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The map label for this gene is pyrC

Identifier: 121637311

GI number: 121637311

Start: 1579348

End: 1580640

Strand: Direct

Name: pyrC

Synonym: BCG_1442

Alternate gene names: 121637311

Gene position: 1579348-1580640 (Clockwise)

Preceding gene: 121637310

Following gene: 121637312

Centisome position: 36.1

GC content: 69.61

Gene sequence:

>1293_bases
GTGAGCGTGCTGATTCGTGGTGTGCGGCCCTACGGCGAGGGGGAGCGGGTCGACGTACTCGTCGATGACGGCCAGATCGC
CCAGATAGGACCGGATCTGGCGATCCCCGATACGGCCGATGTCATTGACGCCACCGGACACGTGCTGCTGCCCGGGTTCG
TCGATCTGCACACCCATCTGCGCGAGCCGGGCCGCGAGTATGCCGAGGACATCGAAACCGGTTCGGCCGCGGCCGCTTTG
GGCGGCTACACCGCGGTGTTCGCGATGGCCAACACCAACCCCGTGGCCGACAGCCCGGTGGTCACCGACCACGTCTGGCA
CCGCGGCCAGCAGGTCGGCCTGGTCGACGTGCACCCCGTCGGCGCGGTCACCGTCGGGCTGGCCGGAGCCGAGCTGACCG
AGATGGGCATGATGAACGCCGGCGCCGCCCAGGTGCGGATGTTCTCCGACGACGGGGTCTGCGTGCATGACCCGCTGATC
ATGCGCCGCGCCCTGGAATATGCCACCGGTTTGGGCGTGCTGATCGCCCAGCACGCCGAGGAGCCCCGGCTGACGGTCGG
CGCCTTCGCGCACGAGGGACCCATGGCGGCGCGGCTGGGCCTGGCGGGATGGCCGCGGGCCGCCGAGGAATCGATCGTCG
CCCGCGACGCCTTGCTGGCCCGTGACGCCGGCGCCCGGGTGCACATCTGTCACGCGTCGGCCGCGGGCACCGTCGAAATC
CTGAAATGGGCTAAGGACCAGGGTATTTCGATCACCGCCGAGGTCACCCCCCACCACCTGTTGCTCGACGATGCCAGATT
GGCCAGCTATGACGGCGTGAACCGGGTCAACCCGCCGCTGCGCGAAGCTTCCGACGCGGTCGCCCTGCGACAGGCGCTGG
CCGACGGGATCATCGACTGTGTGGCCACAGATCACGCCCCGCATGCCGAGCACGAGAAATGCGTCGAATTCGCCGCGGCC
CGGCCCGGCATGCTCGGGTTGCAGACGGCATTGTCGGTGGTGGTGCAGACAATGGTGGCGCCCGGCTTGTTGAGTTGGCG
CGATATCGCGCGGGTGATGAGTGAGAACCCGGCGTGCATCGCACGCTTGCCCGATCAGGGCCGGCCACTGGAGGTGGGGG
AGCCGGCCAACCTGACGGTGGTGGACCCCGACGCCACCTGGACGGTCACCGGCGCCGACCTGGCCAGCCGGTCGGCCAAC
ACGCCGTTTGAGTCGATGAGCCTGCCCGCCACCGTGACCGCGACCCTGCTGCGCGGGAAGGTGACCGCGCGCGACGGGAA
GATCCGGGCATGA

Upstream 100 bases:

>100_bases
CGGCTGTGCTGCAACAGGTTTCCAATGGAGTCCAGGTGCGGATGGCGGTGCTGTTCCATGTGCTGGTGGGAGCGCAGGAT
GCCGGTAAAGAGGGTGCGGC

Downstream 100 bases:

>100_bases
ACTCCGGCACGCTGGCGGGGTCGCTGATCTTCGCGGCGGTGCTCGTCATGCTGATCGCGGTGCTCGCTCGGCTGATGATG
CGCGGCTGGCGGCGCCGTTC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAAL
GGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLI
MRRALEYATGLGVLIAQHAEEPRLTVGAFAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEI
LKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAA
RPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSAN
TPFESMSLPATVTATLLRGKVTARDGKIRA

Sequences:

>Translated_430_residues
MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAAL
GGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLI
MRRALEYATGLGVLIAQHAEEPRLTVGAFAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEI
LKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAA
RPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSAN
TPFESMSLPATVTATLLRGKVTARDGKIRA
>Mature_429_residues
SVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALG
GYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIM
RRALEYATGLGVLIAQHAEEPRLTVGAFAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEIL
KWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAAR
PGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSANT
PFESMSLPATVTATLLRGKVTARDGKIRA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=406, Percent_Identity=30.5418719211823, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4503051, Length=451, Percent_Identity=26.3858093126386, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI62422571, Length=450, Percent_Identity=26.4444444444444, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI19923821, Length=457, Percent_Identity=26.2582056892779, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4503375, Length=465, Percent_Identity=25.8064516129032, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1786722, Length=428, Percent_Identity=30.3738317757009, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87082175, Length=442, Percent_Identity=25.3393665158371, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193204318, Length=407, Percent_Identity=29.97542997543, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI86575075, Length=432, Percent_Identity=24.7685185185185, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=398, Percent_Identity=26.3819095477387, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24642586, Length=398, Percent_Identity=31.4070351758794, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17137462, Length=443, Percent_Identity=23.7020316027088, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221377917, Length=449, Percent_Identity=24.7216035634744, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI18859883, Length=413, Percent_Identity=27.6029055690073, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_MYCBO (Q7U057)

Other databases:

- EMBL:   BX248338
- RefSeq:   NP_855068.1
- ProteinModelPortal:   Q7U057
- SMR:   Q7U057
- EnsemblBacteria:   EBMYCT00000017341
- GeneID:   1090706
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1416
- GeneTree:   EBGT00050000016208
- HOGENOM:   HBG724623
- OMA:   FAMANTH
- ProtClustDB:   PRK09357
- BioCyc:   MBOV233413:MB1416-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 45241; Mature: 45110

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHL
CCEEEECCCCCCCCCEEEEEECCCEEEECCCCCCCCCCHHHHHCCCCEEECCHHHHHHHH
REPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPV
HCCHHHHHHHHCCCCHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHCCCEECEEEECCC
GAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAE
CEEEEECCCCHHHHHCCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHHCHHHHEECCCC
EPRLTVGAFAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEI
CCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
LKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDC
HHHHCCCCCEEEEECCCCEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACI
HCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEE
ARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSANTPFESMSLPATVTATLLRGK
EECCCCCCCCCCCCCCCEEEECCCCCEEEECHHHHCCCCCCCHHHCCCCHHHHHHHHHCE
VTARDGKIRA
EEECCCCCCC
>Mature Secondary Structure 
SVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHL
CEEEECCCCCCCCCEEEEEECCCEEEECCCCCCCCCCHHHHHCCCCEEECCHHHHHHHH
REPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPV
HCCHHHHHHHHCCCCHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHCCCEECEEEECCC
GAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAE
CEEEEECCCCHHHHHCCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHHCHHHHEECCCC
EPRLTVGAFAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEI
CCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
LKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDC
HHHHCCCCCEEEEECCCCEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACI
HCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEE
ARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSANTPFESMSLPATVTATLLRGK
EECCCCCCCCCCCCCCCEEEECCCCCEEEECHHHHCCCCCCCHHHCCCCHHHHHHHHHCE
VTARDGKIRA
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972