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The map label for this gene is uvrC

Identifier: 121637350

GI number: 121637350

Start: 1618830

End: 1620770

Strand: Direct

Name: uvrC

Synonym: BCG_1481

Alternate gene names: 121637350

Gene position: 1618830-1620770 (Clockwise)

Preceding gene: 121637349

Following gene: 121637351

Centisome position: 37.01

GC content: 65.43

Gene sequence:

>1941_bases
GTGCCAGATCCCGCAACGTATCGCCCCGCGCCCGGGTCCATCCCGGTCGAGCCGGGCGTGTACCGATTCCGGGACCAGCA
TGGGCGAGTCATCTACGTCGGCAAGGCCAAGAGCCTGCGTAGCCGGCTGACGTCCTATTTTGCCGACGTGGCCAGCCTAG
CGCCGCGGACCCGGCAGCTGGTGACCACCGCGGCCAAGGTCGAATGGACGGTCGTGGGGACCGAGGTTGAGGCACTGCAG
CTGGAATACACCTGGATCAAGGAGTTCGATCCGCGATTCAACGTCCGCTACCGCGACGACAAGTCCTACCCTGTGCTGGC
GGTCACCCTGGGCGAGGAATTTCCCCGGTTGATGGTCTATCGCGGTCCGCGGCGCAAGGGTGTGCGCTATTTCGGGCCGT
ACTCGCACGCGTGGGCAATCCGGGAAACGCTGGATCTGCTCACCCGGGTGTTTCCGGCGCGAACTTGCTCGGCGGGGGTG
TTTAAGCGGCACAGGCAGATCGATCGTCCATGCCTGCTCGGCTACATCGACAAATGTTCCGCGCCGTGTATTGGCAGGGT
CGATGCGGCCCAGCACCGCCAGATCGTGGCAGACTTCTGCGACTTTCTGTCCGGCAAGACCGACCGGTTCGCCCGCGCCT
TGGAACAGCAAATGAACGCCGCGGCCGAGCAACTGGACTTCGAACGAGCGGCGCGGCTTCGCGACGACCTGTCCGCACTG
AAGCGTGCCATGGAAAAGCAGGCCGTGGTGCTCGGGGACGGCACCGACGCCGACGTGGTGGCATTCGCCGACGACGAACT
CGAGGCGGCGGTGCAAGTGTTCCACGTGCGCGGCGGACGGGTCCGCGGCCAGCGTGGCTGGATTGTCGAAAAGCCAGGAG
AGCCAGGAGATTCCGGAATCCAGTTGGTCGAGCAATTCCTGACACAGTTCTACGGCGACCAGGCGGCGTTGGACGACGCC
GCCGACGAATCCGCCAACCCGGTTCCCCGCGAGGTGCTGGTGCCCTGTTTGCCGTCCAACGCCGAGGAGCTGGCCAGCTG
GCTGTCCGGCCTGCGCGGCTCAAGGGTCGTGCTGCGGGTGCCGCGCCGCGGGGACAAGCGGGCACTGGCCGAAACGGTGC
ACCGAAACGCAGAAGATGCACTGCAACAACACAAGCTGAAGCGGGCCAGCGATTTCAACGCCAGATCCGCTGCGCTGCAG
AGCATTCAGGACTCGTTGGGCCTGGCAGACGCACCCTTGCGGATCGAGTGTGTCGACGTCAGCCATGTGCAGGGCACCGA
CGTGGTCGGGTCACTGGTGGTGTTCGAAGACGGCCTGCCGCGCAAGTCGGACTACCGCCACTTCGGGATCCGGGAAGCCG
CAGGCCAGGGGCGCTCCGACGACGTGGCCTGTATTGCCGAGGTGACCCGGCGCCGCTTCCTGCGGCACCTGCGCGATCAG
AGCGATCCGGATCTTCTTTCTCCGGAAAGGAAGTCGCGTAGATTCGCCTATCCGCCCAATCTGTACGTCGTCGACGGCGG
CGCGCCGCAAGTCAACGCGGCCAGTGCGGTAATCGACGAACTCGGTGTTACCGACGTCGCGGTGATCGGCCTGGCCAAGC
GGCTGGAAGAGGTATGGGTGCCGTCGGAGCCGGACCCGATTATCATGCCGCGCAACAGTGAGGGACTCTATCTGCTGCAG
CGAGTGCGAGACGAGGCACACCGGTTCGCTATCACCTACCATCGCAGCAAGCGGTCGACGCGGATGACTGCCTCAGCGCT
GGACTCGGTGCCGGGATTGGGGGAGCATCGCCGCAAAGCGCTGGTCACCCATTTCGGATCGATCGCTCGCCTCAAGGAGG
CCACCGTCGACGAAATCACCGCTGTTCCCGGTATCGGCGTGGCCACGGCCACGGCCGTCCACGACGCACTGCGACCTGAC
TCATCGGGGGCCGCGCGATGA

Upstream 100 bases:

>100_bases
CAATGCACCCGACCAACAGTGGGATAGCGTGCCGTAACCGGCCTGCCCGGCGAACCCCCGCCTTTCTGGGCGCCGTCGAA
GCGACCACTAGCCTAGATAC

Downstream 100 bases:

>100_bases
TGAACCATGCTAGGGGCGTCGAGAATCGTTCGGAAGGCGGCGGTATCGACGTCGTCTTGGTAACCGGGCTGTCCGGGGCC
GGGCGCGGCACGGCGGCTAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 646; Mature: 645

Protein sequence:

