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The map label for this gene is ctaB

Identifier: 121637381

GI number: 121637381

Start: 1660051

End: 1660977

Strand: Direct

Name: ctaB

Synonym: BCG_1512

Alternate gene names: 121637381

Gene position: 1660051-1660977 (Clockwise)

Preceding gene: 121637372

Following gene: 121637383

Centisome position: 37.95

GC content: 66.02

Gene sequence:

>927_bases
GTGAACGTTCGCGGGCGCGTCGCGCCGCGCCGAGTGACTGGTAGGGCAATGAGCACCCTGCTGGCCTACCTGGCGTTAAC
CAAGCCGCGAGTCATCGAGCTGCTGTTGGTCACCGCGATACCGGCGATGCTGCTGGCCGACCGCGGCGCCATTCATCCGC
TGCTCATGCTCAACACGCTCGTCGGCGGGATGATGGCCGCCACCGGCGCCAACACGCTCAACTGCGTCGCCGACGCCGAT
ATCGACAAGGTGATGAAGCGAACCGCGCGCCGGCCCTTGGCGCGGGAAGCGGTGCCGACCCGAAACGCGTTGGCACTCGG
GTTGACGTTGACGGTGATCTCGTTCTTCTGGCTATGGTGCGCCACGAACCTGCTGGCGGGGGTGCTGGCCCTGGTCACCG
TCGCGTTTTATGTGTTCGTCTACACGCTTTGGCTCAAGCGACGCACGTCACAGAACGTGGTGTGGGGTGGGGCGGCCGGC
TGTATGCCGGTGATGATCGGCTGGTCGGCCATCACCGGCACCATAGCCTGGCCGGCGCTGGCGATGTTCGCGATCATCTT
CTTCTGGACGCCGCCACACACCTGGGCATTGGCGATGCGCTACAAGCAGGACTACCAAGTGGCCGGGGTGCCGATGCTGC
CGGCGGTGGCGACCGAGCGTCAGGTCACCAAGCAGATCTTGATCTACACCTGGCTGACCGTGGCCGCGACGCTGGTGCTG
GCGTTGGCGACCAGTTGGCTTTACGGCGCGGTGGCCCTGGTGGCCGGTGGGTGGTTCCTGACGATGGCCCACCAGTTGTA
TGCCGGGGTGCGCGCCGGCGAGCCGGTCAGGCCGCTGCGGCTGTTTCTGCAGTCGAACAACTATCTGGCGGTGGTGTTCT
GCGCACTGGCCGTCGACTCGGTGATCGCGCTGCCCACGCTGCACTGA

Upstream 100 bases:

>100_bases
TCGTGTGAATCGACCCTGCGGCTCTGCTGCCACAGTTACCCGGTCTACCATCGTGCGTAGTAGAAGCTGCGCGCGGCTGC
GATTCCCGAGGAGTTAGTGC

Downstream 100 bases:

>100_bases
TTGGGGGCCCAGTTCCGCTGCGGTGCCGGCCCTGCTCGGCCAACGTAGTCAGATGGTTGGATCGCCACCGGCGCCACCGG
CGCCGCCCGCGCCACCAGCA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAATGANTLNCVADAD
IDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAG
CMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH

Sequences:

>Translated_308_residues
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAATGANTLNCVADAD
IDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAG
CMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH
>Mature_308_residues
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAATGANTLNCVADAD
IDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAG
CMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=188, Percent_Identity=30.3191489361702, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786631, Length=247, Percent_Identity=33.6032388663968, Blast_Score=125, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325085, Length=277, Percent_Identity=24.9097472924188, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_MYCBO (Q7U021)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855138.1
- EnsemblBacteria:   EBMYCT00000015845
- GeneID:   1092343
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1486
- GeneTree:   EBGT00050000016790
- HOGENOM:   HBG656003
- OMA:   LLKPRIM
- ProtClustDB:   PRK04375
- BioCyc:   MBOV233413:MB1486-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33569; Mature: 33569

Theoretical pI: Translated: 10.68; Mature: 10.68

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12760980)-; HASH(0x15df8b78)-; HASH(0x15df8a64)-; HASH(0x15f2691c)-; HASH(0x15df8e24)-; HASH(0x13b67474)-; HASH(0x13b6748c)-; HASH(0x12dbfff0)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGGMMAATGANTLNCVADADIDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWC
HHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMPVMIGWSAITGTIAWPAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
AMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
VIALPTLH
HHHCCCCH
>Mature Secondary Structure
MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTL
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGGMMAATGANTLNCVADADIDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWC
HHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMPVMIGWSAITGTIAWPAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
AMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVL
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
VIALPTLH
HHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972