTATTAGTTAAGTGACAATCCCGAAGCAAGCCCAAGCAACATCGCTAATTGC
TGGGAAAACAGGAGCAGTCG

Downstream 100 bases:

>100_bases
ATGACAACCAAGACACCCGTGATCGGCAGCTTCGCCGGCGTTCCGCTGCATAGCGAGCGTGCCGCGCAATCGCCCACAGA
GGCCGCGGTGCACACGCATG

Product: putative methylmalonyl-CoA mutase small subunit mutA

Products: NA

Alternate protein names: MCM

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYTAFDELPEPPLPGQWPFVRGG
DPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPAC
DVMLALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATAATELAATV
AAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGGGAAVVHAETSLPMMTQRDPW
VNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLA
RRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYAAGFEALRD
RSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICGTDARYRDE
VADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA

Sequences:

>Translated_615_residues
MSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYTAFDELPEPPLPGQWPFVRGG
DPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPAC
DVMLALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATAATELAATV
AAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGGGAAVVHAETSLPMMTQRDPW
VNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLA
RRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYAAGFEALRD
RSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICGTDARYRDE
VADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA
>Mature_614_residues
SIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYTAFDELPEPPLPGQWPFVRGGD
PLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACD
VMLALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATAATELAATVA
AAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGGGAAVVHAETSLPMMTQRDPWV
NMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLAR
RAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYAAGFEALRDR
SDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICGTDARYRDEV
ADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family

Homologues:

Organism=Homo sapiens, GI156105689, Length=486, Percent_Identity=28.1893004115226, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1789284, Length=468, Percent_Identity=28.4188034188034, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25144500, Length=445, Percent_Identity=26.2921348314607, Blast_Score=138, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTA_MYCBO (P65486)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855181.1
- ProteinModelPortal:   P65486
- SMR:   P65486
- EnsemblBacteria:   EBMYCT00000016301
- GeneID:   1092386
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1529
- GeneTree:   EBGT00050000017027
- HOGENOM:   HBG428755
- OMA:   AHRIARN
- ProtClustDB:   CLSK791197
- BioCyc:   MBOV233413:MB1529-MONOMER
- BRENDA:   5.4.99.2
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608
- Gene3D:   G3DSA:3.40.50.280
- Gene3D:   G3DSA:3.20.20.240
- TIGRFAMs:   TIGR00642

Pfam domain/function: PF01642 MM_CoA_mutase; SSF51703 Cbl-dep_enz_cat

EC number: =5.4.99.2

Molecular weight: Translated: 64745; Mature: 64614

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00544 METMALONYL_COA_MUTASE; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYT
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHH
AFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSAL
HHHHCCCCCCCCCCCCCCCCCCHHHHHCCCEEHHCCCCCCCCCCCCHHHHHHHHCCHHHH
LIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACDVMLALVAQLDPGQRDTLSI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCEEEE
DLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATAATELAATV
ECCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCHHHHHHHHHHH
AAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGG
HHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAG
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECEEEEECCCCCCHHHH
FARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLARRAWQRFQAIEARGGFVEAH
HHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
DFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYAAGFEALRD
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVA
CCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
DAGSPSVAVICGTDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKI
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCHHHHHHH
NVVQALSNLLTRLGA
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYT
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHH
AFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSAL
HHHHCCCCCCCCCCCCCCCCCCHHHHHCCCEEHHCCCCCCCCCCCCHHHHHHHHCCHHHH
LIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACDVMLALVAQLDPGQRDTLSI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCEEEE
DLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATAATELAATV
ECCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCHHHHHHHHHHH
AAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGG
HHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAG
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECEEEEECCCCCCHHHH
FARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLARRAWQRFQAIEARGGFVEAH
HHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
DFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYAAGFEALRD
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVA
CCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
DAGSPSVAVICGTDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKI
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCHHHHHHH
NVVQALSNLLTRLGA
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972