>646_residues
MPDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTSYFADVASLAPRTRQLVTTAAKVEWTVVGTEVEALQ
LEYTWIKEFDPRFNVRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGV
FKRHRQIDRPCLLGYIDKCSAPCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAAEQLDFERAARLRDDLSAL
KRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKPGEPGDSGIQLVEQFLTQFYGDQAALDDA
ADESANPVPREVLVPCLPSNAEELASWLSGLRGSRVVLRVPRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAALQ
SIQDSLGLADAPLRIECVDVSHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGRSDDVACIAEVTRRRFLRHLRDQ
SDPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAVIDELGVTDVAVIGLAKRLEEVWVPSEPDPIIMPRNSEGLYLLQ
RVRDEAHRFAITYHRSKRSTRMTASALDSVPGLGEHRRKALVTHFGSIARLKEATVDEITAVPGIGVATATAVHDALRPD
SSGAAR

Sequences:

>Translated_646_residues
MPDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTSYFADVASLAPRTRQLVTTAAKVEWTVVGTEVEALQ
LEYTWIKEFDPRFNVRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGV
FKRHRQIDRPCLLGYIDKCSAPCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAAEQLDFERAARLRDDLSAL
KRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKPGEPGDSGIQLVEQFLTQFYGDQAALDDA
ADESANPVPREVLVPCLPSNAEELASWLSGLRGSRVVLRVPRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAALQ
SIQDSLGLADAPLRIECVDVSHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGRSDDVACIAEVTRRRFLRHLRDQ
SDPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAVIDELGVTDVAVIGLAKRLEEVWVPSEPDPIIMPRNSEGLYLLQ
RVRDEAHRFAITYHRSKRSTRMTASALDSVPGLGEHRRKALVTHFGSIARLKEATVDEITAVPGIGVATATAVHDALRPD
SSGAAR
>Mature_645_residues
PDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTSYFADVASLAPRTRQLVTTAAKVEWTVVGTEVEALQL
EYTWIKEFDPRFNVRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVF
KRHRQIDRPCLLGYIDKCSAPCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAAEQLDFERAARLRDDLSALK
RAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKPGEPGDSGIQLVEQFLTQFYGDQAALDDAA
DESANPVPREVLVPCLPSNAEELASWLSGLRGSRVVLRVPRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAALQS
IQDSLGLADAPLRIECVDVSHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGRSDDVACIAEVTRRRFLRHLRDQS
DPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAVIDELGVTDVAVIGLAKRLEEVWVPSEPDPIIMPRNSEGLYLLQR
VRDEAHRFAITYHRSKRSTRMTASALDSVPGLGEHRRKALVTHFGSIARLKEATVDEITAVPGIGVATATAVHDALRPDS
SGAAR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=638, Percent_Identity=36.2068965517241, Blast_Score=357, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_MYCBO (P67427)

Other databases:

- EMBL:   BX248338
- RefSeq:   NP_855107.1
- ProteinModelPortal:   P67427
- EnsemblBacteria:   EBMYCT00000016941
- GeneID:   1092312
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1455
- GeneTree:   EBGT00050000016419
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   MBOV233413:MB1455-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71615; Mature: 71484

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTSYFADVASLAPRTRQL
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCHHHHHH
VTTAAKVEWTVVGTEVEALQLEYTWIKEFDPRFNVRYRDDKSYPVLAVTLGEEFPRLMVY
HHHHHEEEEEEECCEEEEEEEEEEEHHHCCCCCCEEEECCCCCCEEEEECCCCCCEEEEE
RGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVFKRHRQIDRPCLLGYIDKCS
ECCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCC
APCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAAEQLDFERAARLRDDLSAL
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKPGEPGDSGI
HHHHHHCEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCEEECCCCCEEECCCCCCHHHH
QLVEQFLTQFYGDQAALDDAADESANPVPREVLVPCLPSNAEELASWLSGLRGSRVVLRV
HHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEC
PRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAALQSIQDSLGLADAPLRIECVDV
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEC
SHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGRSDDVACIAEVTRRRFLRHLRDQ
CCCCCCHHHHEEEEEECCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
SDPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAVIDELGVTDVAVIGLAKRLEEVWV
CCCCCCCCHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
PSEPDPIIMPRNSEGLYLLQRVRDEAHRFAITYHRSKRSTRMTASALDSVPGLGEHRRKA
CCCCCCEEEECCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHH
LVTHFGSIARLKEATVDEITAVPGIGVATATAVHDALRPDSSGAAR
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTSYFADVASLAPRTRQL
CCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCHHHHHH
VTTAAKVEWTVVGTEVEALQLEYTWIKEFDPRFNVRYRDDKSYPVLAVTLGEEFPRLMVY
HHHHHEEEEEEECCEEEEEEEEEEEHHHCCCCCCEEEECCCCCCEEEEECCCCCCEEEEE
RGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVFKRHRQIDRPCLLGYIDKCS
ECCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCC
APCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAAEQLDFERAARLRDDLSAL
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKPGEPGDSGI
HHHHHHCEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCEEECCCCCEEECCCCCCHHHH
QLVEQFLTQFYGDQAALDDAADESANPVPREVLVPCLPSNAEELASWLSGLRGSRVVLRV
HHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEC
PRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAALQSIQDSLGLADAPLRIECVDV
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEC
SHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGRSDDVACIAEVTRRRFLRHLRDQ
CCCCCCHHHHEEEEEECCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
SDPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAVIDELGVTDVAVIGLAKRLEEVWV
CCCCCCCCHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
PSEPDPIIMPRNSEGLYLLQRVRDEAHRFAITYHRSKRSTRMTASALDSVPGLGEHRRKA
CCCCCCEEEECCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHH
LVTHFGSIARLKEATVDEITAVPGIGVATATAVHDALRPDSSGAAR
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972